7SNF: G6PD-WT dimer

Structure of G6PD-WT dimer. Determined by electron microscopy at 3.5 Å resolution. Released 13 Jul 2022.

Method: Electron microscopy
Resolution: 3.5 Å
Organism: Homo sapiens
Chains: 2
Atoms: 7,588
Mol. weight: 120.81 kDa
Released: 13 Jul 2022

Explore 7SNF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7SNF contains 57 α-helices and 44 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 26 helices, 22 β-strands

Element	Residues	Length	Sheet
β-strand	32-37	6	1
α-helix	42-43	2
α-helix	44-48	5
α-helix	49-57	9
β-strand	65-70	6	1
β-strand	71	1	2
α-helix	77-88	12
α-helix	92-94	3
α-helix	95-101	7
β-strand	105-106	2	1
β-strand	109	1	2
α-helix	115-126	12
β-strand	135-136	2	1
β-strand	138-140	3	1
α-helix	144-146	3
α-helix	147-157	11
β-strand	167-169	3	1
α-helix	170	1
α-helix	172	1
α-helix	177-190	14
β-strand	196-198	3	1
α-helix	208-216	9
β-strand	230-238	9	3
α-helix	255	1
α-helix	256-264	9
α-helix	265-272	8
α-helix	281-293	13
α-helix	300-302	3
β-strand	303-309	7	3
α-helix	329	1
β-strand	337-343	7	3
β-strand	344	1	4
β-strand	350	1	4
β-strand	353-356	4	3
β-strand	366-373	8	3
α-helix	374-376	3
β-strand	391-393	3	5
β-strand	399-402	4	5
β-strand	405-407	3	6
α-helix	408	1
β-strand	415-417	3	6
β-strand	420-421	2	5
α-helix	436-446	11
α-helix	455-464	10
α-helix	466-475	10
α-helix	479	1
β-strand	480-483	4	3
α-helix	490-499	10

Chain B: 31 helices, 22 β-strands

Element	Residues	Length	Sheet
β-strand	32-37	6	7
α-helix	42-43	2
α-helix	44-48	5
α-helix	49-57	9
β-strand	65-67	3	7
β-strand	70	1	7
β-strand	71	1	8
α-helix	77-84	8
α-helix	86-88	3
α-helix	92-94	3
α-helix	95-103	9
β-strand	109	1	8
α-helix	115-126	12
β-strand	135-140	6	7
α-helix	144-146	3
α-helix	147-157	11
β-strand	167-169	3	7
α-helix	170	1
α-helix	172	1
α-helix	177-190	14
α-helix	193-195	3
β-strand	197-198	2	7
α-helix	207-216	10
β-strand	230-235	6	9
β-strand	238	1	10
α-helix	247-250	4
α-helix	255	1
α-helix	256-264	9
α-helix	265-272	8
α-helix	281-293	13
α-helix	300-302	3
β-strand	304-309	6	11
α-helix	317-319	3
α-helix	329	1
β-strand	337-339	3	11
β-strand	342	1	9
α-helix	347-349	3
β-strand	354-356	3	9
β-strand	366	1	10
β-strand	369-373	5	9
α-helix	374-376	3
α-helix	386-388	3
β-strand	391-393	3	12
β-strand	399-402	4	12
β-strand	405-407	3	13
α-helix	408	1
β-strand	415-417	3	13
β-strand	420-421	2	12
α-helix	436-446	11
α-helix	455-475	21
α-helix	479	1
β-strand	480-483	4	11
α-helix	490-499	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Glucose-6-phosphate 1-dehydrogenase	A, B	protein	523	Homo sapiens	P11413 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>7SNF_1 Glucose-6-phosphate 1-dehydrogenase (chains A, B)
MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGL
LPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQR
LNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSS
DRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEP
FGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQA
NNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGK
ALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESEL
DLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPI
PYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKLLEHHHHHH

Primary citation

Allosteric role of a structural NADP + molecule in glucose-6-phosphate dehydrogenase activity. Wei, X., Kixmoeller, K., Baltrusaitis, E. et al. Proc Natl Acad Sci U S A (2022) 119:e2119695119-e2119695119. DOI 10.1073/pnas.2119695119 · PubMed

Other PDB entries of the same protein (UniProt P11413 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6JYU 1.89 Å, Crystal structure of Human G6PD Canton
6E08 1.9 Å, Crystal structure of G6PD in complex with structural NADP
7SNH 2.2 Å, Structure of G6PD-D200N tetramer bound to NADP+
7ZVE 2.28 Å, K403 acetylated glucose-6-phosphate dehydrogenase (G6PD)
7ZVD 2.46 Å, K89 acetylated glucose-6-phosphate dehydrogenase (G6PD) in a complex with structural NADP+
2BH9 2.5 Å, X-ray structure of a deletion variant of human glucose 6-phosphate dehydrogenase…
7SNI 2.5 Å, Structure of G6PD-D200N tetramer bound to NADP+ and G6P
7UC2 2.5 Å, Structure of G6PD-D200N tetramer bound to NADP+ with no symmetry applied
6E07 2.6 Å, Crystal structure of Canton G6PD in complex with structural NADP
5UKW 2.65 Å, Crystal structure of human Glucose 6-phosphate Dehydrogenase mutant (A277C) complexed…
7SNG 2.8 Å, structure of G6PD-WT tetramer
2BHL 2.9 Å, X-ray structure of human glucose-6-phosphate dehydrogenase (deletion variant) complexed…

Browse structure collections

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