7TMZ: Integrin alpha-IIb

Integrin alpha IIB beta3 complex with BMS compound 4. Determined by X-ray diffraction at 2.2 Å resolution. Released 17 Aug 2022.

Method: X-ray diffraction
Resolution: 2.2 Å
Organisms: Homo sapiens, Mus musculus
Chains: 8
Atoms: 22,174
Mol. weight: 301.12 kDa
Ligands: CA, MG, NAG, I7R
Released: 17 Aug 2022

Explore 7TMZ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7TMZ contains 81 α-helices and 247 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 47 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	1
β-strand	9-12	4	2
β-strand	22-27	6	3
β-strand	33-39	7	3
β-strand	43	1	4
β-strand	49	1	4
β-strand	51	1	5
β-strand	52-57	6	3
β-strand	63	1	2
β-strand	67	1	3
β-strand	76-79	4	6
β-strand	82-87	6	6
β-strand	93	1	5
β-strand	96-100	5	7
β-strand	103-108	6	7
β-strand	112-117	6	6
β-strand	120-121	2	6
β-strand	125	1	6
β-strand	128	1	8
β-strand	129-134	6	7
β-strand	139-143	5	7
α-helix	152-157	6
β-strand	169	1	8
β-strand	172-175	4	9
β-strand	180-185	6	9
α-helix	188-191	4
β-strand	194-199	6	9
α-helix	200-206	7
β-strand	214	1	10
β-strand	220-221	2	9
α-helix	228-230	3
β-strand	238-242	5	11
β-strand	252-257	6	11
α-helix	260-263	4
β-strand	266-270	5	11
β-strand	276-281	6	11
β-strand	292-296	5	12
β-strand	305-310	6	12
β-strand	314-317	4	13
β-strand	321-324	4	13
β-strand	327-331	5	12
α-helix	332-334	3
β-strand	345-348	4	12
β-strand	359-364	6	14
β-strand	373-378	6	14
β-strand	388-392	5	14
β-strand	394-395	2	15
β-strand	398-399	2	15
β-strand	405-408	4	14
β-strand	420-425	6	2
β-strand	434-439	6	2
α-helix	440-442	3
β-strand	444-448	5	2
α-helix	449	1
β-strand	450	1	1

Chain B: 21 helices, 31 β-strands

Element	Residues	Length	Sheet
α-helix	4-7	4
α-helix	13-19	7
β-strand	23-26	4	16
β-strand	38-40	3	16
α-helix	41-46	6
α-helix	51-53	3
β-strand	54-55	2	16
β-strand	60-65	6	17
α-helix	67-70	4
β-strand	72	1	18
β-strand	83-84	2	19
β-strand	87-92	6	17
β-strand	97-105	9	19
β-strand	108	1	18
β-strand	112-119	8	20
α-helix	122-124	3
α-helix	125-130	6
α-helix	134-142	9
β-strand	149-156	8	20
α-helix	170-174	5
α-helix	185-187	3
β-strand	190-197	8	20
α-helix	201-209	9
β-strand	220	1	21
α-helix	222-231	10
α-helix	233-236	4
β-strand	243-250	8	20
β-strand	254	1	21
α-helix	259-263	5
α-helix	267-269	3
β-strand	275	1	22
β-strand	280	1	20
β-strand	281	1	22
α-helix	288-291	4
α-helix	292-301	10
β-strand	304-311	8	20
α-helix	312-314	3
α-helix	315-324	10
β-strand	329-333	5	20
α-helix	340-351	12
β-strand	355-356	2	23
β-strand	357-360	4	17
β-strand	366-374	9	19
β-strand	378-381	4	19
β-strand	385-386	2	23
β-strand	394-403	10	19
β-strand	411-418	8	17
β-strand	425-431	7	17
α-helix	436-440	5
β-strand	442	1	24
β-strand	453-456	4	24
β-strand	459-462	4	24

