7A5P: Unknown
Human C Complex Spliceosome - Medium-resolution PERIPHERY. Determined by electron microscopy at 5.0 Å resolution. Released 14 Oct 2020.
- Method
- Electron microscopy
- Resolution
- 5.0 Å
- Organism
- Homo sapiens
- Chains
- 48
- Atoms
- 52,703
- Mol. weight
- 3093.74 kDa
- Released
- 14 Oct 2020
Explore 7A5P in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7A5P contains 438 α-helices and 397 β-strands across 44 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 8: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-24 | 19 | |
| α-helix | 28-32 | 5 | |
| α-helix | 43-50 | 8 | |
| α-helix | 56-69 | 14 | |
| α-helix | 93-106 | 14 | |
Chain a: 1 helix, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-12 | 8 | |
| β-strand | 17-22 | 6 | 1 |
| β-strand | 27-35 | 9 | 1 |
| β-strand | 41-49 | 9 | 1 |
| β-strand | 55-63 | 9 | 1 |
| β-strand | 68-73 | 6 | 1 |
Chain A: 18 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 1766-1771 | 6 | |
| β-strand | 1777-1781 | 5 | 2 |
| β-strand | 1787 | 1 | 3 |
| β-strand | 1790 | 1 | 4 |
| β-strand | 1800 | 1 | 4 |
| β-strand | 1803 | 1 | 3 |
| β-strand | 1806 | 1 | 5 |
| β-strand | 1808-1810 | 3 | 2 |
| β-strand | 1816-1819 | 4 | 2 |
| β-strand | 1821 | 1 | 5 |
| α-helix | 1833-1851 | 19 | |
| β-strand | 1860-1863 | 4 | 2 |
| α-helix | 1866-1868 | 3 | |
| α-helix | 1869-1872 | 4 | |
| α-helix | 1882 | 1 | |
| β-strand | 1883-1885 | 3 | 2 |
| α-helix | 1902-1907 | 6 | |
| β-strand | 1915-1918 | 4 | 2 |
| α-helix | 1932-1942 | 11 | |
| α-helix | 1951-1954 | 4 | |
| α-helix | 1973-1995 | 23 | |
| α-helix | 2069-2075 | 7 | |
| α-helix | 2080-2088 | 9 | |
| α-helix | 2092-2094 | 3 | |
| β-strand | 2103-2105 | 3 | 6 |
| α-helix | 2108-2116 | 9 | |
| α-helix | 2123-2124 | 2 | |
| β-strand | 2125-2131 | 7 | 6 |
| β-strand | 2139-2146 | 8 | 6 |
| β-strand | 2150 | 1 | 7 |
| β-strand | 2151-2152 | 2 | 8 |
| β-strand | 2157-2158 | 2 | 8 |
| α-helix | 2162-2164 | 3 | |
| β-strand | 2173-2181 | 9 | 6 |
| α-helix | 2190-2202 | 13 | |
| β-strand | 2213-2217 | 5 | 6 |
| β-strand | 2225-2227 | 3 | 6 |
| β-strand | 2228-2230 | 3 | 9 |
| α-helix | 2232-2240 | 9 | |
| α-helix | 2253-2255 | 3 | |
| β-strand | 2256-2258 | 3 | 9 |
| β-strand | 2260-2262 | 3 | 6 |
| β-strand | 2270-2274 | 5 | 6 |
| β-strand | 2280 | 1 | 7 |
| β-strand | 2296-2299 | 4 | 6 |
Chain b: 1 helix, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 16-21 | 6 | 1 |
| β-strand | 26-33 | 8 | 1 |
| β-strand | 40-48 | 9 | 1 |
| β-strand | 64-72 | 9 | 1 |
| α-helix | 74-76 | 3 | |
| β-strand | 77-84 | 8 | 1 |
Chain c: 4 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-8 | 6 | |
| β-strand | 14-19 | 6 | 1 |
| β-strand | 24-32 | 9 | 1 |
| β-strand | 38-46 | 9 | 1 |
| β-strand | 53-60 | 8 | 1 |
| α-helix | 62-64 | 3 | |
| β-strand | 65-69 | 5 | 1 |
| α-helix | 70-71 | 2 | |
| α-helix | 76-79 | 4 | |
Chain C: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 304-316 | 13 | |
Chain d: 3 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 21-26 | 6 | |
| α-helix | 30-38 | 9 | |
| β-strand | 41-46 | 6 | 1 |
| β-strand | 51-59 | 9 | 1 |
| β-strand | 65-73 | 9 | 1 |
| β-strand | 93-101 | 9 | 1 |
| α-helix | 103-105 | 3 | |
| β-strand | 106-111 | 6 | 1 |
Chains e and j: 2 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 17-27 | 11 | |
| β-strand | 30-35 | 6 | 1 |
| β-strand | 41-50 | 10 | 1 |
| β-strand | 56-65 | 10 | 1 |
| β-strand | 70-79 | 10 | 1 |
| α-helix | 81-83 | 3 | |
| β-strand | 84-90 | 7 | 1 |
