7NVR: PDB entry 7NVR
Human Mediator with RNA Polymerase II Pre-initiation complex. Determined by electron microscopy at 4.5 Å resolution. Released 5 May 2021.
- Method
- Electron microscopy
- Resolution
- 4.5 Å
- Organisms
- Homo sapiens, Sus scrofa, Human mastadenovirus C
- Chains
- 58
- Atoms
- 96,126
- Mol. weight
- 1978.5 kDa
- Ligands
- SF4, ZN, MG
- Released
- 5 May 2021
Explore 7NVR in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7NVR contains 544 α-helices and 499 β-strands across 56 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 0: 35 helices, 25 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-4 | 3 | 1 |
| β-strand | 9-11 | 3 | 1 |
| α-helix | 19-34 | 16 | |
| β-strand | 38-41 | 4 | 2 |
| α-helix | 48-62 | 15 | |
| β-strand | 70-73 | 4 | 2 |
| α-helix | 77-98 | 22 | |
| β-strand | 105-108 | 4 | 2 |
| α-helix | 127-137 | 11 | |
| α-helix | 140-148 | 9 | |
| α-helix | 156-164 | 9 | |
| β-strand | 173-175 | 3 | 2 |
| α-helix | 177-187 | 11 | |
| α-helix | 191-198 | 8 | |
| β-strand | 204-206 | 3 | 2 |
| α-helix | 209-211 | 3 | |
| α-helix | 215-221 | 7 | |
| α-helix | 224-226 | 3 | |
| β-strand | 230-234 | 5 | 2 |
| α-helix | 236-238 | 3 | |
| α-helix | 239-245 | 7 | |
| β-strand | 251-252 | 2 | 3 |
| α-helix | 253-276 | 24 | |
| α-helix | 279-290 | 12 | |
| α-helix | 326-345 | 20 | |
| β-strand | 351-352 | 2 | 3 |
| α-helix | 354-365 | 12 | |
| α-helix | 369-373 | 5 | |
| α-helix | 375-385 | 11 | |
| α-helix | 395-409 | 15 | |
| β-strand | 417-419 | 3 | 3 |
| β-strand | 432-434 | 3 | 3 |
| α-helix | 441-450 | 10 | |
| β-strand | 453-458 | 6 | 2 |
| α-helix | 461-463 | 3 | |
| α-helix | 466-470 | 5 | |
| β-strand | 478-480 | 3 | 2 |
| β-strand | 490 | 1 | 4 |
| β-strand | 493-494 | 2 | 5 |
| β-strand | 495-497 | 3 | 6 |
| β-strand | 503 | 1 | 6 |
| α-helix | 514-530 | 17 | |
| β-strand | 535-539 | 5 | 5 |
| α-helix | 542-554 | 13 | |
| α-helix | 557-564 | 8 | |
| β-strand | 566-569 | 4 | 5 |
| α-helix | 574-589 | 16 | |
| β-strand | 594-599 | 6 | 5 |
| α-helix | 603-607 | 5 | |
| β-strand | 617-621 | 5 | 5 |
| α-helix | 631-642 | 12 | |
| α-helix | 648-664 | 17 | |
| α-helix | 665-668 | 4 | |
| β-strand | 675 | 1 | 4 |
| β-strand | 676-680 | 5 | 5 |
| α-helix | 682-685 | 4 | |
| α-helix | 687-692 | 6 | |
| α-helix | 695-700 | 6 | |
| β-strand | 708-709 | 2 | 6 |
| α-helix | 710-725 | 16 | |
Chain 1: 13 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 109-117 | 9 | |
| α-helix | 122-133 | 12 | |
| α-helix | 140-145 | 6 | |
| α-helix | 191-199 | 9 | |
