7PE9: DEPTOR

cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement. Determined by electron microscopy at 3.7 Å resolution. Released 8 Sept 2021.

Method: Electron microscopy
Resolution: 3.7 Å
Organism: Homo sapiens
Chains: 5
Atoms: 31,076
Mol. weight: 626.05 kDa
Ligands: ACE, ZN, IHP
Released: 8 Sept 2021

Explore 7PE9 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7PE9 contains 236 α-helices and 68 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 141 helices, 15 β-strands

Element	Residues	Length	Sheet
α-helix	18-29	12
α-helix	38-52	15
α-helix	61-73	13
α-helix	83-93	11
α-helix	102-114	13
α-helix	123-134	12
α-helix	141-155	15
α-helix	165-178	14
α-helix	182-184	3
α-helix	188-197	10
α-helix	204-222	19
α-helix	234-245	12
α-helix	262-275	14
α-helix	278-288	11
α-helix	308-311	4
α-helix	314-316	3
α-helix	357-360	4
α-helix	363-375	13
α-helix	387-402	16
α-helix	411-424	14
α-helix	430-443	14
α-helix	452-462	11
α-helix	480-490	11
α-helix	500-511	12
α-helix	515-527	13
α-helix	532-546	15
α-helix	581-591	11
α-helix	600-606	7
α-helix	609-612	4
α-helix	616-628	13
α-helix	649-665	17
α-helix	669-678	10
α-helix	681-685	5
α-helix	690-700	11
α-helix	705-719	15
α-helix	723-743	21
α-helix	747-763	17
α-helix	765-768	4
α-helix	769-771	3
α-helix	772-783	12
α-helix	792-808	17
α-helix	818-828	11
α-helix	838-846	9
α-helix	857-860	4
α-helix	864-874	11
α-helix	878-891	14
α-helix	896-901	6
α-helix	930-936	7
α-helix	943-957	15
α-helix	962-964	3
α-helix	968-982	15
α-helix	987-989	3
α-helix	990-1003	14
α-helix	1007-1022	16
α-helix	1028-1040	13
α-helix	1050-1063	14
α-helix	1067-1069	3
α-helix	1071-1074	4
α-helix	1075-1079	5
α-helix	1088-1090	3
α-helix	1091-1100	10
α-helix	1111-1119	9
α-helix	1129-1143	15
α-helix	1153-1163	11
α-helix	1170-1181	12
α-helix	1186-1191	6
α-helix	1192-1202	11
α-helix	1207-1217	11
α-helix	1229-1237	9
α-helix	1265-1269	5
α-helix	1277-1293	17
α-helix	1298-1301	4
α-helix	1304-1309	6
α-helix	1312-1315	4
α-helix	1318-1328	11
α-helix	1331-1345	15
α-helix	1351-1366	16
α-helix	1371-1373	3
α-helix	1377-1379	3
α-helix	1380-1388	9
α-helix	1393-1406	14
α-helix	1410-1421	12
α-helix	1426-1438	13
α-helix	1447-1452	6
α-helix	1457-1468	12
α-helix	1476-1487	12
α-helix	1490-1500	11
α-helix	1506-1523	18
α-helix	1526-1533	8
α-helix	1541-1553	13
α-helix	1557-1579	23
α-helix	1585-1587	3
α-helix	1590-1607	18
α-helix	1609-1611	3
α-helix	1615-1621	7
α-helix	1630-1639	10
α-helix	1646-1648	3
α-helix	1650-1663	14
α-helix	1666-1677	12
α-helix	1688-1690	3
α-helix	1694-1706	13
α-helix	1710-1728	19
α-helix	1739-1762	24
α-helix	1768-1782	15
α-helix	1787-1808	22
α-helix	1878-1895	18
α-helix	1900-1913	14
α-helix	1917-1929	13
α-helix	1939-1944	6
α-helix	1951-1967	17
α-helix	1973-1980	8
α-helix	1985-2001	17
α-helix	2003-2020	18
α-helix	2023-2036	14
α-helix	2037-2041	5
α-helix	2045-2056	12
α-helix	2065-2073	9
α-helix	2075-2091	17
α-helix	2094-2112	19
β-strand	2120-2122	3	1
α-helix	2123-2126	4
β-strand	2139	1	2
α-helix	2140	1
β-strand	2152	1	2
β-strand	2153-2156	4	3
β-strand	2159-2162	4	1
α-helix	2163	1
β-strand	2170-2171	2	1
β-strand	2173	1	4
β-strand	2174-2176	3	3
β-strand	2183	1	4
β-strand	2184-2188	5	1
α-helix	2193-2210	18
α-helix	2213-2216	4
β-strand	2227-2229	3	1
β-strand	2234-2238	5	1
α-helix	2239-2240	2
β-strand	2243-2245	3	5
α-helix	2246-2256	11
α-helix	2263-2271	9
α-helix	2275-2277	3
α-helix	2280-2293	14
α-helix	2298-2305	8
α-helix	2310-2334	25
α-helix	2341-2343	3
β-strand	2344-2347	4	5
β-strand	2353-2355	3	5
α-helix	2364-2367	4
α-helix	2381-2384	4
α-helix	2395-2409	15
α-helix	2411-2422	12
α-helix	2429-2431	3
α-helix	2495-2507	13
α-helix	2521-2532	12
α-helix	2535-2539	5
α-helix	2543-2545	3

