7OKY: DNA-directed RNA polymerase II subunit RPB1

Name: PDB 7OKY: Structure of active transcription elongation complex Pol II-DSIF-ELL2-EAF1(composite structure)
Published: 2021-07-14
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

Structure of active transcription elongation complex Pol II-DSIF-ELL2-EAF1(composite structure). Determined by electron microscopy at 4.14 Å resolution. Released 14 Jul 2021.

Method: Electron microscopy
Resolution: 4.14 Å
Organisms: Sus scrofa, Homo sapiens, HIV whole-genome vector AA1305#18
Chains: 19
Atoms: 38,341
Mol. weight: 811.56 kDa
Ligands: MG, ZN
Released: 14 Jul 2021

Explore 7OKY in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7OKY contains 210 α-helices and 301 β-strands across 16 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 78 helices, 72 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15	1	1
β-strand	20-22	3	2
β-strand	25	1	3
α-helix	26-27	2
α-helix	28-34	7
β-strand	47-48	2	4
β-strand	51-52	2	4
α-helix	60-62	3
β-strand	86-95	10	5
α-helix	100-107	8
β-strand	110	1	6
β-strand	117	1	6
α-helix	124-132	9
α-helix	137-148	12
β-strand	153	1	7
α-helix	186	1
β-strand	187	1	7
α-helix	188	1
β-strand	190-194	5	8
β-strand	197-201	5	8
β-strand	213-216	4	8
α-helix	218-226	9
α-helix	230-235	6
α-helix	245-248	4
β-strand	249-255	7	5
α-helix	256-257	2
β-strand	264	1	9
α-helix	265-266	2
α-helix	271	1
β-strand	272	1	9
α-helix	273-274	2
α-helix	275-295	21
α-helix	300-318	19
α-helix	326-328	3
β-strand	329	1	10
α-helix	334	1
β-strand	335	1	10
α-helix	336	1
α-helix	339-343	5
α-helix	349-353	5
β-strand	357-359	3	11
β-strand	362-369	8	12
β-strand	377-380	4	12
α-helix	382-385	4
β-strand	389-393	5	13
α-helix	394	1
α-helix	399-408	10
β-strand	416-420	5	13
β-strand	426-428	3	13
α-helix	429-431	3
β-strand	445-449	5	13
α-helix	450	1
β-strand	455-459	5	12
α-helix	466-468	3
β-strand	469-476	8	12
β-strand	482-484	3	12
α-helix	489-492	4
β-strand	500-504	5	12
α-helix	509-518	10
β-strand	520	1	12
α-helix	522-524	3
β-strand	526	1	14
β-strand	533	1	14
α-helix	540-548	9
β-strand	554-555	2	15
α-helix	557-564	8
α-helix	574	1
β-strand	575	1	16
α-helix	576-577	2
β-strand	579-581	3	17
β-strand	585	1	17
β-strand	586-587	2	15
α-helix	588-595	8
β-strand	602-605	4	18
β-strand	627-631	5	18
β-strand	634-637	4	18
α-helix	642-645	4
α-helix	652-660	9
α-helix	662-683	22
β-strand	686	1	19
α-helix	689-691	3
α-helix	696-721	26
α-helix	726-728	3
α-helix	733-758	26
α-helix	765-771	7
α-helix	778-785	8
β-strand	789-790	2	20
β-strand	793	1	21
β-strand	796	1	21
β-strand	822-823	2	20
α-helix	833-868	36
β-strand	872-873	2	22
β-strand	879-880	2	22
β-strand	886-888	3	22
α-helix	891-893	3
β-strand	896	1	23
β-strand	902-905	4	24
α-helix	913-920	8
α-helix	927-933	7
β-strand	934	1	25
α-helix	936-943	8
α-helix	946-969	24
β-strand	976-979	4	24
α-helix	983-993	11
β-strand	1002	1	25
α-helix	1006-1016	11
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1053-1056	4
α-helix	1062-1079	18
β-strand	1080	1	23
α-helix	1081-1082	2
α-helix	1087-1096	10
α-helix	1098-1101	4
α-helix	1121-1128	8
β-strand	1139-1142	4	26
β-strand	1143	1	27
α-helix	1145-1148	4
α-helix	1155-1161	7
β-strand	1164-1165	2	28
β-strand	1170-1177	8	29
α-helix	1190-1196	7
β-strand	1210-1216	7	29
α-helix	1218-1222	5
α-helix	1228-1239	12
β-strand	1243-1247	5	29
β-strand	1255-1261	7	29
α-helix	1281-1293	13
β-strand	1297-1299	3	28
β-strand	1307-1310	4	26
β-strand	1319-1322	4	30
β-strand	1328-1331	4	30
β-strand	1335-1338	4	26
α-helix	1343-1347	5
β-strand	1352	1	27
β-strand	1358-1359	2	26
α-helix	1362-1368	7
α-helix	1371-1388	18
α-helix	1395-1405	11
β-strand	1408-1409	2	31
α-helix	1416-1419	4
α-helix	1426-1432	7
α-helix	1435-1445	11
β-strand	1448-1449	2	2
α-helix	1454-1459	6
α-helix	1467-1469	3
β-strand	1471-1475	5	32
α-helix	1480-1482	3
β-strand	1484	1	33