| α-helix | 201-209 | 9 | |
| α-helix | 217-225 | 9 | |
| α-helix | 298-318 | 21 | |
| α-helix | 380-383 | 4 | |
| α-helix | 397-410 | 14 | |
| α-helix | 424-434 | 11 | |
| α-helix | 456-475 | 20 | |
| α-helix | 486-514 | 29 | |
| α-helix | 524-546 | 23 | |
Chain 2: 25 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 19-24 | 6 | |
| α-helix | 28-34 | 7 | |
| α-helix | 40-47 | 8 | |
| α-helix | 52-58 | 7 | |
| α-helix | 68-73 | 6 | |
| α-helix | 80-93 | 14 | |
| β-strand | 96 | 1 | 10 |
| α-helix | 109 | 1 | |
| β-strand | 110 | 1 | 10 |
| α-helix | 111 | 1 | |
| α-helix | 112-121 | 10 | |
| α-helix | 146-163 | 18 | |
| α-helix | 173-179 | 7 | |
| α-helix | 180-184 | 5 | |
| β-strand | 185-186 | 2 | 11 |
| α-helix | 193-194 | 2 | |
| β-strand | 195-196 | 2 | 11 |
| α-helix | 198-205 | 8 | |
| α-helix | 208-226 | 19 | |
| α-helix | 230-240 | 11 | |
| α-helix | 256-268 | 13 | |
| β-strand | 271-272 | 2 | 12 |
| β-strand | 282-283 | 2 | 12 |
| α-helix | 285-288 | 4 | |
| β-strand | 307-309 | 3 | 13 |
| β-strand | 314-317 | 4 | 13 |
| α-helix | 322-329 | 8 | |
| β-strand | 333-338 | 6 | 13 |
| β-strand | 341-345 | 5 | 13 |
| α-helix | 348-357 | 10 | |
| α-helix | 361-370 | 10 | |
| β-strand | 372 | 1 | 13 |
| α-helix | 374-377 | 4 | |
| α-helix | 385-398 | 14 | |
| β-strand | 402-405 | 4 | 14 |
| β-strand | 407-409 | 3 | 15 |
| α-helix | 415-428 | 14 | |
| β-strand | 431-435 | 5 | 15 |
| β-strand | 440-443 | 4 | 15 |
| α-helix | 445-457 | 13 | |
Chain 3: 12 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-15 | 4 | |
| β-strand | 21-23 | 3 | 17 |
| α-helix | 32-40 | 9 | |
| β-strand | 45 | 1 | 18 |
| β-strand | 52 | 1 | 18 |
| β-strand | 59-61 | 3 | 17 |
| α-helix | 66-79 | 14 | |
| α-helix | 86-88 | 3 | |
| α-helix | 94-111 | 18 | |
| α-helix | 115-148 | 34 | |
| β-strand | 256 | 1 | 19 |
| α-helix | 259-262 | 4 | |
| α-helix | 264-266 | 3 | |
| α-helix | 271-274 | 4 | |
| α-helix | 276-279 | 4 | |
| α-helix | 280-284 | 5 | |
| α-helix | 290-300 | 11 | |
| β-strand | 303 | 1 | 19 |
Chain 4: 15 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 10-15 | 6 | 20 |
| α-helix | 19-28 | 10 | |
| α-helix | 34-51 | 18 | |
| β-strand | 56-62 | 7 | 20 |
| β-strand | 67-71 | 5 | 20 |
| α-helix | 102-120 | 19 | |
| α-helix | 131-132 | 2 | |
| α-helix | 134-150 | 17 | |
| β-strand | 160-164 | 5 | 20 |
| α-helix | 168-170 | 3 | |
| α-helix | 171-173 | 3 | |
| α-helix | 174-187 | 14 | |
| β-strand | 190-193 | 4 | 20 |
| α-helix | 201-210 | 10 | |
| β-strand | 214 | 1 | 20 |
| α-helix | 220-222 | 3 | |
