9RHL: Phospho-DH bound by Sld3-MBD on ARS1 DNA

Phospho-DH bound by Sld3-MBD on ARS1 DNA. Determined by electron microscopy at 3.1 Å resolution. Released 13 May 2026.

Method: Electron microscopy
Resolution: 3.1 Å
Organism: Saccharomyces cerevisiae
Chains: 16
Atoms: 64,409
Mol. weight: 1418.48 kDa
Ligands: MG, ADP, ZN
Released: 13 May 2026

Explore 9RHL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9RHL contains 408 α-helices and 354 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains 2 and a: 31 helices, 27 β-strands

Element	Residues	Length	Sheet
α-helix	186-188	3
α-helix	194-198	5
α-helix	201-215	15
α-helix	226-237	12
β-strand	241-245	5	1
α-helix	246-252	7
α-helix	254-262	9
α-helix	264-282	19
β-strand	294-298	5	1
β-strand	303-304	2	2
α-helix	306-308	3
α-helix	311-313	3
β-strand	317-327	11	2
β-strand	331-337	7	2
β-strand	339-341	3	3
β-strand	347	1	3
β-strand	351-352	2	2
β-strand	373-375	3	3
β-strand	381-391	11	2
α-helix	394-396	3
α-helix	398	1
β-strand	405-411	7	2
α-helix	412-414	3
β-strand	423-433	11	2
β-strand	446	1	4
β-strand	448-458	11	2
α-helix	478-488	11
α-helix	493-499	7
α-helix	509-520	12
β-strand	525-527	3	5
β-strand	531-533	3	5
β-strand	539-543	5	6
α-helix	549-559	11
β-strand	563-567	5	6
β-strand	579-582	4	7
β-strand	589-592	4	7
α-helix	595-598	4
β-strand	603-607	5	6
α-helix	609-611	3
α-helix	614-626	13
β-strand	628-633	6	8
β-strand	636-641	6	8
β-strand	645-650	6	6
α-helix	653-655	3
α-helix	663-666	4
α-helix	671-674	4
β-strand	679-683	5	6
α-helix	689-705	17
α-helix	757-759	3
α-helix	760-773	14
β-strand	777	1	9
α-helix	783-800	18
α-helix	804-805	2
α-helix	807-823	17
β-strand	828	1	9
α-helix	831-847	17
α-helix	851-860	10
α-helix	861-863	3

Chain 3: 30 helices, 31 β-strands

Element	Residues	Length	Sheet
α-helix	19-34	16
α-helix	37-52	16
β-strand	95-99	5	10
α-helix	100-106	7
α-helix	108-116	9
α-helix	118-134	17
β-strand	154-158	5	10
α-helix	162-164	3
β-strand	165-166	2	11
α-helix	173-175	3
β-strand	179-189	11	11
α-helix	190-192	3
β-strand	193-203	11	11
β-strand	208-213	6	11
α-helix	217-219	3
α-helix	229-232	4
β-strand	234	1	12
β-strand	240	1	12
β-strand	241-243	3	11
β-strand	249-259	11	11
α-helix	266	1
β-strand	273-279	7	11
α-helix	280-282	3
β-strand	291-301	11	11
β-strand	306	1	13
β-strand	308	1	13
β-strand	318-330	13	11
α-helix	340-342	3
α-helix	344-354	11
α-helix	359-366	8
α-helix	375-386	12
β-strand	391-392	2	14
β-strand	398-399	2	14
β-strand	405-409	5	15
α-helix	415-425	11
β-strand	429-433	5	15
α-helix	440-443	4
β-strand	446-449	4	16
β-strand	455-458	4	16
α-helix	461-464	4
β-strand	469-473	5	15
α-helix	475-477	3
α-helix	480-492	13
β-strand	494-497	4	17
β-strand	504-507	4	17
β-strand	511-516	6	15
α-helix	529-533	5
α-helix	537-541	5
β-strand	545-549	5	15
α-helix	555-568	14
α-helix	580-583	4
β-strand	589-590	2	11
β-strand	622	1	18
β-strand	651	1	18
α-helix	653-666	14
β-strand	670	1	19
α-helix	673-688	16
α-helix	690-693	4
α-helix	700-715	16
β-strand	720	1	19
α-helix	723-737	15

