8ESC: Yeast NuA4 Histone Acetyltransferase Complex
Structure of the Yeast NuA4 Histone Acetyltransferase Complex. Determined by electron microscopy at 3.1 Å resolution. Released 16 Nov 2022.
- Method
- Electron microscopy
- Resolution
- 3.1 Å
- Organism
- Saccharomyces cerevisiae
- Chains
- 6
- Atoms
- 43,279
- Mol. weight
- 795.72 kDa
- Ligands
- ATP, MG
- Released
- 16 Nov 2022
Explore 8ESC in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8ESC contains 317 α-helices and 104 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 22 helices, 25 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-9 | 2 | 18 |
| β-strand | 12 | 1 | 19 |
| β-strand | 16-19 | 4 | 19 |
| β-strand | 20-21 | 2 | 18 |
| β-strand | 29-32 | 4 | 19 |
| β-strand | 35-36 | 2 | 20 |
| β-strand | 38 | 1 | 21 |
| β-strand | 53-54 | 2 | 20 |
| α-helix | 56-60 | 5 | |
| β-strand | 62 | 1 | 21 |
| β-strand | 65 | 1 | 21 |
| β-strand | 68 | 1 | 20 |
| β-strand | 71 | 1 | 22 |
| β-strand | 76 | 1 | 22 |
| α-helix | 79-88 | 10 | |
| α-helix | 89-93 | 5 | |
| β-strand | 103-107 | 5 | 18 |
| α-helix | 113-121 | 9 | |
| α-helix | 122-127 | 6 | |
| β-strand | 131-136 | 6 | 18 |
| α-helix | 137-144 | 8 | |
| β-strand | 150-155 | 6 | 23 |
| β-strand | 160-166 | 7 | 23 |
| β-strand | 169-170 | 2 | 23 |
| α-helix | 172-174 | 3 | |
| β-strand | 176-178 | 3 | 23 |
| α-helix | 182-195 | 14 | |
| α-helix | 203-215 | 13 | |
| α-helix | 223-232 | 10 | |
| β-strand | 238-241 | 4 | 24 |
| β-strand | 247-250 | 4 | 24 |
| α-helix | 253-256 | 4 | |
| α-helix | 258-261 | 4 | |
| α-helix | 264-267 | 4 | |
| α-helix | 274-283 | 10 | |
| α-helix | 287-294 | 8 | |
| β-strand | 297-300 | 4 | 23 |
| α-helix | 302-304 | 3 | |
| α-helix | 309-320 | 12 | |
| β-strand | 329-330 | 2 | 23 |
| α-helix | 338-347 | 10 | |
| β-strand | 349 | 1 | 25 |
| α-helix | 351-354 | 4 | |
| β-strand | 357-358 | 2 | 18 |
| α-helix | 359-365 | 7 | |
| α-helix | 367-369 | 3 | |
| α-helix | 370-373 | 4 | |
Chain E: 19 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 242-247 | 6 | |
| β-strand | 254 | 1 | 30 |
| β-strand | 267-274 | 8 | 31 |
| β-strand | 280-282 | 3 | 32 |
| α-helix | 287-296 | 10 | |
| α-helix | 299-302 | 4 | |
| α-helix | 312-336 | 25 | |
| β-strand | 343-345 | 3 | 28 |
| α-helix | 346-350 | 5 | |
| α-helix | 360-396 | 37 | |
| α-helix | 399-401 | 3 | |
| β-strand | 402 | 1 | 25 |
| β-strand | 548 | 1 | 33 |
| α-helix | 554-560 | 7 | |
| β-strand | 566 | 1 | 31 |
| β-strand | 598-605 | 8 | 31 |
| α-helix | 613-616 | 4 | |
| α-helix | 635-638 | 4 | |
| α-helix | 640-642 | 3 | |
| β-strand | 649-650 | 2 | 26 |
| α-helix | 652-665 | 14 | |
| α-helix | 669-676 | 8 | |
| α-helix | 693-704 | 12 | |
| α-helix | 718-733 | 16 | |
| β-strand | 741-743 | 3 | 26 |
| α-helix | 753-755 | 3 | |
| α-helix | 757-772 | 16 | |
