7Z1M: Yeast RNA Polymerase III Elongation Complex

Structure of yeast RNA Polymerase III Elongation Complex (EC). Determined by electron microscopy at 3.4 Å resolution. Released 31 Aug 2022.

Method: Electron microscopy
Resolution: 3.4 Å
Organisms: Saccharomyces cerevisiae W303, synthetic construct
Chains: 20
Atoms: 42,122
Mol. weight: 728.46 kDa
Ligands: 4QM, MG, ZN
Released: 31 Aug 2022

Explore 7Z1M in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7Z1M contains 233 α-helices and 279 β-strands across 17 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 75 helices, 64 β-strands

Element	Residues	Length	Sheet
β-strand	4	1	1
α-helix	5-6	2
β-strand	11-17	7	2
α-helix	23-29	7
β-strand	30-33	4	3
β-strand	40-41	2	4
β-strand	47-48	2	4
α-helix	49	1
α-helix	74-76	3
β-strand	81-91	11	3
α-helix	96-103	8
β-strand	106	1	5
β-strand	113	1	5
α-helix	117-127	11
α-helix	134-150	17
β-strand	153	1	6
β-strand	160	1	6
β-strand	163-166	4	7
α-helix	173-176	4
β-strand	178-181	4	7
α-helix	192-205	14
α-helix	212-214	3
β-strand	220-222	3	7
α-helix	224-232	9
α-helix	236-238	3
α-helix	253-256	4
β-strand	257-263	7	3
α-helix	264-265	2
α-helix	270-272	3
α-helix	284-305	22
α-helix	309-327	19
α-helix	329-331	3
α-helix	334-336	3
α-helix	348-350	3
α-helix	353-357	5
α-helix	363	1
α-helix	364-368	5
β-strand	371-372	2	8
β-strand	376-383	8	9
β-strand	391-395	5	9
α-helix	396-399	4
β-strand	403-407	5	10
α-helix	413-422	10
β-strand	430-434	5	10
β-strand	442-443	2	10
α-helix	451-454	4
β-strand	461-465	5	10
α-helix	466	1
β-strand	471-475	5	9
α-helix	482-484	3
β-strand	485-493	9	9
β-strand	498-500	3	9
α-helix	502-504	3
α-helix	505-508	4
β-strand	516-520	5	9
α-helix	525-534	10
β-strand	536	1	9
α-helix	538-540	3
β-strand	542	1	11
β-strand	549	1	11
α-helix	558-564	7
β-strand	570-571	2	12
α-helix	573-584	12
α-helix	592-595	4
β-strand	597	1	13
β-strand	603	1	13
β-strand	604-605	2	12
α-helix	606-614	9
β-strand	626-629	4	14
α-helix	643-645	3
β-strand	651-655	5	14
β-strand	658-661	4	14
α-helix	677-704	28
α-helix	714-716	3
α-helix	719-720	2
α-helix	723-747	25
α-helix	758-783	26
α-helix	785-786	2
α-helix	790-797	8
α-helix	803-810	8
β-strand	814-815	2	15
β-strand	818	1	16
β-strand	821	1	16
β-strand	827	1	17
β-strand	830	1	17
α-helix	842-845	4
β-strand	847-848	2	15
α-helix	858-893	36
β-strand	897-898	2	18
β-strand	904-905	2	18
β-strand	911-913	3	18
α-helix	916-918	3
β-strand	921	1	19
β-strand	928	1	20
β-strand	931	1	20
α-helix	935-945	11
α-helix	952-955	4
α-helix	956-972	17
β-strand	977	1	21
β-strand	983	1	21
α-helix	999-1024	26
α-helix	1052-1059	8
α-helix	1064-1080	17
β-strand	1082	1	19
α-helix	1083-1084	2
α-helix	1089-1098	10
α-helix	1100-1103	4
α-helix	1123-1130	8
β-strand	1140-1144	5	22
β-strand	1145	1	23
α-helix	1151-1161	11
β-strand	1164-1165	2	24
α-helix	1166-1168	3
β-strand	1170-1177	8	25
β-strand	1182-1188	7	25
α-helix	1190-1196	7
α-helix	1202-1210	9
β-strand	1222-1225	4	25
β-strand	1229-1233	5	25
α-helix	1255-1266	12
α-helix	1267-1269	3
β-strand	1271-1273	3	24
β-strand	1281-1285	5	22
β-strand	1291-1296	6	22
α-helix	1300-1305	6
β-strand	1309	1	23
β-strand	1315-1316	2	22
α-helix	1319-1345	27
α-helix	1352-1362	11
α-helix	1373-1379	7
α-helix	1383-1389	7
α-helix	1392-1402	11
β-strand	1405-1407	3	2
α-helix	1412-1417	6
α-helix	1424-1426	3
β-strand	1429-1432	4	1
α-helix	1438-1440	3
α-helix	1442-1445	4
α-helix	1447-1451	5

