8BWS: Yeast RNA Polymerase III elongation complex

Structure of yeast RNA Polymerase III elongation complex at 3.3 A. Determined by electron microscopy at 3.2 Å resolution. Released 5 Apr 2023.

Method: Electron microscopy
Resolution: 3.2 Å
Organism: Saccharomyces cerevisiae S288C
Chains: 20
Atoms: 41,013
Mol. weight: 731.29 kDa
Ligands: ZN, MG, 4QM
Released: 5 Apr 2023

Explore 8BWS in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8BWS contains 219 α-helices and 260 β-strands across 17 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 71 helices, 59 β-strands

Element	Residues	Length	Sheet
β-strand	4	1	1
β-strand	11-17	7	2
α-helix	25-29	5
β-strand	33	1	3
β-strand	40	1	4
α-helix	47	1
β-strand	48	1	4
α-helix	49	1
α-helix	56-58	3
β-strand	82-91	10	3
α-helix	96-104	9
β-strand	106	1	5
β-strand	113	1	5
α-helix	117-127	11
α-helix	134-150	17
β-strand	153	1	6
β-strand	160	1	6
β-strand	163-166	4	7
α-helix	173-176	4
β-strand	178-181	4	7
α-helix	192-207	16
α-helix	209-214	6
β-strand	220-222	3	7
α-helix	224-231	8
α-helix	236-238	3
α-helix	253-256	4
β-strand	257-263	7	3
α-helix	264-265	2
α-helix	270	1
β-strand	271-272	2	8
β-strand	281-282	2	8
α-helix	284-305	22
α-helix	309-327	19
α-helix	353-357	5
α-helix	363-368	6
β-strand	371-373	3	9
β-strand	376-383	8	10
α-helix	388	1
β-strand	391-395	5	10
β-strand	403-407	5	11
α-helix	408	1
α-helix	413-422	10
β-strand	430-434	5	11
β-strand	442-443	2	11
α-helix	449-454	6
β-strand	461-465	5	11
α-helix	466	1
β-strand	471-475	5	10
α-helix	482-484	3
β-strand	485-493	9	10
β-strand	498-500	3	10
α-helix	502-504	3
α-helix	505-508	4
β-strand	516-520	5	10
α-helix	525-534	10
β-strand	536	1	10
α-helix	538-540	3
β-strand	542	1	12
β-strand	549	1	12
α-helix	557-565	9
α-helix	573-583	11
α-helix	592-595	4
β-strand	597	1	13
β-strand	603	1	13
α-helix	606-614	9
β-strand	626-629	4	14
α-helix	643-645	3
β-strand	651-655	5	14
β-strand	658-661	4	14
α-helix	677-708	32
α-helix	719-720	2
α-helix	721-747	27
α-helix	758-784	27
α-helix	790-796	7
α-helix	803-810	8
β-strand	813-815	3	15
β-strand	818	1	16
β-strand	821	1	16
β-strand	827	1	17
β-strand	830	1	17
β-strand	847-848	2	15
α-helix	858-892	35
β-strand	896-898	3	18
β-strand	904-906	3	18
β-strand	911	1	18
α-helix	916-918	3
α-helix	923-925	3
α-helix	935-945	11
α-helix	953-955	3
α-helix	956-966	11
α-helix	969-972	4
β-strand	977	1	19
α-helix	982	1
β-strand	983	1	19
α-helix	984	1
α-helix	999-1024	26
α-helix	1034-1036	3
α-helix	1050-1059	10
α-helix	1064-1080	17
α-helix	1089-1098	10
α-helix	1099-1103	5
β-strand	1110-1111	2	20
β-strand	1114-1118	5	20
α-helix	1123-1131	9
β-strand	1140-1145	6	21
α-helix	1151-1160	10
β-strand	1164-1165	2	22
α-helix	1166-1169	4
β-strand	1173-1177	5	23
β-strand	1182-1187	6	23
α-helix	1190-1195	6
α-helix	1202-1212	11
β-strand	1222-1224	3	23
β-strand	1229-1234	6	23
α-helix	1255-1265	11
β-strand	1271-1273	3	22
β-strand	1278-1285	8	21
α-helix	1287-1289	3
β-strand	1291-1297	7	21
α-helix	1300-1305	6
β-strand	1309-1316	8	21
α-helix	1319-1326	8
α-helix	1329-1345	17
α-helix	1352-1362	11
α-helix	1373-1377	5
α-helix	1383-1389	7
α-helix	1392-1401	10
α-helix	1411-1417	7
α-helix	1424-1426	3
β-strand	1429-1432	4	24