| α-helix | 223-226 | 4 | |
| α-helix | 227-231 | 5 | |
| α-helix | 235-238 | 4 | |
| α-helix | 244-248 | 5 | |
| β-strand | 254 | 1 | 21 |
| β-strand | 261 | 1 | 21 |
| β-strand | 264-267 | 4 | 22 |
| α-helix | 289-291 | 3 | |
Chain 5: 3 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-5 | 2 | 15 |
| β-strand | 8-11 | 4 | 14 |
| α-helix | 14-26 | 13 | |
| β-strand | 36-39 | 4 | 14 |
| β-strand | 42-45 | 4 | 14 |
| α-helix | 47-49 | 3 | |
| α-helix | 50-64 | 15 | |
Chain 6: 17 helices, 25 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-13 | 4 | |
| α-helix | 18-21 | 4 | |
| β-strand | 55 | 1 | 27 |
| β-strand | 59-66 | 8 | 28 |
| α-helix | 69-72 | 4 | |
| α-helix | 80-98 | 19 | |
| β-strand | 103-110 | 8 | 28 |
| β-strand | 113-121 | 9 | 28 |
| α-helix | 124-134 | 11 | |
| α-helix | 145-157 | 13 | |
| β-strand | 164-171 | 8 | 28 |
| α-helix | 182-192 | 11 | |
| β-strand | 195-196 | 2 | 28 |
| β-strand | 199-200 | 2 | 28 |
| α-helix | 206-215 | 10 | |
| β-strand | 220-221 | 2 | 28 |
| α-helix | 225-236 | 12 | |
| α-helix | 238-239 | 2 | |
| β-strand | 240 | 1 | 27 |
| α-helix | 241 | 1 | |
| β-strand | 250-253 | 4 | 22 |
| β-strand | 258 | 1 | 29 |
| β-strand | 262 | 1 | 30 |
| β-strand | 265 | 1 | 30 |
| β-strand | 270 | 1 | 31 |
| β-strand | 285 | 1 | 31 |
| β-strand | 288 | 1 | 29 |
| β-strand | 289 | 1 | 32 |
| β-strand | 298 | 1 | 32 |
| β-strand | 303-304 | 2 | 22 |
| β-strand | 311-312 | 2 | 22 |
| α-helix | 315-319 | 5 | |
| α-helix | 322-325 | 4 | |
| α-helix | 327-331 | 5 | |
| β-strand | 332-334 | 3 | 33 |
| β-strand | 344 | 1 | 34 |
| β-strand | 351 | 1 | 34 |
| β-strand | 357-359 | 3 | 33 |
| β-strand | 367 | 1 | 33 |
| α-helix | 369-374 | 6 | |
| α-helix | 375-379 | 5 | |
| α-helix | 383-386 | 4 | |
Chain 7: 34 helices, 34 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 53 | 1 | 13 |
| β-strand | 59-60 | 2 | 13 |
| β-strand | 76 | 1 | 35 |
| β-strand | 83-87 | 5 | 35 |
| α-helix | 93-103 | 11 | |
| β-strand | 105-108 | 4 | 35 |
| β-strand | 113-117 | 5 | 35 |
| α-helix | 120-128 | 9 | |
| α-helix | 133-143 | 11 | |
| β-strand | 144 | 1 | 35 |
| α-helix | 150-161 | 12 | |
| β-strand | 166-171 | 6 | 36 |
| β-strand | 174-178 | 5 | 36 |
| β-strand | 179 | 1 | 37 |
| α-helix | 182-188 | 7 | |
| α-helix | 192-197 | 6 | |
| β-strand | 268-269 | 2 | 37 |
| β-strand | 271-272 | 2 | 36 |
| α-helix | 277-287 | 11 | |
| α-helix | 290 | 1 | |
| β-strand | 291-292 | 2 | 36 |
| β-strand | 295 | 1 | 38 |
| α-helix | 304-306 | 3 | |
| β-strand | 310 | 1 | 39 |
