7NVS: RPB1

RNA polymerase II core pre-initiation complex with closed promoter DNA in proximal position. Determined by electron microscopy at 2.8 Å resolution. Released 5 May 2021.

Method: Electron microscopy
Resolution: 2.8 Å
Organisms: Sus scrofa, Homo sapiens, unidentified adenovirus
Chains: 22
Atoms: 44,073
Mol. weight: 879.5 kDa
Ligands: MG, ZN
Released: 5 May 2021

Explore 7NVS in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7NVS contains 250 α-helices and 277 β-strands across 20 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 78 helices, 69 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15	1	1
β-strand	20-22	3	2
α-helix	28-34	7
β-strand	43	1	3
β-strand	47	1	4
β-strand	52	1	4
β-strand	56	1	3
β-strand	86-94	9	5
α-helix	100-108	9
β-strand	110	1	6
β-strand	117	1	6
α-helix	124-133	10
α-helix	137-149	13
β-strand	153	1	7
α-helix	186	1
β-strand	187	1	7
α-helix	188-189	2
β-strand	190-194	5	8
β-strand	197-201	5	8
β-strand	213-216	4	8
α-helix	218-227	10
α-helix	230-235	6
α-helix	245-248	4
β-strand	250-255	6	5
β-strand	263-266	4	9
β-strand	270-273	4	9
α-helix	275-296	22
α-helix	300-318	19
β-strand	329	1	10
α-helix	334	1
β-strand	335	1	10
α-helix	336	1
α-helix	339-343	5
α-helix	349-350	2
α-helix	351-355	5
β-strand	357-359	3	11
β-strand	362-369	8	12
β-strand	377-381	5	12
α-helix	382-387	6
β-strand	389-393	5	13
α-helix	394	1
α-helix	399-408	10
β-strand	416-420	5	13
β-strand	426-428	3	13
α-helix	435-438	4
β-strand	445-449	5	13
α-helix	450	1
β-strand	455-459	5	12
α-helix	466-468	3
β-strand	469-477	9	12
β-strand	482-484	3	12
α-helix	489-492	4
β-strand	500-504	5	12
α-helix	509-514	6
α-helix	515-519	5
β-strand	520	1	12
α-helix	522-524	3
β-strand	526-527	2	14
β-strand	532-533	2	14
α-helix	539-548	10
β-strand	554-555	2	15
α-helix	557-564	8
α-helix	573-574	2
β-strand	575	1	16
α-helix	576-577	2
β-strand	579-581	3	17
β-strand	585	1	17
β-strand	586-587	2	15
α-helix	588-595	8
β-strand	602-605	4	18
α-helix	613-615	3
β-strand	627-631	5	18
β-strand	634-637	4	18
α-helix	642-645	4
α-helix	652-683	32
β-strand	686	1	19
α-helix	689-692	4
α-helix	696-721	26
α-helix	725-728	4
α-helix	733-759	27
α-helix	765-772	8
α-helix	778-785	8
β-strand	789-790	2	20
β-strand	792-793	2	21
β-strand	796-797	2	21
α-helix	798-799	2
β-strand	822-823	2	20
α-helix	833-856	24
α-helix	859-868	10
β-strand	872-873	2	22
β-strand	879-880	2	22
β-strand	886-888	3	22
α-helix	891-893	3
β-strand	896	1	23
β-strand	902-905	4	24
α-helix	913-920	8
α-helix	927-933	7
β-strand	934	1	25
α-helix	936-944	9
α-helix	946-969	24
β-strand	976-979	4	24
α-helix	983-993	11
α-helix	1001	1
β-strand	1002	1	25
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1051-1053	3
α-helix	1054-1058	5
α-helix	1062-1079	18
β-strand	1080	1	23
α-helix	1081-1082	2
α-helix	1087-1100	14
α-helix	1120-1128	9
β-strand	1139-1142	4	26
α-helix	1146-1149	4
α-helix	1151-1161	11
β-strand	1164-1165	2	27
α-helix	1166-1169	4
β-strand	1170-1176	7	28
α-helix	1187-1196	10
β-strand	1212-1216	5	28
α-helix	1218-1223	6
α-helix	1228-1239	12
β-strand	1243-1247	5	28
β-strand	1255-1261	7	28
α-helix	1263-1266	4
α-helix	1283-1294	12
β-strand	1297-1299	3	27
β-strand	1307-1310	4	26
β-strand	1319-1322	4	29
β-strand	1328-1331	4	29
β-strand	1335-1338	4	26
α-helix	1343-1348	6
β-strand	1358-1359	2	26
α-helix	1362-1368	7
α-helix	1371-1388	18
α-helix	1395-1406	12
α-helix	1416-1419	4
α-helix	1426-1432	7
α-helix	1435-1445	11
β-strand	1448-1449	2	2
α-helix	1454-1459	6
α-helix	1467-1469	3
β-strand	1471-1475	5	30
α-helix	1477-1481	5