Chains 4 and c: 37 helices, 35 β-strands

Element	Residues	Length	Sheet
β-strand	178-180	3	20
β-strand	186	1	20
α-helix	187-199	13
α-helix	204-208	5
α-helix	209-211	3
α-helix	213-215	3
α-helix	225-236	12
β-strand	240-243	4	21
α-helix	246-250	5
α-helix	252-254	3
α-helix	255-263	9
α-helix	265-287	23
α-helix	294-298	5
β-strand	302-305	4	21
α-helix	314-316	3
α-helix	319-321	3
β-strand	325-335	11	22
α-helix	336-338	3
β-strand	339-349	11	22
β-strand	355-359	5	22
β-strand	361	1	23
β-strand	364-367	4	23
β-strand	370	1	24
β-strand	379	1	24
β-strand	382-384	3	22
α-helix	386-388	3
β-strand	390-401	12	22
α-helix	410-412	3
β-strand	414-420	7	22
α-helix	421-423	3
β-strand	432-442	11	22
β-strand	445	1	25
β-strand	453-454	2	25
β-strand	456	1	26
β-strand	458-467	10	22
α-helix	474-476	3
α-helix	482-491	10
α-helix	499-501	3
α-helix	503-514	12
α-helix	518-525	8
α-helix	534-545	12
β-strand	550-551	2	27
β-strand	557-558	2	27
β-strand	564-568	5	28
α-helix	575-584	10
β-strand	588-592	5	28
β-strand	596	1	29
α-helix	598-601	4
β-strand	604-607	4	30
β-strand	614-617	4	30
α-helix	620-623	4
β-strand	627-632	6	28
α-helix	634-636	3
α-helix	639-651	13
β-strand	653-657	5	31
β-strand	662-666	5	31
β-strand	669-675	7	28
α-helix	688-691	4
α-helix	696-699	4
β-strand	704-708	5	28
α-helix	714-726	13
α-helix	744-757	14
β-strand	761-762	2	32
α-helix	764-779	16
α-helix	795-811	17
β-strand	816-817	2	32
α-helix	819-832	14
α-helix	835-837	3
β-strand	838	1	33
α-helix	844	1
β-strand	845	1	33
α-helix	846	1

Chain 5: 37 helices, 26 β-strands

Element	Residues	Length	Sheet
α-helix	5-7	3
β-strand	8-12	5	34
α-helix	18-19	2
α-helix	24-37	14
α-helix	45-56	12
β-strand	60-64	5	35
α-helix	65-71	7
α-helix	73-81	9
α-helix	83-105	23
β-strand	136-140	5	35
α-helix	148-150	3
α-helix	153-155	3
β-strand	159-169	11	36
α-helix	171-172	2
β-strand	173-183	11	36
β-strand	189-193	5	36
α-helix	213-216	4
α-helix	220-225	6
β-strand	241-243	3	36
α-helix	245-247	3
β-strand	249-259	11	36
α-helix	262-264	3
α-helix	265-266	2
α-helix	269-272	4
β-strand	273-279	7	36
α-helix	280-282	3
β-strand	291-302	12	36
β-strand	323	1	2
β-strand	324-335	12	36
α-helix	351-361	11
α-helix	366-373	8
α-helix	382-393	12
β-strand	398-399	2	37
β-strand	405-406	2	37
β-strand	412-416	5	38
α-helix	422-432	11
β-strand	436-440	5	38
β-strand	446	1	8
β-strand	452-455	4	39
β-strand	462-466	5	39
α-helix	468-471	4
β-strand	476-480	5	38
α-helix	487-498	12
β-strand	501-505	5	40
β-strand	510-514	5	40
β-strand	518-523	6	38
α-helix	524-525	2
α-helix	526-528	3
α-helix	536-538	3
α-helix	544-549	6
β-strand	552-556	5	38
α-helix	562-577	16
α-helix	579	1
α-helix	580-585	6
α-helix	586-588	3
α-helix	596-609	14
β-strand	613-614	2	41
α-helix	616-639	24
α-helix	650-665	16
β-strand	671-672	2	41
α-helix	674-683	10
α-helix	684-688	5
α-helix	689-693	5

