7UI9: Core Mediator-PICearly
Core Mediator-PICearly (Copy A). Determined by electron microscopy at 3.3 Å resolution. Released 15 Feb 2023.
- Method
- Electron microscopy
- Resolution
- 3.3 Å
- Organism
- Saccharomyces cerevisiae S288C
- Chains
- 33
- Atoms
- 63,137
- Mol. weight
- 1247.86 kDa
- Released
- 15 Feb 2023
Explore 7UI9 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7UI9 contains 349 α-helices and 337 β-strands across 33 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain a: 12 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-21 | 15 | |
| α-helix | 28-37 | 10 | |
| β-strand | 41-46 | 6 | 17 |
| β-strand | 51-57 | 7 | 17 |
| β-strand | 61-68 | 8 | 17 |
| β-strand | 73-81 | 9 | 17 |
| β-strand | 91 | 1 | 18 |
| β-strand | 102 | 1 | 18 |
| α-helix | 103-109 | 7 | |
| α-helix | 115-130 | 16 | |
| α-helix | 164-181 | 18 | |
| β-strand | 187-190 | 4 | 19 |
| β-strand | 198-203 | 6 | 19 |
| β-strand | 209-219 | 11 | 19 |
| β-strand | 227-229 | 3 | 20 |
| β-strand | 232-234 | 3 | 21 |
| β-strand | 239-241 | 3 | 21 |
| β-strand | 248-250 | 3 | 20 |
| β-strand | 252-258 | 7 | 19 |
| β-strand | 272-274 | 3 | 22 |
| α-helix | 280-282 | 3 | |
| β-strand | 283-286 | 4 | 19 |
| α-helix | 298-304 | 7 | |
| β-strand | 312-316 | 5 | 23 |
| β-strand | 322-324 | 3 | 22 |
| β-strand | 325-329 | 5 | 19 |
| α-helix | 332-336 | 5 | |
| α-helix | 337-347 | 11 | |
| α-helix | 348-352 | 5 | |
| α-helix | 353-360 | 8 | |
| β-strand | 528-532 | 5 | 23 |
| β-strand | 536-539 | 4 | 23 |
| β-strand | 543-546 | 4 | 23 |
| α-helix | 551-565 | 15 | |
Chain A: 82 helices, 71 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10 | 1 | |
| β-strand | 11 | 1 | 42 |
| β-strand | 14-18 | 5 | 43 |
| α-helix | 24-30 | 7 | |
| β-strand | 34 | 1 | 44 |
| β-strand | 41 | 1 | 45 |
| β-strand | 48 | 1 | 45 |
| α-helix | 49 | 1 | |
| β-strand | 82-91 | 10 | 44 |
| α-helix | 96-104 | 9 | |
| β-strand | 106 | 1 | 46 |
| β-strand | 113 | 1 | 46 |
| α-helix | 120-126 | 7 | |
| α-helix | 131-142 | 12 | |
| β-strand | 147 | 1 | 47 |
| β-strand | 151-153 | 3 | 48 |
| β-strand | 161-163 | 3 | 48 |
| β-strand | 170 | 1 | 47 |
| β-strand | 173-177 | 5 | 49 |
| β-strand | 180-185 | 6 | 49 |
| α-helix | 189-191 | 3 | |
| β-strand | 198-201 | 4 | 49 |
| α-helix | 202-203 | 2 | |
| α-helix | 204-212 | 9 | |
| α-helix | 216-222 | 7 | |
| α-helix | 232-234 | 3 | |
| β-strand | 235-241 | 7 | 44 |
| α-helix | 248-249 | 2 | |
| β-strand | 250-253 | 4 | 50 |
| β-strand | 256-258 | 3 | 50 |
| α-helix | 261-280 | 20 | |
| α-helix | 286-304 | 19 | |
| α-helix | 312-314 | 3 | |
| β-strand | 315 | 1 | 51 |
| α-helix | 316 | 1 | |
| α-helix | 320 | 1 | |
| β-strand | 321 | 1 | 51 |
| α-helix | 322 | 1 | |
| α-helix | 326-329 | 4 | |
| α-helix | 335 | 1 | |
| α-helix | 336-340 | 5 | |
| β-strand | 343-345 | 3 | 52 |
| β-strand | 348-352 | 5 | 53 |
