7ZJS: Centromeric cohesion protection by SGO1

Structural basis of centromeric cohesion protection by SGO1. Determined by X-ray diffraction at 3.24 Å resolution. Released 26 Apr 2023.

Method
X-ray diffraction
Resolution
3.24 Å
Organism
Homo sapiens
Chains
6
Atoms
16,221
Mol. weight
429.18 kDa
Released
26 Apr 2023

Explore 7ZJS in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7ZJS contains 128 α-helices and 16 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 62 helices, 4 β-strands

ElementResiduesLengthSheet
α-helix82-898
α-helix95-10814
α-helix110-12314
α-helix133-1386
α-helix141-15010
α-helix160-1623
α-helix166-18520
α-helix190-1923
α-helix196-20712
β-strand21211
α-helix213-25341
α-helix261-28828
α-helix289-2935
α-helix294-2963
β-strand29912
α-helix302-31817
α-helix320-3234
α-helix326-33510
α-helix341-35616
α-helix362-3709
α-helix372-3776
α-helix378-3803
β-strand38113
α-helix384-39613
α-helix397-3993
α-helix407-4159
α-helix416-4183
β-strand41914
α-helix422-43615
α-helix458-47013
α-helix478-4847
α-helix489-4924
α-helix495-5017
α-helix515-53319
α-helix537-5382
α-helix546-5494
α-helix550-57728
α-helix582-5887
α-helix592-5943
α-helix599-6024
α-helix606-62217
α-helix626-63914
α-helix647-67226
α-helix681-70020
α-helix704-7063
α-helix709-72214
α-helix727-74721
α-helix755-77622
α-helix781-79717
α-helix800-8023
α-helix808-8136
α-helix819-83214
α-helix851-87323
α-helix879-8824
α-helix883-8864
α-helix893-91018
α-helix912-93322
α-helix943-95614
α-helix967-98216
α-helix993-9942
α-helix997-9993
α-helix1000-10078
α-helix1015-102511
α-helix1028-10314
α-helix1036-10383
α-helix1039-10479
Chain B: 5 helices, 4 β-strands
ElementResiduesLengthSheet
β-strand32611
β-strand33112
α-helix334-3429
α-helix345-3473
β-strand34813
β-strand35314
α-helix358-3658
α-helix368-3725
α-helix383-3908
Chain C: 54 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix84-907
α-helix95-10814
α-helix110-12314
α-helix133-1386
α-helix141-15010
α-helix160-1623
α-helix166-18520
α-helix190-1923
α-helix196-20712
β-strand21215
α-helix213-25341
α-helix261-28828
α-helix289-2935
α-helix294-2963
β-strand29916
α-helix302-31817
α-helix320-3234
α-helix326-33510
α-helix341-35616
α-helix362-3709
α-helix372-3776
α-helix378-3803
β-strand38117
α-helix384-39714
α-helix407-4159
α-helix416-4183
β-strand41918
α-helix422-43615
α-helix458-47013
α-helix478-4836
α-helix489-4924
α-helix495-5017
α-helix515-53319
α-helix546-5494
α-helix550-57728
α-helix582-5887
α-helix592-5943
α-helix599-6024
α-helix606-62217
α-helix626-63914
α-helix646-67227
α-helix681-70020
α-helix709-72214
α-helix727-74721
α-helix755-7639
α-helix767-7737
α-helix781-79717
α-helix800-8034
α-helix808-8103
α-helix819-83113
α-helix851-87323
α-helix882-8854
α-helix897-91014
α-helix912-93322
α-helix943-95816
α-helix965-98218
α-helix999-100911
α-helix1012-102413
Chain D: 6 helices, 4 β-strands
ElementResiduesLengthSheet
β-strand32615
β-strand33116
α-helix334-3429
α-helix345-3473
β-strand34817
β-strand35318
α-helix354-3552
α-helix358-3669
α-helix368-3725
α-helix383-3908
Chain E: 1 helix, 0 β-strands
ElementResiduesLengthSheet
α-helix337-3393