Chain C: 11 helices, 47 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	25
β-strand	9-12	4	26
β-strand	22-27	6	27
β-strand	33-39	7	27
β-strand	43	1	28
β-strand	49	1	28
β-strand	51	1	29
β-strand	52-57	6	27
β-strand	63	1	26
β-strand	67	1	27
α-helix	73-75	3
β-strand	76-79	4	30
β-strand	82-87	6	30
β-strand	93	1	29
β-strand	96-100	5	31
β-strand	103-108	6	31
β-strand	112-117	6	30
β-strand	120-121	2	30
β-strand	125	1	30
β-strand	128	1	32
β-strand	129-134	6	31
β-strand	139-143	5	31
α-helix	152-157	6
β-strand	169	1	32
β-strand	172-175	4	33
β-strand	180-185	6	33
α-helix	188-191	4
β-strand	194-199	6	33
α-helix	200-205	6
β-strand	214	1	34
β-strand	220-221	2	33
α-helix	228-230	3
β-strand	238-242	5	35
β-strand	252-257	6	35
α-helix	260-263	4
β-strand	266-270	5	35
β-strand	276-281	6	35
β-strand	292-296	5	36
β-strand	305-310	6	36
α-helix	313	1
β-strand	314-317	4	37
β-strand	321-324	4	37
β-strand	327-331	5	36
α-helix	332-334	3
α-helix	338-340	3
β-strand	345-348	4	36
β-strand	360-364	5	38
β-strand	373-378	6	38
β-strand	388-392	5	38
β-strand	394-395	2	39
β-strand	398-399	2	39
β-strand	405-408	4	38
α-helix	412	1
β-strand	420-425	6	26
β-strand	434-439	6	26
α-helix	440-442	3
β-strand	444-448	5	26
β-strand	450	1	25

Chain D: 22 helices, 31 β-strands

Element	Residues	Length	Sheet
α-helix	4-7	4
α-helix	13-19	7
β-strand	24-26	3	40
β-strand	38-39	2	40
α-helix	41-46	6
α-helix	51-53	3
β-strand	54-55	2	40
β-strand	61-65	5	41
α-helix	67-70	4
β-strand	72	1	42
α-helix	77-79	3
β-strand	83-84	2	43
β-strand	87-92	6	41
β-strand	97-105	9	43
β-strand	108	1	42
β-strand	112-119	8	44
α-helix	122-124	3
α-helix	125-130	6
α-helix	134-142	9
β-strand	149-156	8	44
α-helix	170-174	5
α-helix	185-187	3
β-strand	190-197	8	44
α-helix	201-208	8
β-strand	220	1	45
α-helix	222-231	10
α-helix	233-236	4
β-strand	243-250	8	44
β-strand	254	1	45
α-helix	259-263	5
α-helix	268-269	2
β-strand	275	1	46
β-strand	280	1	44
β-strand	281	1	46
α-helix	288-291	4
α-helix	292-301	10
β-strand	305-311	7	44
α-helix	312-314	3
α-helix	315-324	10
β-strand	329-333	5	44
α-helix	340-351	12
β-strand	355-356	2	47
β-strand	357-360	4	41
β-strand	366-373	8	43
β-strand	379-381	3	43
β-strand	385-386	2	47
β-strand	394-403	10	43
β-strand	411-418	8	41
β-strand	425-431	7	41
α-helix	436-438	3
β-strand	442-445	4	48
β-strand	453-456	4	48
β-strand	459-462	4	48

Chain E: 4 helices, 25 β-strands

Element	Residues	Length	Sheet
β-strand	3-6	4	49
β-strand	10-12	3	50
β-strand	17-25	9	49
α-helix	29-31	3
β-strand	34-40	7	50
β-strand	44-52	9	50
β-strand	57-60	4	50
α-helix	62-64	3
β-strand	68-73	6	49
β-strand	78-84	7	49
α-helix	88-90	3
β-strand	92-98	7	50
β-strand	102	1	34
β-strand	108-109	2	50
β-strand	113-117	5	50
β-strand	123	1	51
β-strand	126-130	5	52
β-strand	141-151	11	52
β-strand	152	1	51
β-strand	157-160	4	53
β-strand	165	1	53
β-strand	169	1	52
α-helix	172-174	3
β-strand	175-176	2	52
β-strand	181-190	10	52
β-strand	200-204	5	53
β-strand	205	1	54
β-strand	210	1	54
β-strand	213-215	3	53

Chain F: 5 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	55
β-strand	10-13	4	56
β-strand	19-25	7	55
β-strand	33-38	6	56
β-strand	44-49	6	56
β-strand	53-54	2	56
α-helix	55	1
β-strand	62-67	6	55
β-strand	70-75	6	55
α-helix	80-82	3
β-strand	85-90	6	56
α-helix	96	1
β-strand	97-98	2	56
β-strand	102-106	5	56
β-strand	111	1	57
β-strand	114-118	5	58
α-helix	122-125	4
β-strand	130-139	10	58
β-strand	140	1	57
β-strand	145-150	6	59
β-strand	153-155	3	59
β-strand	159-163	5	58
β-strand	173-181	9	58
α-helix	183-186	4
β-strand	192-198	7	59
β-strand	201-205	5	59