Chain B: 46 helices, 78 β-strands

Element	Residues	Length	Sheet
α-helix	40-43	4
α-helix	44-46	3
α-helix	47-54	8
α-helix	60-67	8
α-helix	68-72	5
α-helix	73-79	7
β-strand	82-83	2	25
β-strand	93-94	2	25
β-strand	98-100	3	26
α-helix	109-114	6
α-helix	115-121	7
β-strand	126-135	10	26
β-strand	143-153	11	26
α-helix	170-173	4
β-strand	185-187	3	27
β-strand	190-194	5	27
β-strand	196-200	5	28
α-helix	201	1
β-strand	206	1	29
β-strand	210	1	30
β-strand	215	1	30
β-strand	219	1	29
β-strand	223	1	31
β-strand	228	1	31
β-strand	235-236	2	32
β-strand	239-240	2	32
β-strand	241-242	2	33
β-strand	247	1	34
β-strand	251-252	2	33
α-helix	253-259	7
α-helix	267-272	6
α-helix	277-283	7
α-helix	285-288	4
α-helix	289-292	4
α-helix	298-307	10
β-strand	309	1	34
α-helix	319-325	7
α-helix	326-330	5
α-helix	343-361	19
α-helix	372-374	3
β-strand	375-378	4	28
α-helix	380-407	28
α-helix	421-439	19
β-strand	442-443	2	35
β-strand	450-451	2	35
β-strand	455-457	3	27
α-helix	458-459	2
α-helix	463-469	7
β-strand	472-474	3	28
α-helix	491-493	3
β-strand	497	1	36
β-strand	512-513	2	28
β-strand	514	1	36
β-strand	519-520	2	37
α-helix	527-536	10
β-strand	539	1	38
β-strand	554-557	4	38
β-strand	560-564	5	38
α-helix	568-580	13
β-strand	589-593	5	38
β-strand	598-602	5	38
β-strand	608-614	7	37
β-strand	615	1	39
β-strand	620	1	39
α-helix	626-632	7
α-helix	639-642	4
β-strand	646-650	5	37
α-helix	653-656	4
β-strand	659-660	2	37
α-helix	663-665	3
β-strand	672-673	2	37
α-helix	677-680	4
α-helix	684-687	4
α-helix	696-705	10
β-strand	709	1	40
β-strand	724-728	5	41
β-strand	736-737	2	42
α-helix	739-743	5
β-strand	753-759	7	43
β-strand	771-774	4	43
α-helix	778-781	4
β-strand	785-795	11	41
α-helix	796-798	3
β-strand	805	1	44
β-strand	811	1	45
β-strand	817	1	45
β-strand	829	1	46
α-helix	830-831	2
β-strand	832	1	47
β-strand	835-836	2	41
β-strand	839-843	5	46
β-strand	846-848	3	44
β-strand	866-868	3	44
β-strand	871-873	3	46
β-strand	879-888	10	41
β-strand	894-904	11	41
β-strand	911-913	3	48
β-strand	920-921	2	48
β-strand	922-926	5	43
β-strand	933	1	49
β-strand	942	1	43
α-helix	946-948	3
α-helix	955-970	16
β-strand	974-975	2	42
α-helix	984-993	10
β-strand	1001-1002	2	43
β-strand	1005	1	49
β-strand	1012	1	49
β-strand	1017-1024	8	43
β-strand	1025-1026	2	48
β-strand	1027	1	40
α-helix	1031-1033	3
β-strand	1036-1038	3	10
β-strand	1043	1	50
β-strand	1050	1	50
β-strand	1060-1062	3	9
α-helix	1064-1073	10
α-helix	1076-1080	5
α-helix	1081-1085	5
β-strand	1090-1095	6	51
β-strand	1101-1102	2	51
β-strand	1116-1121	6	51
α-helix	1123-1134	12
β-strand	1140-1145	6	2