| β-strand | 355 | 1 | 54 |
| β-strand | 363-367 | 5 | 53 |
| α-helix | 368-373 | 6 | |
| β-strand | 375-379 | 5 | 2 |
| α-helix | 380 | 1 | |
| α-helix | 385-394 | 10 | |
| β-strand | 402-406 | 5 | 2 |
| β-strand | 412-414 | 3 | 2 |
| α-helix | 424-426 | 3 | |
| β-strand | 431-435 | 5 | 2 |
| α-helix | 436 | 1 | |
| β-strand | 441-445 | 5 | 53 |
| α-helix | 452-454 | 3 | |
| β-strand | 455-463 | 9 | 53 |
| β-strand | 469 | 1 | 53 |
| β-strand | 470 | 1 | 54 |
| β-strand | 486-490 | 5 | 53 |
| α-helix | 495-503 | 9 | |
| β-strand | 506 | 1 | 53 |
| α-helix | 507-509 | 3 | |
| β-strand | 512-513 | 2 | 55 |
| β-strand | 518-519 | 2 | 55 |
| α-helix | 525-534 | 10 | |
| β-strand | 540-541 | 2 | 56 |
| α-helix | 543-552 | 10 | |
| α-helix | 559-563 | 5 | |
| β-strand | 565-567 | 3 | 11 |
| β-strand | 571 | 1 | 11 |
| β-strand | 572-573 | 2 | 56 |
| α-helix | 574-578 | 5 | |
| β-strand | 588-590 | 3 | 57 |
| β-strand | 605-608 | 4 | 57 |
| β-strand | 611-614 | 4 | 57 |
| α-helix | 619-622 | 4 | |
| α-helix | 629-636 | 8 | |
| α-helix | 639-660 | 22 | |
| α-helix | 666-668 | 3 | |
| α-helix | 673-697 | 25 | |
| α-helix | 702-704 | 3 | |
| α-helix | 710-736 | 27 | |
| α-helix | 742-749 | 8 | |
| α-helix | 755-758 | 4 | |
| α-helix | 759-763 | 5 | |
| β-strand | 766-767 | 2 | 58 |
| β-strand | 770 | 1 | 59 |
| β-strand | 773 | 1 | 59 |
| α-helix | 794-796 | 3 | |
| β-strand | 799-800 | 2 | 58 |
| α-helix | 810-845 | 36 | |
| β-strand | 849-850 | 2 | 60 |
| β-strand | 856-857 | 2 | 60 |
| β-strand | 863-865 | 3 | 60 |
| α-helix | 868-870 | 3 | |
| β-strand | 873 | 1 | 61 |
| β-strand | 878-882 | 5 | 62 |
| α-helix | 890-897 | 8 | |
| α-helix | 904-906 | 3 | |
| α-helix | 907-909 | 3 | |
| β-strand | 913 | 1 | 63 |
| α-helix | 916-919 | 4 | |
| α-helix | 924-946 | 23 | |
| β-strand | 953-957 | 5 | 62 |
| α-helix | 960-970 | 11 | |
| β-strand | 979 | 1 | 63 |
| α-helix | 983-995 | 13 | |
| α-helix | 1005-1025 | 21 | |
| α-helix | 1028-1029 | 2 | |
| α-helix | 1030-1035 | 6 | |
| α-helix | 1039-1054 | 16 | |
| β-strand | 1057 | 1 | 61 |
| α-helix | 1058-1059 | 2 | |
| α-helix | 1064-1078 | 15 | |
| α-helix | 1083-1088 | 6 | |
| α-helix | 1090-1092 | 3 | |
| α-helix | 1098-1106 | 9 | |
| β-strand | 1116-1119 | 4 | 12 |
| β-strand | 1120 | 1 | 64 |
| α-helix | 1128-1138 | 11 | |
| β-strand | 1141-1142 | 2 | 65 |
| α-helix | 1143-1145 | 3 | |
| β-strand | 1147-1154 | 8 | 66 |
| α-helix | 1164-1174 | 11 | |
| α-helix | 1179-1184 | 6 | |
| α-helix | 1185-1187 | 3 | |
| β-strand | 1191-1197 | 7 | 66 |
| α-helix | 1199-1204 | 6 | |
| α-helix | 1209-1210 | 2 | |
| α-helix | 1211-1215 | 5 | |
| α-helix | 1216-1221 | 6 | |
| β-strand | 1224-1228 | 5 | 66 |
| β-strand | 1236-1242 | 7 | 66 |
| α-helix | 1250-1254 | 5 | |
| α-helix | 1256-1269 | 14 | |
| β-strand | 1272-1274 | 3 | 65 |
| β-strand | 1281-1292 | 12 | 12 |
