7RJO: Human Bromodomain containing protein 4

Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with hnRNPK. Determined by X-ray diffraction at 1.38 Å resolution. Released 3 Aug 2022.

Method: X-ray diffraction
Resolution: 1.38 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,310
Mol. weight: 16.52 kDa
Released: 3 Aug 2022

Explore 7RJO in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7RJO contains 11 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 0 β-strands

Element	Residues	Length
α-helix	44-49	6
α-helix	55-57	3
α-helix	61-65	5
α-helix	66-71	6
α-helix	72-76	5
α-helix	81-83	3
α-helix	97-100	4
α-helix	107-115	9
α-helix	122-139	18
α-helix	141	1
α-helix	145-161	17

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Bromodomain-containing protein 4	A	protein	127	Homo sapiens	O60885 (AlphaFold model)
Heterogeneous nuclear ribonucleoprotein K	B	protein	10	Homo sapiens	P61978 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>7RJO_1 Bromodomain-containing protein 4 (chains A)
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKII
KTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI
NELPTEE

Sequence of entity 2 (B), FASTA

>7RJO_2 Heterogeneous nuclear ribonucleoprotein K (chains B)
VIGKGGKNIK

Primary citation

Uncovering the Bromodomain Interactome using Site-Specific Azide-Acetyllysine Photochemistry, Proteomic Profiling and Structural Characterization. Wagner, S., Fedorov, E., Sudhamalla, B. et al. bioRxiv (2021). DOI 10.1101/2021.07.28.453719

Other PDB entries of the same protein (UniProt O60885 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4QB3 0.94 Å, Crystal structure of the first bromodomain of human BRD4 in complex with Olinone
6FO5 0.95 Å, First domain of human bromodomain BRD4 in complex with inhibitor #17
7Z9W 0.99 Å, BRD4 in complex with FragLite1
4ZC9 0.99 Å, Crystal Structure of the BRD4a/DB-2-190 complex
9P34 0.99 Å, Crystal structure of the Bromo domain 1 in human Bromodomain Containing Protein 4 with a…
6I7Y 1.0 Å, Crystal Structure of the first bromodomain of BRD4 in complex with RT56
7ZAJ 1.0 Å, BRD4 in complex with FragLite16
8YMG 1.01 Å, BRD4-BD1 in complex with 7-[4-chloro-1-(tetrahydropyran-4-ylmethyl)imidazol-2-yl]-5-methy…
8YMI 1.01 Å, BRD4-BD1 in complex with 2-{[(3S)-1-benzylpyrrolidin-3-yl]methyl}-5-methyl-7-(1-methylpyr…
9P33 1.01 Å, Crystal structure of the Bromo domain 1 in human Bromodomain Containing Protein 4 with a…
8YMF 1.01 Å, BRD4-BD1 in complex with 7-[2-(cyclopropylmethoxy)phenyl]-5-methyl-2-[(1-methylsulfonyl-4…
7Z9Y 1.04 Å, BRD4 in complex with FragLite2

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