Chain H: 4 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	3-6	4	60
β-strand	10-12	3	61
β-strand	18-25	8	60
α-helix	29-31	3
β-strand	34-40	7	61
β-strand	44-52	9	61
β-strand	57-60	4	61
α-helix	62-64	3
β-strand	65	1	62
β-strand	68	1	62
β-strand	69-73	5	60
β-strand	78-83	6	60
α-helix	88-90	3
β-strand	92-98	7	61
β-strand	102	1	10
β-strand	108-109	2	61
β-strand	113-117	5	61
β-strand	123	1	63
β-strand	126-130	5	64
β-strand	141-151	11	64
β-strand	152	1	63
β-strand	157-160	4	65
β-strand	169-171	3	64
α-helix	172-174	3
β-strand	175-177	3	64
β-strand	180-190	11	64
β-strand	200-205	6	65
β-strand	210-215	6	65

Chain L: 6 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	66
β-strand	10-13	4	67
β-strand	19-25	7	66
β-strand	33-38	6	67
β-strand	44-49	6	67
β-strand	53-54	2	67
α-helix	55	1
β-strand	62-67	6	66
β-strand	70-75	6	66
β-strand	85-90	6	67
α-helix	96	1
β-strand	97-98	2	67
β-strand	102-106	5	67
β-strand	111	1	68
β-strand	114-118	5	69
α-helix	119-121	3
α-helix	122-127	6
β-strand	129-139	11	69
β-strand	140	1	68
β-strand	145-150	6	70
β-strand	153-155	3	70
β-strand	159-163	5	69
α-helix	164-167	4
β-strand	173-182	10	69
α-helix	183-186	4
β-strand	191-198	8	70
β-strand	201-210	10	70

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Integrin alpha-IIb	A, C	protein	454	Homo sapiens	P08514 (AlphaFold model)
Integrin beta-3	B, D	protein	471	Homo sapiens	P05106 (AlphaFold model)
Fab heavy chain	E, H	protein	216	Mus musculus
Fab light chain	F, L	protein	214	Mus musculus

Sequence of entity 1 (A, C), FASTA

>7TMZ_1 Integrin alpha-IIb (chains A, C)
LNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEETGGVFLCPWRA
EGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSWSDVIVACAPWQHWNVLEKTE
EAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVTQAGE
LVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVA
VGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNG
DGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAI
APLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQVLDSPFPTGSAFGFS
LRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVV

Sequence of entity 2 (B, D), FASTA

>7TMZ_2 Integrin beta-3 (chains B, D)
GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSE
ARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDL
SYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDM
KTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRN
DASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLS
QKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVR
DLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVG
FKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQC

Sequence of entity 3 (E, H), FASTA

>7TMZ_3 Fab heavy chain (chains E, H)
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTYVHWVKQRPEQGLEWIGRIDPANGYTKY
DPKFQGKATITADTSSNTAYLQLSSLTSEDTAVYYCVRPLYDYYAMDYWGQGTSVTVSSA
KTTAPSVYPLAPVCTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTL
SSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR

Sequence of entity 4 (F, L), FASTA

>7TMZ_4 Fab light chain (chains F, L)
DILMTQSPSSMSVSLGDTVSITCHASQGISSNIGWLQQKPGKSFMGLIYYGTNLVDGVPS
RFSGSGSGADYSLTISSLDSEDFADYYCVQYAQLPYTFGGGTKLEIKRADAAPTVSIFPP
SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLT
LTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	12
MG	Magnesium ion	Mg	2
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	2
I7R	(4-{[(5S)-3-{4-[(E)-imino(4-methylpiperazin-1-yl)methyl]phenyl}-4,5-dihydro-1,2…	C22 H32 N6 O3	2

Water and common crystallization additives (SO4, CL) are not listed.

Primary citation

A general chemical principle for creating closure-stabilizing integrin inhibitors. Lin, F.Y., Li, J., Xie, Y. et al. Cell (2022) 185:3533-3550.e27. DOI 10.1016/j.cell.2022.08.008 · PubMed

Other PDB entries of the same protein (UniProt P08514 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7SC4 1.85 Å, filamin complex-1
7UDH 2.0 Å, Integrin alpha IIB beta3 complex with BMS4-3
7UBR 2.05 Å, Integrin alpha IIB beta3 complex with GR144053
3T3P 2.2 Å, A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly…
3NIG 2.25 Å, The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific…
7U9V 2.25 Å, Integrin alpha IIB beta3 complex with BMS4-1
3NID 2.3 Å, The Closed Headpiece of Integrin alphaIIB beta3 and its Complex with an alpahIIB beta3…
7L8P 2.35 Å, Integrin alphaIIbbeta3 in complex with sibrafiban
7UCY 2.35 Å, Integrin alpha IIB beta3 complex with gantofiban
3ZE2 2.35 Å, Integrin alphaIIB beta3 headpiece and RGD peptide complex
7UKT 2.37 Å, Integrin alpha IIB beta3 complex with BMS4.2
2VDR 2.4 Å, Integrin AlphaIIbBeta3 Headpiece Bound to a chimeric Fibrinogen Gamma chain peptide,…

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