Chains 6 and e: 31 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	101-103	3
α-helix	106-121	16
β-strand	124-125	2	42
β-strand	132-133	2	42
α-helix	135-145	11
β-strand	150-154	5	43
α-helix	155-159	5
α-helix	161-164	4
α-helix	165-172	8
α-helix	174-189	16
α-helix	194-197	4
β-strand	264-268	5	43
β-strand	274	1	4
α-helix	281-283	3
β-strand	287-297	11	4
α-helix	298-300	3
β-strand	301-311	11	4
β-strand	317-322	6	4
β-strand	344-346	3	4
β-strand	352-362	11	4
α-helix	368-369	2
α-helix	373-375	3
β-strand	376-382	7	4
α-helix	383-388	6
β-strand	394-405	12	4
α-helix	408-411	4
β-strand	418-421	4	23
β-strand	446	1	23
β-strand	450-462	13	4
α-helix	485-489	5
α-helix	501-507	7
α-helix	510-521	12
α-helix	525-532	8
α-helix	541-550	10
α-helix	553-556	4
β-strand	557-558	2	44
β-strand	564-565	2	44
β-strand	571-574	4	45
α-helix	581-589	9
β-strand	595-598	4	45
β-strand	603	1	31
β-strand	610-614	5	46
β-strand	621-625	5	46
β-strand	635-638	4	45
α-helix	641-643	3
β-strand	660-665	6	47
β-strand	668-673	6	47
β-strand	677-682	6	45
α-helix	695-698	4
α-helix	703-706	4
β-strand	711-714	4	45
α-helix	721-737	17
α-helix	738-741	4
α-helix	748-758	11
β-strand	764-765	2	48
α-helix	767-785	19
α-helix	797-813	17
β-strand	818-819	2	48
α-helix	821-834	14
α-helix	836-839	4

Chain 7: 37 helices, 28 β-strands

Element	Residues	Length	Sheet
β-strand	7-8	2	11
α-helix	16-27	12
α-helix	62-71	10
β-strand	77-81	5	49
α-helix	82-94	13
α-helix	102-107	6
α-helix	113-123	11
α-helix	125-128	4
α-helix	131-132	2
α-helix	138-164	27
α-helix	175-188	14
α-helix	191-193	3
α-helix	194-196	3
β-strand	201-205	5	49
α-helix	209-214	6
β-strand	224-225	2	26
α-helix	232-234	3
β-strand	238-248	11	26
α-helix	249-251	3
β-strand	252-262	11	26
β-strand	267-272	6	26
β-strand	277-278	2	25
β-strand	283	1	50
α-helix	287-291	5
α-helix	296	1
β-strand	297	1	50
β-strand	298-316	19	26
α-helix	319-321	3
α-helix	323	1
α-helix	326-328	3
β-strand	330-336	7	26
α-helix	337-339	3
β-strand	348-359	12	26
β-strand	371	1	11
β-strand	372-383	12	26
α-helix	395-407	13
α-helix	410-416	7
α-helix	426-437	12
β-strand	442-444	3	51
β-strand	448-450	3	51
β-strand	456-460	5	52
α-helix	466-476	11
β-strand	481-483	3	52
α-helix	490-492	3
β-strand	495-499	5	53
β-strand	506-510	5	53
α-helix	512-515	4
β-strand	520-523	4	52
α-helix	526-528	3
α-helix	531-543	13
β-strand	545-550	6	29
β-strand	553-558	6	29
β-strand	562-567	6	52
α-helix	580-583	4
α-helix	588-591	4
β-strand	596-600	5	52
α-helix	606-622	17
α-helix	632-634	3
α-helix	635-646	12
β-strand	651	1	54
α-helix	654-670	17
α-helix	672-676	5
α-helix	686-702	17
β-strand	707	1	54
α-helix	710-728	19