Chain B: 52 helices, 80 β-strands

Element	Residues	Length	Sheet
α-helix	41-46	6
α-helix	47-54	8
α-helix	59-67	9
α-helix	68-72	5
α-helix	73-79	7
β-strand	82-84	3	26
β-strand	92-100	9	26
α-helix	109-111	3
α-helix	115-121	7
β-strand	127-137	11	26
β-strand	140-152	13	26
α-helix	154	1
β-strand	155	1	27
α-helix	168-173	6
β-strand	185-187	3	27
β-strand	190-194	5	27
α-helix	195	1
β-strand	196-200	5	28
α-helix	201	1
β-strand	205-210	6	29
β-strand	215-223	9	29
β-strand	228-236	9	29
β-strand	239-244	6	29
β-strand	247	1	30
β-strand	251-252	2	29
α-helix	253-259	7
α-helix	265-272	8
α-helix	277-292	16
α-helix	298-306	9
β-strand	309	1	30
α-helix	319-325	7
α-helix	326-330	5
α-helix	343-361	19
α-helix	366-368	3
α-helix	372-374	3
β-strand	375-378	4	28
α-helix	380-407	28
α-helix	418-420	3
α-helix	423-439	17
β-strand	442-444	3	31
β-strand	449-451	3	31
β-strand	455-457	3	27
α-helix	463-469	7
β-strand	472-474	3	28
α-helix	491-493	3
β-strand	494	1	32
β-strand	497	1	32
β-strand	511-513	3	28
β-strand	514	1	32
β-strand	519-520	2	33
α-helix	527-536	10
α-helix	538	1
β-strand	539-540	2	34
α-helix	541-543	3
α-helix	549-551	3
β-strand	554-557	4	34
β-strand	560-564	5	34
α-helix	568-581	14
β-strand	589-593	5	34
β-strand	598-602	5	34
β-strand	608-614	7	33
β-strand	615-616	2	35
β-strand	619-620	2	35
α-helix	624-632	9
α-helix	637-642	6
β-strand	646-650	5	33
α-helix	651-655	5
β-strand	659-660	2	33
β-strand	672-673	2	33
α-helix	677-680	4
α-helix	685-687	3
α-helix	691-693	3
α-helix	696-705	10
α-helix	706-708	3
β-strand	709	1	36
β-strand	724-728	5	37
β-strand	732	1	38
β-strand	736-737	2	39
α-helix	739-743	5
β-strand	753-759	7	40
α-helix	764-766	3
β-strand	771-774	4	41
α-helix	775-780	6
β-strand	785-795	11	37
β-strand	797	1	42
β-strand	803	1	42
β-strand	805	1	43
β-strand	811	1	44
β-strand	817	1	44
α-helix	819-821	3
β-strand	829	1	45
α-helix	830-831	2
β-strand	832	1	46
β-strand	835-836	2	37
β-strand	841-843	3	45
β-strand	846-848	3	43
β-strand	866-868	3	43
β-strand	871-872	2	45
β-strand	879-888	10	37
β-strand	894-904	11	37
β-strand	911-912	2	47
β-strand	920-921	2	47
β-strand	922-926	5	41
β-strand	933	1	48
β-strand	942	1	40
β-strand	943-944	2	41
α-helix	948-952	5
α-helix	955-970	16
β-strand	974-975	2	39
α-helix	984-994	11
β-strand	1001-1002	2	40
β-strand	1005	1	48
β-strand	1012	1	48
β-strand	1017-1024	8	40
β-strand	1026	1	47
β-strand	1027	1	36
α-helix	1031-1033	3
β-strand	1036-1037	2	9
β-strand	1043	1	49
β-strand	1050	1	49
α-helix	1054-1056	3
β-strand	1061-1062	2	8
α-helix	1064-1073	10
α-helix	1076-1080	5
α-helix	1081-1085	5
β-strand	1089-1095	7	50
β-strand	1101-1102	2	50
β-strand	1107	1	51
β-strand	1112	1	51
β-strand	1116-1122	7	50
α-helix	1123-1134	12
β-strand	1140-1145	6	2