| β-strand | 1298-1309 | 12 | 12 |
| α-helix | 1313-1316 | 4 | |
| β-strand | 1322 | 1 | 64 |
| β-strand | 1328-1329 | 2 | 12 |
| α-helix | 1332-1338 | 7 | |
| α-helix | 1341-1357 | 17 | |
| α-helix | 1365-1375 | 11 | |
| α-helix | 1386-1389 | 4 | |
| α-helix | 1396-1400 | 5 | |
| α-helix | 1405-1415 | 11 | |
| β-strand | 1418-1419 | 2 | 43 |
| α-helix | 1424-1429 | 6 | |
| β-strand | 1437 | 1 | 67 |
| β-strand | 1441-1445 | 5 | 3 |
| α-helix | 1447-1452 | 6 | |
Chain B: 52 helices, 72 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 27-40 | 14 | |
| α-helix | 45-53 | 9 | |
| α-helix | 54-58 | 5 | |
| α-helix | 59-65 | 7 | |
| β-strand | 69-73 | 5 | 68 |
| α-helix | 80-82 | 3 | |
| β-strand | 84-97 | 14 | 68 |
| α-helix | 98-100 | 3 | |
| β-strand | 101-103 | 3 | 69 |
| β-strand | 109-111 | 3 | 69 |
| α-helix | 114-120 | 7 | |
| β-strand | 125-140 | 16 | 68 |
| β-strand | 150-156 | 7 | 68 |
| α-helix | 161-163 | 3 | |
| β-strand | 164-171 | 8 | 68 |
| β-strand | 173 | 1 | 70 |
| α-helix | 180-183 | 4 | |
| α-helix | 186-191 | 6 | |
| β-strand | 203-205 | 3 | 70 |
| β-strand | 208-212 | 5 | 70 |
| β-strand | 214-218 | 5 | 71 |
| β-strand | 224-227 | 4 | 72 |
| β-strand | 234-241 | 8 | 72 |
| β-strand | 253-259 | 7 | 72 |
| β-strand | 268-272 | 5 | 72 |
| β-strand | 280-281 | 2 | 72 |
| α-helix | 282-289 | 8 | |
| α-helix | 294-301 | 8 | |
| α-helix | 309-321 | 13 | |
| α-helix | 327-336 | 10 | |
| α-helix | 345-359 | 15 | |
| α-helix | 371-389 | 19 | |
| α-helix | 395-397 | 3 | |
| α-helix | 401-403 | 3 | |
| β-strand | 404-407 | 4 | 71 |
| α-helix | 409-437 | 29 | |
| α-helix | 441-443 | 3 | |
| α-helix | 444-447 | 4 | |
| α-helix | 451-463 | 13 | |
| β-strand | 466 | 1 | 73 |
| β-strand | 476 | 1 | 73 |
| β-strand | 480-482 | 3 | 70 |
| α-helix | 483-484 | 2 | |
| α-helix | 488-494 | 7 | |
| β-strand | 497-499 | 3 | 71 |
| α-helix | 516-518 | 3 | |
| β-strand | 522 | 1 | 74 |
| β-strand | 536-538 | 3 | 71 |
| β-strand | 539 | 1 | 74 |
| β-strand | 544-545 | 2 | 75 |
| α-helix | 552-560 | 9 | |
| α-helix | 563 | 1 | |
| β-strand | 564-565 | 2 | 76 |
| α-helix | 566-568 | 3 | |
| α-helix | 577 | 1 | |
| β-strand | 578-582 | 5 | 76 |
| β-strand | 585-590 | 6 | 76 |
| α-helix | 593-605 | 13 | |
| β-strand | 614-618 | 5 | 76 |
| β-strand | 623-627 | 5 | 76 |
| β-strand | 633-638 | 6 | 75 |
| β-strand | 640-643 | 4 | 77 |
| β-strand | 648-651 | 4 | 77 |
| α-helix | 655-667 | 13 | |
| α-helix | 681-686 | 6 | |
| β-strand | 690-694 | 5 | 75 |
| α-helix | 697-700 | 4 | |
| β-strand | 703-704 | 2 | 78 |
| α-helix | 707-710 | 4 | |
| β-strand | 740-741 | 2 | 78 |
| α-helix | 745-748 | 4 | |
| α-helix | 759-761 | 3 | |
| α-helix | 764-773 | 10 | |
| β-strand | 792-796 | 5 | 28 |
| β-strand | 800 | 1 | 79 |
| β-strand | 804-805 | 2 | 80 |
| α-helix | 809-812 | 4 | |
| β-strand | 821-827 | 7 | 81 |
