Discovery of Functionally Selective Transforming Growth Factor beta Type II Receptor (TGF-beta RII) Inhibitors as Anti-Fibrosis Agents. Determined by X-ray diffraction at 2.39 Å resolution. Released 16 Jun 2021.
Explore 7DV6 in 3D Show helices and sheets RCSB PDB PDBe
7DV6 contains 23 α-helices and 15 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 244-252 | 9 | 1 |
| β-strand | 257-263 | 7 | 1 |
| α-helix | 270-271 | 2 | |
| β-strand | 272-280 | 9 | 1 |
| α-helix | 281-283 | 3 | |
| α-helix | 284-294 | 11 | |
| α-helix | 297-299 | 3 | |
| β-strand | 304 | 1 | 2 |
| β-strand | 307-314 | 8 | 1 |
| β-strand | 319-325 | 7 | 1 |
| β-strand | 332 | 1 | 2 |
| α-helix | 333-339 | 7 | |
| α-helix | 341 | 1 | |
| β-strand | 342 | 1 | 3 |
| α-helix | 343 | 1 | |
| α-helix | 344-362 | 19 | |
| β-strand | 365 | 1 | 4 |
| β-strand | 371 | 1 | 4 |
| β-strand | 375-376 | 2 | 5 |
| α-helix | 382-384 | 3 | |
| β-strand | 385-387 | 3 | 2 |
| β-strand | 393-395 | 3 | 2 |
| β-strand | 402-403 | 2 | 5 |
| α-helix | 410-416 | 7 | |
| α-helix | 422-424 | 3 | |
| α-helix | 427-430 | 4 | |
| α-helix | 439-441 | 3 | |
| α-helix | 442-459 | 18 | |
| β-strand | 461 | 1 | 3 |
| α-helix | 462-464 | 3 | |
| α-helix | 468-470 | 3 | |
| α-helix | 484-488 | 5 | |
| α-helix | 489-493 | 5 | |
| α-helix | 502-506 | 5 | |
| α-helix | 508-520 | 13 | |
| α-helix | 525-527 | 3 | |
| α-helix | 529-530 | 2 | |
| α-helix | 531-540 | 10 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| TGF-beta receptor type-2 | A | protein | 323 | Homo sapiens | P37173 (AlphaFold model) |
>7DV6_1 TGF-beta receptor type-2 (chains A) MAHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIF SDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSL ARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLA NSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPF GSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCV AERFSELEHLDRLSGLEHHHHHH
| ID | Name | Formula | Copies |
|---|---|---|---|
| HJF | 5-[(3S)-5,5-dimethyloxolan-3-yl]-6-methoxy-3-(2-methoxypyridin-4-yl)pyrazolo[1,… | C19 H22 N4 O3 | 1 |
Discovery of Selective Transforming Growth Factor beta Type II Receptor Inhibitors as Antifibrosis Agents. Miwa, S., Yokota, M., Ueyama, Y. et al. ACS Med Chem Lett (2021) 12:745-751. DOI 10.1021/acsmedchemlett.0c00679 · PubMed
Other PDB entries of the same protein (UniProt P37173 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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