Chain C: 11 helices, 20 β-strands

Element	Residues	Length	Sheet
β-strand	5-7	3	52
β-strand	12-13	2	52
α-helix	36-39	4
β-strand	41-47	7	52
β-strand	52-57	6	52
α-helix	61-73	13
β-strand	77-88	12	53
α-helix	94-103	10
β-strand	106	1	54
α-helix	115-117	3
β-strand	132-139	8	53
β-strand	141-142	2	55
β-strand	157-158	2	55
β-strand	161-163	3	56
α-helix	164-166	3
α-helix	175-178	4
β-strand	186	1	54
β-strand	192-195	4	56
β-strand	201-211	11	53
α-helix	217-219	3
β-strand	222-226	5	52
β-strand	229-234	6	52
α-helix	242-250	9
β-strand	256-258	3	57
β-strand	265-267	3	57
α-helix	270-272	3
α-helix	279-281	3
β-strand	290-299	10	52
β-strand	301-304	4	52
α-helix	310-330	21
β-strand	334	1	58

Chain D: 9 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	3-5	3	24
β-strand	10	1	1
α-helix	15-26	12
α-helix	31-36	6
α-helix	53-66	14
α-helix	69-70	2
α-helix	100-111	12
α-helix	119-125	7
α-helix	131-137	7
α-helix	141-144	4
α-helix	149-158	10

Chain E: 11 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	2-25	24
β-strand	28	1	59
α-helix	32-35	4
α-helix	39-45	7
β-strand	47	1	60
β-strand	53	1	60
β-strand	60-62	3	61
β-strand	64	1	59
α-helix	66-71	6
β-strand	78-82	5	61
β-strand	87-88	2	62
α-helix	90-102	13
β-strand	107-111	5	61
β-strand	115-116	2	62
α-helix	118-123	6
β-strand	131-134	4	61
α-helix	144-146	3
α-helix	151	1
β-strand	152-155	4	63
α-helix	158-168	11
β-strand	177-178	2	63
α-helix	185-188	4
α-helix	190-191	2
β-strand	195-202	8	63
β-strand	206-214	9	63

Chain F: 4 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	72	1
β-strand	73	1	24
α-helix	74-75	2
β-strand	84	1	64
α-helix	87-102	16
α-helix	117-126	10
β-strand	133-137	5	24
β-strand	143-147	5	24
β-strand	152	1	64

Chain G: 5 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	3-4	2	1
β-strand	6-13	8	24
α-helix	15-17	3
α-helix	22-34	13
β-strand	38-39	2	1
β-strand	43-48	6	1
β-strand	52	1	24
α-helix	54-56	3
β-strand	57-58	2	24
β-strand	66-72	7	24
β-strand	74-77	4	1
β-strand	85-87	3	65
β-strand	88-94	7	66
β-strand	96-100	5	66
β-strand	108-110	3	66
β-strand	120	1	67
β-strand	129	1	67
α-helix	139-141	3
β-strand	146-148	3	65
β-strand	149-155	7	68
α-helix	163-172	10
β-strand	194-199	6	68

Chain H: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-16	13	13
β-strand	23-30	8	13
β-strand	37-43	7	13
β-strand	54-60	7	13
α-helix	81-83	3
β-strand	95-108	14	13
β-strand	111-118	8	13
β-strand	121-127	7	13
β-strand	140-145	6	13

9 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase III subunit RPC1	A	protein	1460	Saccharomyces cerevisiae S288C	P04051 (AlphaFold model)
DNA-directed RNA polymerase III subunit RPC2	B	protein	1149	Saccharomyces cerevisiae S288C	P22276 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae S288C	P07703 (AlphaFold model)
DNA-directed RNA polymerase III subunit RPC9	D	protein	161	Saccharomyces cerevisiae S288C	P47076 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae S288C	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae S288C	P20435
DNA-directed RNA polymerase III subunit RPC8	G	protein	212	Saccharomyces cerevisiae S288C	P35718
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	Saccharomyces cerevisiae S288C	P20436
DNA-directed RNA polymerase III subunit RPC10	I	protein	110	Saccharomyces cerevisiae S288C	Q04307
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	Saccharomyces cerevisiae S288C	P22139
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	142	Saccharomyces cerevisiae S288C	P28000
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	76	Saccharomyces cerevisiae S288C	P40422

