7RJL: Human Bromodomain containing protein 3

Crystal structure of human Bromodomain containing protein 3 (BRD3) in complex with SHMT. Determined by X-ray diffraction at 1.5 Å resolution. Released 3 Aug 2022.

Method: X-ray diffraction
Resolution: 1.5 Å
Organism: Homo sapiens
Chains: 4
Atoms: 2,324
Mol. weight: 31.28 kDa
Released: 3 Aug 2022

Explore 7RJL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7RJL contains 20 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 0 β-strands

Element	Residues	Length
α-helix	23-25	3
α-helix	37-41	5
α-helix	42-47	6
α-helix	48-51	4
α-helix	57-59	3
α-helix	73-76	4
α-helix	83-91	9
α-helix	98-115	18
α-helix	121-138	18
α-helix	140-142	3

Chain B: 10 helices, 0 β-strands

Element	Residues	Length
α-helix	34-36	3
α-helix	37-41	5
α-helix	42-47	6
α-helix	48-52	5
α-helix	57-59	3
α-helix	73-76	4
α-helix	83-91	9
α-helix	98-115	18
α-helix	121-137	17
α-helix	140-143	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Bromodomain-containing protein 3	A, B	protein	123	Homo sapiens	Q15059 (AlphaFold model)
Serine hydroxymethyltransferase, cytosolic	C, D	protein	6	Homo sapiens	P34896 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>7RJL_1 Bromodomain-containing protein 3 (chains A, B)
SMPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPM
DMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMP
QEE

Sequence of entity 2 (C, D), FASTA

>7RJL_2 Serine hydroxymethyltransferase, cytosolic (chains C, D)
RKGVKS

Primary citation

Uncovering the Bromodomain Interactome using Site-Specific Azide-Acetyllysine Photochemistry, Proteomic Profiling and Structural Characterization. Wagner, S., Fedorov, E., Sudhamalla, B. et al. bioRxiv (2021). DOI 10.1101/2021.07.28.453719

Other PDB entries of the same protein (UniProt Q15059 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6QJU 1.2 Å, Crystal structure of human Bromodomain containing protein 3 (BRD3) in complex with…
3S92 1.36 Å, Crystal Structure of the second bromodomain of human BRD3 in complex with the inhibitor…
9NN4 1.37 Å, BET BRD3-BD1 in complex with peptide 7.2
2NXB 1.4 Å, Crystal structure of human Bromodomain containing protein 3 (BRD3)
7TOA 1.41 Å, BRD3-BD1 in complex with RaPID linear peptide 3xAcK.1 (triAcK.1)
7LAY 1.45 Å, Crystal structure of the first bromodomain (BD1) of human BRD3 bound to SG3-179
8CV5 1.47 Å, Peptide 4.2B in complex with BRD3.2
7L72 1.5 Å, Crystal structure of the second bromodomain (BD2) of human BRD3 bound to Ro3280
7TO8 1.5 Å, BRD3-BD1 in complex with RaPID linear peptide 2xAcK.1 (diAcK.1)
7L9L 1.55 Å, Crystal structure of the second bromodomain (BD2) of human BRD3 bound to BI2536
7TO9 1.6 Å, BRD3-BD1 in complex with RaPID linear peptide 2xAcK.4xE (diAcK.4xE)
9MPN 1.6 Å, BRD3-BD1 A128T mutant

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