Chain b: 29 helices, 31 β-strands

Element	Residues	Length	Sheet
α-helix	19-34	16
α-helix	37-52	16
β-strand	95-99	5	65
α-helix	100-106	7
α-helix	108-116	9
α-helix	118-134	17
β-strand	154-158	5	65
α-helix	162-164	3
β-strand	165-166	2	66
α-helix	173-175	3
β-strand	179-189	11	66
α-helix	190-192	3
β-strand	193-203	11	66
β-strand	208-213	6	66
α-helix	229-232	4
β-strand	234	1	67
β-strand	240	1	67
β-strand	241-243	3	66
β-strand	249-259	11	66
α-helix	266	1
β-strand	273-279	7	66
α-helix	280-282	3
β-strand	291-301	11	66
β-strand	306	1	68
β-strand	308	1	68
β-strand	318-330	13	66
α-helix	340-342	3
α-helix	344-354	11
α-helix	359-365	7
α-helix	375-386	12
β-strand	391-392	2	69
β-strand	398-399	2	69
β-strand	405-409	5	70
α-helix	415-425	11
β-strand	429-433	5	70
α-helix	440-443	4
β-strand	445-449	5	71
β-strand	455-459	5	71
α-helix	461-464	4
β-strand	469-473	5	70
α-helix	475-477	3
α-helix	480-492	13
β-strand	494-497	4	72
β-strand	504-507	4	72
β-strand	511-516	6	70
α-helix	529-533	5
α-helix	537-541	5
β-strand	545-549	5	70
α-helix	555-568	14
α-helix	580-583	4
β-strand	589-590	2	66
β-strand	622	1	73
β-strand	651	1	73
α-helix	653-666	14
β-strand	670	1	74
α-helix	673-688	16
α-helix	690-693	4
α-helix	700-715	16
β-strand	720	1	74
α-helix	723-737	15

Chain d: 37 helices, 26 β-strands

Element	Residues	Length	Sheet
α-helix	5-7	3
β-strand	8-12	5	26
α-helix	18-19	2
α-helix	24-37	14
α-helix	45-56	12
β-strand	60-64	5	87
α-helix	65-71	7
α-helix	73-81	9
α-helix	83-106	24
β-strand	136-140	5	87
α-helix	148-150	3
α-helix	153-155	3
β-strand	159-169	11	88
α-helix	171-172	2
β-strand	173-183	11	88
β-strand	189-193	5	88
α-helix	213-216	4
α-helix	220-225	6
β-strand	241-243	3	88
α-helix	245-247	3
β-strand	249-259	11	88
α-helix	262-264	3
α-helix	265-266	2
α-helix	269-272	4
β-strand	273-279	7	88
α-helix	280-282	3
β-strand	291-302	12	88
β-strand	323	1	57
β-strand	324-335	12	88
α-helix	351-361	11
α-helix	366-373	8
α-helix	382-393	12
β-strand	398-399	2	89
β-strand	405-406	2	89
β-strand	412-416	5	90
α-helix	422-432	11
β-strand	436-440	5	90
β-strand	446	1	63
β-strand	452-455	4	91
β-strand	462-466	5	91
α-helix	468-471	4
β-strand	476-480	5	90
α-helix	487-498	12
β-strand	501-505	5	92
β-strand	510-514	5	92
β-strand	518-523	6	90
α-helix	524-525	2
α-helix	526-528	3
α-helix	536-538	3
α-helix	544-549	6
β-strand	552-556	5	90
α-helix	562-577	16
α-helix	579	1
α-helix	580-585	6
α-helix	586-588	3
α-helix	596-609	14
β-strand	613-614	2	93
α-helix	616-639	24
α-helix	650-665	16
β-strand	671-672	2	93
α-helix	674-683	10
α-helix	684-688	5
α-helix	689-693	5

2 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA replication licensing factor MCM2	2, a	protein	868	Saccharomyces cerevisiae	P29469 (AlphaFold model)
DNA replication licensing factor MCM3	3, b	protein	1006	Saccharomyces cerevisiae	P24279 (AlphaFold model)
DNA replication licensing factor MCM4	4, c	protein	933	Saccharomyces cerevisiae	P30665 (AlphaFold model)
Minichromosome maintenance protein 5	5, d	protein	775	Saccharomyces cerevisiae	P29496 (AlphaFold model)
DNA replication licensing factor MCM6	6, e	protein	1017	Saccharomyces cerevisiae	P53091
DNA replication licensing factor MCM7	7, f	protein	845	Saccharomyces cerevisiae	P38132
DNA replication regulator SLD3	H, I	protein	704	Saccharomyces cerevisiae	P53135
DNA (53-mer)	X	DNA	53	Saccharomyces cerevisiae
DNA (53-mer)	Y	DNA	53	Saccharomyces cerevisiae