34 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| U2 snRNA | 2 | RNA | 975 | Homo sapiens | |
| U5 snRNA | 5 | RNA | 116 | Homo sapiens | |
| U6 snRNA | 6 | RNA | 106 | Homo sapiens | |
| Unknown | 8 | protein | 204 | Homo sapiens | |
| Pre-mRNA-processing-splicing factor 8 | A | protein | 2335 | Homo sapiens | Q6P2Q9 (AlphaFold model) |
| SNW domain-containing protein 1 | C | protein | 536 | Homo sapiens | Q13573 (AlphaFold model) |
| Pre-mRNA-processing factor 17 | E | protein | 579 | Homo sapiens | O60508 (AlphaFold model) |
| Pre-mRNA-processing factor 19 | G, H, I, J | protein | 504 | Homo sapiens | Q9UMS4 (AlphaFold model) |
| Pre-mRNA-splicing factor SPF27 | K | protein | 225 | Homo sapiens | O75934 |
| Cell division cycle 5-like protein | L | protein | 802 | Homo sapiens | Q99459 |
| Pre-mRNA-splicing factor SYF1 | M | protein | 855 | Homo sapiens | Q9HCS7 |
| Pre-mRNA-splicing factor SYF2 | N | protein | 243 | Homo sapiens | O95926 |
26 more molecules are not listed.
Sequence of entity 1 (2), FASTA
>7A5P_1 U2 snRNA (chains 2)
AACGGCGGAGGCCACGCCCUCUGUGAAAGGGCGGGGCAUGCAAAUUCGAAAUGAAAGCCC
GGGAACGCCGGAAGAAGCACGGGUGUAAGAUUUCCCUUUUCAAAGGCGGAGAAUAAGAAA
UCAGCCCGAGAGUGUAAGGGCGUCAAUAGCGCUGUGGACGAGACAGAGGGAAUGGGGCAA
GGAGCGAGGCUGGGGCUCUCACCGCGACUUGAAUGUGGAUGAGAGUGGGACGGUGACGGC
GGGCGCGAAGGCGAGCGCAUCGCUUCUCGGCCUUUUGGCUAAGAUCAAGUGUAGUAUCUG
UUCUUAUCAGUUUAAUAUCUGAUACGUCCUCUAUCCGAGGACAAUAUAUUAAAUGGAUUU
UUGGAGCAGGGAGAUGGAAUAGGAGCUUGCUCCGUCCACUCCACGCAUCGACCUGGUAUU
GCAGUACCUCCAGGAACGGUGCACCCCCUCCGGGGUACAACGUGUUUCCUAAAAGUAGAG
GGAGGUGAGAGACGGUAGCACCUGCGGGGCGGCUUGCACGCCGAGUGCCUGUGACGCGCC
GGCUUGACUUAACUGCUUCCCUGAAGUACCGUGAGGUUCCUGAUGUGCGGGCGGUAGACG
GUAGGCUUAUGCGGCACGCUUUCGUUUCCACCGUGGCUACUGCGCUUUGGGAAGGCCACG
ACCUCCUCCUUUGGGGAGGUCCUUAGGAUCUCAGCUUGGCAGUCGAGUGGGUGGCGACCU
UUUAAAGGAAUGGGACCCACCCGGAGUUCUUCUUUCUCCUGUCUCUCUCUCUCUCUCUCU
CUCUCUCUCUCUCUCUCUCUCUUUCUCUCUCUCUCUCUGUCUCUCCGUCUCUCUGUGUCU
GUCUCUGUCUCUCUGUCUCUCUCUCUCUCUCUCUCUCUCUCUCCUCUCUCUGUCUCUCUC
UCUCUUUCCCCCCCCCUCCCCGCCUCUCCCUCGCUCUCUCUUUUGGUUUCCCCCACCCCC
UCCCAAGUUCUGGGG
Sequence of entity 2 (5), FASTA
>7A5P_2 U5 snRNA (chains 5)
AUACUCUGGUUUCUCUUCAGAUCGCAUAAAUCUUUCGCCUUUUACUAAAGAUUUCCGUGG
AGAGGAACAACUCUGAGUCUUAACCCAAUUUUUUGAGCCUUGCCUUGGCAAGGCUA
Sequence of entity 3 (6), FASTA
>7A5P_3 U6 snRNA (chains 6)
GUGCUCGCUUCGGCAGCACAUAUACUAAAAUUGGAACGAUACAGAGAAGAUUAGCAUGGC
CCCUGCGCAAGGAUGACACGCAAAUUCGUGAAGCGUUCCAUAUUUU
Sequence of entity 4 (8), FASTA
>7A5P_4 UNKNOWN (chains 8)
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX
Sequence of entity 5 (A), FASTA
>7A5P_5 Pre-mRNA-processing-splicing factor 8 (chains A)
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKED
MPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLY
HITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYR
LANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDIN
KIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRR
ALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATK
FFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMR
QIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQF
EGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCW
KANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLT
RLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLI
LALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMD
LYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGIN
NLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYK
DMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATE
AAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARM
RLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKC
RTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIV
NKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPK
ELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFI
DSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRT
DFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEG
LFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGI
FMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSY
KMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYA
RAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPAL
YVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTT
KPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQ
IIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLY
DDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVE
VQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLT
ATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKET
GYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLP
GQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTP
GSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWN
YNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA
Sequence of entity 6 (C), FASTA
>7A5P_6 SNW domain-containing protein 1 (chains C)
MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGD
GGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLV
PKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYT
PSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVK
EQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKARE
AVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRR
KERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDS
GFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSG
SDRRQRGREGPVQFEEDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE
Sequence of entity 7 (E), FASTA
>7A5P_7 Pre-mRNA-processing factor 17 (chains E)
MSAAIAALAASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEV
AVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHI
NDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKK
FKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTI
LHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLS
GHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD
TETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGA
VNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQS
MDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTT
KLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD
Sequence of entity 8 (G, H, I, J), FASTA
>7A5P_8 Pre-mRNA-processing factor 19 (chains G, H, I, J)
MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHP
IRPKPPSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARL
TKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKA
TVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTG
GADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQ
VVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP
DGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD
LRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTG
VAFGHHAKFIASTGMDRSLKFYSL
Sequence of entity 9 (K), FASTA
>7A5P_9 Pre-mRNA-splicing factor SPF27 (chains K)
MAGTGLVAGEVVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSA
FETDIMRNEFERLAARQPIELLSMKRYELPAPSSGQKNDITAWQECVNNSMAQLEHQAVR
IENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHIQDLNWQRKNMQLTAGSKLRE
MESNWVSLVSKNYEIERTIVQLENEIYQIKQQHGEANKENIRQDF
Sequence of entity 10 (L), FASTA
>7A5P_10 Cell division cycle 5-like protein (chains L)
MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKK
TEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKAAQRDNEEETTDDP
RKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEAR
RLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFR
KLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAP
QISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSVALRTPRTPASQD
RILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGA
EGLTPRSGTTPKPVINSTPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGL
LGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKA
VQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKG
KTVGFGTNNSEHITYLEHNPYEKFSKEELKKAQDVLVQEMEVVKQGMSHGELSSEAYNQV
WEECYSQVLYLPGQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKIL
LGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQER
EKELQHRYADLLLEKETLKSKF
Sequence of entity 11 (M), FASTA
>7A5P_11 Pre-mRNA-splicing factor SYF1 (chains M)
MVVMARLSRPERPDLVFEEEDLPYEEEIMRNQFSVKCWLRYIEFKQGAPKPRLNQLYERA
LKLLPCSYKLWYRYLKARRAQVKHRCVTDPAYEDVNNCHERAFVFMHKMPRLWLDYCQFL
MDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHPLPETAVRGYRRFLKLSPESA
EEYIEYLKSSDRLDEAAQRLATVVNDERFVSKAGKSNYQLWHELCDLISQNPDKVQSLNV
DAIIRGGLTRFTDQLGKLWCSLADYYIRSGHFEKARDVYEEAIRTVMTVRDFTQVFDSYA
QFEESMIAAKMETASELGREEEDDVDLELRLARFEQLISRRPLLLNSVLLRQNPHHVHEW
HKRVALHQGRPREIINTYTEAVQTVDPFKATGKPHTLWVAFAKFYEDNGQLDDARVILEK
ATKVNFKQVDDLASVWCQCGELELRHENYDEALRLLRKATALPARRAEYFDGSEPVQNRV
YKSLKVWSMLADLEESLGTFQSTKAVYDRILDLRIATPQIVINYAMFLEEHKYFEESFKA
YERGISLFKWPNVSDIWSTYLTKFIARYGGRKLERARDLFEQALDGCPPKYAKTLYLLYA
QLEEEWGLARHAMAVYERATRAVEPAQQYDMFNIYIKRAAEIYGVTHTRGIYQKAIEVLS
DEHAREMCLRFADMECKLGEIDRARAIYSFCSQICDPRTTGAFWQTWKDFEVRHGNEDTI
KEMLRIRRSVQATYNTQVNFMASQMLKVSGSATGTVSDLAPGQSGMDDMKLLEQRAEQLA
AEAERDQPLRAQSKILFVRSDASREELAELAQQVNPEEIQLGEDEDEDEMDLEPNEVRLE
QQSVPAAVFGSLKED
Sequence of entity 12 (N), FASTA
>7A5P_12 Pre-mRNA-splicing factor SYF2 (chains N)
MAAIAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDK
RLKLPANWEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNP
DLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEID
RMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERG
TAV
Primary citation
Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome. Bertram, K., El Ayoubi, L., Dybkov, O. et al. Mol Cell (2020) 80:127-139.e6. DOI 10.1016/j.molcel.2020.09.012 · PubMed
Other PDB entries of the same protein (UniProt Q6P2Q9 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4JK8 1.15 Å, Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Mg ion
- 4JKB 1.3 Å, Open and closed forms of V1788D human PRP8 RNase H-like domain with bound Mg ion
- 4JKA 1.32 Å, Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Co ion
- 4JK7 1.4 Å, Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Mg ion
- 4JK9 1.5 Å, Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Co ion
- 4JKC 1.5 Å, Open and closed forms of T1800E human PRP8 RNase H-like domain with bound Mg ion
- 4JKD 1.55 Å, Open and closed forms of I1790Y human PRP8 RNase H-like domain with bound Mg ion
- 4JKE 1.65 Å, Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion
- 4JKG 1.8 Å, Open and closed forms of mixed T1789P+R1865A and R1865A human PRP8 RNase H-like domain…
- 4JKH 1.8 Å, Open and closed forms of D1781E human PRP8 RNase H-like domain with bound Mg ion
- 3ENB 1.85 Å, Crystal Structure of PRP8 core domain IV
- 3LRU 1.85 Å, hPRP8 Non-Native Subdomain
Browse structure collections
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