8BYQ: PDB entry 8BYQ
RNA polymerase II pre-initiation complex with the proximal +1 nucleosome (PIC-Nuc10W). Determined by electron microscopy at 4.1 Å resolution. Released 3 May 2023.
- Method
- Electron microscopy
- Resolution
- 4.1 Å
- Organisms
- Homo sapiens, Sus scrofa, unidentified adenovirus
- Chains
- 40
- Atoms
- 85,971
- Mol. weight
- 1518.1 kDa
- Ligands
- MG, ZN, SF4
- Released
- 3 May 2023
Explore 8BYQ in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8BYQ contains 496 α-helices and 438 β-strands across 38 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 0: 34 helices, 33 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 38 | 1 | |
| α-helix | 39-43 | 5 | |
| β-strand | 53 | 1 | 1 |
| β-strand | 59-60 | 2 | 1 |
| β-strand | 67 | 1 | 2 |
| β-strand | 76-78 | 3 | 3 |
| β-strand | 83-87 | 5 | 3 |
| α-helix | 93-103 | 11 | |
| β-strand | 105-108 | 4 | 3 |
| β-strand | 113-117 | 5 | 3 |
| α-helix | 120-128 | 9 | |
| α-helix | 133-143 | 11 | |
| β-strand | 144 | 1 | 3 |
| β-strand | 146 | 1 | 2 |
| α-helix | 147-149 | 3 | |
| α-helix | 150-158 | 9 | |
| β-strand | 166-171 | 6 | 4 |
| β-strand | 174-179 | 6 | 4 |
| α-helix | 182-189 | 8 | |
| α-helix | 192-197 | 6 | |
| β-strand | 198-199 | 2 | 4 |
| α-helix | 259-261 | 3 | |
| β-strand | 268-272 | 5 | 4 |
| α-helix | 276-286 | 11 | |
| β-strand | 291-295 | 5 | 4 |
| β-strand | 310 | 1 | 5 |
| α-helix | 318-328 | 11 | |
| β-strand | 333-334 | 2 | 4 |
| β-strand | 336-339 | 4 | 6 |
| α-helix | 346-357 | 12 | |
| β-strand | 361-365 | 5 | 6 |
| α-helix | 368-381 | 14 | |
| β-strand | 382 | 1 | 5 |
| β-strand | 389-392 | 4 | 6 |
| β-strand | 405-409 | 5 | 6 |
| α-helix | 410-413 | 4 | |
| α-helix | 421-432 | 12 | |
| β-strand | 437-440 | 4 | 6 |
| α-helix | 443-445 | 3 | |
| α-helix | 448-458 | 11 | |
| β-strand | 463-467 | 5 | 6 |
| α-helix | 481-484 | 4 | |
| β-strand | 487-490 | 4 | 6 |
| α-helix | 493-498 | 6 | |
| α-helix | 503-504 | 2 | |
| β-strand | 505-512 | 8 | 7 |
| α-helix | 513-515 | 3 | |
| α-helix | 516-524 | 9 | |
| α-helix | 528-530 | 3 | |
| α-helix | 531-535 | 5 | |
| α-helix | 538-553 | 16 | |
| β-strand | 558-561 | 4 | 7 |
| α-helix | 565-575 | 11 | |
| β-strand | 579-580 | 2 | 7 |
| α-helix | 586-597 | 12 | |
| β-strand | 604-607 | 4 | 7 |
| α-helix | 609-612 | 4 | |
| β-strand | 620 | 1 | 8 |
| β-strand | 622-625 | 4 | 7 |
| α-helix | 633-643 | 11 | |
| β-strand | 644 | 1 | 8 |
| β-strand | 657-664 | 8 | 7 |
| α-helix | 669-682 | 14 | |
| β-strand | 687-690 | 4 | 7 |
| α-helix | 706-718 | 13 | |
| α-helix | 721-724 | 4 | |
| α-helix | 726-728 | 3 | |
Chain 1: 41 helices, 25 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-5 | 4 | 11 |
