Crystal structure of the Abl SH3 domain V73E-A74S-S75R-G76T-D77E mutant. Determined by X-ray diffraction at 1.1 Å resolution. Released 14 Sept 2022.
Explore 7PW2 in 3D Show helices and sheets RCSB PDB PDBe
7PW2 contains 1 α-helix and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 65-68 | 4 | 1 |
| β-strand | 72 | 1 | 2 |
| β-strand | 79 | 1 | 1 |
| β-strand | 82 | 1 | 2 |
| β-strand | 87-93 | 7 | 1 |
| β-strand | 99-104 | 6 | 1 |
| β-strand | 107-112 | 6 | 1 |
| α-helix | 113-115 | 3 | |
| β-strand | 116-118 | 3 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Non-specific protein-tyrosine kinase | A | protein | 60 | Homo sapiens | P00519 (AlphaFold model) |
>7PW2_1 Non-specific protein-tyrosine kinase (chains A) GGPNLFVALYDFESRTENTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN
Understanding domain swapping in the c-Src SH3 domain through hinge-loop mutagenesis. Salinas-Garcia, M.C., Plaza-Garrido, M., Martinez, J.C. et al. Acta Crystallogr D Struct Biol (2025). DOI 10.1107/S2059798325006977 · PubMed
Other PDB entries of the same protein (UniProt P00519 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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