7C44: P53-binding domain of human MdmX protein

Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a. Determined by X-ray diffraction at 1.65 Å resolution. Released 17 Jun 2020.

Method: X-ray diffraction
Resolution: 1.65 Å
Organism: Homo sapiens
Chains: 1
Atoms: 857
Mol. weight: 11.89 kDa
Ligands: O4B, NUT
Released: 17 Jun 2020

Explore 7C44 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7C44 contains 5 α-helices and 7 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	13-18	6
β-strand	25-26	2	1
β-strand	27-28	2	2
α-helix	30-38	9
β-strand	46-47	2	1
α-helix	48-62	15
β-strand	65	1	3
β-strand	72-73	2	3
α-helix	79-84	6
β-strand	89-90	2	3
α-helix	95-104	10
β-strand	105-106	2	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Protein Mdm4	A	protein	96	Homo sapiens	O15151 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>7C44_1 Protein Mdm4 (chains A)
DLENLYFQGSQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQH
MVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVT

Ligands and cofactors

ID	Name	Formula	Copies
O4B	1,4,7,10,13,16-hexaoxacyclooctadecane	C12 H24 O6	1
NUT	4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-…	C30 H30 Cl2 N4 O4	1

Primary citation

Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a. Cheng, X.Y., Zhang, B.L., Kuang, Z.K. et al. To be published.

Other PDB entries of the same protein (UniProt O15151 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6Q9Y 1.2 Å, HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 16 AT 1.20A; Structural states of Hdm2 and…
3FEA 1.33 Å, Crystal Structure of HdmX bound to the p53-peptidomimetic…
3FE7 1.35 Å, Crystal Structure of HdmX bound to the p53-peptidomimetic…
3FDO 1.4 Å, Structure of human MDMX in complex with high affinity peptide
3LBJ 1.5 Å, Structure of human MDMX protein in complex with a small molecule inhibitor
4RXZ 1.55 Å, Crystal Structure of MDMX phosporylated Tyr99 in complex with a 12-mer peptide
6Q9W 1.55 Å, X-ray structure of compound 15 bound to HdmX: Structural states of Hdm2 and HdmX: X-ray…
3EQY 1.63 Å, Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor
7C3Y 1.63 Å, Crystal structure of the N-terminal domain of human MdmX protein in complex with Nutlin3a
8HDG 1.73 Å, Small peptide enhances the binding of nutline-3a to MdmX
3JZP 1.74 Å, Human MDMX liganded with a 12mer peptide inhibitor (pDI6W)
3JZO 1.8 Å, Human MDMX liganded with a 12mer peptide (pDI)

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