Chain B: 52 helices, 74 β-strands

Element	Residues	Length	Sheet
α-helix	19-36	18
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
α-helix	63-64	2
β-strand	65-68	4	31
β-strand	83-94	12	31
α-helix	95-96	2
β-strand	97-99	3	32
β-strand	105-107	3	32
α-helix	110-116	7
β-strand	121-133	13	31
β-strand	139-153	15	31
α-helix	168-173	6
β-strand	185-187	3	33
β-strand	190-194	5	33
α-helix	195	1
β-strand	196-200	5	34
α-helix	201	1
β-strand	205-208	4	35
β-strand	215-223	9	35
β-strand	233-240	8	35
α-helix	241	1
α-helix	249-252	4
β-strand	256-259	4	35
β-strand	263	1	36
β-strand	267-268	2	35
α-helix	269-276	8
α-helix	281-288	8
α-helix	295-307	13
α-helix	314-323	10
β-strand	325	1	36
α-helix	332-341	10
α-helix	342-346	5
α-helix	358-377	20
α-helix	381-384	4
α-helix	388-390	3
β-strand	391-394	4	34
α-helix	396-425	30
α-helix	431-434	4
α-helix	438-450	13
α-helix	456-458	3
β-strand	467-469	3	33
α-helix	475-482	8
β-strand	484-486	3	34
α-helix	490-495	6
α-helix	503-505	3
β-strand	509	1	37
β-strand	523-525	3	34
β-strand	526	1	37
β-strand	531-532	2	38
α-helix	539-547	9
β-strand	550-552	3	39
α-helix	558-560	3
β-strand	565-569	5	39
β-strand	572-577	6	39
α-helix	580-593	14
β-strand	602-606	5	39
β-strand	611-615	5	39
β-strand	621-627	7	38
β-strand	628-629	2	40
β-strand	632-633	2	40
α-helix	637-644	8
α-helix	653-658	6
β-strand	662-666	5	38
α-helix	667-670	4
β-strand	675-676	2	38
β-strand	695-696	2	38
α-helix	700-703	4
α-helix	714-716	3
β-strand	717	1	41
α-helix	719-729	11
β-strand	732	1	42
β-strand	734	1	43
β-strand	747-751	5	43
β-strand	755	1	44
β-strand	759-760	2	45
α-helix	762-765	4
β-strand	776-782	7	46
β-strand	783	1	19
β-strand	793-797	5	46
α-helix	798-802	5
β-strand	808-817	10	43
β-strand	827-829	3	47
β-strand	848	1	48
β-strand	853	1	49
β-strand	854	1	48
α-helix	855	1
β-strand	859	1	43
β-strand	865-867	3	49
β-strand	869-872	4	47
β-strand	889-891	3	47
β-strand	894-895	2	49
β-strand	903-911	9	43
β-strand	917-927	11	43
β-strand	934-937	4	46
β-strand	942-949	8	46
β-strand	956	1	50
β-strand	965-967	3	46
α-helix	971-975	5
β-strand	977	1	41
α-helix	978-993	16
α-helix	996	1
β-strand	997-998	2	45
α-helix	1008-1016	9
β-strand	1025-1026	2	46
β-strand	1029	1	50
α-helix	1035	1
β-strand	1036	1	50
α-helix	1037	1
α-helix	1040	1
β-strand	1041-1050	10	46
β-strand	1051	1	42
β-strand	1060-1062	3	12
β-strand	1084-1086	3	11
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1113-1119	7	1
β-strand	1125	1	1
α-helix	1136	1
β-strand	1137	1	51
β-strand	1142	1	51
β-strand	1146-1152	7	1
α-helix	1153-1164	12
β-strand	1171-1172	2	2

Chain C: 11 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	52
β-strand	18-24	7	52
α-helix	28-40	13
β-strand	44-55	12	53
α-helix	61-69	9
β-strand	73	1	54
α-helix	78-81	4
β-strand	98-106	9	53
α-helix	112	1
β-strand	113-116	4	55
α-helix	117-119	3
β-strand	121-122	2	53
β-strand	129	1	54
α-helix	147-148	2
β-strand	149-153	5	55
β-strand	158-168	11	53
α-helix	174-176	3
β-strand	179-185	7	52
α-helix	200-202	3
α-helix	204-206	3
α-helix	218-220	3
β-strand	229-235	7	52
α-helix	241-270	30