| β-strand | 8-11 | 4 | 11 |
| β-strand | 16-17 | 2 | 12 |
| α-helix | 20-33 | 14 | |
| β-strand | 38-42 | 5 | 13 |
| α-helix | 48-62 | 15 | |
| β-strand | 69-73 | 5 | 13 |
| α-helix | 77-98 | 22 | |
| β-strand | 105-108 | 4 | 13 |
| α-helix | 112-114 | 3 | |
| α-helix | 127-137 | 11 | |
| α-helix | 140-148 | 9 | |
| α-helix | 156-160 | 5 | |
| α-helix | 161-165 | 5 | |
| α-helix | 169-171 | 3 | |
| β-strand | 173-175 | 3 | 13 |
| α-helix | 177-187 | 11 | |
| α-helix | 191-199 | 9 | |
| β-strand | 204-207 | 4 | 13 |
| α-helix | 210-213 | 4 | |
| α-helix | 223-226 | 4 | |
| β-strand | 229-233 | 5 | 13 |
| α-helix | 238-247 | 10 | |
| β-strand | 249-252 | 4 | 14 |
| α-helix | 253-276 | 24 | |
| α-helix | 279-289 | 11 | |
| α-helix | 297-300 | 4 | |
| α-helix | 306-308 | 3 | |
| α-helix | 326-344 | 19 | |
| β-strand | 350-352 | 3 | 14 |
| α-helix | 354-363 | 10 | |
| α-helix | 369-373 | 5 | |
| α-helix | 375-385 | 11 | |
| α-helix | 391-409 | 19 | |
| β-strand | 415-419 | 5 | 14 |
| β-strand | 432-436 | 5 | 14 |
| α-helix | 441-450 | 10 | |
| β-strand | 453-458 | 6 | 13 |
| α-helix | 466-470 | 5 | |
| β-strand | 477-481 | 5 | 13 |
| β-strand | 490-493 | 4 | 15 |
| β-strand | 497 | 1 | 16 |
| β-strand | 503 | 1 | 16 |
| α-helix | 514-530 | 17 | |
| β-strand | 535-539 | 5 | 15 |
| α-helix | 542-554 | 13 | |
| α-helix | 557-564 | 8 | |
| β-strand | 566-569 | 4 | 15 |
| α-helix | 574-587 | 14 | |
| β-strand | 594-599 | 6 | 15 |
| α-helix | 604-607 | 4 | |
| β-strand | 617-621 | 5 | 15 |
| α-helix | 630-643 | 14 | |
| α-helix | 648-665 | 18 | |
| β-strand | 675-680 | 6 | 15 |
| α-helix | 682-685 | 4 | |
| α-helix | 687-692 | 6 | |
| α-helix | 695-698 | 4 | |
| α-helix | 703-705 | 3 | |
| α-helix | 710-724 | 15 | |
| α-helix | 732-734 | 3 | |
| β-strand | 739-740 | 2 | 12 |
| α-helix | 741-745 | 5 | |
| α-helix | 748-752 | 5 | |
| α-helix | 753-756 | 4 | |
| β-strand | 757-759 | 3 | 13 |
Chain 2: 19 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 108-120 | 13 | |
| α-helix | 122-133 | 12 | |
| α-helix | 139-144 | 6 | |
| α-helix | 165-167 | 3 | |
| α-helix | 191-199 | 9 | |
| α-helix | 201-209 | 9 | |
| α-helix | 218-223 | 6 | |
| α-helix | 227-229 | 3 | |
| α-helix | 252-255 | 4 | |
| α-helix | 288-289 | 2 | |
| α-helix | 295-318 | 24 | |
| α-helix | 349-358 | 10 | |
| β-strand | 373 | 1 | 17 |
| β-strand | 376 | 1 | 18 |
| α-helix | 380-384 | 5 | |
| α-helix | 397-412 | 16 | |
| α-helix | 418-421 | 4 | |
| α-helix | 424-434 | 11 | |
| α-helix | 454-478 | 25 | |
| α-helix | 486-514 | 29 | |
| α-helix | 523-541 | 19 | |
