7ZVE: Glucose-6-phosphate 1-dehydrogenase
K403 acetylated glucose-6-phosphate dehydrogenase (G6PD). Determined by X-ray diffraction at 2.28 Å resolution. Released 23 Aug 2023.
- Method
- X-ray diffraction
- Resolution
- 2.28 Å
- Organism
- Homo sapiens
- Chains
- 8
- Atoms
- 32,772
- Mol. weight
- 459.97 kDa
- Ligands
- CU
- Released
- 23 Aug 2023
Explore 7ZVE in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7ZVE contains 261 α-helices and 159 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 33 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7 | 1 | 1 |
| α-helix | 9-22 | 14 | |
| β-strand | 32-37 | 6 | 2 |
| α-helix | 42-43 | 2 | |
| α-helix | 44-48 | 5 | |
| α-helix | 49-58 | 10 | |
| β-strand | 65-71 | 7 | 2 |
| α-helix | 77-84 | 8 | |
| α-helix | 85-88 | 4 | |
| α-helix | 92-94 | 3 | |
| α-helix | 95-103 | 9 | |
| β-strand | 105-109 | 5 | 2 |
| α-helix | 115-126 | 12 | |
| β-strand | 135-140 | 6 | 2 |
| α-helix | 144-146 | 3 | |
| α-helix | 147-157 | 11 | |
| β-strand | 165-169 | 5 | 2 |
| α-helix | 170 | 1 | |
| α-helix | 172 | 1 | |
| α-helix | 177-188 | 12 | |
| α-helix | 193-195 | 3 | |
| β-strand | 196-198 | 3 | 2 |
| α-helix | 205-216 | 12 | |
| α-helix | 222-224 | 3 | |
| β-strand | 230-238 | 9 | 3 |
| α-helix | 250-252 | 3 | |
| α-helix | 254-255 | 2 | |
| α-helix | 256-264 | 9 | |
| α-helix | 265-272 | 8 | |
| α-helix | 273-276 | 4 | |
| α-helix | 281-293 | 13 | |
| β-strand | 295 | 1 | 4 |
| α-helix | 296-298 | 3 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303-309 | 7 | 3 |
| α-helix | 316-319 | 4 | |
| β-strand | 337-343 | 7 | 3 |
| β-strand | 344 | 1 | 4 |
| β-strand | 353-359 | 7 | 3 |
| β-strand | 362 | 1 | 5 |
| β-strand | 366-373 | 8 | 3 |
| α-helix | 374-376 | 3 | |
| α-helix | 385-388 | 4 | |
| β-strand | 389-395 | 7 | 3 |
| β-strand | 399-407 | 9 | 3 |
| α-helix | 408 | 1 | |
| β-strand | 415-421 | 7 | 3 |
| β-strand | 431 | 1 | 1 |
| α-helix | 436-445 | 10 | |
| α-helix | 455-475 | 21 | |
| α-helix | 477-479 | 3 | |
| β-strand | 480-483 | 4 | 3 |
| β-strand | 486 | 1 | 5 |
| α-helix | 490-499 | 10 | |
Chain B: 33 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7 | 1 | 6 |
| α-helix | 9-22 | 14 | |
| β-strand | 32-37 | 6 | 7 |
| α-helix | 42-43 | 2 | |
| α-helix | 44-48 | 5 | |
| α-helix | 49-58 | 10 | |
| β-strand | 65-71 | 7 | 7 |
| α-helix | 77-84 | 8 | |
| α-helix | 85-88 | 4 | |
| α-helix | 92-94 | 3 | |
| α-helix | 95-103 | 9 | |
| β-strand | 105-109 | 5 | 7 |
| α-helix | 115-126 | 12 | |
| β-strand | 135-140 | 6 | 7 |
| α-helix | 144-146 | 3 | |
| α-helix | 147-157 | 11 | |
| β-strand | 165-169 | 5 | 7 |
| α-helix | 170 | 1 | |
| α-helix | 172 | 1 | |
| α-helix | 177-188 | 12 | |
| α-helix | 193-195 | 3 | |
| β-strand | 196-198 | 3 | 7 |
| α-helix | 205-216 | 12 | |
| α-helix | 222-224 | 3 | |
| β-strand | 230-238 | 9 | 8 |
| α-helix | 248-251 | 4 | |
| α-helix | 254-255 | 2 | |
| α-helix | 256-264 | 9 | |
| α-helix | 265-272 | 8 | |
| α-helix | 273-276 | 4 | |
| α-helix | 281-292 | 12 | |
| β-strand | 295 | 1 | 9 |
| α-helix | 296-298 | 3 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303-309 | 7 | 8 |
| α-helix | 316-319 | 4 | |
| β-strand | 337-342 | 6 | 8 |
| β-strand | 344 | 1 | 9 |
| β-strand | 354-359 | 6 | 8 |
