6XTX: Human CMG

CryoEM structure of human CMG bound to ATPgammaS and DNA. Determined by electron microscopy at 3.29 Å resolution. Released 27 May 2020.

Method: Electron microscopy
Resolution: 3.29 Å
Organisms: Homo sapiens, synthetic construct
Chains: 12
Atoms: 40,834
Mol. weight: 742.89 kDa
Ligands: ZN, ADP, AGS, MG
Released: 27 May 2020

Explore 6XTX in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6XTX contains 233 α-helices and 236 β-strands across 11 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 2: 32 helices, 33 β-strands

Element	Residues	Length	Sheet
α-helix	182-186	5
α-helix	189-204	16
β-strand	207	1	1
β-strand	213	1	1
α-helix	214-223	10
β-strand	229-233	5	2
α-helix	234-240	7
α-helix	244-247	4
α-helix	248-250	3
α-helix	252-270	19
α-helix	274-276	3
β-strand	282-286	5	2
β-strand	291	1	3
α-helix	299-301	3
β-strand	307	1	3
β-strand	310-315	6	4
β-strand	321-324	4	5
β-strand	327-328	2	6
β-strand	335	1	6
β-strand	340	1	5
β-strand	362-363	2	6
β-strand	369-371	3	5
β-strand	374-379	6	4
β-strand	393-398	6	4
β-strand	411-412	2	4
β-strand	415	1	3
β-strand	416-422	7	4
α-helix	426-430	5
β-strand	434	1	7
β-strand	435-441	7	4
α-helix	461-468	8
α-helix	473-478	6
α-helix	489-500	12
β-strand	519-521	3	8
α-helix	529-539	11
β-strand	544-547	4	8
β-strand	559-562	4	9
β-strand	569-572	4	9
β-strand	583-587	5	8
α-helix	589-591	3
α-helix	594-605	12
β-strand	608-612	5	10
β-strand	617-621	5	10
β-strand	625-629	5	8
α-helix	633-635	3
α-helix	643-646	4
α-helix	651-654	4
β-strand	659	1	8
α-helix	669-682	14
α-helix	719-729	11
β-strand	734	1	11
α-helix	744-755	12
α-helix	764-774	11
α-helix	775-777	3
α-helix	778-781	4
β-strand	785	1	11
α-helix	790-803	14
α-helix	810-814	5
α-helix	815-819	5
α-helix	820-821	2
α-helix	830-848	19
β-strand	858	1	12
α-helix	864-872	9
α-helix	878-882	5
β-strand	902	1	12

Chain 3: 22 helices, 36 β-strands

Element	Residues	Length	Sheet
α-helix	57-69	13
α-helix	78-85	8
β-strand	91-92	2	13
β-strand	95	1	14
α-helix	96-102	7
α-helix	104-110	7
α-helix	114-121	8
α-helix	123-130	8
α-helix	136-138	3
β-strand	144-145	2	13
β-strand	148	1	14
β-strand	169	1	15
β-strand	172-174	3	16
β-strand	175-176	2	15
β-strand	185-190	6	17
β-strand	201-203	3	17
β-strand	237-239	3	17
β-strand	241	1	18
β-strand	244-247	4	15
α-helix	250-252	3
β-strand	261-264	4	15
β-strand	267	1	18
β-strand	280-282	3	16
β-strand	284-289	6	15
β-strand	296-297	2	19
β-strand	300-301	2	20
β-strand	302-307	6	15
β-strand	312	1	16
α-helix	323-335	13
α-helix	341-346	6
α-helix	356-367	12
β-strand	372	1	21
β-strand	380	1	21
β-strand	386-389	4	22
α-helix	396-406	11
β-strand	410-413	4	22
β-strand	418	1	23
β-strand	425-428	4	24
β-strand	437-440	4	24
α-helix	442-445	4
β-strand	450-454	5	22
α-helix	461-464	4
α-helix	465-467	3
β-strand	475-479	5	25
β-strand	484-488	5	25
β-strand	492-497	6	22
α-helix	498-499	2
α-helix	520-523	4
β-strand	526-529	4	22
α-helix	536-549	14
α-helix	610-620	11
β-strand	626	1	26
α-helix	632-642	11
β-strand	652-654	3	27
α-helix	660-673	14
β-strand	681	1	26
α-helix	689-698	10
β-strand	699-701	3	27