Chain 3: 25 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 11-12 | 2 | |
| α-helix | 19-23 | 5 | |
| α-helix | 28-34 | 7 | |
| α-helix | 38-47 | 10 | |
| α-helix | 50-59 | 10 | |
| β-strand | 66-67 | 2 | 20 |
| α-helix | 68-72 | 5 | |
| β-strand | 75 | 1 | 21 |
| α-helix | 77-92 | 16 | |
| β-strand | 96-100 | 5 | 20 |
| α-helix | 101 | 1 | |
| β-strand | 106-110 | 5 | 20 |
| α-helix | 112-122 | 11 | |
| α-helix | 139 | 1 | |
| α-helix | 145-164 | 20 | |
| α-helix | 173-181 | 9 | |
| α-helix | 198-205 | 8 | |
| α-helix | 208-223 | 16 | |
| α-helix | 230-241 | 12 | |
| β-strand | 249-250 | 2 | 22 |
| α-helix | 256-267 | 12 | |
| β-strand | 271-273 | 3 | 22 |
| β-strand | 280-283 | 4 | 22 |
| α-helix | 285-288 | 4 | |
| β-strand | 307-309 | 3 | 1 |
| β-strand | 314-317 | 4 | 1 |
| α-helix | 322-331 | 10 | |
| β-strand | 332-337 | 6 | 1 |
| β-strand | 342-346 | 5 | 1 |
| α-helix | 348-356 | 9 | |
| α-helix | 361-370 | 10 | |
| β-strand | 372 | 1 | 1 |
| α-helix | 374-376 | 3 | |
| α-helix | 385-398 | 14 | |
| β-strand | 402-409 | 8 | 23 |
| α-helix | 415-428 | 14 | |
| β-strand | 431-435 | 5 | 23 |
| β-strand | 440-443 | 4 | 23 |
| α-helix | 445-447 | 3 | |
| α-helix | 448-455 | 8 | |
Chain 4: 19 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 23-25 | 3 | |
| α-helix | 29-31 | 3 | |
| α-helix | 34-37 | 4 | |
| β-strand | 53 | 1 | 17 |
| β-strand | 55 | 1 | 24 |
| β-strand | 59-66 | 8 | 25 |
| α-helix | 69-72 | 4 | |
| α-helix | 80-98 | 19 | |
| β-strand | 103-109 | 7 | 25 |
| β-strand | 115-121 | 7 | 25 |
| α-helix | 124-134 | 11 | |
| α-helix | 145-156 | 12 | |
| β-strand | 164-171 | 8 | 25 |
| α-helix | 183-191 | 9 | |
| β-strand | 195-201 | 7 | 25 |
| α-helix | 206-215 | 10 | |
| β-strand | 219-222 | 4 | 25 |
| α-helix | 225-236 | 12 | |
| α-helix | 238-239 | 2 | |
| β-strand | 240 | 1 | 24 |
| β-strand | 249-253 | 5 | 26 |
| α-helix | 255-256 | 2 | |
| β-strand | 257-258 | 2 | 27 |
| β-strand | 270-271 | 2 | 28 |
| β-strand | 284-285 | 2 | 28 |
| β-strand | 288-290 | 3 | 27 |
| α-helix | 291 | 1 | |
| β-strand | 297-298 | 2 | 27 |
| β-strand | 303-304 | 2 | 26 |
| β-strand | 311-312 | 2 | 26 |
| α-helix | 315-319 | 5 | |
| α-helix | 322-324 | 3 | |
| α-helix | 330-331 | 2 | |
| β-strand | 332-334 | 3 | 29 |
| β-strand | 344 | 1 | 30 |
| β-strand | 351 | 1 | 30 |
| β-strand | 357-359 | 3 | 29 |
| β-strand | 366-367 | 2 | 29 |
| α-helix | 369-370 | 2 | |
| α-helix | 371-379 | 9 | |
| α-helix | 383-386 | 4 | |
Chain 5: 12 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 9-16 | 8 | 35 |
| α-helix | 19-27 | 9 | |
| α-helix | 34-51 | 18 | |
| β-strand | 56-62 | 7 | 35 |
| β-strand | 67-69 | 3 | 35 |
| α-helix | 103-120 | 18 | |