| β-strand | 838-842 | 5 | 81 |
| α-helix | 843-847 | 5 | |
| β-strand | 853-862 | 10 | 28 |
| β-strand | 873-874 | 2 | 82 |
| β-strand | 882-883 | 2 | 82 |
| α-helix | 890-892 | 3 | |
| β-strand | 898 | 1 | 83 |
| β-strand | 904-905 | 2 | 28 |
| β-strand | 910 | 1 | 84 |
| β-strand | 912 | 1 | 83 |
| β-strand | 914-917 | 4 | 82 |
| β-strand | 934-936 | 3 | 82 |
| β-strand | 940 | 1 | 84 |
| α-helix | 941-942 | 2 | |
| β-strand | 947-956 | 10 | 28 |
| β-strand | 962-972 | 11 | 28 |
| β-strand | 980-982 | 3 | 81 |
| β-strand | 987-994 | 8 | 81 |
| β-strand | 1001-1002 | 2 | 85 |
| β-strand | 1010-1012 | 3 | 81 |
| α-helix | 1014-1016 | 3 | |
| α-helix | 1023-1038 | 16 | |
| α-helix | 1041 | 1 | |
| β-strand | 1042-1043 | 2 | 80 |
| α-helix | 1052-1060 | 9 | |
| β-strand | 1069-1070 | 2 | 81 |
| β-strand | 1072-1073 | 2 | 85 |
| β-strand | 1080 | 1 | 85 |
| β-strand | 1085-1094 | 10 | 81 |
| α-helix | 1099-1101 | 3 | |
| β-strand | 1104-1106 | 3 | 53 |
| α-helix | 1118-1119 | 2 | |
| β-strand | 1128-1130 | 3 | 52 |
| α-helix | 1132-1141 | 10 | |
| β-strand | 1143 | 1 | 67 |
| α-helix | 1144-1148 | 5 | |
| α-helix | 1149-1153 | 5 | |
| β-strand | 1158-1163 | 6 | 42 |
| β-strand | 1172-1174 | 3 | 86 |
| β-strand | 1179-1181 | 3 | 86 |
| β-strand | 1182 | 1 | 87 |
| β-strand | 1187 | 1 | 87 |
| β-strand | 1191-1196 | 6 | 42 |
| α-helix | 1198-1208 | 11 | |
| β-strand | 1215-1218 | 4 | 43 |
| α-helix | 1219-1222 | 4 | |
Chain C: 12 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-13 | 7 | 88 |
| β-strand | 17-23 | 7 | 88 |
| α-helix | 27-39 | 13 | |
| β-strand | 43-54 | 12 | 89 |
| α-helix | 60-67 | 8 | |
| β-strand | 72 | 1 | 90 |
| α-helix | 77-79 | 3 | |
| β-strand | 97-104 | 8 | 89 |
| β-strand | 111-114 | 4 | 91 |
| β-strand | 119-120 | 2 | 89 |
| α-helix | 131 | 1 | |
| β-strand | 132 | 1 | 90 |
| α-helix | 133 | 1 | |
| β-strand | 143-147 | 5 | 91 |
| β-strand | 152-162 | 11 | 89 |
| α-helix | 168-170 | 3 | |
| β-strand | 173-179 | 7 | 88 |
| α-helix | 197-200 | 4 | |
| α-helix | 202-204 | 3 | |
| α-helix | 205-209 | 5 | |
| α-helix | 211-214 | 4 | |
| α-helix | 218-219 | 2 | |
| β-strand | 228-234 | 7 | 88 |
| α-helix | 240-270 | 31 | |
Chain d: 8 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 32-39 | 8 | |
| α-helix | 41-61 | 21 | |
| α-helix | 67-88 | 22 | |
| α-helix | 92-127 | 36 | |
| α-helix | 132-147 | 16 | |
| α-helix | 150-164 | 15 | |
| α-helix | 185-190 | 6 | |
| α-helix | 192-198 | 7 | |
Chain D: 10 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 36-38 | 3 | 92 |
| β-strand | 44-46 | 3 | 92 |
| β-strand | 49 | 1 | 7 |
| α-helix | 52-77 | 26 | |
| α-helix | 111-114 | 4 | |
| α-helix | 119-133 | 15 | |
| α-helix | 139-150 | 12 | |
| α-helix | 157-168 | 12 | |
| α-helix | 174-182 | 9 | |
| α-helix | 188-194 | 7 | |
| α-helix | 196-198 | 3 | |