Chain 4: 26 helices, 31 β-strands

Element	Residues	Length	Sheet
α-helix	160-171	12
α-helix	192-202	11
β-strand	209	1	28
α-helix	214-218	5
α-helix	223-226	4
α-helix	230-232	3
α-helix	234-242	9
α-helix	243-245	3
β-strand	261	1	28
β-strand	283-284	2	29
β-strand	287-288	2	30
β-strand	298-301	4	31
β-strand	304-306	3	32
β-strand	316	1	31
β-strand	337-339	3	32
α-helix	340	1
β-strand	345-347	3	31
β-strand	351-355	5	29
β-strand	369-373	5	29
β-strand	387-388	2	30
β-strand	391-397	7	29
β-strand	400	1	33
β-strand	408-409	2	33
β-strand	411	1	34
β-strand	413-420	8	29
α-helix	443-452	10
α-helix	459-463	5
α-helix	474-482	9
β-strand	506-510	5	35
α-helix	517-523	7
β-strand	531-533	3	35
β-strand	538	1	36
α-helix	540-543	4
β-strand	547-549	3	37
β-strand	556-558	3	37
α-helix	563-566	4
β-strand	568	1	38
β-strand	571-573	3	35
α-helix	581-584	4
α-helix	587-590	4
β-strand	595-599	5	39
β-strand	604-608	5	39
β-strand	610	1	38
β-strand	613-617	5	35
α-helix	620-622	3
α-helix	630-633	4
α-helix	638-641	4
β-strand	646-650	5	35
α-helix	656-668	13
α-helix	687-696	10
β-strand	701	1	40
α-helix	704-710	7
α-helix	712-724	13
α-helix	731-745	15
α-helix	746-748	3
β-strand	752	1	40
α-helix	756-766	11

Chain 5: 24 helices, 33 β-strands

Element	Residues	Length	Sheet
α-helix	22-31	10
α-helix	36-39	4
β-strand	43-44	2	41
β-strand	52-53	2	41
α-helix	54-63	10
β-strand	71-73	3	42
α-helix	74-80	7
α-helix	84-90	7
α-helix	93-106	14
α-helix	108-111	4
α-helix	112	1
α-helix	114	1
β-strand	127-129	3	42
α-helix	137-139	3
α-helix	142-144	3
β-strand	148	1	43
β-strand	151-158	8	44
β-strand	162-172	11	20
β-strand	178-183	6	20
β-strand	189	1	45
β-strand	191-192	2	19
β-strand	212-224	13	20
β-strand	227-230	4	44
α-helix	231-232	2
α-helix	233-235	3
α-helix	241-243	3
β-strand	244-246	3	44
β-strand	247-248	2	43
β-strand	262-265	4	44
β-strand	267-271	5	43
β-strand	273	1	45
β-strand	289	1	5
β-strand	292-296	5	43
β-strand	301	1	44
α-helix	316-327	12
α-helix	331-337	7
α-helix	348-356	9
β-strand	364	1	46
β-strand	370	1	46
β-strand	376-380	5	47
α-helix	386-396	11
β-strand	401-404	4	47
β-strand	417-420	4	48
β-strand	427-430	4	48
β-strand	438-445	8	47
α-helix	452-464	13
β-strand	466-471	6	23
β-strand	474-479	6	23
β-strand	481-487	7	47
β-strand	517-519	3	47
α-helix	526-540	15
α-helix	556-566	11
β-strand	573-574	2	49
α-helix	576-597	22
α-helix	610-623	14
β-strand	631-632	2	49
α-helix	634-655	22