| α-helix | 793-795 | 3 | |
| α-helix | 796-810 | 15 | |
Chain P: 12 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 489-490 | 2 | 26 |
| β-strand | 500 | 1 | 27 |
| β-strand | 504 | 1 | 6 |
| α-helix | 505-530 | 26 | |
| β-strand | 535-537 | 3 | 28 |
| β-strand | 545-549 | 5 | 29 |
| β-strand | 552 | 1 | 30 |
| α-helix | 560-562 | 3 | |
| α-helix | 564-567 | 4 | |
| β-strand | 572-577 | 6 | 29 |
| α-helix | 581-585 | 5 | |
| β-strand | 594-596 | 3 | 31 |
| β-strand | 601 | 1 | 31 |
| α-helix | 612-615 | 4 | |
| α-helix | 617 | 1 | |
| β-strand | 618-620 | 3 | 32 |
| β-strand | 631-642 | 12 | 31 |
| β-strand | 648-654 | 7 | 31 |
| α-helix | 673-681 | 9 | |
| β-strand | 691-693 | 3 | 17 |
| α-helix | 698-708 | 11 | |
| α-helix | 714-716 | 3 | |
| α-helix | 722-724 | 3 | |
| α-helix | 725-729 | 5 | |
| α-helix | 734-770 | 37 | |
Chain R: 25 helices, 24 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 17-20 | 4 | 11 |
| β-strand | 25 | 1 | 12 |
| β-strand | 27-30 | 4 | 11 |
| β-strand | 38 | 1 | 11 |
| β-strand | 41 | 1 | 12 |
| β-strand | 44-47 | 4 | 13 |
| β-strand | 55-56 | 2 | 13 |
| α-helix | 59-62 | 4 | |
| β-strand | 69-72 | 4 | 13 |
| β-strand | 75-76 | 2 | 14 |
| β-strand | 79-80 | 2 | 14 |
| α-helix | 83-96 | 14 | |
| β-strand | 107-112 | 6 | 11 |
| α-helix | 118-125 | 8 | |
| α-helix | 126-131 | 6 | |
| β-strand | 136-141 | 6 | 11 |
| α-helix | 142-150 | 9 | |
| β-strand | 155-160 | 6 | 15 |
| β-strand | 165-171 | 7 | 15 |
| β-strand | 174-175 | 2 | 15 |
| β-strand | 181-183 | 3 | 15 |
| α-helix | 187-197 | 11 | |
| α-helix | 206-208 | 3 | |
| β-strand | 209-211 | 3 | 16 |
| β-strand | 217-218 | 2 | 16 |
| α-helix | 227-233 | 7 | |
| α-helix | 234-238 | 5 | |
| α-helix | 239-245 | 7 | |
| α-helix | 266 | 1 | |
| β-strand | 267-271 | 5 | 17 |
| β-strand | 277-279 | 3 | 17 |
| α-helix | 280-281 | 2 | |
| α-helix | 282-287 | 6 | |
| α-helix | 290-292 | 3 | |
| α-helix | 297-299 | 3 | |
| α-helix | 305-307 | 3 | |
| β-strand | 311 | 1 | 15 |
| α-helix | 385-395 | 11 | |
| α-helix | 398-406 | 9 | |
| β-strand | 408-411 | 4 | 15 |
| α-helix | 414-416 | 3 | |
| α-helix | 420-431 | 12 | |
| β-strand | 439-440 | 2 | 15 |
| α-helix | 445-449 | 5 | |
| α-helix | 451-459 | 9 | |
| α-helix | 469 | 1 | |
| β-strand | 470-471 | 2 | 11 |
| α-helix | 472-477 | 6 | |
| α-helix | 480-486 | 7 | |
Chain S: 19 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 42-49 | 8 | |
| β-strand | 57-58 | 2 | 31 |
| β-strand | 60 | 1 | 33 |
| α-helix | 75-77 | 3 | |
| β-strand | 78-84 | 7 | 34 |
| β-strand | 91-96 | 6 | 34 |
| α-helix | 99-102 | 4 | |
| α-helix | 106 | 1 | |
| β-strand | 107-108 | 2 | 34 |
| α-helix | 109 | 1 | |
| α-helix | 110-113 | 4 | |
| α-helix | 125-133 | 10 | |
| α-helix | 166-178 | 13 | |
| α-helix | 183-188 | 6 | |