| α-helix | 318-327 | 10 | |
| β-strand | 333 | 1 | 38 |
| α-helix | 334-335 | 2 | |
| β-strand | 337-339 | 3 | 40 |
| α-helix | 342-344 | 3 | |
| α-helix | 346-357 | 12 | |
| β-strand | 361-365 | 5 | 40 |
| α-helix | 368-381 | 14 | |
| β-strand | 382 | 1 | 39 |
| α-helix | 386-388 | 3 | |
| β-strand | 389-391 | 3 | 40 |
| β-strand | 405-409 | 5 | 40 |
| α-helix | 410-413 | 4 | |
| α-helix | 421-432 | 12 | |
| β-strand | 435-441 | 7 | 40 |
| α-helix | 443-445 | 3 | |
| α-helix | 449-457 | 9 | |
| β-strand | 460-462 | 3 | 40 |
| β-strand | 465-467 | 3 | 40 |
| α-helix | 477-483 | 7 | |
| β-strand | 487-490 | 4 | 40 |
| α-helix | 493-499 | 7 | |
| β-strand | 505-510 | 6 | 41 |
| β-strand | 511-512 | 2 | 42 |
| α-helix | 513-515 | 3 | |
| α-helix | 516-524 | 9 | |
| α-helix | 530-534 | 5 | |
| α-helix | 538-553 | 16 | |
| β-strand | 558-561 | 4 | 41 |
| α-helix | 565-574 | 10 | |
| β-strand | 579 | 1 | 41 |
| α-helix | 586-598 | 13 | |
| β-strand | 604-607 | 4 | 41 |
| α-helix | 610-613 | 4 | |
| α-helix | 617-619 | 3 | |
| β-strand | 622-625 | 4 | 41 |
| α-helix | 633-640 | 8 | |
| α-helix | 641-644 | 4 | |
| β-strand | 657-661 | 5 | 41 |
| β-strand | 663-664 | 2 | 42 |
| α-helix | 668-676 | 9 | |
| α-helix | 678-683 | 6 | |
| β-strand | 688-690 | 3 | 41 |
| α-helix | 706-719 | 14 | |
48 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| TFIIH basal transcription factor complex helicase XPD subunit | 0 | protein | 760 | Homo sapiens | P18074 (AlphaFold model) |
| General transcription factor IIH subunit 1 | 1 | protein | 548 | Homo sapiens | P32780 (AlphaFold model) |
| General transcription factor IIH subunit 4 | 2 | protein | 462 | Homo sapiens | Q92759 (AlphaFold model) |
| CDK-activating kinase assembly factor MAT1 | 3 | protein | 309 | Homo sapiens | P51948 (AlphaFold model) |
| General transcription factor IIH subunit 3 | 4 | protein | 308 | Homo sapiens | Q13889 |
| General transcription factor IIH subunit 5 | 5 | protein | 71 | Homo sapiens | Q6ZYL4 |
| General transcription factor IIH subunit 2 | 6 | protein | 395 | Homo sapiens | Q13888 |
| General transcription and DNA repair factor IIH helicase subunit XPB | 7 | protein | 782 | Homo sapiens | P19447 |
| Cyclin-dependent kinase 7 | 8 | protein | 346 | Homo sapiens | P50613 |
| Cyclin-H | 9 | protein | 323 | Homo sapiens | P51946 |
| DNA-directed RNA polymerase subunit | A | protein | 1970 | Sus scrofa | A0A8D1DPV6 |
| DNA-directed RNA polymerase subunit beta | B | protein | 1174 | Sus scrofa | I3LGP4 |
46 more molecules are not listed.