Chain 6: 33 helices, 31 β-strands

Element	Residues	Length	Sheet
α-helix	21-36	16
β-strand	39-40	2	50
β-strand	42	1	50
α-helix	45-47	3
α-helix	52-54	3
β-strand	60-62	3	51
α-helix	67-71	5
α-helix	76-82	7
α-helix	87-90	4
α-helix	92-95	4
α-helix	99-101	3
β-strand	111-113	3	51
β-strand	131	1	52
β-strand	137-138	2	52
β-strand	139	1	53
β-strand	143-144	2	52
α-helix	145-147	3
β-strand	148-154	7	7
β-strand	156-158	3	54
β-strand	164	1	54
β-strand	168-169	2	7
β-strand	191-193	3	54
β-strand	199-203	5	7
β-strand	204-209	6	52
β-strand	210	1	53
α-helix	212-214	3
α-helix	215-216	2
β-strand	223-228	6	52
β-strand	242-251	10	52
α-helix	254-256	3
β-strand	295-305	11	52
α-helix	322-328	7
α-helix	331-342	12
α-helix	346-349	4
α-helix	351-354	4
α-helix	362-373	12
β-strand	392-396	5	55
α-helix	403-412	10
β-strand	416-419	4	55
β-strand	424	1	39
α-helix	426-429	4
β-strand	431-436	6	56
β-strand	441-446	6	56
β-strand	456-459	4	55
α-helix	469-479	11
β-strand	481-485	5	57
β-strand	490-494	5	57
β-strand	498-503	6	55
α-helix	510-511	2
α-helix	516-518	3
α-helix	526-528	3
β-strand	533-536	4	55
α-helix	544-557	14
α-helix	569-578	10
α-helix	579-581	3
β-strand	585-586	2	58
α-helix	588-602	15
α-helix	603-605	3
α-helix	625-634	10
β-strand	639-640	2	58
α-helix	642-655	14
α-helix	721-727	7
α-helix	745-753	9
α-helix	765-779	15

Chain 7: 31 helices, 25 β-strands

Element	Residues	Length	Sheet
α-helix	9-19	11
β-strand	21-22	2	59
β-strand	30-31	2	59
α-helix	32-41	10
β-strand	47-51	5	60
α-helix	55-58	4
α-helix	62-66	5
α-helix	73-88	16
β-strand	135-139	5	60
α-helix	140-141	2
α-helix	154-156	3
β-strand	160-168	9	61
β-strand	176-183	8	34
β-strand	191-194	4	34
β-strand	199-200	2	33
α-helix	209-215	7
β-strand	221-230	10	34
β-strand	232-238	7	61
α-helix	248-251	4
β-strand	252-258	7	61
α-helix	265-266	2
β-strand	270-279	10	61
α-helix	280-281	2
β-strand	293	1	17
β-strand	296-305	10	61
α-helix	321-327	7
α-helix	332-338	7
α-helix	350-359	10
β-strand	377-381	5	62
α-helix	387-396	10
β-strand	401-405	5	62
α-helix	406-408	3
β-strand	409	1	25
α-helix	411-414	4
β-strand	416-420	5	63
β-strand	427-431	5	63
α-helix	433-436	4
β-strand	441-445	5	62
α-helix	452-454	3
α-helix	456-458	3
α-helix	459-463	5
β-strand	466-469	4	64
β-strand	470	1	36
β-strand	476-479	4	64
β-strand	483-486	4	62
α-helix	509-512	4
β-strand	517-521	5	62
α-helix	529-543	15
α-helix	553-555	3
α-helix	556-567	12
α-helix	575-577	3
α-helix	578-591	14
α-helix	606-611	6
α-helix	616-619	4
α-helix	627-636	10
α-helix	642-644	3

Chain A: 8 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	6-8	3
α-helix	10-13	4
α-helix	26-49	24
α-helix	56-58	3
α-helix	59-82	24
α-helix	85-92	8
α-helix	110-125	16
β-strand	147-148	2	65
β-strand	150	1	66
β-strand	151	1	67
β-strand	156-159	4	68
β-strand	167-169	3	68
β-strand	174-175	2	67
β-strand	177-178	2	65
α-helix	179-186	8
β-strand	193	1	66

Chain B: 9 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	3-10	8
β-strand	14-17	4	69
β-strand	23	1	70
β-strand	26-28	3	71
β-strand	31-33	3	71
β-strand	36	1	70
β-strand	42-45	4	69
α-helix	46-54	9
α-helix	70-80	11
α-helix	92-102	11
α-helix	110-124	15
α-helix	126-131	6
α-helix	134-137	4
β-strand	144-145	2	72
α-helix	150-155	6
α-helix	157-171	15