Chain C: 0 helices, 28 β-strands

Element	Residues	Length	Sheet
β-strand	14-19	6	6
β-strand	23-27	5	6
β-strand	34-39	6	6
β-strand	47-50	4	7
β-strand	56-60	5	7
β-strand	65-69	5	7
β-strand	79-81	3	7
β-strand	88-93	6	8
β-strand	99-104	6	8
β-strand	108-113	6	8
β-strand	124-126	3	8
β-strand	131-136	6	9
β-strand	142-147	6	9
β-strand	152-156	5	9
β-strand	162-165	4	9
β-strand	173-178	6	10
β-strand	185-189	5	10
β-strand	194-198	5	10
β-strand	211-216	6	10
β-strand	223-228	6	11
β-strand	234-239	6	11
β-strand	243-248	6	11
β-strand	254-259	6	11
β-strand	273-278	6	12
β-strand	284-289	6	12
β-strand	293-298	6	12
β-strand	306-308	3	12
β-strand	315-321	7	6

Chain E: 75 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	33-42	10
α-helix	46-48	3
α-helix	53-69	17
α-helix	81-89	9
α-helix	97-110	14
α-helix	114-122	9
α-helix	126-133	8
α-helix	140-156	17
α-helix	158-160	3
α-helix	163-174	12
α-helix	185-197	13
α-helix	199-204	6
α-helix	207-216	10
α-helix	221-234	14
α-helix	241-243	3
α-helix	250-254	5
α-helix	255-258	4
α-helix	273-292	20
α-helix	295-301	7
α-helix	308-314	7
α-helix	315-317	3
α-helix	322-334	13
α-helix	346-351	6
α-helix	360-362	3
α-helix	370-374	5
α-helix	378-379	2
β-strand	386	1	13
α-helix	387-402	16
α-helix	404-413	10
α-helix	417-434	18
α-helix	441-443	3
α-helix	450-457	8
α-helix	463-485	23
α-helix	492-504	13
α-helix	525-534	10
α-helix	548-555	8
α-helix	568-581	14
β-strand	592	1	14
α-helix	598-614	17
α-helix	616-637	22
α-helix	647-651	5
β-strand	654	1	14
α-helix	655-657	3
α-helix	660-664	5
α-helix	670-679	10
α-helix	682-687	6
α-helix	696-704	9
α-helix	712-722	11
α-helix	726-734	9
α-helix	738-741	4
α-helix	747-750	4
α-helix	752-757	6
α-helix	758-760	3
α-helix	764-777	14
α-helix	781-788	8
α-helix	799-805	7
α-helix	806-810	5
α-helix	812-818	7
α-helix	824-830	7
α-helix	838-850	13
β-strand	877	1	13
α-helix	878-880	3
α-helix	882-885	4
α-helix	890-898	9
α-helix	902-910	9
α-helix	917-933	17
α-helix	937-940	4
α-helix	949-955	7
α-helix	962-975	14
α-helix	979-987	9
β-strand	990-992	3	15
β-strand	1428-1430	3	15
α-helix	1433-1435	3
α-helix	1480-1484	5
α-helix	1489-1493	5
α-helix	1525-1528	4
α-helix	1610-1622	13
α-helix	1629-1642	14
α-helix	1650-1662	13
α-helix	1667-1672	6
α-helix	1683-1693	11

