7MW1: Homo sapiens NUP93-NUP53 complex

Crystal structure of the Homo sapiens NUP93-NUP53 complex (NUP93 residues 174-819; NUP53 residues 84-150). Determined by X-ray diffraction at 3.4 Å resolution. Released 15 Jun 2022.

Method
X-ray diffraction
Resolution
3.4 Å
Organism
Homo sapiens
Chains
4
Atoms
10,194
Mol. weight
167.68 kDa
Released
15 Jun 2022

Explore 7MW1 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7MW1 contains 84 α-helices and 24 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 42 helices, 11 β-strands

ElementResiduesLengthSheet
α-helix180-19718
α-helix205-2139
α-helix218-23114
α-helix241-2466
α-helix248-27427
α-helix278-2847
α-helix286-2883
α-helix289-30012
α-helix304-3052
β-strand312-31321
β-strand316-31721
α-helix318-32811
α-helix331-3399
α-helix342-3454
α-helix348-35710
α-helix359-3613
α-helix365-37814
α-helix385-39410
α-helix410-4189
β-strand421-42222
β-strand435-43622
α-helix437-44711
α-helix450-4534
α-helix459-4679
α-helix472-48110
α-helix486-49712
β-strand50413
β-strand513-51423
β-strand525-52623
α-helix528-53912
α-helix544-5518
α-helix552-5543
β-strand55814
β-strand56414
α-helix565-57713
α-helix5801
α-helix581-5855
β-strand58715
β-strand59315
α-helix597-6004
α-helix606-61813
α-helix622-63110
α-helix635-64612
α-helix647-6493
α-helix659-67618
α-helix683-70220
α-helix707-71711
α-helix724-7263
α-helix727-7359
α-helix739-7424
α-helix745-76117
α-helix781-79818
α-helix804-81815
Chain B: 42 helices, 12 β-strands
ElementResiduesLengthSheet
α-helix180-19718
α-helix205-2139
α-helix218-23114
α-helix241-2466
α-helix248-27427
α-helix278-2847
α-helix286-2883
α-helix289-30012
α-helix304-3052
β-strand312-31326
β-strand316-31726
α-helix318-32811
α-helix331-3399
α-helix348-35710
α-helix359-3613
α-helix365-37814
α-helix385-39410
β-strand40917
α-helix410-4189
β-strand421-42228
β-strand435-43628
α-helix437-4426
α-helix443-4475
α-helix450-4545
α-helix459-4679
α-helix472-48110
α-helix486-49813
β-strand50419
β-strand513-51429
β-strand525-52629
α-helix528-53912
α-helix544-5518
α-helix552-5565
β-strand558110
β-strand564110
α-helix565-57713
α-helix5801
α-helix581-5855
β-strand587111
β-strand593111
α-helix597-6015
α-helix606-61813
α-helix622-63110
α-helix635-64612
α-helix647-6493
α-helix659-67517
α-helix683-70220
α-helix707-71711
α-helix724-7263
α-helix727-7348
α-helix739-7424
α-helix745-76117
α-helix781-79818
α-helix804-81815
Chain D: 0 helices, 1 β-strand
ElementResiduesLengthSheet
β-strand9217

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Nuclear pore complex protein Nup93A, Bprotein672Homo sapiensQ8N1F7 (AlphaFold model)
Nucleoporin Nup35C, Dprotein68Homo sapiensQ8NFH5 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>7MW1_1 Nuclear pore complex protein Nup93 (chains A, B)
SSGLNDIFEAQKIEWHEGSAGGSGGSGRSSLDNIEMAYARQIYIYNEKIVNGHLQPNLVD
LCASVAELDDKSISDMWTMVKQMTDVLLTPATDALKNRSSVEVRMEFVRQALAYLEQSYK
NYTLVTVFGNLHQAQLGGVPGTYQLVRSFLNIKLPAPLPGLQDGEVEGHPVWALIYYCMR
CGDLLAASQVVNRAQHQLGEFKTWFQEYMNSKDRRLSPATENKLRLHYRRALRNNTDPYK
RAVYCIIGRCDVTDNQSEVADKTEDYLWLKLNQVCFDDDGTSSPQDRLTLSQFQKQLLED
YGESHFTVNQQPFLYFQVLFLTAQFEAAVAFLFRMERLRCHAVHVALVLFELKLLLKSSG
QSAQLLSHEPGDPPCLRRLNFVRLLMLYTRKFESTDPREALQYFYFLRDEKDSQGENMFL
RCVSELVIESREFDMILGKLENDGSRKPGVIDKFTSDTKPIINKVASVAENKGLFEEAAK
LYDLAKNADKVLELMNKLLSPVVPQISAPQSNKERLKNMALSIAERYRAQGISANKFVDS
TFYLLLDLITFFDEYHSGHIDRAFDIIERLKLVPLNQESVEERVAAFRNFSDEIRHNLSE
VLLATMNILFTQFKRLKGTSPSSSSRPQRVIEDRDSQLRSQARTLITFAGMIPYRTSGDT
NARLVQMEVLMN
Sequence of entity 2 (C, D), FASTA
>7MW1_2 Nucleoporin Nup35 (chains C, D)
SDKSGAPPVRSIYDDISSPGLGSTPLTSRRQPNISVMQSPLVGVTSTPGTGQSMFSPASI
GQPRKTTL

Primary citation

Architecture of the linker-scaffold in the nuclear pore. Petrovic, S., Samanta, D., Perriches, T. et al. Science (2022) 376:eabm9798-eabm9798. DOI 10.1126/science.abm9798 · PubMed

Other PDB entries of the same protein (UniProt Q8N1F7 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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