8 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>8BWS_1 DNA-directed RNA polymerase III subunit RPC1 (chains A)
MKEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKANGALDPKMGV
SSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQILQGICKNCSAILLSETDK
RQFLHELRRPGVDNLRRMGILKKILDQCKKQRRCLHCGALNGVVKKAAAGAGSAALKIIH
DTFRWVGKKSAPEKDIWVGEWKEVLAHNPELERYVKRCMDDLNPLKTLNLFKQIKSADCE
LLGIDATVPSGRPETYIWRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIK
AGLDKGISINNMMEHWDYLQLTVAMYINSDSVNPAMLPGSSNGGGKVKPIRGFCQRLKGK
QGRFRGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEKVTRYNRHKLQELI
VNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVVERHLEDGDVVLFNRQPSL
HRLSILSHYAKIRPWRTFRLNECVCTPYNADFDGDEMNLHVPQTEEARAEAINLMGVKNN
LLTPKSGEPIIAATQDFITGSYLISHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKP
YYLWTGKQVFSLLIKPNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQIL
SGVMDKSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSIGINDVTPA
DDLKQKKEELVEIAYHKCDELITLFNKGELETQPGCNEEQTLEAKIGGLLSKVREEVGDV
CINELDNWNAPLIMATCGSKGSTLNVSQMVAVVGQQIISGNRVPDGFQDRSLPHFPKNSK
TPQSKGFVRNSFFSGLSPPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQY
DNTVRTSANGIVQFTYGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPYAIM
ETANEILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHSLREYINGKATALA
NLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRISEKSVRKFLEIALFKYRK
ARLEPGTAIGAIGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINASKVISTPI
INAVLVNDNDERAARVVKGRVEKTLLSDVAFYVQDVYKDNLSFIQVRIDLGTIDKLQLEL
TIEDIAVAITRASKLKIQASDVNIIGKDRIAINVFPEGYKAKSISTSAKEPSENDVFYRM
QQLRRALPDVVVKGLPDISRAVINIRDDGKRELLVEGYGLRDVMCTDGVIGSRTTTNHVL
EVFSVLGIEAARYSIIREINYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMR
DSVLQLASFEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMSIGTGSFKVVKGTNISEKD
LVPKRCLFESLSNEAALKAN

Sequence of entity 2 (B), FASTA

>8BWS_2 DNA-directed RNA polymerase III subunit RPC2 (chains B)
MVAATKRRKTHIHKHVKDEAFDDLLKPVYKGKKLTDEINTAQDKWHLLPAFLKVKGLVKQ
HLDSFNYFVDTDLKKIIKANQLILSDVDPEFYLKYVDIRVGKKSSSSTKDYLTPPHECRL
RDMTYSAPIYVDIEYTRGRNIIMHKDVEIGRMPIMLRSNKCILYDADESKMAKLNECPLD
PGGYFIVNGTEKVILVQEQLSKNRIIVEADEKKGIVQASVTSSTHERKSKTYVITKNGKI
YLKHNSIAEEIPIAIVLKACGILSDLEIMQLVCGNDSSYQDIFAVNLEESSKLDIYTQQQ
ALEYIGAKVKTMRRQKLTILQEGIEAIATTVIAHLTVEALDFREKALYIAMMTRRVVMAM
YNPKMIDDRDYVGNKRLELAGQLISLLFEDLFKKFNNDFKLSIDKVLKKPNRAMEYDALL
SINVHSNNITSGLNRAISTGNWSLKRFKMERAGVTHVLSRLSYISALGMMTRISSQFEKS
RKVSGPRALQPSQFGMLCTADTPEGEACGLVKNLALMTHITTDDEEEPIKKLCYVLGVED
ITLIDSASLHLNYGVYLNGTLIGSIRFPTKFVTQFRHLRRTGKVSEFISIYSNSHQMAVH
IATDGGRICRPLIIVSDGQSRVKDIHLRKLLDGELDFDDFLKLGLVEYLDVNEENDSYIA
LYEKDIVPSMTHLEIEPFTILGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIAYNQFKR
IDTLLYLMTYPQQPMVKTKTIELIDYDKLPAGQNATVAVMSYSGYDIEDALVLNKSSIDR
GFGRCETRRKTTTVLKRYANHTQDIIGGMRVDENGDPIWQHQSLGPDGLGEVGMKVQSGQ
IYINKSVPTNSADAPNPNNVNVQTQYREAPVIYRGPEPSHIDQVMMSVSDNDQALIKVLL
RQNRRPELGDKFSSRHGQKGVCGIIVKQEDMPFNDQGIVPDIIMNPHGFPSRMTVGKMIE
LISGKAGVLNGTLEYGTCFGGSKLEDMSKILVDQGFNYSGKDMLYSGITGECLQAYIFFG
PIYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCVIAYGASQLLL
ERLMISSDAFEVDVCDKCGLMGYSGWCTTCKSAENIIKMTIPYAAKLLFQELLSMNIAPR
LRLEDIFQQ

