7EIF: GAS41 YEATS domain

Crystal structure of GAS41 YEATS domain. Determined by X-ray diffraction at 1.58 Å resolution. Released 6 Apr 2022.

Method: X-ray diffraction
Resolution: 1.58 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,278
Mol. weight: 17.35 kDa
Released: 6 Apr 2022

Explore 7EIF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7EIF contains 3 α-helices and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	20-33	14	1
β-strand	45-53	9	1
α-helix	59-61	3
β-strand	63-69	7	2
β-strand	78-81	4	2
β-strand	87-92	6	1
β-strand	97-104	8	2
α-helix	110-111	2
β-strand	112-117	6	2
β-strand	133-145	13	1
α-helix	149-155	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
YEATS domain-containing protein 4	A	protein	148	Homo sapiens	O95619 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>7EIF_1 YEATS domain-containing protein 4 (chains A)
GSSGSASVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLH
ESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGK
KTVVSEFYDEMIFQDPTAMMQQLLTTSR

Primary citation

GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Kikuchi, M., Takase, S., Konuma, T. et al. Proc Natl Acad Sci U S A (2023) 120:e2304103120-e2304103120. DOI 10.1073/pnas.2304103120 · PubMed

Other PDB entries of the same protein (UniProt O95619 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8IJ0 1.52 Å, Crystal structure of GAS41 YEATS domain in complex with H3K9ac peptide
5R68 1.64 Å, XChem group deposition -- Crystal Structure of human YEATS4 in complex with FM000199e
9X8S 1.7 Å, Crystal structure of the human GAS41 YEATS domain in complex with an acetylated YFV…
5R69 1.83 Å, XChem group deposition -- Crystal Structure of human YEATS4 in complex with XS038644e
5VNA 2.1 Å, Crystal structure of human YEATS domain
8IIZ 2.1 Å, Crystal structure of MBP fused GAS41 YEATS domain in complex with H3K27ac peptide
7JFY 2.1 Å, GAS41 YEATS domain in complex with 5
5XTZ 2.1 Å, Crystal structure of GAS41 YEATS bound to H3K27ac peptide
8IIY 2.15 Å, Crystal structure of MBP fused GAS41 YEATS domain in complex with H3K14ac peptide
8I60 2.3 Å, Crystal structure of GAS41 YEATS domain in complex with histone H3K27cr
9O4Y 2.3 Å, GAS41 YEATS domain in complex with DLG-1
5VNB 2.4 Å, YEATS in complex with histone H3

Browse structure collections

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