Chain G: 5 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	7-20	14
α-helix	27-30	4
α-helix	33-35	3
α-helix	85-99	15
β-strand	104-106	3	7
α-helix	120-123	4

Chain I: 15 helices, 18 β-strands

Element	Residues	Length	Sheet
α-helix	21-23	3
α-helix	24-28	5
α-helix	29-47	19
β-strand	51-55	5	16
β-strand	58-63	6	16
β-strand	64-65	2	17
α-helix	66-76	11
α-helix	82-95	14
β-strand	98-100	3	17
β-strand	114-117	4	17
α-helix	118-120	3
α-helix	128-144	17
β-strand	152-156	5	18
β-strand	159-164	6	18
β-strand	165-166	2	19
α-helix	167-177	11
α-helix	183-196	14
β-strand	199-201	3	19
α-helix	206-208	3
β-strand	214-217	4	19
α-helix	224-226	3
α-helix	227-229	3
α-helix	316-320	5
β-strand	329-333	5	20
β-strand	342-344	3	21
β-strand	351	1	22
β-strand	352-355	4	21
α-helix	360-363	4
β-strand	371	1	22
β-strand	372-375	4	20
β-strand	378-379	2	20
α-helix	385-394	10
β-strand	399-403	5	20

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Serine/threonine-protein kinase mTOR	A	protein	2571	Homo sapiens	P42345 (AlphaFold model)
Target of rapamycin complex subunit LST8	C	protein	326	Homo sapiens	Q9BVC4 (AlphaFold model)
Rapamycin-insensitive companion of mTOR	E	protein	1708	Homo sapiens	Q6R327 (AlphaFold model)
Target of rapamycin complex 2 subunit MAPKAP1	G	protein	522	Homo sapiens	Q9BPZ7 (AlphaFold model)
DEP domain-containing mTOR-interacting protein	I	protein	409	Homo sapiens	Q8TB45

Sequence of entity 1 (A), FASTA

>7PE9_1 Serine/threonine-protein kinase mTOR (chains A)
MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDGSTSGSGDYKDDDDKGSTSGSGDRIHGALLILNELVRISSME
GERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSS
HQGLMGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPR
LAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDI
IRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALT
AVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASD
VGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLIS
GHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFV
ALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLG
HLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVD
ELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQ
GTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNM
GNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFL
NVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQ
IVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPI
VKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLS
SLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLR
SGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSP
SLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLL
NLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLIS
INNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELML
GRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPR
DTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSE
LEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYAS
LCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQ
HFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSA
ATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAATA
TTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGN
NLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIH
QLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIR
VAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDL
MEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLEL
AVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERV
MQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKK
ILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRT
NYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFR
LTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKG
NKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAI
QIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW

Sequence of entity 2 (C), FASTA

>7PE9_2 Target of rapamycin complex subunit LST8 (chains C)
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA
GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ
CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP
DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA
DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE
TGEIKREYGGHQKAVVCLAFNDSVLG

