7PT6: MCM2-7 DH

Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state III. Determined by electron microscopy at 3.2 Å resolution. Released 8 Jun 2022.

Method: Electron microscopy
Resolution: 3.2 Å
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Chains: 18
Atoms: 74,358
Mol. weight: 1501.13 kDa
Ligands: ADP, ZN, MG, AGS
Released: 8 Jun 2022

Explore 7PT6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7PT6 contains 430 α-helices and 415 β-strands across 16 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains 2 and B: 29 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	183-186	4
α-helix	194-199	6
α-helix	201-217	17
α-helix	226-237	12
β-strand	241-242	2	1
β-strand	245	1	2
α-helix	246-252	7
α-helix	254-262	9
α-helix	270-282	13
β-strand	294-295	2	1
β-strand	298	1	2
α-helix	311-313	3
β-strand	316-327	12	3
β-strand	331-337	7	3
β-strand	339-341	3	4
β-strand	347	1	4
α-helix	348-350	3
β-strand	351-352	2	3
β-strand	373-375	3	4
β-strand	381-391	11	3
α-helix	398	1
β-strand	405-411	7	3
β-strand	423-433	11	3
β-strand	446	1	5
β-strand	448-458	11	3
α-helix	478-488	11
α-helix	493-500	8
α-helix	509-520	12
β-strand	525-526	2	6
β-strand	532-533	2	6
β-strand	539-543	5	7
α-helix	549-559	11
β-strand	563-567	5	7
β-strand	579-582	4	8
β-strand	589-592	4	8
α-helix	595-598	4
β-strand	603-607	5	7
α-helix	614-626	13
β-strand	628-633	6	9
β-strand	636-641	6	9
α-helix	644	1
β-strand	645-650	6	7
α-helix	663-665	3
α-helix	671-676	6
β-strand	679-683	5	7
α-helix	689-705	17
α-helix	757-759	3
α-helix	760-773	14
β-strand	777	1	10
α-helix	780-782	3
α-helix	783-800	18
α-helix	807-823	17
β-strand	828	1	10
α-helix	831-847	17
α-helix	855	1
α-helix	856-860	5
α-helix	861-863	3

Chains 3 and C: 28 helices, 34 β-strands

Element	Residues	Length	Sheet
α-helix	19-34	16
α-helix	37-55	19
α-helix	91-93	3
β-strand	95-99	5	11
α-helix	100-106	7
α-helix	108-116	9
α-helix	118-136	19
α-helix	140-142	3
α-helix	152-153	2
β-strand	154-158	5	11
α-helix	162-164	3
β-strand	165-166	2	12
α-helix	173-175	3
β-strand	179-189	11	12
β-strand	193-203	11	12
β-strand	208-213	6	12
α-helix	229-231	3
β-strand	234	1	13
α-helix	239	1
β-strand	240	1	13
β-strand	241-243	3	12
β-strand	249-259	11	12
α-helix	266	1
β-strand	273-279	7	12
β-strand	291-301	11	12
β-strand	317	1	14
β-strand	318-330	13	12
α-helix	344-354	11
α-helix	359-365	7
α-helix	375-386	12
β-strand	391-392	2	15
β-strand	398-399	2	15
β-strand	405-409	5	16
α-helix	415-425	11
β-strand	429-433	5	16
β-strand	434	1	17
β-strand	437	1	17
α-helix	439-442	4
β-strand	445-446	2	18
β-strand	457-458	2	18
α-helix	461-464	4
β-strand	469-473	5	16
α-helix	480-492	13
β-strand	494-496	3	19
β-strand	499	1	20
β-strand	502	1	20
β-strand	505-507	3	19
β-strand	511-516	6	16
α-helix	529-533	5
α-helix	537-542	6
β-strand	545-549	5	16
α-helix	555-569	15
α-helix	580-583	4
β-strand	589-590	2	12
β-strand	622	1	21
β-strand	651	1	21
α-helix	653-666	14
β-strand	670-671	2	22
α-helix	673-688	16
α-helix	699-715	17
β-strand	720-721	2	22
α-helix	723-738	16