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Cohesin subunit SA-2A, Cprotein1231Homo sapiensQ8N3U4 (AlphaFold model)
Double-strand-break repair protein rad21 homologB, Dprotein631Homo sapiensO60216 (AlphaFold model)
Shugoshin 1E, Fprotein11Homo sapiensQ5FBB7 (AlphaFold model)
Sequence of entity 1 (A, C), FASTA
>7ZJS_1 Cohesin subunit SA-2 (chains A, C)
MIAAPEIPTDFNLLQESETHFSSDTDFEDIEGKNQKQGKGKTCKKGKKGPAEKGKGGNGG
GKPPSGPNRMNGHHQQNGVENMMLFEVVKMGKSAMQSVVDDWIESYKHDRDIALLDLINF
FIQCSGCKGVVTAEMFRHMQNSEIIRKMTEEFDEDSGDYPLTMAGPQWKKFKSSFCEFIG
VLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSIN
MDNTQRQYEAERNKMIGKRANERLELLLQKRKELQENQDEIENMMNAIFKGVFVHRYRDA
IAEIRAICIEEIGIWMKMYSDAFLNDSYLKYVGWTMHDKQGEVRLKCLTALQGLYYNKEL
NSKLELFTSRFKDRIVSMTLDKEYDVAVQAIKLLTLVLQSSEEVLTAEDCENVYHLVYSA
HRPVAVAAGEFLYKKLFSRRDPEEDGMMKRRGRQGPNANLVKTLVFFFLESELHEHAAYL
VDSMWDCATELLKDWECMNSLLLEEPLSGEEALTDRQESALIEIMLCTIRQAAECHPPVG
RGTGRKVLTAKEKKTQLDDRTKITELFAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIY
TTGRLEKHLDALLRQIRNIVEKHTDTDVLEACSKTYHALCNEEFTIFNRVDISRSQLIDE
LADKFNRLLEDFLQEGEEPDEDDAYQVLSTLKRITAFHNAHDLSKWDLFACNYKLLKTGI
ENGDMPEQIVIHALQCTHYVILWQLAKITESSSTKEDLLRLKKQMRVFCQICQHYLTNVN
TTVKEQAFTILCDILMIFSHQIMSGGRDMLEPLVYTPDSSLQSELLSFILDHVFIEQDDD
NNSADGQQEDEASKIEALHKRRNLLAAFCKLIVYTVVEMNTAADIFKQYMKYYNDYGDII
KETMSKTRQIDKIQCAKTLILSLQQLFNEMIQENGYNFDRSSSTFSGIKELARRFALTFG
LDQLKTREAIAMLHKDGIEFAFKEPNPQGESHPPLNLAFLDILSEFSSKLLRQDKRTVYV
YLEKFMTFQMSLRREDVWLPLMSYRNSLLAGGDDDTMSVISGISSRGSTVRSKKSKPSTG
KRKVVEGMQLSLTEESSSSDSMWLSREQTLHTPVMMQTPQLTSTIMREPKRLRPEDSFMS
VYPMQTEHHQTPLDYNRRGTSLMEDDEEPIVEDVMMSSEGRIEDLNEGMDFDTMDIDLPP
SKNRRERTELKPDFFDPASIMDESVLGVSMF
Sequence of entity 2 (B, D), FASTA
>7ZJS_2 Double-strand-break repair protein rad21 homolog (chains B, D)
MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLL
LGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQP
LPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDD
DMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGG
IFDDPPALSEAGVMLPEQPAHDDMDEDDNVSMGGPDSPDSVDPVEPMPTMTDQTTLVPNE
EEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKL
MMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEF
ENPEVPREDQQQQHQQRDVIDEPIIEEPSRLQESVMEASRTNIDESAMPPPPPQGVKRKA
GQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEE
DEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSF
LVLKKQQAIELTQEEPYSDIIATPGPRFHII
Sequence of entity 3 (E, F), FASTA
>7ZJS_3 Shugoshin 1 (chains E, F)
SNDAYNFNLEE

Primary citation

Structural basis of centromeric cohesion protection. Garcia-Nieto, A., Patel, A., Li, Y. et al. Nat Struct Mol Biol (2023) 30:853-859. DOI 10.1038/s41594-023-00968-y · PubMed

Other PDB entries of the same protein (UniProt Q8N3U4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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