8GCN: Importin ALPHA1/BETA heterodimer

cryo-EM structure of importin ALPHA1/BETA heterodimer. Determined by electron microscopy at 3.95 Å resolution. Released 6 Mar 2024.

Method
Electron microscopy
Resolution
3.95 Å
Organism
Homo sapiens
Chains
2
Atoms
7,173
Mol. weight
102.55 kDa
Released
6 Mar 2024

Explore 8GCN in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8GCN contains 56 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 54 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix3-97
α-helix15-3117
α-helix33-4513
α-helix51-6515
α-helix70-8112
α-helix85-9814
α-helix108-12316
α-helix129-13810
α-helix144-16017
α-helix163-1664
α-helix170-18011
α-helix188-20114
α-helix202-2043
α-helix206-2094
α-helix212-22514
α-helix231-24717
α-helix252-2543
α-helix256-2605
α-helix261-2699
α-helix273-30331
α-helix306-3072
α-helix314-32916
α-helix344-35916
α-helix364-37411
α-helix380-39213
α-helix399-41719
α-helix422-43817
α-helix440-4434
α-helix446-45914
α-helix464-48522
α-helix499-5024
α-helix503-51412
α-helix517-5237
α-helix525-53713
α-helix541-5433
α-helix544-56118
α-helix571-59222
α-helix597-61721
α-helix622-63918
α-helix640-64910
α-helix651-6588
α-helix664-68118
α-helix682-6854
α-helix686-70116
α-helix710-72415
α-helix725-7284
α-helix729-74416
α-helix752-77726
α-helix785-7939
α-helix794-80613
α-helix812-82817
α-helix831-8388
α-helix842-85211
α-helix856-87318
Chain B: 2 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix14-163
α-helix24-5128

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Importin subunit beta-1Aprotein876Homo sapiensQ14974 (AlphaFold model)
Importin subunit alpha-1Bprotein43Homo sapiensP52292 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>8GCN_1 Importin subunit beta-1 (chains A)
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ
IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE
IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQG
MRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN
LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA
AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE
DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDP
SVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA
AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSA
KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA
LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKN
YAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI
ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQ
ENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEAR
PMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA
Sequence of entity 2 (B), FASTA
>8GCN_2 Importin subunit alpha-1 (chains B)
AARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNV

Primary citation

Structural basis for nuclear import of hepatitis B virus (HBV) nucleocapsid core. Yang, R., Ko, Y.H., Li, F. et al. Sci Adv (2024) 10:eadi7606-eadi7606. DOI 10.1126/sciadv.adi7606 · PubMed

Other PDB entries of the same protein (UniProt Q14974 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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