| α-helix | 204-217 | 14 | |
| α-helix | 219-220 | 2 | |
Chain E: 13 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-25 | 23 | |
| β-strand | 28 | 1 | 93 |
| α-helix | 32-35 | 4 | |
| α-helix | 39-45 | 7 | |
| β-strand | 47 | 1 | 94 |
| β-strand | 53 | 1 | 94 |
| α-helix | 55-58 | 4 | |
| β-strand | 60-62 | 3 | 95 |
| β-strand | 64 | 1 | 93 |
| α-helix | 66-71 | 6 | |
| β-strand | 78-82 | 5 | 95 |
| β-strand | 87-88 | 2 | 96 |
| α-helix | 90-103 | 14 | |
| β-strand | 107-112 | 6 | 95 |
| β-strand | 115-116 | 2 | 96 |
| α-helix | 118-121 | 4 | |
| α-helix | 124-126 | 3 | |
| β-strand | 131-136 | 6 | 95 |
| α-helix | 137-139 | 3 | |
| α-helix | 144-146 | 3 | |
| β-strand | 152-155 | 4 | 97 |
| α-helix | 158-168 | 11 | |
| α-helix | 172-174 | 3 | |
| β-strand | 177-178 | 2 | 97 |
| α-helix | 183-188 | 6 | |
| β-strand | 195-202 | 8 | 97 |
| β-strand | 206-214 | 9 | 97 |
Chain f: 6 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 14-19 | 6 | |
| α-helix | 27-32 | 6 | |
| α-helix | 42-55 | 14 | |
| α-helix | 89-96 | 8 | |
| α-helix | 98-107 | 10 | |
| β-strand | 113-121 | 9 | 26 |
| β-strand | 125-134 | 10 | 26 |
| β-strand | 146-156 | 11 | 26 |
| β-strand | 159-161 | 3 | 26 |
| α-helix | 166-191 | 26 | |
| β-strand | 193-195 | 3 | 27 |
| β-strand | 199-201 | 3 | 27 |
25 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Transcription initiation factor IIB | M | protein | 345 | Saccharomyces cerevisiae S288C | P29055 (AlphaFold model) |
| Transcription initiation factor IIF subunit alpha | P | protein | 735 | Saccharomyces cerevisiae S288C | P41895 (AlphaFold model) |
| Transcription initiation factor IIF subunit beta | Q | protein | 400 | Saccharomyces cerevisiae S288C | P41896 (AlphaFold model) |
| Transcription elongation factor S-II | S | protein | 309 | Saccharomyces cerevisiae S288C | P07273 (AlphaFold model) |
| Mediator of RNA polymerase II transcription subunit 1 | a | protein | 566 | Saccharomyces cerevisiae S288C | Q12321 |
| Mediator of RNA polymerase II transcription subunit 4 | d | protein | 284 | Saccharomyces cerevisiae S288C | Q12343 |
| Mediator of RNA polymerase II transcription subunit 6 | f | protein | 295 | Saccharomyces cerevisiae S288C | P38782 |
| Mediator of RNA polymerase II transcription subunit 7 | g | protein | 222 | Saccharomyces cerevisiae S288C | Q08278 |
| Mediator of RNA polymerase II transcription subunit 8 | h | protein | 223 | Saccharomyces cerevisiae S288C | P38304 |
| Mediator of RNA polymerase II transcription subunit 9 | i | protein | 149 | Saccharomyces cerevisiae S288C | P33308 |
| Mediator of RNA polymerase II transcription subunit 10 | j | protein | 157 | Saccharomyces cerevisiae S288C | Q06213 |
| Mediator of RNA polymerase II transcription subunit 11 | k | protein | 115 | Saccharomyces cerevisiae S288C | Q99278 |
21 more molecules are not listed.
