8EBS: PDB entry 8EBS

Initial DNA-lesion (Cy5) binding by XPC and TFIIH. Determined by electron microscopy at 4.0 Å resolution. Released 19 Apr 2023.

Method: Electron microscopy
Resolution: 4.0 Å
Organisms: Homo sapiens, synthetic construct
Chains: 12
Atoms: 31,035
Mol. weight: 585.99 kDa
Ligands: CA, ZN, SF4
Released: 19 Apr 2023

Explore 8EBS in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8EBS contains 197 α-helices and 154 β-strands across 10 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 34 helices, 38 β-strands

Element	Residues	Length	Sheet
β-strand	53	1	1
β-strand	59-60	2	1
β-strand	67	1	2
β-strand	76-78	3	3
β-strand	83-87	5	3
α-helix	93-103	11
β-strand	105-108	4	3
β-strand	113-117	5	3
α-helix	120-129	10
α-helix	133-143	11
β-strand	144	1	3
β-strand	146	1	2
α-helix	147-149	3
α-helix	150-161	12
β-strand	166-171	6	4
β-strand	174-178	5	4
α-helix	182-188	7
α-helix	192-197	6
β-strand	198	1	4
α-helix	199	1
β-strand	200	1	5
α-helix	205	1
β-strand	206	1	5
α-helix	207	1
β-strand	271-272	2	4
α-helix	277-286	10
β-strand	291-292	2	4
β-strand	294	1	6
β-strand	310	1	7
α-helix	318-327	10
β-strand	329	1	8
β-strand	332	1	8
β-strand	334	1	6
β-strand	336-339	4	9
α-helix	346-357	12
β-strand	361-365	5	9
α-helix	368-381	14
β-strand	382	1	7
α-helix	386-388	3
β-strand	389-391	3	9
β-strand	405-409	5	9
α-helix	410-414	5
α-helix	421-432	12
β-strand	435-441	7	9
α-helix	443-445	3
α-helix	449-457	9
β-strand	460-467	8	9
α-helix	480-483	4
β-strand	487-490	4	9
α-helix	493-499	7
β-strand	505-512	8	10
α-helix	513-515	3
α-helix	516-524	9
α-helix	528-530	3
α-helix	531-535	5
α-helix	538-553	16
β-strand	558-562	5	10
α-helix	565-575	11
β-strand	579-580	2	10
α-helix	586-598	13
β-strand	604-607	4	10
α-helix	609-611	3
α-helix	616-619	4
β-strand	620	1	11
β-strand	622-627	6	10
α-helix	633-643	11
β-strand	644	1	11
β-strand	657-664	8	10
α-helix	668-676	9
α-helix	678-682	5
β-strand	688-690	3	10
α-helix	706-718	13

Chain B: 45 helices, 27 β-strands

Element	Residues	Length	Sheet
β-strand	2-5	4	12
β-strand	8-11	4	12
β-strand	17	1	13
α-helix	19-34	16
β-strand	38-41	4	14
α-helix	48-62	15
β-strand	70-74	5	14
α-helix	77-98	22
β-strand	105-108	4	14
α-helix	112-114	3
α-helix	127-138	12
α-helix	140-148	9
α-helix	156-160	5
α-helix	161-165	5
α-helix	169-171	3
β-strand	173-174	2	14
α-helix	177-187	11
α-helix	191-198	8
β-strand	204-208	5	14
α-helix	210-213	4
α-helix	215-222	8
β-strand	230-234	5	14
α-helix	239-247	9
β-strand	249-251	3	15
α-helix	253-276	24
α-helix	279-290	12
α-helix	293-297	5
α-helix	303-305	3
α-helix	312-316	5
α-helix	318-320	3
α-helix	321-324	4
α-helix	326-343	18
β-strand	350-352	3	15
α-helix	354-365	12
α-helix	369-373	5
α-helix	375-385	11
α-helix	391-394	4
α-helix	395-409	15
β-strand	414-421	8	15
β-strand	429-437	9	15
α-helix	441-450	10
β-strand	453-458	6	14
α-helix	466-470	5
β-strand	477-481	5	14
β-strand	490-494	5	16
β-strand	497	1	17
β-strand	503	1	17
α-helix	508-511	4
α-helix	514-530	17
β-strand	535-539	5	16
α-helix	542-555	14
α-helix	557-564	8
β-strand	566-569	4	16
α-helix	574-589	16
β-strand	594-599	6	16
α-helix	604-607	4
β-strand	617-620	4	16
α-helix	631-644	14
α-helix	648-665	18
β-strand	675-679	5	16
α-helix	683-685	3
α-helix	687-690	4
α-helix	695-698	4
α-helix	703-705	3
α-helix	710-725	16
α-helix	730-733	4
β-strand	734	1	18
β-strand	738	1	18
β-strand	739	1	13
α-helix	741-744	4
α-helix	747-756	10
β-strand	757-759	3	14