| β-strand | 362 | 1 | 10 |
| β-strand | 366-373 | 8 | 8 |
| α-helix | 374-376 | 3 | |
| α-helix | 385-388 | 4 | |
| β-strand | 389-395 | 7 | 8 |
| β-strand | 399-407 | 9 | 8 |
| α-helix | 408 | 1 | |
| β-strand | 415-421 | 7 | 8 |
| β-strand | 431 | 1 | 6 |
| α-helix | 436-445 | 10 | |
| α-helix | 455-475 | 21 | |
| α-helix | 477-479 | 3 | |
| β-strand | 480-483 | 4 | 8 |
| β-strand | 486 | 1 | 10 |
| α-helix | 490-499 | 10 | |
Chain C: 31 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-22 | 13 | |
| β-strand | 32-37 | 6 | 11 |
| α-helix | 42-43 | 2 | |
| α-helix | 44-48 | 5 | |
| α-helix | 49-58 | 10 | |
| β-strand | 65-71 | 7 | 11 |
| α-helix | 77-84 | 8 | |
| α-helix | 85-87 | 3 | |
| α-helix | 92-94 | 3 | |
| α-helix | 95-103 | 9 | |
| β-strand | 105-109 | 5 | 11 |
| α-helix | 115-126 | 12 | |
| β-strand | 135-140 | 6 | 11 |
| α-helix | 144-146 | 3 | |
| α-helix | 147-157 | 11 | |
| β-strand | 165-169 | 5 | 11 |
| α-helix | 177-188 | 12 | |
| α-helix | 193-195 | 3 | |
| β-strand | 196-198 | 3 | 11 |
| α-helix | 205-216 | 12 | |
| α-helix | 222-224 | 3 | |
| β-strand | 230-238 | 9 | 12 |
| α-helix | 250-252 | 3 | |
| α-helix | 254-255 | 2 | |
| α-helix | 256-264 | 9 | |
| α-helix | 265-272 | 8 | |
| α-helix | 273-276 | 4 | |
| α-helix | 281-292 | 12 | |
| β-strand | 295 | 1 | 13 |
| α-helix | 296-298 | 3 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303-309 | 7 | 12 |
| α-helix | 316-319 | 4 | |
| β-strand | 337-342 | 6 | 12 |
| β-strand | 344 | 1 | 13 |
| β-strand | 354-359 | 6 | 12 |
| β-strand | 362 | 1 | 14 |
| β-strand | 366-373 | 8 | 12 |
| α-helix | 374-376 | 3 | |
| α-helix | 385-388 | 4 | |
| β-strand | 389-395 | 7 | 12 |
| β-strand | 399-407 | 9 | 12 |
| α-helix | 408 | 1 | |
| β-strand | 415-421 | 7 | 12 |
| α-helix | 436-446 | 11 | |
| α-helix | 455-475 | 21 | |
| α-helix | 477-479 | 3 | |
| β-strand | 480-483 | 4 | 12 |
| β-strand | 486 | 1 | 14 |
| α-helix | 490-499 | 10 | |
Chain D: 33 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7 | 1 | 15 |
| α-helix | 9-22 | 14 | |
| β-strand | 32-37 | 6 | 16 |
| α-helix | 42-43 | 2 | |
| α-helix | 44-48 | 5 | |
| α-helix | 49-58 | 10 | |
| β-strand | 65-71 | 7 | 16 |
| α-helix | 77-84 | 8 | |
| α-helix | 85-88 | 4 | |
| α-helix | 92-94 | 3 | |
| α-helix | 95-103 | 9 | |
| β-strand | 105-109 | 5 | 16 |
| α-helix | 115-126 | 12 | |
| β-strand | 135-140 | 6 | 16 |
| α-helix | 144-146 | 3 | |
| α-helix | 147-157 | 11 | |
| β-strand | 165-169 | 5 | 16 |
| α-helix | 170 | 1 | |
| α-helix | 172 | 1 | |
| α-helix | 177-188 | 12 | |
| α-helix | 193-195 | 3 | |
| β-strand | 196-198 | 3 | 16 |
| α-helix | 205-216 | 12 | |
| α-helix | 222-224 | 3 | |
| β-strand | 230-238 | 9 | 17 |
| α-helix | 248-251 | 4 | |
| α-helix | 254-255 | 2 | |
| α-helix | 256-264 | 9 | |
| α-helix | 265-272 | 8 | |
| α-helix | 273-276 | 4 | |
| α-helix | 281-292 | 12 | |
| α-helix | 296-298 | 3 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303-309 | 7 | 17 |
| α-helix | 316-319 | 4 | |
| β-strand | 337-343 | 7 | 17 |
| β-strand | 353-359 | 7 | 17 |
| β-strand | 362 | 1 | 18 |
| β-strand | 366-373 | 8 | 17 |
| α-helix | 374-376 | 3 | |
| α-helix | 385-388 | 4 | |
| β-strand | 389-395 | 7 | 17 |