| α-helix | 198-215 | 18 | |
| α-helix | 221-226 | 6 | |
| α-helix | 230-244 | 15 | |
| α-helix | 250-266 | 17 | |
| α-helix | 268-282 | 15 | |
| α-helix | 285-287 | 3 | |
| α-helix | 297-308 | 12 | |
| β-strand | 314 | 1 | 27 |
| α-helix | 315-316 | 2 | |
| α-helix | 325-330 | 6 | |
| α-helix | 331-333 | 3 | |
Chain Z: 220 helices, 26 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-15 | 10 | |
| α-helix | 21-29 | 9 | |
| α-helix | 31-37 | 7 | |
| α-helix | 41-61 | 21 | |
| α-helix | 63-64 | 2 | |
| α-helix | 71-79 | 9 | |
| α-helix | 81-85 | 5 | |
| α-helix | 87-88 | 2 | |
| α-helix | 90-95 | 6 | |
| α-helix | 96-106 | 11 | |
| α-helix | 107-109 | 3 | |
| α-helix | 113-127 | 15 | |
| α-helix | 137-148 | 12 | |
| α-helix | 154-159 | 6 | |
| α-helix | 223-225 | 3 | |
| α-helix | 227-236 | 10 | |
| α-helix | 242-258 | 17 | |
| α-helix | 262-272 | 11 | |
| α-helix | 288-310 | 23 | |
| α-helix | 319-323 | 5 | |
| α-helix | 325-334 | 10 | |
| α-helix | 342-356 | 15 | |
| α-helix | 358-363 | 6 | |
| α-helix | 367-371 | 5 | |
| α-helix | 381-385 | 5 | |
| α-helix | 388-401 | 14 | |
| α-helix | 408-423 | 16 | |
| α-helix | 429-441 | 13 | |
| α-helix | 443-450 | 8 | |
| α-helix | 457-479 | 23 | |
| α-helix | 482-503 | 22 | |
| α-helix | 513-521 | 9 | |
| α-helix | 564-566 | 3 | |
| α-helix | 573-575 | 3 | |
| α-helix | 579-595 | 17 | |
| α-helix | 600-604 | 5 | |
| α-helix | 605-607 | 3 | |
| α-helix | 616-619 | 4 | |
| α-helix | 628-646 | 19 | |
| α-helix | 677-689 | 13 | |
| α-helix | 699-715 | 17 | |
| α-helix | 717-719 | 3 | |
| α-helix | 720-728 | 9 | |
| α-helix | 733-748 | 16 | |
| α-helix | 756-775 | 20 | |
| α-helix | 777-800 | 24 | |
| α-helix | 805-819 | 15 | |
| α-helix | 825-847 | 23 | |
| α-helix | 854-863 | 10 | |
| α-helix | 873-875 | 3 | |
| α-helix | 876-888 | 13 | |
| α-helix | 891-893 | 3 | |
| α-helix | 894-907 | 14 | |
| α-helix | 914-917 | 4 | |
| α-helix | 918-920 | 3 | |
| α-helix | 921-931 | 11 | |
| α-helix | 939-951 | 13 | |
| α-helix | 961 | 1 | |
| α-helix | 963 | 1 | |
| β-strand | 968 | 1 | 1 |
| β-strand | 977-980 | 4 | 2 |
| β-strand | 982 | 1 | 3 |
| β-strand | 989-992 | 4 | 2 |
| α-helix | 997-1004 | 8 | |
| α-helix | 1011-1028 | 18 | |
| α-helix | 1031-1033 | 3 | |
| α-helix | 1039-1047 | 9 | |
| α-helix | 1062-1064 | 3 | |
| α-helix | 1069-1089 | 21 | |
| α-helix | 1096-1124 | 29 | |
| β-strand | 1140 | 1 | 4 |
| α-helix | 1144-1153 | 10 | |
| α-helix | 1158-1179 | 22 | |
| α-helix | 1181-1186 | 6 | |
| α-helix | 1189-1200 | 12 | |
| α-helix | 1206-1222 | 17 | |
| α-helix | 1229-1246 | 18 | |
| α-helix | 1254-1271 | 18 | |
| α-helix | 1283-1294 | 12 | |
| α-helix | 1301-1318 | 18 | |
| α-helix | 1322-1325 | 4 | |
| α-helix | 1330-1339 | 10 | |
| α-helix | 1347-1361 | 15 | |
| α-helix | 1372-1377 | 6 | |
| α-helix | 1385-1389 | 5 | |