Chain C: 13 helices, 20 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	52
β-strand	12-13	2	52
α-helix	33-39	7
β-strand	41-47	7	52
β-strand	51-57	7	52
α-helix	61-73	13
β-strand	77-86	10	53
α-helix	94-102	9
β-strand	106	1	54
α-helix	110-112	3
α-helix	115-117	3
α-helix	122-125	4
β-strand	132-139	8	53
β-strand	142	1	55
α-helix	153-156	4
β-strand	157	1	55
β-strand	161-163	3	56
β-strand	168-170	3	53
α-helix	175-178	4
β-strand	186	1	54
β-strand	192-195	4	56
β-strand	201-211	11	53
α-helix	217-219	3
β-strand	222-235	14	52
β-strand	240	1	57
α-helix	242-249	8
β-strand	256-259	4	57
β-strand	264-267	4	57
α-helix	278-280	3
α-helix	283-285	3
β-strand	289-304	16	52
α-helix	310-330	21
β-strand	334	1	58

Chain D: 8 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	2-11	10	1
α-helix	13-27	15
α-helix	31-37	7
α-helix	53-67	15
β-strand	68	1	59
β-strand	92	1	59
α-helix	95-97	3
α-helix	100-111	12
α-helix	117-126	10
α-helix	131-137	7
α-helix	147-158	12

Chain E: 12 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	2-25	24
β-strand	28	1	60
α-helix	32-35	4
α-helix	39-45	7
β-strand	47	1	61
β-strand	53	1	61
β-strand	60-62	3	62
β-strand	64	1	60
α-helix	66-71	6
β-strand	78-82	5	62
β-strand	87-88	2	63
α-helix	90-102	13
β-strand	107-112	6	62
β-strand	115-116	2	63
α-helix	118-121	4
β-strand	131-136	6	62
α-helix	138-140	3
β-strand	152-155	4	64
α-helix	158-168	11
α-helix	172-174	3
α-helix	176	1
β-strand	177-178	2	64
α-helix	183-188	6
α-helix	190-191	2
β-strand	195-202	8	64
β-strand	206-214	9	64

Chain F: 3 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	73-75	3
α-helix	87-102	16
α-helix	117-126	10
β-strand	132-135	4	1
β-strand	138	1	65
β-strand	142	1	65
β-strand	145-147	3	1

Chain G: 4 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	2-13	12	1
α-helix	15-17	3
α-helix	22-34	13
β-strand	37-39	3	1
β-strand	43-54	12	1
α-helix	56	1
β-strand	57-59	3	1
β-strand	66-77	12	1
β-strand	84-92	9	66
β-strand	96-100	5	66
β-strand	108-111	4	66
β-strand	120-122	3	67
β-strand	127-129	3	67
β-strand	139	1	67
β-strand	145-155	11	66
α-helix	163-174	12
β-strand	194-199	6	66
β-strand	207	1	66

Chain H: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-16	13	13
β-strand	23-30	8	13
β-strand	37-43	7	13
β-strand	54-60	7	13
α-helix	81-83	3
α-helix	89-91	3
β-strand	95-108	14	13
β-strand	111-118	8	13
β-strand	121-127	7	13
β-strand	139-145	7	13

9 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase III subunit RPC1	A	protein	1460	Saccharomyces cerevisiae W303	P04051 (AlphaFold model)
DNA-directed RNA polymerase III subunit RPC2	B	protein	1149	Saccharomyces cerevisiae W303	P22276 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae W303	P07703 (AlphaFold model)
DNA-directed RNA polymerase III subunit RPC9	D	protein	161	Saccharomyces cerevisiae W303	P47076 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae W303	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae W303	P20435
DNA-directed RNA polymerase III subunit RPC8	G	protein	212	Saccharomyces cerevisiae W303	P35718
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	Saccharomyces cerevisiae W303	P20436
DNA-directed RNA polymerase III subunit RPC10	I	protein	110	Saccharomyces cerevisiae W303	Q04307
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	Saccharomyces cerevisiae W303	P22139
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	142	Saccharomyces cerevisiae W303	P28000
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	70	Saccharomyces cerevisiae W303	P40422

