7CIZ: DNAJC9 HBD helix2
Crystal structure of DNAJC9 HBD helix2 in complex with H3.3-H4 dimer and MCM2 HBD. Determined by X-ray diffraction at 1.8 Å resolution. Released 14 Apr 2021.
- Method
- X-ray diffraction
- Resolution
- 1.8 Å
- Organism
- Homo sapiens
- Chains
- 12
- Atoms
- 6,707
- Mol. weight
- 109.99 kDa
- Released
- 14 Apr 2021
Explore 7CIZ in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7CIZ contains 33 α-helices and 18 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 3 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 64-76 | 13 | |
| β-strand | 83-84 | 2 | 1 |
| α-helix | 86-113 | 28 | |
| β-strand | 118-119 | 2 | 2 |
| α-helix | 121-130 | 10 | |
Chain B: 4 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 25-28 | 4 | |
| α-helix | 31-40 | 10 | |
| β-strand | 45-47 | 3 | 2 |
| α-helix | 50-75 | 26 | |
| β-strand | 80-81 | 2 | 1 |
| α-helix | 83-96 | 14 | |
Chain C: 3 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 69-71 | 3 | 2 |
| α-helix | 77-81 | 5 | |
| β-strand | 95 | 1 | 1 |
| α-helix | 103-106 | 4 | |
| α-helix | 107-124 | 18 | |
Chains D, H and L: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 213-242 | 30 | |
Chain E: 3 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 64-75 | 12 | |
| β-strand | 83-84 | 2 | 3 |
| α-helix | 86-113 | 28 | |
| β-strand | 118-119 | 2 | 4 |
| α-helix | 121-130 | 10 | |
Chain F: 4 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 25-28 | 4 | |
| α-helix | 31-40 | 10 | |
| β-strand | 45-47 | 3 | 4 |
| α-helix | 49-75 | 27 | |
| β-strand | 80-81 | 2 | 3 |
| α-helix | 83-96 | 14 | |
Chain G: 2 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 69-71 | 3 | 4 |
| α-helix | 77-81 | 5 | |
| β-strand | 95 | 1 | 3 |
| α-helix | 107-124 | 18 | |
Chain I: 3 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 64-76 | 13 | |
| β-strand | 83-84 | 2 | 5 |
| α-helix | 86-113 | 28 | |
| β-strand | 118-119 | 2 | 6 |
| α-helix | 121-131 | 11 | |
2 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Histone H3.3 | A, E, I | protein | 79 | Homo sapiens | P84243 (AlphaFold model) |
| Histone H4 | B, F, J | protein | 102 | Homo sapiens | P62805 (AlphaFold model) |
| DNA replication licensing factor MCM2 | C, G, K | protein | 70 | Homo sapiens | P49736 (AlphaFold model) |
| DnaJ homolog subfamily C member 9 | D, H, L | protein | 75 | Homo sapiens | Q8WXX5 (AlphaFold model) |
Sequence of entity 1 (A, E, I), FASTA
>7CIZ_1 Histone H3.3 (chains A, E, I)
STELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKR
VTIMPKDIQLARRIRGERA
Sequence of entity 2 (B, F, J), FASTA
>7CIZ_2 Histone H4 (chains B, F, J)
SGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKV
FLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
Sequence of entity 3 (C, G, K), FASTA
>7CIZ_3 DNA replication licensing factor MCM2 (chains C, G, K)
GPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQR
DREAGRGLGR
Sequence of entity 4 (D, H, L), FASTA
>7CIZ_4 DnaJ homolog subfamily C member 9 (chains D, H, L)
GPLGSKESKQKMNARKRRAQEEAKEAEMSRKELGLDEGVDSLKAAIQSRQKDRQKEMDNF
LAQMEAKYSKSSKGG
Primary citation
DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network. Hammond, C.M., Bao, H., Hendriks, I.A. et al. Mol Cell (2021) 81:2533-2548.e9. DOI 10.1016/j.molcel.2021.03.041 · PubMed
Other PDB entries of the same protein (UniProt P84243 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 3QL9 0.93 Å, Monoclinic complex structure of ATRX ADD bound to histone H3K9me3 peptide
- 4GNE 1.47 Å, Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3 peptide 1-7
- 4L58 1.48 Å, Crystal structure of the MLL5 PHD finger in complex with H3K4me3
- 5JLB 1.5 Å, Crystal structure of SETD2 bound to histone H3.3 K36I peptide
- 4GNF 1.55 Å, Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3 peptide 1-15
- 3QLA 1.6 Å, Hexagonal complex structure of ATRX ADD bound to H3K9me3 peptide
- 3MUL 1.65 Å, Crystal structure of Brd4 bromodomain 1 with butyrylated histone H3-K(buty)14
- 9G4A 1.65 Å, Structure of human SETD2 T1663M mutant in complex with SAM and H3K36M peptide
- 4GNG 1.73 Å, Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3K9me3 peptide
- 3MUK 1.75 Å, Crystal structure of Brd4 bromodomain 1 with propionylated histone H3-K(prop)23
- 4QQ4 1.75 Å, CW-type zinc finger of MORC3 in complex with the amino terminus of histone H3
- 1PDQ 1.76 Å, Polycomb chromodomain complexed with the histone H3 tail containing trimethyllysine 27.
Browse structure collections
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