Chains 4 and D: 34 helices, 36 β-strands

Element	Residues	Length	Sheet
β-strand	179-180	2	23
β-strand	186	1	23
α-helix	187-199	13
β-strand	202	1	24
α-helix	203-209	7
α-helix	213-215	3
β-strand	224	1	24
α-helix	225-236	12
β-strand	240-241	2	25
α-helix	245-250	6
α-helix	255-263	9
α-helix	265-286	22
α-helix	294-297	4
β-strand	302-303	2	25
α-helix	319-321	3
β-strand	324-335	12	26
α-helix	336-338	3
β-strand	339-346	8	26
β-strand	347-349	3	27
β-strand	357-359	3	26
α-helix	360	1
β-strand	361	1	28
β-strand	364-367	4	28
β-strand	382-384	3	27
α-helix	386-388	3
β-strand	390-401	12	26
β-strand	414-420	7	26
β-strand	432-442	11	26
α-helix	443-444	2
β-strand	445	1	29
α-helix	452	1
β-strand	453-454	2	29
β-strand	456	1	30
β-strand	458-467	10	26
α-helix	474-476	3
α-helix	478-480	3
α-helix	482-491	10
α-helix	503-513	11
α-helix	518-525	8
α-helix	531-532	2
α-helix	534-545	12
β-strand	550-551	2	31
β-strand	557-558	2	31
β-strand	564-568	5	32
α-helix	574-584	11
β-strand	590-591	2	32
β-strand	596	1	33
β-strand	604-607	4	34
β-strand	614-617	4	34
α-helix	620-623	4
β-strand	628-631	4	32
α-helix	644-650	7
β-strand	653-658	6	35
β-strand	661-666	6	35
β-strand	670-675	6	32
α-helix	678-680	3
α-helix	688-692	5
α-helix	696-699	4
β-strand	704-708	5	32
α-helix	714-726	13
α-helix	744-757	14
β-strand	761-762	2	36
α-helix	764-777	14
α-helix	796-811	16
β-strand	816-817	2	36
α-helix	819-832	14
α-helix	835-837	3
β-strand	838	1	37
β-strand	845	1	37
α-helix	847-849	3

Chains 5 and E: 30 helices, 24 β-strands

Element	Residues	Length	Sheet
α-helix	5-7	3
β-strand	8-12	5	38
α-helix	18-20	3
α-helix	24-37	14
α-helix	45-55	11
β-strand	60-64	5	39
α-helix	65-71	7
α-helix	73-81	9
α-helix	83-106	24
α-helix	134-135	2
β-strand	136-140	5	39
α-helix	144-147	4
α-helix	148-150	3
α-helix	153-155	3
β-strand	158-169	12	14
α-helix	170-172	3
β-strand	173-183	11	14
β-strand	189-193	5	14
β-strand	241-259	19	14
α-helix	270-272	3
β-strand	273-279	7	14
α-helix	280-282	3
β-strand	291-301	11	14
β-strand	323	1	3
β-strand	325-335	11	14
α-helix	351-361	11
α-helix	366-371	6
α-helix	382-393	12
β-strand	398-399	2	40
β-strand	405-406	2	40
β-strand	412-416	5	41
α-helix	422-432	11
β-strand	436-439	4	41
β-strand	452-454	3	42
β-strand	463-466	4	42
α-helix	468-471	4
β-strand	476-480	5	41
α-helix	487-498	12
β-strand	501-505	5	43
β-strand	510-514	5	43
β-strand	518-523	6	41
α-helix	546-549	4
β-strand	552-556	5	41
α-helix	557-559	3
α-helix	562-573	12
α-helix	574-578	5
α-helix	580-588	9
α-helix	596-609	14
β-strand	613-614	2	44
α-helix	616-639	24
α-helix	643-644	2
α-helix	650-666	17
β-strand	671-672	2	44
α-helix	674-686	13