Sequence of entity 3 (C), FASTA

>8BWS_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 4 (D), FASTA

>8BWS_4 DNA-directed RNA polymerase III subunit RPC9 (chains D)
MKVLEERNAFLSDYEVLKFLTDLEKKHLWDQKSLAALKKSRSKGKQNRPYNHPELQGITR
NVVNYLSINKNFINQEDEGEERESSGAKDAEKSGISKMSDESFAELMTKLNSFKLFKAEK
LQIVNQLPANMVHLYSIVEECDARFDEKTIEEMLEIISGYA

Sequence of entity 5 (E), FASTA

>8BWS_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 6 (F), FASTA

>8BWS_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 7 (G), FASTA

>8BWS_7 DNA-directed RNA polymerase III subunit RPC8 (chains G)
MFILSKIADLVRIPPDQFHRDTISAITHQLNNKFANKIIPNVGLCITIYDLLTVEEGQLK
PGDGSSYINVTFRAVVFKPFLGEIVTGWISKCTAEGIKVSLLGIFDDIFIPQNMLFEGCY
YTPEESAWIWPMDEETKLYFDVNEKIRFRIEREVFVDVKPKSPKERELEERAQLENEIEG
KNEETPQNEKPPAYALLGSCQTDGMGLVSWWE

Sequence of entity 8 (H), FASTA

>8BWS_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 9 (I), FASTA

>8BWS_9 DNA-directed RNA polymerase III subunit RPC10 (chains I)
MLSFCPSCNNMLLITSGDSGVYTLACRSCPYEFPIEGIEIYDRKKLPRKEVDDVLGGGWD
NVDQTKTQCPNYDTCGGESAYFFQLQIRSADEPMTTFYKCVNCGHRWKEN

Sequence of entity 10 (J), FASTA

>8BWS_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 11 (K), FASTA

>8BWS_11 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTS
ASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKG
LKDLMDLCDVVESKFTEKIKSM

Sequence of entity 12 (L), FASTA

>8BWS_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
XXXXXXMSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHR
ILLKARTKRLVQFEAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	6
MG	Magnesium ion	Mg	1
4QM	(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4…	C24 H42 O3	3

Primary citation

Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration. Nguyen, P.Q., Huecas, S., Asif-Laidin, A. et al. Nat Commun (2023) 14:1729-1729. DOI 10.1038/s41467-023-37109-4 · PubMed

Other PDB entries of the same protein (UniProt P04051 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7Z0H 2.6 Å, Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.6 A (focus subunit AC40).
7Z1O 2.7 Å, Structure of yeast RNA Polymerase III PTC + NTPs
7Z31 2.76 Å, Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.7 A (focus subunit C11,…
7Z1L 2.8 Å, Structure of yeast RNA Polymerase III Pre-Termination Complex (PTC)
7Z30 2.9 Å, Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.9 A (focus subunit C11…
7Z2Z 3.07 Å, Structure of yeast RNA Polymerase III-DNA-Ty1 integrase complex (Pol III-DNA-IN1) at 3.1 A
6TUT 3.25 Å, Cryo-EM structure of the RNA Polymerase III-Maf1 complex
6EU3 3.3 Å, Apo RNA Polymerase III - closed conformation (cPOL3)
6EU1 3.4 Å, RNA Polymerase III - open DNA complex (OC-POL3).
6EU2 3.4 Å, Apo RNA Polymerase III - open conformation (oPOL3)
7Z1M 3.4 Å, Structure of yeast RNA Polymerase III Elongation Complex (EC)
6F40 3.7 Å, RNA Polymerase III open complex

Browse structure collections

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