| β-strand | 399-407 | 9 | 17 |
| α-helix | 408 | 1 | |
| β-strand | 415-421 | 7 | 17 |
| β-strand | 431 | 1 | 15 |
| α-helix | 436-445 | 10 | |
| α-helix | 455-475 | 21 | |
| α-helix | 477-479 | 3 | |
| β-strand | 480-483 | 4 | 17 |
| β-strand | 486 | 1 | 18 |
| α-helix | 490-499 | 10 | |
Chain E: 31 helices, 20 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7 | 1 | 19 |
| α-helix | 9-22 | 14 | |
| β-strand | 32-37 | 6 | 20 |
| α-helix | 42-43 | 2 | |
| α-helix | 44-48 | 5 | |
| α-helix | 49-58 | 10 | |
| β-strand | 65-71 | 7 | 20 |
| α-helix | 77-84 | 8 | |
| α-helix | 85-88 | 4 | |
| α-helix | 92-94 | 3 | |
| α-helix | 95-103 | 9 | |
| β-strand | 105-109 | 5 | 20 |
| α-helix | 115-126 | 12 | |
| β-strand | 135-140 | 6 | 20 |
| α-helix | 144-146 | 3 | |
| α-helix | 147-157 | 11 | |
| β-strand | 165-169 | 5 | 20 |
| α-helix | 177-188 | 12 | |
| α-helix | 193-195 | 3 | |
| β-strand | 196-198 | 3 | 20 |
| α-helix | 205-216 | 12 | |
| α-helix | 222-224 | 3 | |
| β-strand | 230-238 | 9 | 21 |
| α-helix | 248-251 | 4 | |
| α-helix | 254-255 | 2 | |
| α-helix | 256-264 | 9 | |
| α-helix | 265-272 | 8 | |
| α-helix | 273-276 | 4 | |
| α-helix | 281-292 | 12 | |
| α-helix | 296-298 | 3 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303-309 | 7 | 21 |
| α-helix | 316-319 | 4 | |
| β-strand | 337-343 | 7 | 21 |
| β-strand | 353-359 | 7 | 21 |
| β-strand | 362 | 1 | 22 |
| β-strand | 366-373 | 8 | 21 |
| α-helix | 374-376 | 3 | |
| α-helix | 385-388 | 4 | |
| β-strand | 389-393 | 5 | 21 |
| β-strand | 399-407 | 9 | 21 |
| α-helix | 408 | 1 | |
| β-strand | 415-421 | 7 | 21 |
| β-strand | 431 | 1 | 19 |
| α-helix | 436-445 | 10 | |
| β-strand | 453 | 1 | 20 |
| α-helix | 455-475 | 21 | |
| α-helix | 477-479 | 3 | |
| β-strand | 480-483 | 4 | 21 |
| β-strand | 486 | 1 | 22 |
| α-helix | 490-499 | 10 | |
Chain F: 34 helices, 20 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-20 | 11 | |
| β-strand | 32-37 | 6 | 23 |
| α-helix | 42-43 | 2 | |
| α-helix | 44-48 | 5 | |
| α-helix | 49-58 | 10 | |
| β-strand | 65-71 | 7 | 23 |
| α-helix | 77-84 | 8 | |
| α-helix | 85-88 | 4 | |
| α-helix | 92-94 | 3 | |
| α-helix | 95-103 | 9 | |
| β-strand | 105-109 | 5 | 23 |
| α-helix | 115-126 | 12 | |
| β-strand | 135-140 | 6 | 23 |
| α-helix | 144-146 | 3 | |
| α-helix | 147-157 | 11 | |
| β-strand | 165-169 | 5 | 23 |
| α-helix | 170 | 1 | |
| α-helix | 172 | 1 | |
| α-helix | 177-188 | 12 | |
| α-helix | 193-195 | 3 | |
| β-strand | 196-198 | 3 | 23 |
| α-helix | 205-216 | 12 | |
| α-helix | 222-224 | 3 | |
| β-strand | 230-238 | 9 | 24 |
| α-helix | 250-252 | 3 | |
| α-helix | 254-255 | 2 | |
| α-helix | 256-264 | 9 | |
| α-helix | 265-272 | 8 | |
| α-helix | 273-276 | 4 | |
| α-helix | 281-292 | 12 | |
| β-strand | 295 | 1 | 25 |
| α-helix | 296-298 | 3 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303-309 | 7 | 24 |
| α-helix | 316-319 | 4 | |
| β-strand | 337-342 | 6 | 24 |
| β-strand | 344 | 1 | 25 |
| β-strand | 354-359 | 6 | 24 |
| β-strand | 362 | 1 | 26 |
| β-strand | 366-373 | 8 | 24 |
| α-helix | 374-376 | 3 | |
| α-helix | 385-388 | 4 | |
| β-strand | 389-395 | 7 | 24 |
| β-strand | 399-407 | 9 | 24 |
| α-helix | 408 | 1 | |
| β-strand | 415-421 | 7 | 24 |
| α-helix | 432-434 | 3 | |