| α-helix | 1403-1422 | 20 | |
| α-helix | 1438-1446 | 9 | |
| α-helix | 1455-1468 | 14 | |
| α-helix | 1475-1481 | 7 | |
| α-helix | 1483-1487 | 5 | |
| α-helix | 1497-1509 | 13 | |
| α-helix | 1517-1528 | 12 | |
| α-helix | 1532-1537 | 6 | |
| α-helix | 1547-1557 | 11 | |
| α-helix | 1570-1583 | 14 | |
| α-helix | 1593-1602 | 10 | |
| α-helix | 1605-1613 | 9 | |
| α-helix | 1618-1628 | 11 | |
| α-helix | 1636-1639 | 4 | |
| α-helix | 1641-1643 | 3 | |
| α-helix | 1644-1658 | 15 | |
| α-helix | 1662-1680 | 19 | |
| α-helix | 1682-1686 | 5 | |
| α-helix | 1690-1709 | 20 | |
| α-helix | 1715-1734 | 20 | |
| α-helix | 1740-1752 | 13 | |
| α-helix | 1762-1769 | 8 | |
| α-helix | 1777-1790 | 14 | |
| α-helix | 1796-1801 | 6 | |
| α-helix | 1802-1808 | 7 | |
| α-helix | 1809-1816 | 8 | |
| α-helix | 1832-1837 | 6 | |
| α-helix | 1838-1842 | 5 | |
| α-helix | 1845-1848 | 4 | |
| α-helix | 1859-1873 | 15 | |
| α-helix | 1876-1878 | 3 | |
| α-helix | 1880-1882 | 3 | |
| α-helix | 1883-1890 | 8 | |
| α-helix | 1891-1895 | 5 | |
| α-helix | 1901-1915 | 15 | |
| α-helix | 1920-1932 | 13 | |
| α-helix | 1939-1956 | 18 | |
| α-helix | 1965-1976 | 12 | |
| α-helix | 1982-1987 | 6 | |
| α-helix | 2004-2015 | 12 | |
| α-helix | 2022-2042 | 21 | |
| α-helix | 2094-2103 | 10 | |
| α-helix | 2115-2128 | 14 | |
| α-helix | 2140-2143 | 4 | |
| α-helix | 2144-2147 | 4 | |
| α-helix | 2157-2174 | 18 | |
| α-helix | 2177-2182 | 6 | |
| α-helix | 2184-2190 | 7 | |
| α-helix | 2192-2196 | 5 | |
| α-helix | 2202-2220 | 19 | |
| α-helix | 2233-2247 | 15 | |
| α-helix | 2250-2252 | 3 | |
| α-helix | 2253-2266 | 14 | |
| α-helix | 2268-2270 | 3 | |
| α-helix | 2276-2290 | 15 | |
| α-helix | 2298-2319 | 22 | |
| α-helix | 2329-2341 | 13 | |
| α-helix | 2348-2361 | 14 | |
| α-helix | 2371-2378 | 8 | |
| α-helix | 2382-2385 | 4 | |
| α-helix | 2388-2403 | 16 | |
| α-helix | 2414-2416 | 3 | |
| α-helix | 2417-2423 | 7 | |
| α-helix | 2429-2441 | 13 | |
| α-helix | 2447-2455 | 9 | |
| α-helix | 2460-2463 | 4 | |
| α-helix | 2469-2477 | 9 | |
| β-strand | 2480 | 1 | 3 |
| β-strand | 2485 | 1 | 5 |
| β-strand | 2488 | 1 | 2 |
| β-strand | 2494 | 1 | 4 |
| α-helix | 2499-2502 | 4 | |
| α-helix | 2517-2533 | 17 | |
| β-strand | 2537 | 1 | 5 |
| α-helix | 2538-2549 | 12 | |
| α-helix | 2553-2568 | 16 | |
| α-helix | 2572 | 1 | |
| α-helix | 2576-2587 | 12 | |
| α-helix | 2602-2611 | 10 | |
| α-helix | 2620-2629 | 10 | |
| α-helix | 2633-2641 | 9 | |
| α-helix | 2652-2669 | 18 | |
| α-helix | 2672-2682 | 11 | |
| α-helix | 2686-2697 | 12 | |
| α-helix | 2700-2713 | 14 | |
| β-strand | 2721 | 1 | 6 |
| α-helix | 2723-2739 | 17 | |
| α-helix | 2743-2753 | 11 | |
| α-helix | 2756-2763 | 8 | |
| α-helix | 2773-2783 | 11 | |
| α-helix | 2789-2805 | 17 | |
| α-helix | 2810-2830 | 21 | |
