6ZFD: 14-3-3 zeta

14-3-3 zeta bound to the phosphorylated 18E6 C-terminus. Determined by X-ray diffraction at 1.9 Å resolution. Released 17 Feb 2021.

Method: X-ray diffraction
Resolution: 1.9 Å
Organisms: Homo sapiens, Human papillomavirus type 18
Chains: 2
Atoms: 4,467
Mol. weight: 55.16 kDa
Released: 17 Feb 2021

Explore 6ZFD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6ZFD contains 30 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 15 helices, 0 β-strands

Element	Residues	Length
α-helix	3-15	13
α-helix	19-31	13
α-helix	35-37	3
α-helix	38-68	31
α-helix	73-100	28
α-helix	101-105	5
α-helix	106-108	3
α-helix	112-132	21
α-helix	138-159	22
α-helix	165-176	12
α-helix	177-181	5
α-helix	185-200	16
α-helix	203-205	3
α-helix	208-229	22
α-helix	235-236	2

Chain B: 15 helices, 0 β-strands

Element	Residues	Length
α-helix	3-15	13
α-helix	19-31	13
α-helix	35-37	3
α-helix	38-67	30
α-helix	74-100	27
α-helix	101-105	5
α-helix	106-108	3
α-helix	112-132	21
α-helix	136-159	24
α-helix	165-176	12
α-helix	177-181	5
α-helix	185-200	16
α-helix	203-205	3
α-helix	208-229	22
α-helix	234-237	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
14-3-3 protein zeta/delta,Protein E6	A, B	protein	243	Homo sapiens, Human papillomavirus type 18	P06463 (AlphaFold model), P63104 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>6ZFD_1 14-3-3 protein zeta/delta,Protein E6 (chains A, B)
GPHMDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRS
AWRVVSSIEQKTEGAAAAQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVF
YLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISAAAMQPTHPIRLGLALNFSVF
YYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTGGGGRRRE
TQV

Primary citation

Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Gogl, G., Tugaeva, K.V., Eberling, P. et al. Nat Commun (2021) 12:1677-1677. DOI 10.1038/s41467-021-21908-8 · PubMed

Other PDB entries of the same protein (UniProt P06463 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4JOR 1.34 Å, CFTR Associated Ligand (CAL) PDZ domain bound to HPV18 E6 oncoprotein C-terminal peptide…
5K4F 1.36 Å, CAL PDZ mutant C319A with a peptide
5IC3 1.7 Å, CAL PDZ domain with peptide and inhibitor
6ZFG 1.85 Å, 14-3-3 zeta chimera with 18E6 and fusicoccin
8OEP 1.87 Å, Crystal structure of the PTPN3 PDZ domain bound to the HPV18 E6 oncoprotein C-terminal…
6SJV 2.03 Å, Structure of HPV18 E6 oncoprotein in complex with mutant E6AP LxxLL motif
2I04 2.15 Å, X-ray crystal structure of MAGI-1 PDZ1 bound to the C-terminal peptide of HPV18 E6
2I0L 2.31 Å, X-ray crystal structure of Sap97 PDZ2 bound to the C-terminal peptide of HPV18 E6.
2I0I 2.8 Å, X-ray crystal structure of Sap97 PDZ3 bound to the C-terminal peptide of HPV18 E6
8B82 2.8 Å, Crystal structure of Scribble PDZ1 with human papillomavirus strain 16 E6 peptide

Browse structure collections

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