Chain 6: 30 helices, 34 β-strands

Element	Residues	Length	Sheet
α-helix	102-104	3
α-helix	106-121	16
β-strand	124	1	45
β-strand	133	1	45
α-helix	135-145	11
β-strand	150-154	5	46
α-helix	155-160	6
α-helix	161-164	4
α-helix	165-172	8
α-helix	174-191	18
α-helix	194-196	3
β-strand	264-268	5	46
β-strand	274	1	5
α-helix	281-283	3
β-strand	284	1	5
β-strand	287-297	11	5
α-helix	298-300	3
β-strand	301-311	11	5
β-strand	317-322	6	5
β-strand	344-346	3	5
β-strand	352-362	11	5
α-helix	363-364	2
α-helix	372-375	4
β-strand	376-382	7	5
α-helix	383-385	3
β-strand	394-405	12	5
α-helix	407-409	3
β-strand	418-421	4	28
β-strand	446-447	2	28
β-strand	450-461	12	5
α-helix	501-506	6
α-helix	510-521	12
α-helix	525-531	7
α-helix	541-552	12
β-strand	557	1	47
β-strand	565	1	47
β-strand	571-575	5	48
α-helix	581-588	8
β-strand	589	1	49
β-strand	592	1	49
β-strand	595-599	5	48
β-strand	603	1	35
α-helix	605-608	4
β-strand	611-613	3	50
β-strand	622-624	3	50
α-helix	627-630	4
β-strand	635-639	5	48
α-helix	646-658	13
β-strand	660-662	3	51
β-strand	671-673	3	51
β-strand	677-681	5	48
α-helix	685-687	3
α-helix	695-698	4
α-helix	703-707	5
β-strand	711-715	5	48
α-helix	721-736	16
α-helix	748-758	11
β-strand	764-765	2	52
α-helix	767-783	17
β-strand	791	1	53
α-helix	797-814	18
β-strand	818-819	2	52
α-helix	821-834	14
β-strand	837	1	53

Chains 7 and G: 31 helices, 29 β-strands

Element	Residues	Length	Sheet
β-strand	7-8	2	12
α-helix	14-27	14
α-helix	62-71	10
β-strand	77-81	5	54
α-helix	82-94	13
α-helix	102-108	7
α-helix	110-123	14
α-helix	126-128	3
α-helix	138-164	27
α-helix	178-188	11
α-helix	191-193	3
β-strand	201-205	5	54
α-helix	206-208	3
β-strand	224-225	2	30
β-strand	238-247	10	30
β-strand	252-262	11	30
β-strand	267-272	6	30
β-strand	277-278	2	29
β-strand	283	1	55
α-helix	287-291	5
β-strand	297	1	55
β-strand	298-300	3	30
β-strand	306-316	11	30
β-strand	330-336	7	30
α-helix	337-339	3
β-strand	348-359	12	30
α-helix	364-366	3
β-strand	371	1	12
β-strand	372-383	12	30
α-helix	388-390	3
α-helix	395-405	11
α-helix	410-416	7
α-helix	426-437	12
β-strand	442-443	2	56
β-strand	449-450	2	56
β-strand	456-460	5	57
α-helix	466-476	11
β-strand	480-484	5	57
β-strand	495-500	6	58
β-strand	505-510	6	58
α-helix	512-515	4
β-strand	520-524	5	57
α-helix	526-528	3
α-helix	531-543	13
β-strand	545-550	6	33
β-strand	553-558	6	33
β-strand	562-567	6	57
α-helix	570-572	3
α-helix	580-583	4
α-helix	588-593	6
β-strand	596-600	5	57
α-helix	607-621	15
α-helix	632-634	3
α-helix	635-646	12
β-strand	651-652	2	59
α-helix	654-673	20
α-helix	686-702	17
β-strand	707-708	2	59
α-helix	710-722	13
α-helix	725-727	3