| α-helix | 133-150 | 18 | |
| β-strand | 158-165 | 8 | 35 |
| α-helix | 171-173 | 3 | |
| α-helix | 174-186 | 13 | |
| β-strand | 190-195 | 6 | 35 |
| α-helix | 201-210 | 10 | |
| β-strand | 214-216 | 3 | 35 |
| α-helix | 220-222 | 3 | |
| α-helix | 223-226 | 4 | |
| α-helix | 227-231 | 5 | |
| α-helix | 235-238 | 4 | |
| β-strand | 241 | 1 | 21 |
| α-helix | 244-250 | 7 | |
| β-strand | 254 | 1 | 36 |
| β-strand | 261 | 1 | 36 |
| β-strand | 264-268 | 5 | 26 |
| β-strand | 274-275 | 2 | 26 |
| β-strand | 281 | 1 | 37 |
| β-strand | 285 | 1 | 18 |
| β-strand | 288 | 1 | 37 |
Chain 6: 2 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-11 | 8 | 23 |
| α-helix | 14-25 | 12 | |
| β-strand | 34-37 | 4 | 23 |
| β-strand | 42-45 | 4 | 23 |
| α-helix | 47-64 | 18 | |
Chain 7: 15 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 11-15 | 5 | |
| β-strand | 22-23 | 2 | 42 |
| β-strand | 30 | 1 | 42 |
| α-helix | 32-40 | 9 | |
| β-strand | 45 | 1 | 43 |
| β-strand | 52 | 1 | 43 |
| β-strand | 59-60 | 2 | 42 |
| α-helix | 66-79 | 14 | |
| α-helix | 86-88 | 3 | |
| α-helix | 92-111 | 20 | |
| α-helix | 114-128 | 15 | |
| α-helix | 129-135 | 7 | |
| α-helix | 136-189 | 54 | |
| α-helix | 194-209 | 16 | |
| α-helix | 258-262 | 5 | |
| α-helix | 263-266 | 4 | |
| α-helix | 269-275 | 7 | |
| α-helix | 277-279 | 3 | |
| α-helix | 280-284 | 5 | |
| α-helix | 289-301 | 13 | |
30 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| General transcription and DNA repair factor IIH helicase subunit XPB | 0 | protein | 782 | Homo sapiens | P19447 (AlphaFold model) |
| TFIIH basal transcription factor complex helicase XPD subunit | 1 | protein | 760 | Homo sapiens | P18074 (AlphaFold model) |
| General transcription factor IIH subunit 1 | 2 | protein | 548 | Homo sapiens | P32780 (AlphaFold model) |
| General transcription factor IIH subunit 4 | 3 | protein | 462 | Homo sapiens | Q92759 (AlphaFold model) |
| General transcription factor IIH subunit 2 | 4 | protein | 395 | Homo sapiens | Q13888 |
| General transcription factor IIH subunit 3 | 5 | protein | 308 | Homo sapiens | Q13889 |
| General transcription factor IIH subunit 5 | 6 | protein | 71 | Homo sapiens | Q6ZYL4 |
| CDK-activating kinase assembly factor MAT1 | 7 | protein | 309 | Homo sapiens | P51948 |
| Cyclin-dependent kinase 7 | 8 | protein | 346 | Homo sapiens | P50613 |
| Cyclin-H | 9 | protein | 323 | Homo sapiens | P51946 |
| DNA-directed RNA polymerase subunit | A | protein | 1970 | Sus scrofa | A0A7M4DUC2 |
| DNA-directed RNA polymerase subunit beta | B | protein | 1174 | Sus scrofa | I3LGP4 |
24 more molecules are not listed.