Chain C: 21 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	112-120	9
α-helix	122-132	11
α-helix	139-146	8
α-helix	165-167	3
β-strand	177-179	3	19
β-strand	183-185	3	19
α-helix	190-199	10
α-helix	201-210	10
α-helix	217-226	10
α-helix	269-271	3
α-helix	297-319	23
α-helix	347-358	12
β-strand	373	1	20
α-helix	380-383	4
α-helix	388-389	2
α-helix	399-412	14
α-helix	419-421	3
α-helix	424-434	11
α-helix	449-452	4
α-helix	455-478	24
α-helix	484-500	17
α-helix	501-505	5
α-helix	506-515	10
α-helix	521-547	27

Chain D: 26 helices, 18 β-strands

Element	Residues	Length	Sheet
α-helix	19-24	6
α-helix	28-35	8
α-helix	38-46	9
α-helix	50-58	9
α-helix	59-61	3
β-strand	66-67	2	21
α-helix	68-72	5
β-strand	75	1	22
α-helix	80-93	14
β-strand	96-100	5	21
β-strand	106-110	5	21
α-helix	112-123	12
α-helix	133-135	3
α-helix	145-164	20
α-helix	173-182	10
β-strand	185-186	2	23
α-helix	193-194	2
β-strand	195-196	2	23
α-helix	198-204	7
α-helix	208-221	14
α-helix	223-226	4
α-helix	230-241	12
β-strand	249-250	2	24
α-helix	256-268	13
β-strand	271-272	2	25
β-strand	280-281	2	24
β-strand	282-283	2	25
α-helix	285-290	6
α-helix	302-305	4
β-strand	307-310	4	1
β-strand	314-317	4	1
α-helix	322-329	8
β-strand	333-337	5	1
β-strand	342-345	4	1
α-helix	348-356	9
α-helix	361-370	10
β-strand	372	1	1
α-helix	374-377	4
α-helix	385-398	14
β-strand	402-409	8	26
α-helix	415-428	14
β-strand	431-435	5	26
β-strand	440-443	4	26
α-helix	445-461	17

Chain E: 18 helices, 22 β-strands

Element	Residues	Length	Sheet
α-helix	11-13	3
β-strand	53	1	20
β-strand	55	1	27
β-strand	59-66	8	28
α-helix	69-72	4
α-helix	80-98	19
β-strand	103-110	8	28
β-strand	113-121	9	28
α-helix	124-134	11
α-helix	145-156	12
β-strand	164-171	8	28
α-helix	183-191	9
β-strand	194-200	7	28
α-helix	206-214	9
β-strand	219-221	3	28
α-helix	225-236	12
α-helix	238-239	2
β-strand	240	1	27
α-helix	241-242	2
β-strand	249-253	5	29
β-strand	257-258	2	30
α-helix	259-261	3
β-strand	270-271	2	31
α-helix	273-276	4
β-strand	284-285	2	31
β-strand	288-290	3	30
β-strand	297-298	2	30
β-strand	303-304	2	29
β-strand	311-312	2	29
α-helix	315-320	6
α-helix	322-325	4
α-helix	327-331	5
β-strand	332-335	4	32
β-strand	344	1	33
β-strand	351	1	33
β-strand	356-359	4	32
β-strand	366-367	2	32
α-helix	369-374	6
α-helix	375-379	5
α-helix	383-386	4

Chain F: 11 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	7-16	10	34
α-helix	19-28	10
α-helix	34-51	18
β-strand	56-62	7	34
β-strand	67-69	3	34
α-helix	102-120	19
α-helix	133-150	18
β-strand	156-165	10	34
α-helix	174-187	14
β-strand	190-195	6	34
α-helix	201-210	10
β-strand	214-216	3	34
α-helix	220-222	3
α-helix	223-226	4
α-helix	227-231	5
α-helix	235-240	6
β-strand	241	1	22
α-helix	244-248	5
β-strand	253-254	2	35
β-strand	261-262	2	35
β-strand	264-268	5	29
β-strand	274-275	2	29
β-strand	281	1	36
β-strand	288	1	36

Chain G: 2 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	6-11	6	26
α-helix	14-26	13
β-strand	36-37	2	26
β-strand	42-45	4	26
α-helix	47-63	17

