7A31: Proto-oncogene tyrosine-protein kinase Src

Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 4.5. Determined by X-ray diffraction at 0.94 Å resolution. Released 25 Aug 2021.

Method: X-ray diffraction
Resolution: 0.94 Å
Organism: Gallus gallus
Chains: 2
Atoms: 1,103
Mol. weight: 13.44 kDa
Released: 25 Aug 2021

Explore 7A31 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7A31 contains 4 α-helices and 16 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	86-88	3	1
β-strand	92	1	2
β-strand	99	1	1
α-helix	100-101	2
β-strand	102	1	2
β-strand	107-112	6	1
β-strand	118-123	6	1
β-strand	129-133	5	1
α-helix	134-136	3
β-strand	137-139	3	1

Chain B: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	86-88	3	3
β-strand	92	1	4
β-strand	99	1	3
α-helix	100-101	2
β-strand	102	1	4
β-strand	107-115	9	3
β-strand	118-123	6	3
β-strand	129-133	5	3
α-helix	134-136	3
β-strand	137-138	2	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Proto-oncogene tyrosine-protein kinase Src	A, B	protein	60	Gallus gallus	P00523 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>7A31_1 Proto-oncogene tyrosine-protein kinase Src (chains A, B)
GVTTFVALYDYEARTEDDLSFKKGERLQILNSSEGDWWLAHSLTTGQTGYIPSNYVAPSD

Primary citation

Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 4.5. Camara-Artigas, A., Plaza-Garrido, M., Salinas-Garcia, M.C. To be published.

Other PDB entries of the same protein (UniProt P00523 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6XVM 0.9 Å, Crystal structure of c-Src SH3 domain without ATCUN motif: monomer 2
5OAV 0.95 Å, High resolution crystal structure of the c-Src-SH3 domain mutant E93V in complex with…
7A33 0.96 Å, Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 3.0
4RTZ 0.98 Å, Crystal structure of the c-Src-SH3 domain in complex with the high affinity peptide VSL12
4HVU 0.98 Å, Crystal structure of the T98D c-Src-SH3 domain mutant in complex with the high affinity…
4HVW 0.98 Å, Crystal structure of the T98E c-Src-SH3 domain mutant in complex with the high affinity…
4OMO 1.04 Å, Crystal structure of the c-Src tyrosine kinase SH3 domain mutant Q128E
6XX4 1.05 Å, Crystal structure of the c-Src SH3 domain H122R-Q128E mutant in complex with Ni(II) at…
4HVV 1.1 Å, Crystal structure of the T98E c-Src-SH3 domain mutant in complex with the high affinity…
7A32 1.15 Å, Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 7.0
5ECA 1.16 Å, Crystal structure of a chimeric c-Src-SH3 domain with the sequence of the RT-loop from…
5OB0 1.17 Å, Crystal structure of the c-Src-SH3 domain Q128E mutant in complex with the high affinity…

Browse structure collections

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