Sequence of entity 1 (0), FASTA
>8BYQ_1 General transcription and DNA repair factor IIH helicase subunit XPB (chains 0)
MGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPSAAGKQVDESGTKVDEYGAKD
YRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTA
YSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCTVSYGKVKLVLKHNRYFVESC
HPDVIQHLLQDPVIRECRLRNSEGEATELITETFTSKSAISKTAESSGGPSTSRVTDPQG
KSDIPMDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRND
SVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKR
CLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGHTTKRS
WEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDL
NFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNK
FRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNP
KINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFY
SLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQKVLAAT
DLDAEEEVVAGEFGSRSSQASRRFGTMSSMSGADDTVYMEYHSSRSKAPSKHVHPLFKRF
RK
Sequence of entity 2 (1), FASTA
>8BYQ_2 TFIIH basal transcription factor complex helicase XPD subunit (chains 1)
MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ
RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE
VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL
KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE
TDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG
LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP
FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT
FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT
SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA
RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA
AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF
LRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL
Sequence of entity 3 (2), FASTA
>8BYQ_3 General transcription factor IIH subunit 1 (chains 2)
MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGK
AKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQE
DPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQDVGISAAFLADVRPQTDG
CNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSK
DLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSASNSKSIKENSN
AAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEY
EDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQ
VLSSSAASSTITALSPGGALMQGGTQQAINQMVPNDIQSELKHLYVAVGELLRHFWSCFP
VNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLSTNLVSHIEEMLQTAYNKLHTWQ
SRRLMKKT
Sequence of entity 4 (3), FASTA
>8BYQ_4 General transcription factor IIH subunit 4 (chains 3)
MESTPSRGLNRVHLQCRNLQEFLGGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRML
FLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPIFRQNLRI
ALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLS
QAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQL
SFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGT
VHQPGFIVVETNYRLYAYTESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGIT
AQQIIHFLRTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFEL
LLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQKHSS
Sequence of entity 5 (4), FASTA
>8BYQ_5 General transcription factor IIH subunit 2 (chains 4)
MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRH
LYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTEL
SGNPRKHITSLKKAVDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPS
NIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTHHVSPPP
ASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCE
LPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYVC
AVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV
Sequence of entity 6 (5), FASTA
>8BYQ_6 General transcription factor IIH subunit 3 (chains 5)
MVSDEDELNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSNKLAVI
ASHIQESRFLYPGKNGRLGDFFGDPGNPPEFNPSGSKDGKYELLTSANEVIVEEIKDLMT
KSDIKGQHTETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNV
IFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQ
LILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAK
KKKLKVSA
Sequence of entity 7 (6), FASTA
>8BYQ_7 General transcription factor IIH subunit 5 (chains 6)
MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVFVIAELVNVLQERVGEL
MDQNAFSLTQK
Sequence of entity 8 (7), FASTA
>8BYQ_8 CDK-activating kinase assembly factor MAT1 (chains 7)
MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV
QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK
KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK
QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK
LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA
FSGLFWQPS
Sequence of entity 9 (8), FASTA
>8BYQ_9 Cyclin-dependent kinase 7 (chains 8)
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
Sequence of entity 10 (9), FASTA
>8BYQ_10 Cyclin-H (chains 9)
MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYY
EKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNV
SSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPI
LENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKE
NRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDD
DYVSKKSKHEEEEWTDDDLVESL
Sequence of entity 11 (A), FASTA
>8BYQ_11 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN
Sequence of entity 12 (B), FASTA
>8BYQ_12 DNA-directed RNA polymerase subunit beta (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 1 |
| ZN | Zinc ion | Zn | 16 |
| SF4 | Iron/sulfur cluster | Fe4 S4 | 1 |
Primary citation
Structural basis of transcription reduction by a promoter-proximal +1 nucleosome. Abril-Garrido, J., Dienemann, C., Grabbe, F. et al. Mol Cell (2023) 83:1798. DOI 10.1016/j.molcel.2023.04.011 · PubMed
Other PDB entries of the same protein (UniProt P19447 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4ERN 1.8 Å, Crystal structure of the C-terminal domain of human XPB/ERCC-3 excision repair protein…
- 7NVV 2.9 Å, XPB-containing part of TFIIH in a post-translocated state (with ADP-BeF3)
- 28JM 3.29 Å, Cryo-EM structure of the human holo-TFIIH and XPC initial encounter complex
- 7EGB 3.3 Å, TFIID-based holo PIC on SCP promoter
- 8EBU 3.3 Å, XPC release from Core7-XPA-DNA (Cy5)
- 9PD3 3.3 Å, NER dual incision complex - DuIS
- 28JS 3.32 Å, Cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA…
- 9PD4 3.4 Å, NER dual incision complex - DuIM
- 6RO4 3.5 Å, Structure of the core TFIIH-XPA-DNA complex
- 7AD8 3.5 Å, Core TFIIH-XPA-DNA complex with modelled p62 subunit
- 9XYU 3.5 Å, NER complex - C7CAD.ATP
- 28KE 3.6 Å, Cryo-EM structure of the human holo-TFIIH-XPC-XPA complex bound to bulky lesion-mimic DNA
Browse structure collections
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