3 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA replication licensing factor MCM2	2	protein	904	Homo sapiens	P49736 (AlphaFold model)
DNA replication licensing factor MCM3	3	protein	853	Homo sapiens	P25205 (AlphaFold model)
DNA replication licensing factor MCM4	4	protein	883	Homo sapiens	P33991 (AlphaFold model)
DNA replication licensing factor MCM5	5	protein	734	Homo sapiens	P33992 (AlphaFold model)
DNA replication licensing factor MCM6	6	protein	821	Homo sapiens	Q14566
DNA replication licensing factor MCM7	7	protein	719	Homo sapiens	P33993
DNA replication complex GINS protein PSF1	A	protein	196	Homo sapiens	Q14691
DNA replication complex GINS protein PSF2	B	protein	222	Homo sapiens	Q9Y248
DNA replication complex GINS protein PSF3	C	protein	216	Homo sapiens	Q9BRX5
DNA replication complex GINS protein SLD5	D	protein	223	Homo sapiens	Q9BRT9
Cell division control protein 45 homolog	E	protein	566	Homo sapiens	O75419
DNA (5'-d(ptptptptptptptptptptp*t)-3')	M	DNA	70	synthetic construct

Sequence of entity 1 (2), FASTA

>6XTX_1 DNA replication licensing factor MCM2 (chains 2)
MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTE
GPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQR
DREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGH
SVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAR
EHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQL
HLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGP
FEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHN
NYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFAS
IAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVS
SRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSI
HEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDIL
CVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVL
KKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARI
HLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLV
AEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMI
LQQF

Sequence of entity 2 (3), FASTA

>6XTX_2 DNA replication licensing factor MCM3 (chains 3)
MLPRSPPLPRGNLWWREEFGSFRAGVESSWEPPRDFGGGSSLAAGMAGTVVLDDVELREA
QRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVA
FQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCS
LVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKD
HQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGT
FRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKK
AILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSG
VGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAK
AGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDR
EISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGT
KKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTA
RTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETE
DEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQ
KVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEEPFSSVEIQAALSKMQDD
NQVMVSEGIIFLI

Sequence of entity 3 (4), FASTA

>6XTX_3 DNA replication licensing factor MCM4 (chains 4)
MHHHHHHHHENLYFQGSSATMSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGE
DSTSTGELQPMPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVE
GTPRSGVRGTPVRQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVA
ACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDK
NLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDID
QLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALI
HNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIR
VNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYE
RLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLL
QYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMN
ESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTL
LSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMP
RLSEEASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEE
AKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKY
QQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL

Sequence of entity 4 (5), FASTA

>6XTX_4 DNA replication licensing factor MCM5 (chains 5)
MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELK
RHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEV
LQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLT
NIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGE
MPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQ
VDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGG
SRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMR
DPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNS
RCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLH
VSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDS
DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGV
EGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQLMLRRGE
IQHRMQRKVLYRLK

Sequence of entity 5 (6), FASTA

>6XTX_5 DNA replication licensing factor MCM6 (chains 6)
MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNT
LVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTR
HKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNIC
RNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGD
KCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLA
CCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHG
NDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTS
GKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQ
TISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDEC
NEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKH
LRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVE
TPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEY
CRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVIHRL
THYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLED

Sequence of entity 6 (7), FASTA

>6XTX_6 DNA replication licensing factor MCM7 (chains 7)
MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDP
ELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVR
SPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVA
TYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEH
SDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEA
HRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVG
GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLR
DSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNA
RCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYV
HQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATY
TSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADV
IFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV

Sequence of entity 7 (A), FASTA

>6XTX_7 DNA replication complex GINS protein PSF1 (chains A)
MFCEKAMELIRELHRAPEGQLPAFNEDGLRQVLEEMKALYEQNQSDVNEAKSGGRSDLIP
TIKFRHCSLLRNRRCTVAYLYDRLLRIRALRWEYGSVLPNALRFHMAAEEMEWFNNYKRS
LATYMRSLGGDEGLDITQDMKPPKSLYIEVRCLKDYGEFEVDDGTSVLLKKNSQHFLPRW
KCEQLIRQGVLEHILS

Sequence of entity 8 (B), FASTA

>6XTX_8 DNA replication complex GINS protein PSF2 (chains B)
MDAAEVEFLAEKELVTIIPNFSLDKIYLIGGDLGPFNPGLPVEVPLWLAINLKQRQKCRL
LPPEWMDVEKLEKMRDHERKEETFTPMPSPYYMELTKLLLNHASDNIPKADEIRTLVKDM
WDTRIAKLRVSADSFVRQQEAHAKLDNLTLMEINTSGTFLTQALNHMYKLRTNLQPLEST
QSQDFENLYFQGSAWSHPQFEKGGGSGGGSGGSAWSHPQFEK