| α-helix | 436-446 | 11 | |
| β-strand | 453 | 1 | 23 |
| α-helix | 455-475 | 21 | |
| α-helix | 477-479 | 3 | |
| β-strand | 480-483 | 4 | 24 |
| β-strand | 486 | 1 | 26 |
| α-helix | 490-499 | 10 | |
Chain G: 33 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-22 | 14 | |
| β-strand | 32-37 | 6 | 27 |
| α-helix | 42-43 | 2 | |
| α-helix | 44-48 | 5 | |
| α-helix | 49-58 | 10 | |
| β-strand | 65-71 | 7 | 27 |
| α-helix | 77-84 | 8 | |
| α-helix | 85-87 | 3 | |
| α-helix | 92-94 | 3 | |
| α-helix | 95-103 | 9 | |
| β-strand | 105-109 | 5 | 27 |
| α-helix | 115-126 | 12 | |
| β-strand | 135-140 | 6 | 27 |
| α-helix | 144-146 | 3 | |
| α-helix | 147-157 | 11 | |
| β-strand | 165-169 | 5 | 27 |
| α-helix | 170 | 1 | |
| α-helix | 172 | 1 | |
| α-helix | 177-188 | 12 | |
| α-helix | 193-195 | 3 | |
| β-strand | 196-198 | 3 | 27 |
| α-helix | 205-216 | 12 | |
| α-helix | 222-224 | 3 | |
| β-strand | 230-238 | 9 | 28 |
| α-helix | 248-251 | 4 | |
| α-helix | 254-255 | 2 | |
| α-helix | 256-264 | 9 | |
| α-helix | 265-272 | 8 | |
| α-helix | 273-276 | 4 | |
| α-helix | 281-293 | 13 | |
| β-strand | 295 | 1 | 29 |
| α-helix | 296-298 | 3 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303-309 | 7 | 28 |
| α-helix | 316-319 | 4 | |
| β-strand | 337-342 | 6 | 28 |
| β-strand | 344 | 1 | 29 |
| β-strand | 354-359 | 6 | 28 |
| β-strand | 366-373 | 8 | 28 |
| α-helix | 374-376 | 3 | |
| α-helix | 385-388 | 4 | |
| β-strand | 389-395 | 7 | 28 |
| β-strand | 399-407 | 9 | 28 |
| α-helix | 408 | 1 | |
| β-strand | 415-421 | 7 | 28 |
| α-helix | 436-445 | 10 | |
| β-strand | 453 | 1 | 27 |
| α-helix | 455-475 | 21 | |
| α-helix | 477-479 | 3 | |
| β-strand | 480-483 | 4 | 28 |
| α-helix | 490-499 | 10 | |
Chain H: 33 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7 | 1 | 30 |
| α-helix | 9-22 | 14 | |
| β-strand | 32-37 | 6 | 31 |
| α-helix | 42-43 | 2 | |
| α-helix | 44-48 | 5 | |
| α-helix | 49-58 | 10 | |
| β-strand | 65-71 | 7 | 31 |
| α-helix | 77-84 | 8 | |
| α-helix | 85-88 | 4 | |
| α-helix | 92-94 | 3 | |
| α-helix | 95-103 | 9 | |
| β-strand | 105-109 | 5 | 31 |
| α-helix | 115-126 | 12 | |
| β-strand | 135-140 | 6 | 31 |
| α-helix | 144-146 | 3 | |
| α-helix | 147-157 | 11 | |
| β-strand | 165-169 | 5 | 31 |
| α-helix | 170 | 1 | |
| α-helix | 172 | 1 | |
| α-helix | 177-188 | 12 | |
| α-helix | 193-195 | 3 | |
| β-strand | 196-198 | 3 | 31 |
| α-helix | 205-216 | 12 | |
| α-helix | 222-224 | 3 | |
| β-strand | 230-238 | 9 | 32 |
| α-helix | 248-251 | 4 | |
| α-helix | 254-255 | 2 | |
| α-helix | 256-264 | 9 | |
| α-helix | 265-272 | 8 | |
| α-helix | 273-276 | 4 | |
| α-helix | 281-293 | 13 | |
| β-strand | 295 | 1 | 33 |
| α-helix | 296-298 | 3 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303-309 | 7 | 32 |
| α-helix | 316-319 | 4 | |
| β-strand | 337-342 | 6 | 32 |
| β-strand | 344 | 1 | 33 |
| β-strand | 354-359 | 6 | 32 |
| β-strand | 362 | 1 | 34 |
| β-strand | 366-373 | 8 | 32 |
| α-helix | 374-376 | 3 | |
| α-helix | 385-388 | 4 | |
| β-strand | 389-395 | 7 | 32 |
| β-strand | 399-407 | 9 | 32 |
| α-helix | 408 | 1 | |
| β-strand | 415-421 | 7 | 32 |
| β-strand | 431 | 1 | 30 |
| α-helix | 436-445 | 10 | |
| α-helix | 455-475 | 21 | |