Sequence of entity 1 (0), FASTA
>7NVR_1 TFIIH basal transcription factor complex helicase XPD subunit (chains 0)
MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ
RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE
VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL
KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE
TDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG
LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP
FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT
FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT
SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA
RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA
AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF
LRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL
Sequence of entity 2 (1), FASTA
>7NVR_2 General transcription factor IIH subunit 1 (chains 1)
MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGK
AKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQE
DPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQDVGISAAFLADVRPQTDG
CNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSK
DLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSASNSKSIKENSN
AAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEY
EDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQ
VLSSSAASSTITALSPGGALMQGGTQQAINQMVPNDIQSELKHLYVAVGELLRHFWSCFP
VNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLSTNLVSHIEEMLQTAYNKLHTWQ
SRRLMKKT
Sequence of entity 3 (2), FASTA
>7NVR_3 General transcription factor IIH subunit 4 (chains 2)
MESTPSRGLNRVHLQCRNLQEFLGGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRML
FLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPIFRQNLRI
ALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLS
QAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQL
SFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGT
VHQPGFIVVETNYRLYAYTESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGIT
AQQIIHFLRTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFEL
LLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQKHSS
Sequence of entity 4 (3), FASTA
>7NVR_4 CDK-activating kinase assembly factor MAT1 (chains 3)
MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV
QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK
KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK
QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK
LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA
FSGLFWQPS
Sequence of entity 5 (4), FASTA
>7NVR_5 General transcription factor IIH subunit 3 (chains 4)
MVSDEDELNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSNKLAVI
ASHIQESRFLYPGKNGRLGDFFGDPGNPPEFNPSGSKDGKYELLTSANEVIVEEIKDLMT
KSDIKGQHTETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNV
IFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQ
LILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAK
KKKLKVSA
Sequence of entity 6 (5), FASTA
>7NVR_6 General transcription factor IIH subunit 5 (chains 5)
MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVFVIAELVNVLQERVGEL
MDQNAFSLTQK
Sequence of entity 7 (6), FASTA
>7NVR_7 General transcription factor IIH subunit 2 (chains 6)
MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRH
LYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTEL
SGNPRKHITSLKKAVDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPS
NIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTHHVSPPP
ASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCE
LPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYVC
AVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV
Sequence of entity 8 (7), FASTA
>7NVR_8 General transcription and DNA repair factor IIH helicase subunit XPB (chains 7)
MGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPSAAGKQVDESGTKVDEYGAKD
YRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTA
YSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCTVSYGKVKLVLKHNRYFVESC
HPDVIQHLLQDPVIRECRLRNSEGEATELITETFTSKSAISKTAESSGGPSTSRVTDPQG
KSDIPMDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRND
SVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKR
CLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGHTTKRS
WEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDL
NFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNK
FRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNP
KINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFY
SLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQKVLAAT
DLDAEEEVVAGEFGSRSSQASRRFGTMSSMSGADDTVYMEYHSSRSKAPSKHVHPLFKRF
RK
Sequence of entity 9 (8), FASTA
>7NVR_9 Cyclin-dependent kinase 7 (chains 8)
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
Sequence of entity 10 (9), FASTA
>7NVR_10 Cyclin-H (chains 9)
MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYY
EKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNV
SSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPI
LENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKE
NRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDD
DYVSKKSKHEEEEWTDDDLVESL
Sequence of entity 11 (A), FASTA
>7NVR_11 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN
Sequence of entity 12 (B), FASTA
>7NVR_12 DNA-directed RNA polymerase subunit beta (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| SF4 | Iron/sulfur cluster | Fe4 S4 | 1 |
| ZN | Zinc ion | Zn | 18 |
| MG | Magnesium ion | Mg | 1 |
Primary citation
Structures of mammalian RNA polymerase II pre-initiation complexes. Aibara, S., Schilbach, S., Cramer, P. Nature (2021) 594:124-128. DOI 10.1038/s41586-021-03554-8 · PubMed
Other PDB entries of the same protein (UniProt P18074 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6TUN 2.07 Å, Helicase domain complex
- 28JM 3.29 Å, Cryo-EM structure of the human holo-TFIIH and XPC initial encounter complex
- 7EGB 3.3 Å, TFIID-based holo PIC on SCP promoter
- 8EBU 3.3 Å, XPC release from Core7-XPA-DNA (Cy5)
- 9PD3 3.3 Å, NER dual incision complex - DuIS
- 28JS 3.32 Å, Cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA…
- 9PD4 3.4 Å, NER dual incision complex - DuIM
- 6RO4 3.5 Å, Structure of the core TFIIH-XPA-DNA complex
- 7AD8 3.5 Å, Core TFIIH-XPA-DNA complex with modelled p62 subunit
- 9XYU 3.5 Å, NER complex - C7CAD.ATP
- 28KE 3.6 Å, Cryo-EM structure of the human holo-TFIIH-XPC-XPA complex bound to bulky lesion-mimic DNA
- 8EBX 3.6 Å, XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (AP)
Browse structure collections
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