Sequence of entity 9 (C), FASTA

>6XTX_9 DNA replication complex GINS protein PSF3 (chains C)
MSEAYFRVESGALGPEENFLSLDDILMSHEKLPVRTETAMPRLGAFFLERSAGAETDNAV
PQGSKLELPLWLAKGLFDNKRRILSVELPKIYQEGWRTVFSADPNVVDLHKMGPHFYGFG
SQLLHFDSPENADISQSLLQTFIGRFRRIMDSSQNAYNEDTSALVARLDEMERGLFQTGQ
KGLNDFQCWEKGQASQITASNLVQNYKKRKFTDMED

Sequence of entity 10 (D), FASTA

>6XTX_10 DNA replication complex GINS protein SLD5 (chains D)
MTEEVDFLGQDSDGGSEEVVLTPAELIERLEQAWMNEKFAPELLESKPEIVECVMEQLEH
MEENLRRAKREDLKVSIHQMEMERIRYVLSSYLRCRLMKIEKFFPHVLEKEKTRPEGEPS
SLSPEELAFAREFMANTESYLKNVALKHMPPNLQKVDLFRAVPKPDLDSYVFLRVRERQE
NILVEPDTDEQRDYVIDLEKGSQHLIRYKTIAPLVASGAVQLI

Sequence of entity 11 (E), FASTA

>6XTX_11 Cell division control protein 45 homolog (chains E)
MFVSDFRKEFYEVVQSQRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELET
AFLEHKEQFHYFILINCGANVDLLDILQPDEDTIFFVCDTHRPVNVVNVYNDTQIKLLIK
QDDDLEVPAYEDIFRDEEEDEEHSGNDSDGSEPSEKRTRLEEEIVEQTMRRRQRREWEAR
RRDILFDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVT
DVGVLQRHVSRHNHRNEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARF
KLWSVHGQKRLQEFLADMGLPLKQVKQKFQAMDISLKENLREMIEQSANKFGMKDMRVQT
FSIHFGFKHKFLASDVVFATMSLMESPEKDGSGTDHFIQALDSLSRSNLDKLYHGLELAK
KQLRATQQTIASCLCTNLVISQGPFLYCSLMEGTPDVMLFSRPASLSLLSKHLLKSFVCS
TKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHN
HFDLSVIELKAEDRSKFLDALISLLS

Sequence of entity 12 (M), FASTA

>6XTX_12 DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3') (chains M)
CGTTTTACAACGTCGTGACTGGGCACTTGATCGGCCAACCTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTT

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	5
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	2
AGS	Phosphothiophosphoric acid-adenylate ester	C10 H16 N5 O12 P3 S	3
MG	Magnesium ion	Mg	3

Primary citation

CryoEM structures of human CMG-ATP gamma S-DNA and CMG-AND-1 complexes. Rzechorzek, N.J., Hardwick, S.W., Jatikusumo, V.A. et al. Nucleic Acids Res (2020) 48:6980-6995. DOI 10.1093/nar/gkaa429 · PubMed

Other PDB entries of the same protein (UniProt P49736 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6YA7 1.67 Å, Cdc7-Dbf4 bound to an Mcm2-S40 derived bivalent substrate
7CIZ 1.8 Å, Crystal structure of DNAJC9 HBD helix2 in complex with H3.3-H4 dimer and MCM2 HBD
5BNX 2.31 Å, Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.3-H4 dimer
5JA4 2.42 Å, Crystal structure of human TONSL and MCM2 HBDs binding to a histone H3-H4 tetramer
7CJ0 2.5 Å, Crystal structure of DNAJC9 HBD in complex with H3.3-H4 dimer and MCM2 HBD
7W1Y 2.59 Å, Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA)
9E2Z 2.6 Å, Cryo-EM structure of human CMG helicase stalled at G4-containing DNA template
5BNV 2.79 Å, Crystal structure of Human MCM2 HBD chaperoning a histone H3-H4 tetramer
7PLO 2.8 Å, H. sapiens replisome-CUL2/LRR1 complex
8W0F 2.8 Å, Cryo-EM structure of a human MCM2-7 double hexamer on dsDNA
4UUZ 2.9 Å, MCM2-histone complex
5BO0 2.91 Å, Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.2-H4 dimer

Browse structure collections

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