Chain H: 27 helices, 26 β-strands

Element	Residues	Length	Sheet
α-helix	170-224	55
α-helix	227-236	10
α-helix	239-242	4
α-helix	246-248	3
α-helix	251-264	14
α-helix	279-289	11
α-helix	295-308	14
β-strand	313-318	6	37
β-strand	531-536	6	37
β-strand	541-546	6	37
β-strand	551-552	2	37
α-helix	555-561	7
β-strand	569-573	5	37
β-strand	578-580	3	37
α-helix	582-585	4
α-helix	589-593	5
α-helix	594-596	3
α-helix	600-607	8
α-helix	615-629	15
β-strand	649	1	38
β-strand	658	1	39
β-strand	669-670	2	40
β-strand	673-674	2	40
β-strand	675	1	38
α-helix	678-680	3
β-strand	682	1	39
β-strand	685	1	41
α-helix	687-692	6
β-strand	695-697	3	42
α-helix	698	1
α-helix	701-703	3
β-strand	705-707	3	43
α-helix	712-720	9
α-helix	722-724	3
β-strand	730-732	3	43
β-strand	733	1	41
β-strand	738-740	3	42
α-helix	741	1
β-strand	745	1	44
β-strand	747	1	45
β-strand	750	1	45
β-strand	759-760	2	46
α-helix	764-766	3
α-helix	768	1
β-strand	769	1	44
β-strand	771-774	4	46
α-helix	779-785	7
β-strand	791-798	8	46
β-strand	805-814	10	46
α-helix	815-817	3
α-helix	818-864	47
α-helix	890-901	12
α-helix	904-912	9

2 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
TFIIH basal transcription factor complex helicase XPB subunit	A	protein	782	Homo sapiens	P19447 (AlphaFold model)
General transcription and DNA repair factor IIH helicase subunit XPD	B	protein	768	Homo sapiens	P18074 (AlphaFold model)
General transcription factor IIH subunit 1	C	protein	548	Homo sapiens	P32780 (AlphaFold model)
General transcription factor IIH subunit 4, p52	D	protein	462	Homo sapiens	Q92759 (AlphaFold model)
General transcription factor IIH subunit 2	E	protein	417	Homo sapiens	Q13888
General transcription factor IIH subunit 3	F	protein	308	Homo sapiens	Q13889
General transcription factor IIH subunit 5	G	protein	71	Homo sapiens	Q6ZYL4
Xeroderma pigmentosum, complementation group C, isoform CRA_a	H	protein	950	Homo sapiens	Q01831
UV excision repair protein RAD23 homolog B	I	protein	417	Homo sapiens	P54727
Centrin-2	J	protein	172	Homo sapiens	P41208
DNA (Cy5)	L	DNA	52	synthetic construct
DNA	M	DNA	53	synthetic construct

Sequence of entity 1 (A), FASTA

>8EBS_1 TFIIH basal transcription factor complex helicase XPB subunit (chains A)
MGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPSAAGKQVDESGTKVDEYGAKD
YRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTA
YSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCTVSYGKVKLVLKHNRYFVESC
HPDVIQHLLQDPVIRECRLRNSEGEATELITETFTSKSAISKTAESSGGPSTSRVTDPQG
KSDIPMDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRND
SVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKR
CLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGHTTKRS
WEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDL
NFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNK
FRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNP
KINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFY
SLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQKVLAAT
DLDAEEEVVAGEFGSRSSQASRRFGTMSSMSGADDTVYMEYHSSRSKAPSKHVHPLFKRF
RK

Sequence of entity 2 (B), FASTA

>8EBS_2 General transcription and DNA repair factor IIH helicase subunit XPD (chains B)
MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ
RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE
VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL
KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE
TDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG
LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP
FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT
FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT
SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA
RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA
AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF
LRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQLDYKDDDDK

Sequence of entity 3 (C), FASTA

>8EBS_3 General transcription factor IIH subunit 1 (chains C)
MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGK
AKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQE
DPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQDVGISAAFLADVRPQTDG
CNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSK
DLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSASNSKSIKENSN
AAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEY
EDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQ
VLSSSAASSTITALSPGGALMQGGTQQAINQMVPNDIQSELKHLYVAVGELLRHFWSCFP
VNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLSTNLVSHIEEMLQTAYNKLHTWQ
SRRLMKKT

Sequence of entity 4 (D), FASTA

>8EBS_4 General transcription factor IIH subunit 4,  p52 (chains D)
MESTPSRGLNRVHLQCRNLQEFLGGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRML
FLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPIFRQNLRI
ALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLS
QAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQL
SFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGT
VHQPGFIVVETNYRLYAYTESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGIT
AQQIIHFLRTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFEL
LLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQKHSS

Sequence of entity 5 (E), FASTA

>8EBS_5 General transcription factor IIH subunit 2 (chains E)
MGSSHHHHHHSSGLEVLFQGPHMDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDIL
FKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQ
NPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLSIAMQTLKH
MPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGT
YHVILDESHYKELLTHHVSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDG
NTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEE
YNGERFCYGCQGELKDQHVYVCAVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV

Sequence of entity 6 (F), FASTA

>8EBS_6 General transcription factor IIH subunit 3 (chains F)
MVSDEDELNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSNKLAVI
ASHIQESRFLYPGKNGRLGDFFGDPGNPPEFNPSGSKDGKYELLTSANEVIVEEIKDLMT
KSDIKGQHTETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNV
IFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQ
LILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAK
KKKLKVSA

Sequence of entity 7 (G), FASTA

>8EBS_7 General transcription factor IIH subunit 5 (chains G)
MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVFVIAELVNVLQERVGEL
MDQNAFSLTQK

Sequence of entity 8 (H), FASTA

>8EBS_8 Xeroderma pigmentosum, complementation group C, isoform CRA_a (chains H)
MDYKDDDDKHMARKRAAGGEPRGRELRSQKSKAKSKARREEEEEDAFEDEKPPKKSLLSK
VSQGKRKRGCSHPGGSADGPAKKKVAKVTVKSENLKVIKDEALSDGDDLRDFPSDLKKAH
HLKRGATMNEDSNEEEEESENDWEEVEELSEPVLGDVRESTAFSRSLLPVKPVEIEIETP
EQAKTRERSEKIKLEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQPDLH
AIGLSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSASEQDNLQTTLERRFAIY
SARDDEELVHIFLLILRALQLLTRLVLSLQPIPLKSATAKGKKPSKERLTADPGGSSETS
SQVLENHTKPKTSKGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSEEDEGPGDKQE
KATQRRPHGRERRVASRVSYKEESGSDEAGSGSDFELSSGEASDPSDEDSEPGPPKQRKA
PAPQRTKAGSKSASRTHRGSHRKDPSLPVASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQ
WLEVFCEQEEKWVCVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWM
TVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALK
RHLLKYEAIYPETAAILGYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGF
SNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIG
CVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQA
VIERKEKEKKEKRALGNWKLLAKGLLIRERLKRRYGPKSEAAAPHTDAGGGLSSDEEEGT
SSQAEAARILAASWPQNREDEEKQKLKGGPKKTKREKKAAASHLFPFEKL

Sequence of entity 9 (I), FASTA

>8EBS_9 UV excision repair protein RAD23 homolog B (chains I)
MQVTLKTLQQQTFKIDIDPEETVKALKEKIESEKGKDAFPVAGQKLIYAGKILNDDTALK
EYKIDEKNFVVVMVTKPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPT
STPASITPASATASSEPAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDA
TSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLLMGIPGDRESQAVVD
PPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLP
ALLQQIGRENPQLLQQISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYI
QVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNFDEDLEHHHHHH

Sequence of entity 10 (J), FASTA

>8EBS_10 Centrin-2 (chains J)
MASNFKKANMASSSQRKRMSPKPELTEEQKQEIREAFDLFDADGTGTIDVKELKVAMRAL
GFEPKKEEIKKMISEIDKEGTGKMNFGDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGK
ISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVSEQEFLRIMKKTSLY

Sequence of entity 11 (L), FASTA

>8EBS_11 DNA (Cy5) (chains L)
AGGTAGTCACAGCTGATTGCGCTGAGGATXTAGACGTGCGATATCTATGCCA

Sequence of entity 12 (M), FASTA

>8EBS_12 DNA (chains M)
TGGCATAGATATCGCACGTCTATTATCCTCAGCGCAATCAGCTGTGACTACCT

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	2
ZN	Zinc ion	Zn	5
SF4	Iron/sulfur cluster	Fe4 S4	1

Primary citation

Lesion recognition by XPC, TFIIH and XPA in DNA excision repair. Kim, J., Li, C.L., Chen, X. et al. Nature (2023) 617:170-175. DOI 10.1038/s41586-023-05959-z · PubMed

Other PDB entries of the same protein (UniProt P19447 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4ERN 1.8 Å, Crystal structure of the C-terminal domain of human XPB/ERCC-3 excision repair protein…
7NVV 2.9 Å, XPB-containing part of TFIIH in a post-translocated state (with ADP-BeF3)
28JM 3.29 Å, Cryo-EM structure of the human holo-TFIIH and XPC initial encounter complex
7EGB 3.3 Å, TFIID-based holo PIC on SCP promoter
8EBU 3.3 Å, XPC release from Core7-XPA-DNA (Cy5)
9PD3 3.3 Å, NER dual incision complex - DuIS
28JS 3.32 Å, Cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA…
9PD4 3.4 Å, NER dual incision complex - DuIM
6RO4 3.5 Å, Structure of the core TFIIH-XPA-DNA complex
7AD8 3.5 Å, Core TFIIH-XPA-DNA complex with modelled p62 subunit
9XYU 3.5 Å, NER complex - C7CAD.ATP
28KE 3.6 Å, Cryo-EM structure of the human holo-TFIIH-XPC-XPA complex bound to bulky lesion-mimic DNA

Browse structure collections

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