8 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>7Z1M_1 DNA-directed RNA polymerase III subunit RPC1 (chains A)
MKEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKANGALDPKMGV
SSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQILQGICKNCSAILLSETDK
RQFLHELRRPGVDNLRRMGILKKILDQCKKQRRCLHCGALNGVVKKAAAGAGSAALKIIH
DTFRWVGKKSAPEKDIWVGEWKEVLAHNPELERYVKRCMDDLNPLKTLNLFKQIKSADCE
LLGIDATVPSGRPETYIWRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIK
AGLDKGISINNMMEHWDYLQLTVAMYINSDSVNPAMLPGSSNGGGKVKPIRGFCQRLKGK
QGRFRGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEKVTRYNRHKLQELI
VNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVVERHLEDGDVVLFNRQPSL
HRLSILSHYAKIRPWRTFRLNECVCTPYNADFDGDEMNLHVPQTEEARAEAINLMGVKNN
LLTPKSGEPIIAATQDFITGSYLISHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKP
YYLWTGKQVFSLLIKPNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQIL
SGVMDKSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSIGINDVTPA
DDLKQKKEELVEIAYHKCDELITLFNKGELETQPGCNEEQTLEAKIGGLLSKVREEVGDV
CINELDNWNAPLIMATCGSKGSTLNVSQMVAVVGQQIISGNRVPDGFQDRSLPHFPKNSK
TPQSKGFVRNSFFSGLSPPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQY
DNTVRTSANGIVQFTYGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPYAIM
ETANEILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHSLREYINGKATALA
NLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRISEKSVRKFLEIALFKYRK
ARLEPGTAIGAIGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINASKVISTPI
INAVLVNDNDERAARVVKGRVEKTLLSDVAFYVQDVYKDNLSFIQVRIDLGTIDKLQLEL
TIEDIAVAITRASKLKIQASDVNIIGKDRIAINVFPEGYKAKSISTSAKEPSENDVFYRM
QQLRRALPDVVVKGLPDISRAVINIRDDGKRELLVEGYGLRDVMCTDGVIGSRTTTNHVL
EVFSVLGIEAARYSIIREINYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMR
DSVLQLASFEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMSIGTGSFKVVKGTNISEKD
LVPKRCLFESLSNEAALKAN

Sequence of entity 2 (B), FASTA

>7Z1M_2 DNA-directed RNA polymerase III subunit RPC2 (chains B)
MVAATKRRKTHIHKHVKDEAFDDLLKPVYKGKKLTDEINTAQDKWHLLPAFLKVKGLVKQ
HLDSFNYFVDTDLKKIIKANQLILSDVDPEFYLKYVDIRVGKKSSSSTKDYLTPPHECRL
RDMTYSAPIYVDIEYTRGRNIIMHKDVEIGRMPIMLRSNKCILYDADESKMAKLNECPLD
PGGYFIVNGTEKVILVQEQLSKNRIIVEADEKKGIVQASVTSSTHERKSKTYVITKNGKI
YLKHNSIAEEIPIAIVLKACGILSDLEIMQLVCGNDSSYQDIFAVNLEESSKLDIYTQQQ
ALEYIGAKVKTMRRQKLTILQEGIEAIATTVIAHLTVEALDFREKALYIAMMTRRVVMAM
YNPKMIDDRDYVGNKRLELAGQLISLLFEDLFKKFNNDFKLSIDKVLKKPNRAMEYDALL
SINVHSNNITSGLNRAISTGNWSLKRFKMERAGVTHVLSRLSYISALGMMTRISSQFEKS
RKVSGPRALQPSQFGMLCTADTPEGEACGLVKNLALMTHITTDDEEEPIKKLCYVLGVED
ITLIDSASLHLNYGVYLNGTLIGSIRFPTKFVTQFRHLRRTGKVSEFISIYSNSHQMAVH
IATDGGRICRPLIIVSDGQSRVKDIHLRKLLDGELDFDDFLKLGLVEYLDVNEENDSYIA
LYEKDIVPSMTHLEIEPFTILGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIAYNQFKR
IDTLLYLMTYPQQPMVKTKTIELIDYDKLPAGQNATVAVMSYSGYDIEDALVLNKSSIDR
GFGRCETRRKTTTVLKRYANHTQDIIGGMRVDENGDPIWQHQSLGPDGLGEVGMKVQSGQ
IYINKSVPTNSADAPNPNNVNVQTQYREAPVIYRGPEPSHIDQVMMSVSDNDQALIKVLL
RQNRRPELGDKFSSRHGQKGVCGIIVKQEDMPFNDQGIVPDIIMNPHGFPSRMTVGKMIE
LISGKAGVLNGTLEYGTCFGGSKLEDMSKILVDQGFNYSGKDMLYSGITGECLQAYIFFG
PIYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCVIAYGASQLLL
ERLMISSDAFEVDVCDKCGLMGYSGWCTTCKSAENIIKMTIPYAAKLLFQELLSMNIAPR
LRLEDIFQQ