| α-helix | 477-479 | 3 | |
| β-strand | 480-483 | 4 | 32 |
| β-strand | 486 | 1 | 34 |
| α-helix | 490-499 | 10 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Glucose-6-phosphate 1-dehydrogenase | A | protein | 501 | Homo sapiens | P11413 (AlphaFold model) |
| Glucose-6-phosphate 1-dehydrogenase | B | protein | 498 | Homo sapiens | P11413 (AlphaFold model) |
| Glucose-6-phosphate 1-dehydrogenase | C | protein | 497 | Homo sapiens | P11413 (AlphaFold model) |
| Glucose-6-phosphate 1-dehydrogenase | D, H | protein | 499 | Homo sapiens | P11413 (AlphaFold model) |
| Glucose-6-phosphate 1-dehydrogenase | E | protein | 500 | Homo sapiens | P11413 (AlphaFold model) |
| Glucose-6-phosphate 1-dehydrogenase | F | protein | 497 | Homo sapiens | P11413 (AlphaFold model) |
| Glucose-6-phosphate 1-dehydrogenase | G | protein | 496 | Homo sapiens | P11413 (AlphaFold model) |
Sequence of entity 1 (A), FASTA
>7ZVE_1 Glucose-6-phosphate 1-dehydrogenase (chains A)
VALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPEN
TFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSH
MNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLS
NHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTE
GRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVV
LGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNE
RKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTY
GNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPIPYIY
GSRGPTEADELMKRVGFQYEG
Sequence of entity 2 (B), FASTA
>7ZVE_2 Glucose-6-phosphate 1-dehydrogenase (chains B)
ALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPENT
FIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSHM
NALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSN
HISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEG
RGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVVL
GQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNER
KAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTYG
NRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPIPYIYG
SRGPTEADELMKRVGFQY
Sequence of entity 3 (C), FASTA
>7ZVE_3 Glucose-6-phosphate 1-dehydrogenase (chains C)
LSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPENTF
IVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSHMN
ALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSNH
ISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGR
GGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVVLG
QYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNERK
AEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGN
RYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPIPYIYGS
RGPTEADELMKRVGFQY
Sequence of entity 4 (D, H), FASTA
>7ZVE_4 Glucose-6-phosphate 1-dehydrogenase (chains D, H)
VALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPEN
TFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSH
MNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLS
NHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTE
GRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVV
LGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNE
RKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTY
GNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPIPYIY
GSRGPTEADELMKRVGFQY
