Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with SHMT. Determined by X-ray diffraction at 1.25 Å resolution. Released 3 Aug 2022.
Explore 7RJP in 3D Show helices and sheets RCSB PDB PDBe
7RJP contains 10 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 43-49 | 7 | |
| α-helix | 61-65 | 5 | |
| α-helix | 66-71 | 6 | |
| α-helix | 72-76 | 5 | |
| α-helix | 81-83 | 3 | |
| α-helix | 97-100 | 4 | |
| α-helix | 107-115 | 9 | |
| α-helix | 122-139 | 18 | |
| α-helix | 145-161 | 17 | |
| α-helix | 164-167 | 4 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Bromodomain-containing protein 4 | A | protein | 127 | Homo sapiens | O60885 (AlphaFold model) |
| Serine hydroxymethyltransferase, cytosolic | B | protein | 6 | Homo sapiens | P34896 (AlphaFold model) |
>7RJP_1 Bromodomain-containing protein 4 (chains A) SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKII KTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI NELPTEE
>7RJP_2 Serine hydroxymethyltransferase, cytosolic (chains B) RKGVKS
Uncovering the Bromodomain Interactome using Site-Specific Azide-Acetyllysine Photochemistry, Proteomic Profiling and Structural Characterization. Wagner, S., Fedorov, E., Sudhamalla, B. et al. To be published.
Other PDB entries of the same protein (UniProt O60885 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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