Sequence of entity 1 (2, a), FASTA

>9RHL_1 DNA replication licensing factor MCM2 (chains 2, a)
MSDNRRRRREEDDSDSENELPPSSPQQHFRGGMNPVSSPIGSPDMINPEGDDNEVDDVPD
IDEVEEQMNEVDLMDDNMYEDYAADHNRDRYDPDQVDDREQQELSLSERRRIDAQLNERD
RLLRNVAYIDDEDEEQEGAAQLDEMGLPVQRRRRRRQYEDLENSDDDLLSDMDIDPLREE
LTLESLSNVKANSYSEWITQPNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSE
SLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDF
PTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIR
ISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKP
GEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEE
EREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVL
LLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLAD
KGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNST
LPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELK
NNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQ
MDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKV
VVDSFVDAQKVSVRRQLRRSFAIYTLGH

Sequence of entity 2 (3, b), FASTA

>9RHL_2 DNA replication licensing factor MCM3 (chains 3, b)
MKRRWKKNFIAVSAANRFKKISSSGALENLYFQGEMEGSTGFDGDATTFFAPDAVFGDRV
RRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQDDADERDLLGDDDGDDLEKEKKAAS
STSLNILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDDVPHPNAS
AVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAK
TGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMPEMA
PAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLILGNT
VYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLML
MGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAA
VTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTT
LNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHV
LRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINPEEHSNSGAGVENEGEDDEDHVFEKF
NPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTD
LRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALLGEDIGND
IDEEESEYEEALSKRSPQKSPKKRQRVRQPASNSGSPIKSTPRRSTASSVNATPSSARRI
LRFQDDEQNAGEDDNDIMSPLPADEEAELQRRLQLGLRVSPRRREHLHAPEEGSSGPLTE
VGTPRLPNVSSAGQDDEQQQSVISFDNVEPGTISTGRLSLISGIIARLMQTEIFEEESYP
VASLFERINEELPEEEKFSAQEYLAGLKIMSDRNNLMVADDKVWRV

Sequence of entity 3 (4, c), FASTA

>9RHL_3 DNA replication licensing factor MCM4 (chains 4, c)
MSQQSSSPTKEDNNSSSPVVPNPDSVPPQLSSPALFYSSSSSQGDIYGRNNSQNLSQGEG
NIRAAIGSSPLNFPSSSQRQNSDVFQSQGRQGRIRSSASASGRSRYHSDLRSDRALPTSS
SSLGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNTLDTSSSSAPPSEASEPLRII
WGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSN
LNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKF
YKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEI
DRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVY
DELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTST
IEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGI
LLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVG
LTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAG
IITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDREL
AKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKM
GDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATDP
KTGKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQASDSMSFNELIKQINEHSQDRVES
SDIQEALSRLQQEDKVIVLGEGVRRSVRLNNRV

Sequence of entity 4 (5, d), FASTA

>9RHL_4 Minichromosome maintenance protein 5 (chains 5, d)
MSFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYS
LTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENT
SMDTDSLLLNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLS
IMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDP
YIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSI
YNSKNGAGSGRSGGGNGGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQL
SRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGT
AKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCID
EFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNI
DFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMK
RYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRIT
ESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLNQASGTSLSEIRRFEQELKR
RLPIGWSTSYQTLRREFVDTHRFSQLALDKALYALEKHETIQLRHQGQNIYRSGV

Sequence of entity 5 (6, e), FASTA

>9RHL_5 DNA replication licensing factor MCM6 (chains 6, e)
MSSPFPADTPSSNRPSNSSPPPSSIGAGFGSSSGLDSQIGSRLHFPSSSQPHVSNSQTGP
FVNDSTQFSSQRLQTDGSATNDMEGNEPARSFKSRALNHVKKVDDVTGEKVREAFEQFLE
DFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPF
LQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGN
GTSAMATRSITTSTSPEQTERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEV
RPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVR
IQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSST
LDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRET
ELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGH
EAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSG
KASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQT
ISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCN
EKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKEL
RKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDV
DDVEMDEEFDNIESQSHAASGNNDDNDDGTGSGVITSEPPADIEEGQSEATARPGTSEKK
KTTVTYDKYVSMMNMIVRKIAEVDREGAEELTAVDIVDWYLLQKENDLGSLAEYWEERRL
AFKVIKRLVKDRILMEIHGTRHNLRDLENEENENNKTVYVIHPNCEVLDQLEPQDSS