| α-helix | 2838-2862 | 25 | |
| α-helix | 2875-2886 | 12 | |
| α-helix | 2895-2914 | 20 | |
| α-helix | 2940-2956 | 17 | |
| α-helix | 2960-2968 | 9 | |
| α-helix | 2978-2993 | 16 | |
| α-helix | 3000-3008 | 9 | |
| α-helix | 3016-3032 | 17 | |
| α-helix | 3038-3050 | 13 | |
| α-helix | 3054-3070 | 17 | |
| α-helix | 3075-3089 | 15 | |
| α-helix | 3097-3108 | 12 | |
| α-helix | 3118-3122 | 5 | |
| α-helix | 3131-3136 | 6 | |
| α-helix | 3137-3142 | 6 | |
| α-helix | 3143-3145 | 3 | |
| α-helix | 3149-3162 | 14 | |
| α-helix | 3164-3181 | 18 | |
| α-helix | 3204-3217 | 14 | |
| α-helix | 3220-3236 | 17 | |
| α-helix | 3241-3260 | 20 | |
| α-helix | 3264 | 1 | |
| α-helix | 3270-3273 | 4 | |
| α-helix | 3274-3284 | 11 | |
| α-helix | 3293-3296 | 4 | |
| α-helix | 3297-3301 | 5 | |
| α-helix | 3309-3326 | 18 | |
| β-strand | 3331-3332 | 2 | 7 |
| α-helix | 3334-3337 | 4 | |
| α-helix | 3339-3342 | 4 | |
| α-helix | 3344-3346 | 3 | |
| α-helix | 3352 | 1 | |
| β-strand | 3353 | 1 | 8 |
| α-helix | 3354 | 1 | |
| α-helix | 3368-3369 | 2 | |
| β-strand | 3370 | 1 | 8 |
| β-strand | 3371-3374 | 4 | 7 |
| β-strand | 3378-3382 | 5 | 7 |
| β-strand | 3387-3395 | 9 | 7 |
| β-strand | 3400-3406 | 7 | 7 |
| α-helix | 3409-3410 | 2 | |
| α-helix | 3414-3424 | 11 | |
| α-helix | 3427-3432 | 6 | |
| α-helix | 3434-3438 | 5 | |
| β-strand | 3448-3450 | 3 | 7 |
| β-strand | 3456-3459 | 4 | 7 |
| β-strand | 3464-3466 | 3 | 9 |
| α-helix | 3467-3478 | 12 | |
| α-helix | 3484-3495 | 12 | |
| α-helix | 3506-3520 | 15 | |
| α-helix | 3526-3534 | 9 | |
| β-strand | 3535 | 1 | 1 |
| α-helix | 3538-3560 | 23 | |
| α-helix | 3569-3571 | 3 | |
| β-strand | 3572-3575 | 4 | 9 |
| β-strand | 3581-3583 | 3 | 9 |
| β-strand | 3592 | 1 | 10 |
| α-helix | 3597-3600 | 4 | |
| β-strand | 3612 | 1 | 10 |
| α-helix | 3626-3632 | 7 | |
| α-helix | 3635-3636 | 2 | |
| α-helix | 3637-3641 | 5 | |
| α-helix | 3642-3653 | 12 | |
| α-helix | 3658-3677 | 20 | |
| α-helix | 3681-3684 | 4 | |
| α-helix | 3685-3706 | 22 | |
| α-helix | 3718-3728 | 11 | |
| α-helix | 3730-3733 | 4 | |
| α-helix | 3738-3740 | 3 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Transcription-associated protein 1 | Z | protein | 3744 | Saccharomyces cerevisiae | P38811 |
| Actin-related protein 4 | R | protein | 489 | Saccharomyces cerevisiae | P80428 (AlphaFold model) |
| Actin | A | protein | 375 | Saccharomyces cerevisiae | P60010 (AlphaFold model) |
| Enhancer of polycomb-like protein 1 | P | protein | 832 | Saccharomyces cerevisiae | P43572 (AlphaFold model) |
| Chromatin modification-related protein EAF1 | E | protein | 982 | Saccharomyces cerevisiae | Q06337 |
| SWR1-complex protein 4 | S | protein | 476 | Saccharomyces cerevisiae | P53201 |
Sequence of entity 1 (Z), FASTA