Sequence of entity 3 (E), FASTA

>7PE9_3 Rapamycin-insensitive companion of mTOR (chains E)
MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHL
NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV
LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER
DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT
RQYVRADVELERILAPYTDFHYRHSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIIN
LCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVTEEFIEALLSVDPGRFQD
SWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHIS
VRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALNCLKRFH
EMKKRGPKPYSLHLDHIIQKAIATHQKRDQYLRVQKDIFILKDTEEALLINLRDSQVLQH
KENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYANLDLDFAKAKQ
LTVVGCQFTEFLLESEEDGQGYLEDLVKDIVQWLNASSGMKPERSLQNNGLLTTLSQHYF
LFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILSKI
LTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACED
KANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHREYNSKYV
DLIEEQLNEALTTYRKPVDGDNYVRRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEVQN
IITELCRNVRTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCE
VLSIRGTCVYVLGLIAKTKQGCDILKCHNWDAVRHSRKHLWPVVPDDVEQLCNELSSIPS
TLSLNSESTSSRHNSESESVPSSMFILEDDRFGSSSTSTFFLDINEDTEPTFYDRSGPIK
DKNSFPFFASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVD
FNHSDDFTPISTVQKTLQLETSFMGNKHIEDTGSTPSIGENDLKFTKNFGTENHRENTSR
ERLVVESSTSSHMKIRSQSFNTDTTTSGISSMSSSPSRETVGVDATTMDTDCGSMSTVVS
TKTIKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFS
YTSSRDAFGYATLKRLQQQRMHPSLSHSEALASPAKDVLFTDTITMKANSFESRLTPSRF
MKALSYASLDKEDLLSPINQNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDIFQVK
DIPYFQTKNIPPHDDRGARAFAHDAGGLPSGTGGLVKNSFHLLRQQMSLTEIMNSIHSDA
SLFLESTEDTGLQEHTDDNCLYCVCIEILGFQPSNQLSAICSHSDFQDIPYSDWCEQTIH
NPLEVVPSKFSGISGCSDGVSQEGSASSTKSTELLLGVKTIPDDTPMCRILLRKEVLRLV
INLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQDV
QFLQMHEEAEAVLATPPKQPIVDTSAES

Sequence of entity 4 (G), FASTA

>7PE9_4 Target of rapamycin complex 2 subunit MAPKAP1 (chains G)
MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE
TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL
KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY
LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE
VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT
MKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRAD
GVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKAS
TKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVL
KVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ

Sequence of entity 5 (I), FASTA

>7PE9_5 DEP domain-containing mTOR-interacting protein (chains I)
MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTY
PNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKD
DGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEA
TTRKEAEQLCHRLMEHGIIQHVSSKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQE
THDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSP
PVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGP
AAAAGMKVCQFVVSVNGLNVLHVDYRTVNNLILTGPRTIVMEVMEELEC

Ligands and cofactors

ID	Name	Formula	Copies
ACE	Acetyl group	C2 H4 O	1
ZN	Zinc ion	Zn	1
IHP	Inositol hexakisphosphate	C6 H18 O24 P6	1

Primary citation

Regulation of human mTOR complexes by DEPTOR. Walchli, M., Berneiser, K., Mangia, F. et al. Elife (2021) 10. DOI 10.7554/eLife.70871 · PubMed

Other PDB entries of the same protein (UniProt P42345 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4DRI 1.45 Å, Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of…
9DBO 1.55 Å, Crystal structure of a synthetic Fab (R3E9) in complex with the FRB domain of mTOR
5GPG 1.67 Å, Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB…
5WBH 1.75 Å, Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1
4DRJ 1.8 Å, o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
3FAP 1.85 Å, Atomic structures of the rapamycin analogs in complex with both human FKBP12 and frb…
8PPZ 1.85 Å, Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR
8XI9 1.85 Å, Crystal structure of FRB-FKBP fusion protein in complex with rapamycin
9PIW 1.9 Å, Crystal structure of a synthetic Fab (1A) in complex with the FRB domain of mTOR
9DL0 2.0 Å, Crystal structure of a synthetic Fab (R3H8) in complex with the FRB domain of mTOR
9PJ1 2.05 Å, Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of…
9PIU 2.18 Å, Crystal structure of a synthetic Fab (2C) in complex with the FRB domain of mTOR

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