Sequence of entity 5 (E), FASTA
>7ZVE_5 Glucose-6-phosphate 1-dehydrogenase (chains E)
VALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPEN
TFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSH
MNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLS
NHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTE
GRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVV
LGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNE
RKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTY
GNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPIPYIY
GSRGPTEADELMKRVGFQYE
Sequence of entity 6 (F), FASTA
>7ZVE_6 Glucose-6-phosphate 1-dehydrogenase (chains F)
LSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPENTF
IVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSHMN
ALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSNH
ISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGR
GGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVVLG
QYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNERK
AEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGN
RYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPIPYIYGS
RGPTEADELMKRVGFQY
Sequence of entity 7 (G), FASTA
>7ZVE_7 Glucose-6-phosphate 1-dehydrogenase (chains G)
SRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPENTFI
VGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSHMNA
LHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSNHI
SSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGRG
GYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVVLGQ
YVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNERKA
EVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGNR
YKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPIPYIYGSR
GPTEADELMKRVGFQY
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| CU | Copper (II) ion | Cu | 1 |
Water and common crystallization additives (GOL) are not listed.
Primary citation
Acetylation-dependent coupling between G6PD activity and apoptotic signaling. Wu, F., Muskat, N.H., Dvilansky, I. et al. Nat Commun (2023) 14:6208-6208. DOI 10.1038/s41467-023-41895-2 · PubMed
Other PDB entries of the same protein (UniProt P11413 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6JYU 1.89 Å, Crystal structure of Human G6PD Canton
- 6E08 1.9 Å, Crystal structure of G6PD in complex with structural NADP
- 7SNH 2.2 Å, Structure of G6PD-D200N tetramer bound to NADP+
- 7ZVD 2.46 Å, K89 acetylated glucose-6-phosphate dehydrogenase (G6PD) in a complex with structural NADP+
- 2BH9 2.5 Å, X-ray structure of a deletion variant of human glucose 6-phosphate dehydrogenase…
- 7SNI 2.5 Å, Structure of G6PD-D200N tetramer bound to NADP+ and G6P
- 7UC2 2.5 Å, Structure of G6PD-D200N tetramer bound to NADP+ with no symmetry applied
- 6E07 2.6 Å, Crystal structure of Canton G6PD in complex with structural NADP
- 5UKW 2.65 Å, Crystal structure of human Glucose 6-phosphate Dehydrogenase mutant (A277C) complexed…
- 7SNG 2.8 Å, structure of G6PD-WT tetramer
- 2BHL 2.9 Å, X-ray structure of human glucose-6-phosphate dehydrogenase (deletion variant) complexed…
- 7SEH 2.9 Å, Glucose-6-phosphate 1-dehydrogenase (K403QdLtL)
Browse structure collections
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