>8ESC_1 Transcription-associated protein 1 (chains Z)
MSLTEQIEQFASRFRDDDATLQSRYSTLSELYDIMELLNSPEDYHFFLQAVIPLLLNQLK
EVPISYDAHSPEQKLRNSMLDIFNRCLMNQTFQPYAMEVLEFLLSVLPKENEENGILCMK
VLTTLFKSFKSILQDKLDSFIRIIIQIYKNTPNLINQTFYEAGKAEQGDLDSPKEPQADE
LLDEFSKNDEEKDFPSKQSSTEPRFENSTSSNGLRSSMFSFKILSECPITMVTLYSSYKQ
LTSTSLPEFTPLIMNLLNIQIKQQQEAREQAESRGEHFTSISTEIINRPAYCDFILAQIK
ATSFLAYVFIRGYAPEFLQDYVNFVPDLIIRLLQDCPSELSSARKELLHATRHILSTNYK
KLFLPKLDYLFDERILIGNGFTMHETLRPLAYSTVADFIHNIRSELQLSEIEKTIKIYTG
YLLDESLALTVQIMSAKLLLNLVERILKLGKENPQEAPRAKKLLMIIIDSYMNRFKTLNR
QYDTIMKYYGRYETHKKEKAEKLKNSIQDNDKESEEFMRKVLEPSDDDHLMPQPKKEDIN
DSPDVEMTESDKVVKNDVEMFDIKNYAPILLLPTPTNDPIKDAFYLYRTLMSFLKTIIHD
LKVFNPPPNEYTVANPKLWASVSRVFSYEEVIVFKDLFHECIIGLKFFKDHNEKLSPETT
KKHFDISMPSLPVSATKDARELMDYLAFMFMQMDNATFNEIIEQELPFVYERMLEDSGLL
HVAQSFLTSEITSPNFAGILLRFLKGKLKDLGNVDFNTSNVLIRLFKLSFMSVNLFPNIN
EVVLLPHLNDLILNSLKYSTTAEEPLVYFYLIRTLFRSIGGGRFENLYRSIKPILQVLLQ
SLNQMILTARLPHERELYVELCITVPVRLSVLAPYLPFLMKPLVFALQQYPDLVSQGLRT
LELCIDNLTAEYFDPIIEPVIDDVSKALFNLLQPQPFNHAISHNVVRILGKLGGRNRQFL
KPPTDLTEKTELDIDAIADFKINGMPEDVPLSVTPGIQSALNILQSYKSDIHYRKSAYKY
LTCVLLLMTKSSAEFPTNYTELLKTAVNSIKLERIGIEKNFDLEPTVNKRDYSNQENLFL
RLLESVFYATSIKELKDDAMDLLNNLLDHFCLLQVNTTLLNKRNYNGTFNIDLKNPNFML
DSSLILDAIPFALSYYIPEVREVGVLAYKRIYEKSCLIYGEELALSHSFIPELAKQFIHL
CYDETYYNKRGGVLGIKVLIDNVKSSSVFLKKYQYNLANGLLFVLKDTQSEAPSAITDSA
EKLLIDLLSITFADVKEEDLGNKVLENTLTDIVCELSNANPKVRNACQKSLHTISNLTGI
PIVKLMDHSKQFLLSPIFAKPLRALPFTMQIGNVDAITFCLSLPNTFLTFNEELFRLLQE
SIVLADAEDESLSTNIQKTTEYSTSEQLVQLRIACIKLLAIALKNEEFATAQQGNIRIRI
LAVFFKTMLKTSPEIINTTYEALKGSLAENSKLPKELLQNGLKPLLMNLSDHQKLTVPGL
DALSKLLELLIAYFKVEIGRKLLDHLTAWCRVEVLDTLFGQDLAEQMPTKIIVSIINIFH
LLPPQADMFLNDLLLKVMLLERKLRLQLDSPFRTPLARYLNRFHNPVTEYFKKNMTLRQL
VLFMCNIVQRPEAKELAEDFEKELDNFYDFYISNIPKNQVRVVSFFTNMVDLFNTMVITN
GDEWLKKKGNMILKLKDMLNLTLKTIKENSFYIDHLQLNQSIAKFQALYLRFTELSERDQ
NPLLLDFIDFSFSNGIKASYSLKKFIFHNIIASSNKEKQNNFINDATLFVLSDKCLDARI
FVLKNVINSTLIYEVATSGSLKSYLVEDKKPKWLELLHNKIWKNSNAILAYDVLDHHDLF
RFELLQLSAIFIKADPEIIAEIKKDIIKFCWNFIKLEDTLIKQSAYLVTSYFISKFDFPI
KVVTQVFVALLRSSHVEARYLVKQSLDVLTPVLHERMNAAGTPDTWINWVKRVMVENSSS
QNNILYQFLISHPDLFFNSRDLFISNIIHHMNKITFMSNSNSDSHTLAIDLASLILYWEN
KTLEITNVNNTKTDSDGDVVMSDSKSDINPVEADTTAIIVDANNNSPISLHLREACTAFL
IRYVCASNHRAIETELGLRAINILSELISDKHWTNVNVKLVYFEKFLIFQDLDSENILYY
CMNALDVLYVFFKNKTKEWIMENLPTIQNLLEKCIKSDHHDVQEALQKVLQVIMKAIKAQ
GVSVIIEEESPGKTFIQMLTSVITQDLQETSSVTAGVTLAWVLFMNFPDNIVPLLTPLMK
TFSKLCKDHLSISQPKDAMALEEARITTKLLEKVLYILSLKVSLLGDSRRPFLSTVALLI
DHSMDQNFLRKIVNMSRSWIFNTEIFPTVKEKAAILTKMLAFEIRGEPSLSKLFYEIVLK
LFDQEHFNNTEITVRMEQPFLVGTRVEDIGIRKRFMTILDNSLERDIKERLYYVIRDQNW
EFIADYPWLNQALQLLYGSFNREKELSLKNIYCLSPPSILQEYLPENAEMVTEVNDLELS
NFVKGHIASMQGLCRIISSDFIDSLIEIFYQDPKAIHRAWVTLFPQVYKSIPKNEKYGFV
RSIITLLSKPYHTRQISSRTNVINMLLDSISKIESLELPPHLVKYLAISYNAWYQSINIL
ESIQSNTSIDNTKIIEANEDALLELYVNLQEEDMFYGLWRRRAKYTETNIGLSYEQIGLW