Sequence of entity 1 (M), FASTA
>7UI9_1 Transcription initiation factor IIB (chains M)
MMTRESIDKRAGRRGPNLNIVLTCPECKVYPPKIVERFSEGDVVCALCGLVLSDKLVDTR
SEWRTFSNDDHNGDDPSRVGEASNPLLDGNNLSTRIGKGETTDMRFTKELNKAQGKNVMD
KKDNEVQAAFAKITMLCDAAELPKIVKDCAKEAYKLCHDEKTLKGKSMESIMAASILIGC
RRAEVARTFKEIQSLIHVKTKEFGKTLNIMKNILRGKSEDGFLKIDTDNMSGAQNLTYIP
RFCSHLGLPMQVTTSAEYTAKKCKEIKEIAGKSPITIAVVSIYLNILLFQIPITAAKVGQ
TLQVTEGTIKSGYKILYEHRDKLVDPQLIANGVVSLDNLPGVEKK
Sequence of entity 2 (P), FASTA
>7UI9_2 Transcription initiation factor IIF subunit alpha (chains P)
MSRRNPPGSRNGGGPTNASPFIKRDRMRRNFLRMRMGQNGSNSSSPGVPNGDNSRGSLVK
KDDPEYAEEREKMLLQIGVEADAGRSNVKVKDEDPNEYNEFPLRAIPKEDLENMRTHLLK
FQSKKKINPVTDFHLPVRLHRKDTRNLQFQLTRAEIVQRQKEISEYKKKAEQERSTPNSG
GMNKSGTVSLNNTVKDGSQTPTVDSVTKDNTANGVNSSIPTVTGSSVPPASPTTVSAVES
NGLSNGSTSAANGLDGNASTANLANGRPLVTKLEDAGPAEDPTKVGMVKYDGKEVTNEPE
FEEGTMDPLADVAPDGGGRAKRGNLRRKTRQLKVLDENAKKLRFEEFYPWVMEDFDGYNT
WVGSYEAGNSDSYVLLSVEDDGSFTMIPADKVYKFTARNKYATLTIDEAEKRMDKKSGEV
PRWLMKHLDNIGTTTTRYDRTRRKLKAVADQQAMDEDDRDDNSEVELDYDEEFADDEEAP
IIDGNEQENKESEQRIKKEMLQANAMGLRDEEAPSENEEDELFGEKKIDEDGERIKKALQ
KTELAALYSSDENEINPYLSESDIENKENESPVKKEEDSDTLSKSKRSSPKKQQKKATNA
HVHKEPTLRVKSIKNCVIILKGDKKILKSFPEGEWNPQTTKAVDSSNNASNTVPSPIKQE
EGLNSTVAEREETPAPTITEKDIIEAIGDGKVNIKEFGKFIRRKYPGAENKKLMFAIVKK
LCRKVGNDHMELKKE
Sequence of entity 3 (Q), FASTA
>7UI9_3 Transcription initiation factor IIF subunit beta (chains Q)
MSSGSAGAPALSNNSTNSVAKEKSGNISGDEYLSQEEEVFDGNDIENNETKVYEESLDLD
LERSNRQVWLVRLPMFLAEKWRDRNNLHGQELGKIRINKDGSKITLLLNENDNDSIPHEY
DLELTKKVVENEYVFTEQNLKKYQQRKKELEADPEKQRQAYLKKQEREEELKKKQQQQKR
RNNRKKFNHRVMTDRDGRDRYIPYVKTIPKKTAIVGTVCHECQVMPSMNDPNYHKIVEQR
RNIVKLNNKERITTLDETVGVTMSHTGMSMRSDNSNFLKVGREKAKSNIKSIRMPKKEIL
DYLFKLFDEYDYWSLKGLKERTRQPEAHLKECLDKVATLVKKGPYAFKYTLRPEYKKLKE
EERKATLGELADEQTGSAGDNAQGDAEADLEDEIEMEDVV
Sequence of entity 4 (S), FASTA
>7UI9_4 Transcription elongation factor S-II (chains S)
MDSKEVLVHVKNLEKNKSNDAAVLEILHVLDKEFVPTEKLLRETKVGVEVNKFKKSTNVE
ISKLVKKMISSWKDAINKNKRSRQAQQHHQDHAPGNAEDKTTVGESVNGVQQPASSQSDA
MKQDKYVSTKPRNSKNDGVDTAIYHHKLRDQVLKALYDVLAKESEHPPQSILHTAKAIES
EMNKVNNCDTNEAAYKARYRIIYSNVISKNNPDLKHKIANGDITPEFLATCDAKDLAPAP