Chain B: 58 helices, 88 β-strands

Element	Residues	Length	Sheet
β-strand	93	1	34
α-helix	96-98	3
α-helix	99-113	15
α-helix	118-126	9
α-helix	127-131	5
α-helix	132-138	7
α-helix	140-141	2
β-strand	142-144	3	35
β-strand	160-170	11	35
β-strand	174-176	3	36
β-strand	182-184	3	36
α-helix	187-192	6
β-strand	198-210	13	35
β-strand	219-230	12	35
α-helix	231	1
β-strand	232	1	37
α-helix	245-250	6
β-strand	262-264	3	37
β-strand	267-271	5	37
α-helix	272	1
β-strand	273-277	5	38
α-helix	278	1
β-strand	282-285	4	39
β-strand	292-300	9	39
β-strand	310-317	8	39
β-strand	333-336	4	39
β-strand	340	1	40
β-strand	344-345	2	39
α-helix	346-352	7
α-helix	358-365	8
α-helix	372-377	6
α-helix	379-384	6
α-helix	391-399	9
β-strand	402	1	40
α-helix	409-418	10
α-helix	419-423	5
α-helix	426-428	3
α-helix	435-453	19
α-helix	458-461	4
α-helix	465-467	3
β-strand	468-471	4	38
α-helix	473-501	29
α-helix	515-527	13
β-strand	530	1	41
β-strand	540	1	41
β-strand	544-546	3	37
α-helix	547-548	2
α-helix	552-559	8
β-strand	561-563	3	38
α-helix	574-576	3
α-helix	580-582	3
β-strand	586	1	42
β-strand	600-602	3	38
β-strand	603	1	42
β-strand	608-609	2	43
α-helix	616-624	9
β-strand	628-629	2	44
α-helix	630-632	3
α-helix	635-637	3
β-strand	642-646	5	44
β-strand	649-654	6	44
α-helix	657-669	13
β-strand	679-683	5	44
β-strand	688-692	5	44
β-strand	698-704	7	43
β-strand	705	1	45
β-strand	710	1	45
β-strand	713	1	34
α-helix	714-720	7
α-helix	723-726	4
α-helix	730-735	6
β-strand	739-743	5	43
α-helix	744-747	4
β-strand	752-753	2	43
α-helix	756-759	4
β-strand	772-773	2	43
α-helix	777-780	4
α-helix	791-793	3
α-helix	796-805	10
β-strand	809	1	46
β-strand	824-828	5	47
β-strand	832	1	48
β-strand	836-837	2	49
α-helix	839-842	4
β-strand	853-859	7	50
β-strand	860	1	19
β-strand	870-874	5	50
α-helix	875-879	5
β-strand	885-895	11	47
β-strand	897-898	2	51
β-strand	902-903	2	51
β-strand	904-906	3	52
β-strand	914-915	2	52
β-strand	921	1	53
α-helix	922-924	3
β-strand	925	1	54
β-strand	930	1	55
β-strand	931	1	54
α-helix	932	1
β-strand	936-938	3	47
β-strand	941	1	53
β-strand	942-944	3	55
β-strand	946-949	4	52
β-strand	966-968	3	52
β-strand	971-972	2	55
α-helix	973-974	2
β-strand	978-988	11	47
β-strand	994-1004	11	47
β-strand	1011-1014	4	50
β-strand	1019-1026	8	50
β-strand	1033	1	56
β-strand	1042-1044	3	50
α-helix	1046-1048	3
α-helix	1055-1070	16
β-strand	1074-1075	2	49
α-helix	1085-1093	9
β-strand	1102-1103	2	50
β-strand	1106	1	56
α-helix	1112	1
β-strand	1113	1	56
α-helix	1114	1
α-helix	1117	1
β-strand	1118-1127	10	50
β-strand	1128	1	46
β-strand	1137-1139	3	12
β-strand	1144	1	57
β-strand	1151	1	57
β-strand	1153	1	58
α-helix	1155-1157	3
α-helix	1159	1
β-strand	1160	1	58
β-strand	1161-1163	3	11
α-helix	1165-1174	10
α-helix	1177-1181	5
α-helix	1182-1186	5
β-strand	1192-1196	5	1
β-strand	1202	1	1
α-helix	1203	1
β-strand	1204-1206	3	59
β-strand	1211-1213	3	59
β-strand	1214	1	60
β-strand	1219	1	60
β-strand	1223-1227	5	1
α-helix	1230-1240	11
β-strand	1244	1	3
β-strand	1247-1249	3	2

