Pre-mRNA-processing factor 19 (PRPF19) is a 504-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UMS4.
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The mean pLDDT of this model is 88.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 76% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:30705154). Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal…
Homotetramer. Component of activated, catalytic and post-catalytic spliceosomes (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:30705154). Component of the Prp19 complex/PRP19C/Nineteen complex/NTC and related complexes described as PRP19-CDC5L splicing complex and PSO4 complex. A homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2 constitute the core of those complexes.…
Nucleus, Nucleus, nucleoplasm, Cytoplasm, cytoskeleton, spindle, Cytoplasm, Lipid droplet
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4LG8 | X-ray | 1.89 Å | A=169-504 |
| 8C6J | EM | 2.8 Å | t/u/v/w=1-504 |
| 6ID1 | EM | 2.86 Å | q/r/s/t=1-504 |
| 6ID0 | EM | 2.9 Å | q/r/s/t=1-504 |
| 6ICZ | EM | 3.0 Å | q/r/s/t=1-504 |
| 8I0T | EM | 3.0 Å | q/r/s/t=1-504 |
| 8I0V | EM | 3.0 Å | q/r/s/t=1-504 |
| 6QDV | EM | 3.3 Å | t/u/v/w=1-504 |
| 8I0U | EM | 3.3 Å | q/r/s/t=1-504 |
| 9FMD | EM | 3.3 Å | q/r/s/t=1-504 |
| 8I0W | EM | 3.4 Å | q/r/s/t=1-504 |
| 8RO2 | EM | 3.5 Å | q/r/s/t=1-504 |
| 5XJC | EM | 3.6 Å | q/r/s/t=1-504 |
| 7W59 | EM | 3.6 Å | q/r/s/t=1-504 |
| 7W5A | EM | 3.6 Å | q/r/s/t=1-504 |
| 5YZG | EM | 4.1 Å | q/r/s/t=1-504 |
| 7W5B | EM | 4.3 Å | q/r/s/t=1-504 |
| 6FF7 | EM | 4.5 Å | G/H/I/J=1-504 |
| 7A5P | EM | 5.0 Å | G/H/I/J=1-504 |
| 5Z56 | EM | 5.1 Å | q/r/s/t=1-504 |
Showing 20 of 23 experimental structures (best resolution first).
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