Chain 8: 16 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	13-25	13
α-helix	27-29	3
β-strand	34-41	8	60
β-strand	45-51	7	60
β-strand	73-78	6	60
α-helix	84-96	13
β-strand	108-112	5	60
β-strand	115-121	7	60
β-strand	126	1	61
α-helix	128-131	4
α-helix	137-157	21
β-strand	159-160	2	62
β-strand	169-172	4	61
β-strand	177-180	4	61
β-strand	187-188	2	62
α-helix	189	1
β-strand	264-266	3	63
α-helix	272-274	3
α-helix	287-290	4
α-helix	299-312	14
α-helix	325-336	12
α-helix	338-347	10
β-strand	350-355	6	64
α-helix	369-383	15
α-helix	392-403	12
α-helix	427-449	23
α-helix	460-464	5
α-helix	467-469	3

Chain 9: 17 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	112-115	4
β-strand	125-128	4	65
α-helix	138-156	19
β-strand	161-162	2	65
β-strand	172-175	4	65
α-helix	190-196	7
β-strand	200-203	4	65
α-helix	204-213	10
α-helix	234-242	9
β-strand	258-260	3	63
α-helix	261	1
β-strand	265-270	6	64
β-strand	279-282	4	64
α-helix	285-288	4
α-helix	320-332	13
α-helix	334-343	10
α-helix	350-352	3
α-helix	374-384	11
α-helix	519-521	3
α-helix	522-527	6
α-helix	528-530	3
β-strand	531-532	2	66
β-strand	659-661	3	67
β-strand	666-668	3	67
α-helix	671-674	4
α-helix	678-685	8
α-helix	692-700	9

3 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Undefined Mcm4 flexible N-terminal tail	1, A	protein	4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
DNA replication licensing factor MCM2	2, B	protein	868	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P29469 (AlphaFold model)
DNA replication licensing factor MCM3	3, C	protein	971	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P24279 (AlphaFold model)
DNA replication licensing factor MCM4	4, D	protein	933	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P30665 (AlphaFold model)
Minichromosome maintenance protein 5	5, E	protein	775	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P29496 (AlphaFold model)
DNA replication licensing factor MCM6	6, F	protein	1017	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P53091
DNA replication licensing factor MCM7	7, G	protein	845	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P38132
Cell division control protein 7	8, H	protein	507	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P06243
DDK kinase regulatory subunit DBF4	9, I	protein	704	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P32325

Sequence of entity 1 (1, A), FASTA

>7PT6_1 Undefined Mcm4 flexible N-terminal tail (chains 1, A)
XXXX

Sequence of entity 2 (2, B), FASTA

>7PT6_2 DNA replication licensing factor MCM2 (chains 2, B)
MSDNRRRRREEDDSDSENELPPSSPQQHFRGGMNPVSSPIGSPDMINPEGDDNEVDDVPD
IDEVEEQMNEVDLMDDNMYEDYAADHNRDRYDPDQVDDREQQELSLSERRRIDAQLNERD
RLLRNVAYIDDEDEEQEGAAQLDEMGLPVQRRRRRRQYEDLENSDDDLLSDMDIDPLREE
LTLESLSNVKANSYSEWITQPNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSE
SLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDF
PTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIR
ISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKP
GEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEE
EREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVL
LLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLAD
KGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNST
LPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELK
NNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQ
MDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKV
VVDSFVDAQKVSVRRQLRRSFAIYTLGH

Sequence of entity 3 (3, C), FASTA

>7PT6_3 DNA replication licensing factor MCM3 (chains 3, C)
MEGSTGFDGDATTFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQ
DDADERDLLGDDDGDDLEKEKKAASSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAY
FIPPAEKALTDLADSMDDVPHPNASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLV
SVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNK
LTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKS
LGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIF
DILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLR
FVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTD
VDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLL
SRFDLLFVVTDDINEIRDRSISEHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINP
EEHSNSGAGVENEGEDDEDHVFEKFNPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYV
QYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKT
VNKVDAKVAANLLRFALLGEDIGNDIDEEESEYEEALSKRSPQKSPKKRQRVRQPASNSG
SPIKSTPRRSTASSVNATPSSARRILRFQDDEQNAGEDDNDIMSPLPADEEAELQRRLQL
GLRVSPRRREHLHAPEEGSSGPLTEVGTPRLPNVSSAGQDDEQQQSVISFDNVEPGTIST
GRLSLISGIIARLMQTEIFEEESYPVASLFERINEELPEEEKFSAQEYLAGLKIMSDRNN
LMVADDKVWRV

