Cryo-EM structure of an apo-form of human DICER. Determined by electron microscopy at 4.04 Å resolution. Released 8 Mar 2023.
Explore 7XW3 in 3D Show helices and sheets RCSB PDB PDBe
7XW3 contains 58 α-helices and 48 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 47-49 | 3 | |
| α-helix | 52-57 | 6 | |
| β-strand | 60-61 | 2 | 1 |
| α-helix | 71-78 | 8 | |
| α-helix | 79-84 | 6 | |
| β-strand | 95 | 1 | 2 |
| β-strand | 97-99 | 3 | 3 |
| α-helix | 103-114 | 12 | |
| β-strand | 121 | 1 | 4 |
| α-helix | 129-132 | 4 | |
| α-helix | 135-144 | 10 | |
| β-strand | 147 | 1 | 4 |
| β-strand | 148-150 | 3 | 3 |
| α-helix | 152-160 | 9 | |
| β-strand | 169 | 1 | 2 |
| β-strand | 172-174 | 3 | 1 |
| α-helix | 177-181 | 5 | |
| α-helix | 185-195 | 11 | |
| β-strand | 202-204 | 3 | 1 |
| α-helix | 216-230 | 15 | |
| β-strand | 234 | 1 | 1 |
| β-strand | 248-256 | 9 | 5 |
| α-helix | 267-281 | 15 | |
| α-helix | 296-312 | 17 | |
| α-helix | 315-335 | 21 | |
| α-helix | 339-362 | 24 | |
| α-helix | 375-384 | 10 | |
| β-strand | 444-448 | 5 | 5 |
| α-helix | 454-465 | 12 | |
| α-helix | 469-472 | 4 | |
| β-strand | 477-478 | 2 | 5 |
| α-helix | 493-509 | 17 | |
| β-strand | 515-519 | 5 | 5 |
| β-strand | 533-536 | 4 | 5 |
| α-helix | 543-551 | 9 | |
| β-strand | 557-564 | 8 | 5 |
| α-helix | 568-588 | 21 | |
| β-strand | 589-590 | 2 | 6 |
| β-strand | 593-594 | 2 | 6 |
| α-helix | 603-605 | 3 | |
| α-helix | 628-637 | 10 | |
| β-strand | 652-657 | 6 | 7 |
| β-strand | 663-668 | 6 | 7 |
| β-strand | 684 | 1 | 7 |
| α-helix | 687-704 | 18 | |
| β-strand | 746-750 | 5 | 8 |
| α-helix | 755-757 | 3 | |
| β-strand | 768-772 | 5 | 9 |
| β-strand | 776-777 | 2 | 10 |
| α-helix | 790-792 | 3 | |
| β-strand | 801-802 | 2 | 11 |
| β-strand | 805-806 | 2 | 9 |
| α-helix | 811-814 | 4 | |
| β-strand | 816 | 1 | 12 |
| β-strand | 819-821 | 3 | 13 |
| β-strand | 823-824 | 2 | 13 |
| β-strand | 825-826 | 2 | 10 |
| β-strand | 827 | 1 | 12 |
| β-strand | 830-836 | 7 | 9 |
| α-helix | 840-852 | 13 | |
| α-helix | 853-857 | 5 | |
| β-strand | 865-867 | 3 | 14 |
| β-strand | 880-883 | 4 | 11 |
| β-strand | 890-892 | 3 | 11 |
| α-helix | 894-902 | 9 | |
| β-strand | 916 | 1 | 15 |
| β-strand | 919 | 1 | 15 |
| β-strand | 931-934 | 4 | 16 |
| β-strand | 945-950 | 6 | 16 |
| α-helix | 968-973 | 6 | |
| β-strand | 988-991 | 4 | 16 |
| β-strand | 1033 | 1 | 16 |
| α-helix | 1035-1037 | 3 | |
| β-strand | 1038-1041 | 4 | 16 |
| α-helix | 1045-1052 | 8 | |
| α-helix | 1054-1077 | 24 | |
| α-helix | 1092-1094 | 3 | |
| α-helix | 1294-1301 | 8 | |
| α-helix | 1313-1332 | 20 | |
| α-helix | 1341-1350 | 10 | |
| α-helix | 1353-1360 | 8 | |
| α-helix | 1365-1368 | 4 | |
| α-helix | 1376-1379 | 4 | |
| α-helix | 1381-1382 | 2 | |
| β-strand | 1385-1387 | 3 | 14 |
| α-helix | 1447-1451 | 5 | |
| β-strand | 1551-1555 | 5 | 8 |
| α-helix | 1557-1585 | 29 | |
| α-helix | 1596-1600 | 5 | |
| α-helix | 1640-1642 | 3 | |
| α-helix | 1657-1667 | 11 | |
| α-helix | 1681-1687 | 7 | |
| β-strand | 1688 | 1 | 17 |
| α-helix | 1702-1721 | 20 | |
| α-helix | 1742-1751 | 10 | |
| β-strand | 1759 | 1 | 17 |
| α-helix | 1763-1777 | 15 | |
| α-helix | 1793-1800 | 8 | |
| α-helix | 1808-1822 | 15 | |
| α-helix | 1827-1845 | 19 | |
| α-helix | 1853-1860 | 8 | |
| α-helix | 1868-1870 | 3 | |
| β-strand | 1878-1881 | 4 | 18 |
| α-helix | 1882 | 1 | |
| β-strand | 1891-1894 | 4 | 18 |
| α-helix | 1897-1915 | 19 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Endoribonuclease Dicer | A | protein | 1922 | Homo sapiens | Q9UPY3 (AlphaFold model) |
>7XW3_1 Endoribonuclease Dicer (chains A) MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNT IVCLNTGSGKTFIAVLLTKELSYQIRGDFSRNGKRTVFLVNSANQVAQQVSAVRTHSDLK VGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLA ILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDL VVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEEALNFINDCNISVHSKERDSTLISK QILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCE EHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDE DEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFIT GHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLP TEYRSYVQSKGRARAPISNYIMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGETD IDPVMDDDDVFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPD GTFYSTLYLPINSPLRASIVGPPMSCVRLAERVVALICCEKLHKIGELDDHLMPVGKETV KYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRDSYPRPDQPCYLYVIGMVLTTP LPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSL QMLELITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDI EKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKF PSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKR KAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGV GVRSLPADFRYPNLDFGWKKSIDSKSFISISNSSSAENDNYCKHSTIVPENAAHQGANRT SSLENHDQMSVNCRTLLSESPGKLHVEVSADLTAINGLSYNQNLANGSYDLANRDFCQGN QLNYYKQEIPVQPTTSYSIQNLYSYENQPQPSDECTLLSNKYLDGNANKSTSDGSPVMAV MPGTTDTIQVLKGRMDSEQSPSIGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGD SFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNW LPPGYVVNQDKSNTDKWEKDEMTKDCMLANGKLDEDYEEEDEEEESLMWRAPKEEADYED DFLEYDQEHIRFIDNMLMGSGAFVKKISLSPFSTTDSAYEWKMPKKSSLGSMPFSSDFED FDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSIA DCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTDREKALCPTRENFNSQQKNLSVS CAAASVASSRSSVLKDSEYGCLKIPPRCMFDHPDADKTLNHLISGFENFEKKINYRFKNK AYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALV NNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEE DIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLEM EPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVP NS
Structure of the human DICER-pre-miRNA complex in a dicing state. Lee, Y.Y., Lee, H., Kim, H. et al. Nature (2023) 615:331-338. DOI 10.1038/s41586-023-05723-3 · PubMed
Other PDB entries of the same protein (UniProt Q9UPY3 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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