Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1). Determined by electron microscopy at 4.2 Å resolution. Released 27 Jul 2022.
Explore 7SYF in 3D Show helices and sheets RCSB PDB PDBe
7SYF contains 61 α-helices and 50 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 43-71 | 29 | |
| α-helix | 72-78 | 7 | |
| α-helix | 79-81 | 3 | |
| α-helix | 93-120 | 28 | |
| α-helix | 132-142 | 11 | |
| α-helix | 145-164 | 20 | |
| α-helix | 166-179 | 14 | |
| α-helix | 188-191 | 4 | |
| α-helix | 194-212 | 19 | |
| α-helix | 219-236 | 18 | |
| α-helix | 238-256 | 19 | |
| β-strand | 257-258 | 2 | 1 |
| α-helix | 265-268 | 4 | |
| β-strand | 272-281 | 10 | 1 |
| β-strand | 287-294 | 8 | 1 |
| β-strand | 297-302 | 6 | 1 |
| β-strand | 325-332 | 8 | 1 |
| β-strand | 338-340 | 3 | 1 |
| β-strand | 345 | 1 | 2 |
| β-strand | 355 | 1 | 2 |
| β-strand | 358-363 | 6 | 1 |
| β-strand | 368-373 | 6 | 1 |
| α-helix | 377-420 | 44 | |
| β-strand | 429 | 1 | 3 |
| β-strand | 441 | 1 | 3 |
| β-strand | 442-443 | 2 | 4 |
| α-helix | 444-454 | 11 | |
| α-helix | 460-472 | 13 | |
| β-strand | 476-478 | 3 | 4 |
| β-strand | 491-494 | 4 | 4 |
| α-helix | 505-522 | 18 | |
| β-strand | 530-533 | 4 | 5 |
| β-strand | 538-542 | 5 | 5 |
| β-strand | 543-544 | 2 | 6 |
| α-helix | 545-554 | 10 | |
| α-helix | 561-573 | 13 | |
| β-strand | 577-579 | 3 | 6 |
| α-helix | 584-586 | 3 | |
| β-strand | 592-595 | 4 | 6 |
| α-helix | 596-602 | 7 | |
| α-helix | 607-609 | 3 | |
| β-strand | 615-628 | 14 | 7 |
| β-strand | 637-642 | 6 | 8 |
| β-strand | 645-651 | 7 | 8 |
| α-helix | 656-660 | 5 | |
| β-strand | 667 | 1 | 8 |
| β-strand | 668-671 | 4 | 7 |
| β-strand | 674 | 1 | 7 |
| α-helix | 676-678 | 3 | |
| α-helix | 681-693 | 13 | |
| α-helix | 696-697 | 2 | |
| β-strand | 698-703 | 6 | 7 |
| β-strand | 707-713 | 7 | 9 |
| β-strand | 721-724 | 4 | 9 |
| β-strand | 730-735 | 6 | 9 |
| α-helix | 739-743 | 5 | |
| β-strand | 750-754 | 5 | 9 |
| β-strand | 757-758 | 2 | 9 |
| α-helix | 764-768 | 5 | |
| α-helix | 772-777 | 6 | |
| α-helix | 778-781 | 4 | |
| β-strand | 787-789 | 3 | 9 |
| α-helix | 792-805 | 14 | |
| β-strand | 841-847 | 7 | 9 |
| β-strand | 852-860 | 9 | 7 |
| β-strand | 861 | 1 | 10 |
| β-strand | 866-874 | 9 | 7 |
| α-helix | 879-907 | 29 | |
| α-helix | 914-945 | 32 | |
| β-strand | 953 | 1 | 11 |
| α-helix | 954-956 | 3 | |
| α-helix | 964-967 | 4 | |
| α-helix | 969 | 1 | |
| β-strand | 970 | 1 | 11 |
| β-strand | 973-980 | 8 | 7 |
| β-strand | 1017-1026 | 10 | 7 |
| α-helix | 1027-1028 | 2 | |
| α-helix | 1064-1067 | 4 | |
| α-helix | 1070-1107 | 38 | |
| α-helix | 1213-1236 | 24 | |
| α-helix | 1239-1247 | 9 | |
| α-helix | 1257-1262 | 6 | |
| α-helix | 1264-1280 | 17 | |
| α-helix | 1285-1314 | 30 | |
| α-helix | 1317-1345 | 29 | |
| α-helix | 1354-1356 | 3 | |
| α-helix | 1360-1374 | 15 | |
| β-strand | 1376-1381 | 6 | 7 |
| α-helix | 1390-1406 | 17 | |
| β-strand | 1410-1415 | 6 | 12 |
| β-strand | 1421 | 1 | 9 |
| β-strand | 1426-1431 | 6 | 12 |
| β-strand | 1438-1443 | 6 | 12 |
| α-helix | 1445-1449 | 5 | |
| α-helix | 1453-1456 | 4 | |
| α-helix | 1459-1460 | 2 | |
| β-strand | 1461-1462 | 2 | 12 |
| β-strand | 1463-1468 | 6 | 7 |
| α-helix | 1474-1476 | 3 | |
| α-helix | 1478-1480 | 3 | |
| α-helix | 1481-1516 | 36 | |
| α-helix | 1522-1550 | 29 | |
| α-helix | 1552-1553 | 2 | |
| α-helix | 1564-1575 | 12 | |
| β-strand | 1578-1583 | 6 | 7 |
| α-helix | 1589-1605 | 17 | |
| β-strand | 1608 | 1 | 10 |
| α-helix | 1610-1612 | 3 | |
| α-helix | 1613-1623 | 11 | |
| α-helix | 1627-1630 | 4 | |
| α-helix | 1650-1654 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Endolysin chimera | A | protein | 1690 | Homo sapiens | D9IEF7, Q8TCU6 (AlphaFold model) |
>7SYF_1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Endolysin chimera (chains A) MGHHHHHHHHSSGSENLYFQGRESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRI RQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFK DKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRI CKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEG WEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSNIFEMLRIDEGLRL KIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAV RGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAK SRWYNQTPNRAKRVITTFRTGTWDAYSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVT NGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKL YHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGII HHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHL KTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFH ADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSL AEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQP DTLCFQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRS RREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLC EDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSV FVENCRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAP LEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMS YTQHCITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQ DAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDTSDKQDKLHGCLEHLFNQV DSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKEECTIRGRSLIQISIQEDPWNLPNSI KTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSEQLLAALGYR YNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVTLSELDNV TFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLRLHTALFT KVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDASTTAVKI DQLIRPINALDELCRLMKSFVHPKPGAAGSVGAGLIPISSELCYRLGACQMVMCGTGMQR STLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLRVKDQMPQGAPRLYR LCQPPVDGDL
Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Chang, Y.G., Lupton, C.J., Bayly-Jones, C. et al. Nat Struct Mol Biol (2022) 29:767-773. DOI 10.1038/s41594-022-00804-9 · PubMed
Other PDB entries of the same protein (UniProt D9IEF7), best resolution first:
MolViewer shows 7SYF directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.