Sequence of entity 4 (4, D), FASTA

>7PT6_4 DNA replication licensing factor MCM4 (chains 4, D)
MSQQSSSPTKEDNNSSSPVVPNPDSVPPQLSSPALFYSSSSSQGDIYGRNNSQNLSQGEG
NIRAAIGSSPLNFPSSSQRQNSDVFQSQGRQGRIRSSASASGRSRYHSDLRSDRALPTSS
SSLGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNTLDTSSSSAPPSEASEPLRII
WGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSN
LNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKF
YKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEI
DRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVY
DELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTST
IEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGI
LLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVG
LTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAG
IITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDREL
AKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKM
GDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATDP
KTGKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQASDSMSFNELIKQINEHSQDRVES
SDIQEALSRLQQEDKVIVLGEGVRRSVRLNNRV

Sequence of entity 5 (5, E), FASTA

>7PT6_5 Minichromosome maintenance protein 5 (chains 5, E)
MSFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYS
LTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENT
SMDTDSLLLNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLS
IMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDP
YIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSI
YNSKNGAGSGRSGGGNGGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQL
SRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGT
AKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCID
EFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNI
DFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMK
RYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRIT
ESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLNQASGTSLSEIRRFEQELKR
RLPIGWSTSYQTLRREFVDTHRFSQLALDKALYALEKHETIQLRHQGQNIYRSGV

Sequence of entity 6 (6, F), FASTA

>7PT6_6 DNA replication licensing factor MCM6 (chains 6, F)
MSSPFPADTPSSNRPSNSSPPPSSIGAGFGSSSGLDSQIGSRLHFPSSSQPHVSNSQTGP
FVNDSTQFSSQRLQTDGSATNDMEGNEPARSFKSRALNHVKKVDDVTGEKVREAFEQFLE
DFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPF
LQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGN
GTSAMATRSITTSTSPEQTERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEV
RPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVR
IQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSST
LDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRET
ELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGH
EAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSG
KASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQT
ISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCN
EKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKEL
RKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDV
DDVEMDEEFDNIESQSHAASGNNDDNDDGTGSGVITSEPPADIEEGQSEATARPGTSEKK
KTTVTYDKYVSMMNMIVRKIAEVDREGAEELTAVDIVDWYLLQKENDLGSLAEYWEERRL
AFKVIKRLVKDRILMEIHGTRHNLRDLENEENENNKTVYVIHPNCEVLDQLEPQDSS

Sequence of entity 7 (7, G), FASTA

>7PT6_7 DNA replication licensing factor MCM7 (chains 7, G)
MSAALPSIQLPVDYNNLFNEITDFLVTFKQDTLSSDATRNENEDENLDAENIEQHLLEKG
PKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRA
IDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDA
LREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLIT
VRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFM
STRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPY
TGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAP
EIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRG
VYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEV
MEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLM
LDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYV
VQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLV
RVSKESLYQETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRGFTMLQLS
NCIQEYSYLNVWHLINEGNTLKFVDDGTMDTDQEDSLVSTPKLAPQTTASANVSAQDSDI
DLQDA

Sequence of entity 8 (8, H), FASTA

>7PT6_8 Cell division control protein 7 (chains 8, H)
MTSKTKNIDDIPPEIKEEMIQLYHDLPGIENEYKLIDKIGEGTFSSVYKAKDITGKITKK
FASHFWNYGSNYVALKKIYVTSSPQRIYNELNLLYIMTGSSRVAPLCDAKRVRDQVIAVL
PYYPHEEFRTFYRDLPIKGIKKYIWELLRALKFVHSKGIIHRDIKPTNFLFNLELGRGVL
VDFGLAEAQMDYKSMISSQNDYDNYANTNHDGGYSMRNHEQFCPCIMRNQYSPNSHNQTP
PMVTIQNGKVVHLNNVNGVDLTKGYPKNETRRIKRANRAGTRGFRAPEVLMKCGAQSTKI
DIWSVGVILLSLLGRRFPMFQSLDDADSLLELCTIFGWKELRKCAALHGLGFEASGLIWD
KPNGYSNGLKEFVYDLLNKECTIGTFPEYSVAFETFGFLQQELHDRMSIEPQLPDPKTNM
DAVDAYELKKYQEEIWSDHYWCFQVLEQCFEMDPQKRSSAEDLLKTPFFNELNENTYLLD
GESTDEDDVVSSSEADLLDKDVLLISE