Sequence of entity 6 (7, f), FASTA

>9RHL_6 DNA replication licensing factor MCM7 (chains 7, f)
MSAALPSIQLPVDYNNLFNEITDFLVTFKQDTLSSDATRNENEDENLDAENIEQHLLEKG
PKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRA
IDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDA
LREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLIT
VRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFM
STRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPY
TGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAP
EIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRG
VYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEV
MEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLM
LDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYV
VQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLV
RVSKESLYQETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRGFTMLQLS
NCIQEYSYLNVWHLINEGNTLKFVDDGTMDTDQEDSLVSTPKLAPQTTASANVSAQDSDI
DLQDA

Sequence of entity 7 (H, I), FASTA

>9RHL_7 DNA replication regulator SLD3 (chains H, I)
METWEVIASVKEATKGLDLSLDHPLIIKSEDVPSNILQLLQQKNRRQLKHICMKSRKEYF
LLEEYGPGFWVKWPYNYFNGYSLPERRTEVVTTVERERAKRETLKTWDELKFKELLHLWS
EEPKGSCKLEKDKDLKLDMNPPDMKGESKINDYYSDPKEYIESKYYDALFSIHTPLAYFV
KSNLVRLKNTCRTKYGSDSYKIAYQAMLQKFLLSIVQFKDRHDNRLLLEPFSSPIADEKR
KNCLTKFVIQDENKNSSTIADLCVVLKSREIKLQILLLLEIIGLNDLDWNFRDFEKKYKL
KLKKRSLNLTKKGLVRRRSKKKTSEKDKGIERITTSLDYCEQLDLYLDRACILDILLSSE
TPNPDAIEASNGTIQEHKKNILDKSKEASLVGFINYVLIPYFNKKVPHAVEFIIQKLKGP
SMRPKRALKKVNDSTNVSSPNTVETYNRLSTSQRASRSSIINSVPSSPALRRVDANLFSR
KSIASPTPELLNSRTNSNLNEFLESETRSLKRPSQLGRTKSDLTMNHLQKRQFSVSDLST
TRVPNSSTITLKTPFSHSTINAYKTMNNSFRRVGKRKDINETIRLHERVDSEENVQVQAT
PAVKKRTVTPNKKAQLQSIIESPLNFKDDDTHEGRKNTSNITSTPTNKPPENSSKRRVRR
RLFAPESTENLYFQGWSHPQFEKGGGSGGGSGGSSAWSHPQFEK

Sequence of entity 8 (X), FASTA

>9RHL_8 DNA (53-MER) (chains X)
GCATGCATGCGCATGCATGCATGCATGCTGCATGCATGCATGCGCATGCATGC

Sequence of entity 9 (Y), FASTA

>9RHL_9 DNA (53-MER) (chains Y)
GCATGCATGCGCATGCATGCATGCAGCATGCATGCATGCATGCGCATGCATGC

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	4
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	4
ZN	Zinc ion	Zn	10

Primary citation

Structure of the pre-initiation complex explains CMGE biogenesis. Puhringer, T., Canal, B., Palm, G. et al. Nature (2026) 655:1330-1338. DOI 10.1038/s41586-026-10657-7 · PubMed

Other PDB entries of the same protein (UniProt P29469 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7W8G 2.52 Å, Cryo-EM structure of MCM double hexamer
28VY 2.7 Å, sCMGE assembled on ARS1 DNA with Sld2 and RPA
8RIF 2.79 Å, Cryo-EM structure of the MCM double hexamer loaded onto dsDNA.
7V3V 2.9 Å, Cryo-EM structure of MCM double hexamer bound with DDK in State I
9TH8 2.9 Å, Cryo-EM structure of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA
7P30 3.0 Å, 3.0 A resolution structure of a DNA-loaded MCM double hexamer
8KG6 3.07 Å, Yeast replisome in state I
7PMK 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
7PMN 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II)
7PT6 3.2 Å, Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state III
7V3U 3.2 Å, Cryo-EM structure of MCM double hexamer with structured Mcm4-NSD
9E2Y 3.2 Å, Cryo-EM structure of yeast CMG helicase stalled at G4-containing DNA template, state 3

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