Sequence of entity 3 (C), FASTA

>7Z1M_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 4 (D), FASTA

>7Z1M_4 DNA-directed RNA polymerase III subunit RPC9 (chains D)
MKVLEERNAFLSDYEVLKFLTDLEKKHLWDQKSLAALKKSRSKGKQNRPYNHPELQGITR
NVVNYLSINKNFINQEDEGEERESSGAKDAEKSGISKMSDESFAELMTKLNSFKLFKAEK
LQIVNQLPANMVHLYSIVEECDARFDEKTIEEMLEIISGYA

Sequence of entity 5 (E), FASTA

>7Z1M_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 6 (F), FASTA

>7Z1M_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 7 (G), FASTA

>7Z1M_7 DNA-directed RNA polymerase III subunit RPC8 (chains G)
MFILSKIADLVRIPPDQFHRDTISAITHQLNNKFANKIIPNVGLCITIYDLLTVEEGQLK
PGDGSSYINVTFRAVVFKPFLGEIVTGWISKCTAEGIKVSLLGIFDDIFIPQNMLFEGCY
YTPEESAWIWPMDEETKLYFDVNEKIRFRIEREVFVDVKPKSPKERELEERAQLENEIEG
KNEETPQNEKPPAYALLGSCQTDGMGLVSWWE

Sequence of entity 8 (H), FASTA

>7Z1M_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 9 (I), FASTA

>7Z1M_9 DNA-directed RNA polymerase III subunit RPC10 (chains I)
MLSFCPSCNNMLLITSGDSGVYTLACRSCPYEFPIEGIEIYDRKKLPRKEVDDVLGGGWD
NVDQTKTQCPNYDTCGGESAYFFQLQIRSADEPMTTFYKCVNCGHRWKEN

Sequence of entity 10 (J), FASTA

>7Z1M_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 11 (K), FASTA

>7Z1M_11 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTS
ASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKG
LKDLMDLCDVVESKFTEKIKSM

Sequence of entity 12 (L), FASTA

>7Z1M_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Ligands and cofactors

ID	Name	Formula	Copies
4QM	(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4…	C24 H42 O3	2
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	7

Primary citation

Architecture of the yeast Pol III pre-termination complex and pausing mechanism on poly(dT) termination signals. Girbig, M., Xie, J., Grotsch, H. et al. Cell Rep (2022) 40:111316-111316. DOI 10.1016/j.celrep.2022.111316 · PubMed

Other PDB entries of the same protein (UniProt P04051 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7Z0H 2.6 Å, Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.6 A (focus subunit AC40).
7Z1O 2.7 Å, Structure of yeast RNA Polymerase III PTC + NTPs
7Z31 2.76 Å, Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.7 A (focus subunit C11,…
7Z1L 2.8 Å, Structure of yeast RNA Polymerase III Pre-Termination Complex (PTC)
7Z30 2.9 Å, Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.9 A (focus subunit C11…
7Z2Z 3.07 Å, Structure of yeast RNA Polymerase III-DNA-Ty1 integrase complex (Pol III-DNA-IN1) at 3.1 A
8BWS 3.2 Å, Structure of yeast RNA Polymerase III elongation complex at 3.3 A
6TUT 3.25 Å, Cryo-EM structure of the RNA Polymerase III-Maf1 complex
6EU3 3.3 Å, Apo RNA Polymerase III - closed conformation (cPOL3)
6EU1 3.4 Å, RNA Polymerase III - open DNA complex (OC-POL3).
6EU2 3.4 Å, Apo RNA Polymerase III - open conformation (oPOL3)
6F40 3.7 Å, RNA Polymerase III open complex

Browse structure collections

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