Chain D: 11 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	56
β-strand	21	1	56
α-helix	24-26	3
α-helix	29	1
β-strand	30	1	30
α-helix	31	1
α-helix	34-49	16
α-helix	55-58	4
α-helix	59-71	13
α-helix	77-89	13
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-137	14

Chain E: 13 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	3-23	21
β-strand	26	1	57
α-helix	30-33	4
α-helix	37-42	6
β-strand	60-63	4	58
β-strand	64	1	57
β-strand	71-75	5	58
β-strand	81-82	2	59
α-helix	84-97	14
β-strand	101-106	6	58
β-strand	109-110	2	59
α-helix	112-121	10
β-strand	126-131	6	58
α-helix	132-135	4
α-helix	139-141	3
α-helix	146	1
β-strand	147-151	5	60
α-helix	152	1
α-helix	153-163	11
α-helix	167-169	3
β-strand	172-173	2	60
α-helix	178-183	6
α-helix	185-186	2
β-strand	190-197	8	60
β-strand	201-209	9	60

Chain F: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	56	1	61
α-helix	57-58	2
α-helix	59-74	16
α-helix	77-79	3
α-helix	89-99	11
β-strand	104-109	6	30
α-helix	110	1
β-strand	115-119	5	30
α-helix	120-122	3
β-strand	124	1	61
α-helix	125	1

Chain G: 3 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	2-13	12	30
α-helix	15-17	3
α-helix	22-34	13
β-strand	38-39	2	30
β-strand	43-54	12	30
β-strand	57-59	3	30
α-helix	60	1
β-strand	66-77	12	30
β-strand	84-92	9	62
β-strand	96-101	6	62
β-strand	104-109	6	62
β-strand	118-119	2	63
β-strand	128-129	2	63
β-strand	136-137	2	63
β-strand	142-153	12	62
β-strand	156-162	7	62

Chain H: 2 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	4-14	11	17
β-strand	25-32	8	17
β-strand	38-44	7	17
β-strand	55-61	7	17
β-strand	74	1	16
α-helix	84-87	4
β-strand	90-101	12	17
β-strand	111-118	8	17
β-strand	121-128	8	17
α-helix	129-132	4
β-strand	140-145	6	17
β-strand	147-148	2	17

12 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
RPB1	A	protein	1970	Sus scrofa	A0A8D1DPV6
DNA-directed RNA polymerase subunit beta	B	protein	1174	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Sus scrofa	I3LCH3 (AlphaFold model)
RPOL4c domain-containing protein	D	protein	142	Sus scrofa	A0A287ADR4 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	I3LSI7
DNA-directed RNA polymerase II subunit F	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa	A0A8W4F9W9
RNA_pol_L_2 domain-containing protein	K	protein	117	Sus scrofa	F1RKE4
RNA polymerase II subunit K	L	protein	58	Sus scrofa	A0A4X1TRS6

10 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>7NVS_1 RPB1 (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Sequence of entity 2 (B), FASTA

>7NVS_2 DNA-directed RNA polymerase subunit beta (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>7NVS_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>7NVS_4 RPOL4c domain-containing protein (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Sequence of entity 5 (E), FASTA

>7NVS_5 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>7NVS_6 DNA-directed RNA polymerase II subunit F (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 7 (G), FASTA

>7NVS_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>7NVS_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>7NVS_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>7NVS_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>7NVS_11 RNA_pol_L_2 domain-containing protein (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>7NVS_12 RNA polymerase II subunit K (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	10

Primary citation

Structures of mammalian RNA polymerase II pre-initiation complexes. Aibara, S., Schilbach, S., Cramer, P. Nature (2021) 594:124-128. DOI 10.1038/s41586-021-03554-8 · PubMed

Other PDB entries of the same protein (UniProt A0A8D1DPV6), best resolution first:

9HVQ 2.0 Å, Structure of the transcribing Pol II-DSIF-PAF-SPT6-RECQL5 complex
7NVU 2.5 Å, RNA polymerase II core pre-initiation complex with open promoter DNA
8QEP 2.5 Å, RNA polymerase II bound to Alu RNA right arm
8B3D 2.6 Å, Structure of the Pol II-TCR-ELOF1 complex.
7OOB 2.7 Å, Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2)
8UHG 2.7 Å, Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated
8UI0 2.7 Å, Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated
8WAV 2.72 Å, De novo transcribing complex 12 (TC12), the early elongation complex with Pol II…
8WAX 2.75 Å, De novo transcribing complex 14 (TC14), the early elongation complex with Pol II…
8WAZ 2.76 Å, De novo transcribing complex 16 (TC16), the early elongation complex with Pol II…
7F4G 2.78 Å, Structure of RPAP2-bound RNA polymerase II
8WAU 2.78 Å, De novo transcribing complex 11 (TC11), the early elongation complex with Pol II…

Browse structure collections

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