DKAQQLYEVAQVKARSGALPYSQSEYALWEDNWIQCAEKLQHWDVLTELAKHEGFTDLLL
ECGWRVADWNSDRDALEQSVKSVMDVPTPRRQMFKTFLALQNFAESRKGDQEVRKLCDEG
IQLSLIKWVSLPIRYTPAHKWLLHGFQQYMEFLEATQIYANLHTTTVQNLDSKAQEIKRI
LQAWRDRLPNTWDDVNMWNDLVTWRQHAFQVINNAYLPLIPALQQSNSNSNINTHAYRGY
HEIAWVINRFAHVARKHNMPDVCISQLARIYTLPNIEIQEAFLKLREQAKCHYQNMNELT
TGLDVISNTNLVYFGTVQKAEFFTLKGMFLSKLRAYEEANQAFATAVQIDLNLAKAWAQW
GFFNDRRLSEEPNNISFASNAISCYLQAAGLYKNSKIRELLCRILWLISIDDASGMLTNA
FDSFRGEIPVWYWITFIPQLLTSLSHKEANMVRHILIRIAKSYPQALHFQLRTTKEDFAV
IQRQTMAVMGDKPDTNDRNGRRQPWEYLQELNNILKTAYPLLALSLESLVAQINDRFKST
TDEDLFRLINVLLIDGTLNYNRLPFPRKNPKLPENTEKNLVKFSTTLLAPYIRPKFNADF
IDNKPDYETYIKRLRYWRRRLENKLDRASKKENLEVLCPHLSNFHHQKFEDIEIPGQYLL
NKDNNVHFIKIARFLPTVDFVRGTHSSYRRLMIRGHDGSVHSFAVQYPAVRHSRREERMF
QLYRLFNKSLSKNVETRRRSIQFNLPIAIPLSPQVRIMNDSVSFTTLHEIHNEFCKKKGF
DPDDIQDFMADKLNAAHDDALPAPDMTILKVEIFNSIQTMFVPSNVLKDHFTSLFTQFED
FWLFRKQFASQYSSFVFMSYMMMINNRTPHKIHVDKTSGNVFTLEMLPSRFPYERVKPLL
KNHDLSLPPDSPIFHNNEPVPFRLTPNIQSLIGDSALEGIFAVNLFTISRALIEPDNELN
TYLALFIRDEIISWFSNLHRPIIENPQLREMVQTNVDLIIRKVAQLGHLNSTPTVTTQFI
LDCIGSAVSPRNLARTDVNFMPWF
Sequence of entity 2 (R), FASTA
>8ESC_2 Actin-related protein 4 (chains R)
MSNAALQVYGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQ
SIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTEN
RKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKST
RRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQ
ECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDI
PANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSAD
TPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGL
SDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVGV
ERLLNDRFR
Sequence of entity 3 (A), FASTA
>8ESC_3 Actin (chains A)
MDSEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQS
KRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMT
QIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDL
AGRDLTDYLMKILSERGYSFSTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSSIEKSY
ELPDGQVITIGNERFRAPEALFHPSVLGLESAGIDQTTYNSIMKCDVDVRKELYGNIVMS
GGTTMFPGIAERMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLTTFQQMWISKQ
EYDESGPSIVHHKCF
Sequence of entity 4 (P), FASTA
>8ESC_4 Enhancer of polycomb-like protein 1 (chains P)
MPTPSNAIEINDGSHKSGRSTRRSGSRSAHDDGLDSFSKGDSGAGASAGSSNSRFRHRKI
SVKQHLKIYLPNDLKHLDKDELQQREVVEIETGVEKNEEKEVHLHRILQMGSGHTKHKDY
IPTPDASMTWNEYDKFYTGSFQETTSYIKFSATVEDCCGTNYNMDERDETFLNEQVNKGS
SDILTEDEFEILCSSFEHAIHERQPFLSMDPESILSFEELKPTLIKSDMADFNLRNQLNH
EINSHKTHFITQFDPVSQMNTRPLIQLIEKFGSKIYDYWRERKIEVNGYEIFPQLKFERP
GEKEEIDPYVCFRRREVRHPRKTRRIDILNSQRLRALHQELKNAKDLALLVAKRENVSLN
WINDELKIFDQRVKIKNLKRSLNISGEDDDLINHKRKRPTIVTVEQREAELRKAELKRAA
AAAAAAKAKNNKRNNQLEDKSSRLTKQQQQQLLQQQQQQQQNALKTENGKQLANASSSST
SQPITSHVYVKLPSSKIPDIVLEDVDALLNSKEKNARKFVQEKMEKRKIEDADVFFNLTD
DPFNPVFDMSLPKNFSTSNVPFASIASSKFQIDRSFYSSHLPEYLKGISDDIRIYDSNGR