Chain C: 11 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	8-15	8	61
β-strand	18-24	7	61
α-helix	28-40	13
β-strand	44-55	12	62
α-helix	61-69	9
β-strand	73	1	63
β-strand	98-106	9	62
α-helix	112	1
β-strand	113-116	4	64
α-helix	117-119	3
β-strand	121-122	2	62
β-strand	129	1	63
α-helix	130-132	3
α-helix	147-148	2
β-strand	149-153	5	64
β-strand	158-168	11	62
α-helix	174-176	3
β-strand	179-186	8	61
α-helix	200-202	3
α-helix	204-205	2
α-helix	218-220	3
β-strand	228-235	8	61
α-helix	241-269	29

Chain D: 9 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	66-68	3
α-helix	71	1
β-strand	72-73	2	32
α-helix	80-83	4
α-helix	85-91	7
α-helix	101-112	12
α-helix	119-131	13
α-helix	152-156	5
α-helix	158-160	3
α-helix	168-179	12

Chain E: 10 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	4-23	20
β-strand	26	1	65
α-helix	30-33	4
α-helix	37-43	7
β-strand	60-63	4	66
β-strand	64	1	65
β-strand	71-75	5	66
β-strand	81-82	2	67
α-helix	84-97	14
β-strand	101-106	6	66
β-strand	109-110	2	67
α-helix	112-120	9
β-strand	126-131	6	66
α-helix	139-141	3
β-strand	147-150	4	31
α-helix	151-152	2
α-helix	153-162	10
α-helix	167-169	3
β-strand	172-173	2	31
α-helix	178-183	6
β-strand	190-197	8	31
β-strand	201-209	9	31

Chain F: 6 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	56	1	68
α-helix	57-58	2
α-helix	59-74	16
α-helix	77-78	2
β-strand	79	1	33
α-helix	89-98	10
β-strand	104-109	6	32
α-helix	110	1
β-strand	115-119	5	32
α-helix	120-122	3
β-strand	124	1	68

Chain G: 5 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	2-4	3	32
β-strand	6-13	8	32
α-helix	15-17	3
α-helix	22-34	13
β-strand	44-54	11	32
β-strand	57-59	3	32
α-helix	60	1
β-strand	66-77	12	32
α-helix	79-80	2
β-strand	84-92	9	69
β-strand	96-101	6	69
β-strand	104-109	6	69
α-helix	115-117	3
β-strand	120	1	70
β-strand	127	1	70
β-strand	128-129	2	71
β-strand	136-137	2	71
β-strand	142-152	11	69
β-strand	157-162	6	69
β-strand	170	1	69