LKQKIEEIAKQNLYNAQGATIERSVTDRFTCGKCKEKKVSYYQLQTRSADEPLTTFCTCE
ACGNRWKFS
Sequence of entity 5 (a), FASTA
>7UI9_5 Mediator of RNA polymerase II transcription subunit 1 (chains a)
MVEGDSYVETLDSMIELFKDYKPGSITLENITRLCQTLGLESFTEELSNELSRLSTASKI
IVIDVDYNKKQDRIQDVKLVLASNFDNFDYFNQRDGEHEKSNILLNSLTKYPDLKAFHNN
LKFLYLLDAYSHIESDSTSHNNGSSDKSLDSSNASFNNQGKLDLFKYFTELSHYIRQCFQ
DNCCDFKVRTNLNDKFGIYILTQGINGKEVPLAKIYLEENKSDSQYRFYEYIYSQETKSW
INESAENFSNGISLVMEIVANAKESNYTDLIWFPEDFISPELIIDKVTCSSNSSSSPPII
DLFSNNNYNSRIQLMNDFTTKLINIKKFDISNDNLDLISEILKWVQWSRIVLQNVFKLVS
TPSSNSNSSELEPDYQAPFSTSTKDKNSSTSNTEPIPRSNRHGSVVEASRRRRSSTNKSK
RPSITEAMMLKEEGLQQFNLHEILSEPAIEEENGDSIKEHSTTMDGANDLGFTASVSNQE
NAGTDIVMEDHGVLQGTSQNYGTATADDADIEMKDVSSKPSKPESSVLQLIVSEDHIILD
TISECNLYDDVKCWSKFIEKFQDIVS
Sequence of entity 6 (d), FASTA
>7UI9_6 Mediator of RNA polymerase II transcription subunit 4 (chains d)
MSVQDTKAVEFSMGHIRSSSVSLVAEATSNTNSEDKLSKVQLYEDLCRYEDTLSKLVESV
DRFKPNLDIAKDLIRTDEALFENVKLLAEYDNIYRNLQKIDKDSEELDSKTRKILEILNE
CHDELKALPMLEQVEFEKNTILQQRSKINSTELLDYATKLSKFTKIPPTFDKGAVGPNNF
IWPAEDALRRGMLAMASLHSKELTRIPGEEVEETEVPTVPPSQSEEQKGQMAKKEGTPKT
DSFIFDGTAKEVGDEADNTKDKEKEENNDDALDLDLDLFDPDDF
Sequence of entity 7 (f), FASTA
>7UI9_7 Mediator of RNA polymerase II transcription subunit 6 (chains f)
MNVTPLDELQWKSPEWIQVFGLRTENVLDYFAESPFFDKTSNNQVIKMQRQFSQLNDPNA
AVNMTQNIMTLPDGKNGNLEEEFAYVDPARRQILFKYPMYMQLEEELMKLDGTEYVLSSV
REPDFWVIRKQRRTNNSGVGSAKGPEIIPLQDYYIIGANIYQSPTIFKIVQSRLMSTSYH
LNSTLESLYDLIEFQPSQGVHYKVPTDTSTTATAATNGNNAGGGSNKSSVRPTGGANMAT
VPSTTNVNMTVNTMGTGGQTIDNGTGRTGNGNMGITTEMLDKLMVTSIRSTPNYI
Sequence of entity 8 (g), FASTA
>7UI9_8 Mediator of RNA polymerase II transcription subunit 7 (chains g)
MSNDPGNEVSSLYPPPPPYVKFFTQSNLEKLPKYKEKKAASAKQTAPNNSNGGSEEEITC
ALDYLIPPPMPKNQQYRAFGSIWQVKDQLPDLESMGLTQLYKKSTENESTNYQYKIQELR
KLLKSLLLNYLELIGVLSINPDMYERKVENIRTILVNIHHLLNEYRPHQSRESLIMLLEE
QLEYKRGEIREIEQVCKQVHDKLTSIQDTLRTGSQSPPSSSQ
Sequence of entity 9 (h), FASTA
>7UI9_9 Mediator of RNA polymerase II transcription subunit 8 (chains h)
MSQSTASLVPEGNQGSLQEDVSFDFNGVPGQALDAVRMRLAQLTHSLRRIRDEMSKAELP
QWYTLQSQLNVTLSQLVSVTSTLQHFQETLDSTVVYPLPKFPTTSHESLVTTLLRKKNIP
EVDEWMKYVRETSGVTTALLKDEEIEKLLQQDREITNWARTTFRNEYGKHDFKNEESLSE