Sequence of entity 9 (9, I), FASTA

>7PT6_9 DDK kinase regulatory subunit DBF4 (chains 9, I)
MVSPTKMIIRSPLKETDTNLKHNNGIAASTTAAGHLNVFSNDNNCNNNNTTESFPKKRSL
ERLELQQQQHLHEKKRARIERARSIEGAVQVSKGTGLKNVEPRVTPKELLEWQTNWKKIM
KRDSRIYFDITDDVEMNTYNKSKMDKRRDLLKRGFLTLGAQITQFFDTTVTIVITRRSVE
NIYLLKDTDILSRAKKNYMKVWSYEKAARFLKNLDVDLDHLSKTKSASLAAPTLSNLLHN
EKLYGPTDRDPRTKRDDIHYFKYPHVYLYDLWQTWAPIITLEWKPQELTNLDELPYPILK
IGSFGRCPFIGDRNYDESSYKRVVKRYSRDKANKKYALQLRALFQYHADTLLNTSSVNDQ
TKNLIFIPHTCNDSTKSFKKWMQEKAKNFEKTELKKTDDSAVQDVRNEHADQTDEKNSIL
LNETETKEPPLKEEKENKQSIAEESNKYPQRKELAATPKLNHPVLATFARQETEEVPDDL
CTLKTKSRQAFEIKASGAHQSNDVATSFGNGLGPTRASVMSKNMKSLSRLMVDRKLGVKQ
TNGNNKNYTATIATTAETSKENRHRLDFNALKKDEAPSKETGKDSAVHLETNRKPQNFPK
VATKSVSADSKVHNDIKITTTESPTASKKSTSTNVTLHFNAQTAQTAQPVKKETVKNSGY
CENCRVKYESLEQHIVSEKHLSFAENDLNFEAIDSLIENLRFQI

Ligands and cofactors

ID	Name	Formula	Copies
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	4
ZN	Zinc ion	Zn	14
MG	Magnesium ion	Mg	14
AGS	Phosphothiophosphoric acid-adenylate ester	C10 H16 N5 O12 P3 S	12

Primary citation

The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer. Saleh, A., Noguchi, Y., Aramayo, R. et al. Nat Commun (2022) 13:2915-2915. DOI 10.1038/s41467-022-30576-1 · PubMed

Other PDB entries of the same protein (UniProt P29469 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7W8G 2.52 Å, Cryo-EM structure of MCM double hexamer
28VY 2.7 Å, sCMGE assembled on ARS1 DNA with Sld2 and RPA
8RIF 2.79 Å, Cryo-EM structure of the MCM double hexamer loaded onto dsDNA.
7V3V 2.9 Å, Cryo-EM structure of MCM double hexamer bound with DDK in State I
9TH8 2.9 Å, Cryo-EM structure of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA
7P30 3.0 Å, 3.0 A resolution structure of a DNA-loaded MCM double hexamer
8KG6 3.07 Å, Yeast replisome in state I
9RHL 3.1 Å, Phospho-DH bound by Sld3-MBD on ARS1 DNA
7PMK 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
7PMN 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II)
7V3U 3.2 Å, Cryo-EM structure of MCM double hexamer with structured Mcm4-NSD
9E2Y 3.2 Å, Cryo-EM structure of yeast CMG helicase stalled at G4-containing DNA template, state 3

Browse structure collections

About this viewer

MolViewer shows 7PT6 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.