Chain H: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	4-15	12	17
β-strand	25-32	8	17
β-strand	38-44	7	17
β-strand	55-61	7	17
β-strand	65	1	72
β-strand	74	1	16
β-strand	83	1	72
α-helix	84-87	4
β-strand	90-101	12	17
β-strand	111-118	8	17
β-strand	121-128	8	17
α-helix	129-131	3
β-strand	140-147	8	17

8 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase II subunit RPB1	A	protein	1970	Sus scrofa	A0A8D1DPV6
DNA-directed RNA polymerase subunit beta	B	protein	1251	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Sus scrofa	I3LCH3 (AlphaFold model)
RNA polymerase II subunit D	D	protein	184	Sus scrofa	A0A287ADR4 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	I3LSI7
DNA-directed RNA polymerase II subunit F	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa	A0A8W4F9W9
RNA_pol_L_2 domain-containing protein	K	protein	117	Sus scrofa	F1RKE4
RNA polymerase II subunit K	L	protein	58	Sus scrofa	A0A4X1TRS6

7 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>7OKY_1 DNA-directed RNA polymerase II subunit RPB1 (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Sequence of entity 2 (B), FASTA

>7OKY_2 DNA-directed RNA polymerase subunit beta (chains B)
MCSTNLSQALAYFRAGANLTAASLWAGFRGSRRIFWERRKRKSLCLALRPGGACWRWLLA
VSCVSLRGLGAPGSCANMYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQ
LDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDG
APSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLL
NGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRS
CLENSSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRD
ILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVL
QKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFL
FRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQAR
AGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLV
KNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQL
MNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQL
KEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMI
LGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRS
MEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGF
DQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGT
NRRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKG
TCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFN
DAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRA
RGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCG
IMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>7OKY_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>7OKY_4 RNA polymerase II subunit D (chains D)
MWGPAQPYSDSALSPKPRPFRAVFRGSALPFPAVRVEVRGRSMAAGGSDPRAGDVEEDAS
QLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRE
TIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKR
SFQY

Sequence of entity 5 (E), FASTA

>7OKY_5 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>7OKY_6 DNA-directed RNA polymerase II subunit F (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 7 (G), FASTA

>7OKY_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>7OKY_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>7OKY_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>7OKY_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>7OKY_11 RNA_pol_L_2 domain-containing protein (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>7OKY_12 RNA polymerase II subunit K (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	9

Primary citation

Allosteric transcription stimulation by RNA polymerase II super elongation complex. Chen, Y., Vos, S.M., Dienemann, C. et al. Mol Cell (2021) 81:3386-3399.e10. DOI 10.1016/j.molcel.2021.06.019 · PubMed

Other PDB entries of the same protein (UniProt A0A8D1DPV6), best resolution first:

9HVQ 2.0 Å, Structure of the transcribing Pol II-DSIF-PAF-SPT6-RECQL5 complex
7NVU 2.5 Å, RNA polymerase II core pre-initiation complex with open promoter DNA
8QEP 2.5 Å, RNA polymerase II bound to Alu RNA right arm
8B3D 2.6 Å, Structure of the Pol II-TCR-ELOF1 complex.
7OOB 2.7 Å, Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2)
8UHG 2.7 Å, Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated
8UI0 2.7 Å, Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated
8WAV 2.72 Å, De novo transcribing complex 12 (TC12), the early elongation complex with Pol II…
8WAX 2.75 Å, De novo transcribing complex 14 (TC14), the early elongation complex with Pol II…
8WAZ 2.76 Å, De novo transcribing complex 16 (TC16), the early elongation complex with Pol II…
7F4G 2.78 Å, Structure of RPAP2-bound RNA polymerase II
8WAU 2.78 Å, De novo transcribing complex 11 (TC11), the early elongation complex with Pol II…

Browse structure collections

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