EHASLLVRDSKPSKPFNVDDVLKFTFTGEKPIITGSTSTSSSN
Sequence of entity 10 (i), FASTA
>7UI9_10 Mediator of RNA polymerase II transcription subunit 9 (chains i)
MNLQNNVLNQIHQILLPTNPTLDKPNAEATKEEFSSAENRDEKDYLTNQQPKNLSTPSTS
SNGEFIPHIFYSLHQIRKDPNNLSNQLETLTGSIRHRLKLCKSLISENEDTKDLLSKSPS
EWQDIIHQREQELQIKRDVLDDLYRKLQR
Sequence of entity 11 (j), FASTA
>7UI9_11 Mediator of RNA polymerase II transcription subunit 10 (chains j)
MNGNSTNNEQLQQELATTQDQVASIIESFVELGVSIYDFPGTPEATKGMITNLQRNVDRL
YKLNVRSNDPQSSLSKVDIPLEVVQYIEDGRNPDIYTREFVEAIRRSNQYQRGKMHGLKQ
LRDSLADKIVDEFPELKEPVEDIIKRTSPIDNVSNTH
Sequence of entity 12 (k), FASTA
>7UI9_12 Mediator of RNA polymerase II transcription subunit 11 (chains k)
MQPPYIQERLKSLNDIETQLCSMLQEASQVTFIFGELKRGNESVKPQFENHVKQFYERLD
KSTTQLRKEIQLLDENVGTRLLPINVNKKALGQDTEKMEEQLDLLSAILDPSKSK
Primary citation
Structural basis of a transcription pre-initiation complex on a divergent promoter. Gorbea Colon, J.J., Palao 3rd, L., Chen, S.F. et al. Mol Cell (2023) 83:574. DOI 10.1016/j.molcel.2023.01.011 · PubMed
Other PDB entries of the same protein (UniProt P29055 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7O4J 2.9 Å, Yeast RNA polymerase II transcription pre-initiation complex (consensus)
- 7ML0 3.0 Å, RNA polymerase II pre-initiation complex (PIC1)
- 8CEN 3.0 Å, Yeast RNA polymerase II transcription pre-initiation complex with core Mediator
- 7ML4 3.1 Å, RNA polymerase II initially transcribing complex (ITC)
- 7ZS9 3.1 Å, Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome…
- 7O4I 3.2 Å, Yeast RNA polymerase II transcription pre-initiation complex with initial transcription…
- 7O75 3.2 Å, Yeast RNA polymerase II transcription pre-initiation complex with open promoter DNA
- 7UIO 3.3 Å, Mediator-PIC Early (Composite Model)
- 4BBR 3.4 Å, Structure of RNA polymerase II-TFIIB complex
- 7ML2 3.4 Å, RNA polymerase II pre-initiation complex (PIC3)
- 7O72 3.4 Å, Yeast RNA polymerase II transcription pre-initiation complex with closed promoter DNA
- 7O73 3.4 Å, Yeast RNA polymerase II transcription pre-initiation complex with closed distorted…
Browse structure collections
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