SRNKDNYNLDTKRIKKTELYDPFQENLEIHSREYPIKFRKRVGRSNIKYVDRMPNFTTSS
TKSACSLMDFVDFDSIEKEQYSREGSNDTDSINVYDSKYDEFVRLYDKWKYDSPQNEYGI
KFSDEPARLNQISNDTQVIRFGTMLGTKSYEQLREATIKYRRDYITRLKQKHIQHLQQQQ
QQQQQQQQQAQQQKQKSQNNNSNSSNSLKKLNDSLINSEAKQNSSITQKNSS
Sequence of entity 5 (E), FASTA
>8ESC_5 Chromatin modification-related protein EAF1 (chains E)
MSSRPSSAVPNSASLSEDQSSDRSKFPKADDLIDERDRKLTELYCVSRLNQLLELTDENK
LRKEIDAFLKKNDIRRGIRFDEASLPKLLHTAATPITKKKLKDVNLINVPNQRLSDSKMS
RELPENSENVSVKSESHFVPSHDNSIRENMMDSLRPAEKTGGMWNKRPLESTMGGEEERH
EKRQKMQSQSLESSNNSEMASLPISPRPPVPNALAHYTYYENIEYPPADPTEVQPAVKFK
DPLIKNIMAKEIDTSDHYNENNVDALETVFLLMNDYIPSKIPQALPLAELKYMSQTLPLI
NLIPRAHKALTTNIINNALNEARITVVGSRIEELRRLGLWSLRQPKRFIDPWKQHNTHQN
ILLEEAKWMQADFKEGHKYKVAICTAMAQAIKDYWTYGEICCVKRKTLLPGKENKLSDDG
RISEKSGRPSDTSRNDSDISIAGKDDIGIIANVDDITEKESAAANDNDENGKNEAGAKSD
FDFADGLLSQEGAHDQIISSIDTKLLLKKPSSSSEVVLIQHEVAASSALIETEESKKELA
PPFKLSIFVDELNTFEKTLIQDLPLYNGINEERPKKDDSLPFIPISKSVVSLDDNGFYKL
LERQLIDEEPSISQLSKRRGMFYGNRRNHYLRPPAVPSLRYLQNRTPTIWLSEDDQELVK
NINTYGYNWELISAHMTHRLTYSYLSNIERRTPWQCFERFVQLNERFNFSDLKGPRAHSA
QQWLIEAHKFQQRQNRRISPLGVNTESIQRGHRRLRWASMFEAIRKCMKKRENTPRPNPT
QPRKPLDCKNMKVPTPAEMSLLKAQRDEALRRDIQLRRTVKNRLQQRQQQSQQAHSSRAQ
SPIPSNGKSSSNLARNGQASAPRPNQKQYTEQDIIESYSRKLLEQKPDIGPEMALKAAKN
YYRTLREQQQQLKQHQIQQQRQQLQEESSHVQQLQQLQPGSQAPPPKSSPSQSSLSNISN
INSAPRIKSPTPQEILQRFQKQ
Sequence of entity 6 (S), FASTA
>8ESC_6 SWR1-complex protein 4 (chains S)
MSSSDIFDVLNIKQKSRSPTNGQVSVPSSSAANRPKPQVTGMQRELFNLLGENQPPVVIK
SGNNFKEKMLSTSKPSPWSFVEFKANNSVTLRHWVKGSKELIGDTPKESPYSKFNQHLSI
PSFTKEEYEAFMNENEGTQKSVESEKNHNENFTNEKKDESKNSWSFEEIEYLFNLCKKYD
LRWFLIFDRYSYNNSRTLEDLKEKFYYTCRNYFKASDPSNPLLSSLNFSAEKEIERKKYL
QRLLSRSAAEIAEEEALVVESKKFEMAAKRTLAERESLLRLLDSPHSDQTITQYLTSQGM
SQLYNALLADKTRKRKHDLNIPENPWMKQQQQFAQHRQLQQLNVKKSEVKENLSPKKTKR
QRQEMQTALKRKSESAYAEQLLKDFNSDERKALGVITHGEKLSPGVYLRSTKLSTFKPAL
QNKILAILQELSLPSRPVMPSFDVMERQEELLKKINTLIDLKKHVDKYEAGMSITK
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 1 |
| MG | Magnesium ion | Mg | 2 |
Primary citation
Structure and flexibility of the yeast NuA4 histone acetyltransferase complex. Zukin, S.A., Marunde, M.R., Popova, I.K. et al. Elife (2022) 11. DOI 10.7554/eLife.81400 · PubMed
Other PDB entries of the same protein (UniProt P38811), best resolution first:
- 7VVY 3.1 Å, TRA module of NuA4
- 6T9J 3.4 Å, SAGA Tra1 module
- 5OJS 3.7 Å, Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1
- 7YFN 3.8 Å, Core module of the NuA4 complex in S. cerevisiae
- 6T9I 3.9 Å, cryo-EM structure of transcription coactivator SAGA
- 7YFP 4.0 Å, The NuA4 histone acetyltransferase complex from S. cerevisiae
- 6IG9 4.6 Å, Tra1 subunit from Saccharomyces cerevisiae SAGA complex
- 5Y81 4.7 Å, NuA4 TEEAA sub-complex
- 7VVZ 8.8 Å, NuA4 bound to the nucleosome
Browse structure collections
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