Pre-mRNA-processing factor 17 (CDC40) is a 579-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O60508.
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The mean pLDDT of this model is 85.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 70% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177). Plays an important role in embryonic brain development; this function does not require proline isomerization (PubMed:33220177)
Component of the pre-catalytic and catalytic spliceosome complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316). Component of the postcatalytic spliceosome P complex (PubMed:30705154). Interacts with PPIL1; this interaction leads to CDC40 isomerization (PubMed:33220177)
Nucleus, Nucleus speckle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8C6J | EM | 2.8 Å | o=1-579 |
| 6ID1 | EM | 2.86 Å | W=1-579 |
| 6ID0 | EM | 2.9 Å | W=1-579 |
| 6ICZ | EM | 3.0 Å | W=1-579 |
| 8I0T | EM | 3.0 Å | W=1-579 |
| 8I0V | EM | 3.0 Å | W=1-579 |
| 6QDV | EM | 3.3 Å | o=67-579 |
| 8I0U | EM | 3.3 Å | W=1-579 |
| 9FMD | EM | 3.3 Å | W=1-579 |
| 6ZYM | EM | 3.4 Å | E=1-579 |
| 8I0W | EM | 3.4 Å | W=1-579 |
| 8RO2 | EM | 3.5 Å | W=1-579 |
| 5XJC | EM | 3.6 Å | W=1-579 |
| 7W59 | EM | 3.6 Å | W=1-579 |
| 7W5A | EM | 3.6 Å | W=1-579 |
| 5YZG | EM | 4.1 Å | W=1-579 |
| 7AAV | EM | 4.2 Å | 8=1-579 |
| 7W5B | EM | 4.3 Å | W=1-579 |
| 6FF7 | EM | 4.5 Å | E=1-579 |
| 7A5P | EM | 5.0 Å | E=1-579 |
Showing 20 of 26 experimental structures (best resolution first).
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