8H6K: Pre-mRNA-processing-splicing factor 8
Cryo-EM structure of human exon-defined spliceosome in the mature B state. Determined by electron microscopy at 2.7 Å resolution. Released 1 May 2024.
- Method
- Electron microscopy
- Resolution
- 2.7 Å
- Organism
- Homo sapiens
- Chains
- 63
- Atoms
- 98,459
- Mol. weight
- 2629.83 kDa
- Ligands
- IHP, GTP, MG, ZN
- Released
- 1 May 2024
Explore 8H6K in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8H6K contains 628 α-helices and 648 β-strands across 58 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains 2a and 5a: 3 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-10 | 4 | |
| β-strand | 16-21 | 6 | 73 |
| β-strand | 26-33 | 8 | 73 |
| β-strand | 40-48 | 9 | 73 |
| β-strand | 64-72 | 9 | 73 |
| α-helix | 74-76 | 3 | |
| β-strand | 77-84 | 8 | 73 |
| α-helix | 85-87 | 3 | |
Chains 2b and 5b: 4 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-8 | 6 | |
| β-strand | 14-19 | 6 | 73 |
| β-strand | 24-32 | 9 | 73 |
| β-strand | 38-46 | 9 | 73 |
| β-strand | 53-60 | 8 | 73 |
| α-helix | 62-64 | 3 | |
| β-strand | 65-69 | 5 | 73 |
| α-helix | 70-71 | 2 | |
| α-helix | 76-79 | 4 | |
Chain 2B: 8 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-10 | 5 | |
| β-strand | 14-16 | 3 | 97 |
| β-strand | 22-25 | 4 | 97 |
| α-helix | 37-40 | 4 | |
| β-strand | 46-48 | 3 | 97 |
| β-strand | 56-57 | 2 | 98 |
| β-strand | 68-70 | 3 | 97 |
| β-strand | 78-79 | 2 | 98 |
| α-helix | 83-86 | 4 | |
| β-strand | 92-94 | 3 | 97 |
| α-helix | 103-111 | 9 | |
| β-strand | 117-119 | 3 | 97 |
| α-helix | 124-127 | 4 | |
| α-helix | 131-138 | 8 | |
| β-strand | 144-145 | 2 | 97 |
| β-strand | 148-149 | 2 | 97 |
| α-helix | 150-151 | 2 | |
| α-helix | 152-160 | 9 | |
Chain 2c: 3 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 21-26 | 6 | |
| α-helix | 30-38 | 9 | |
| β-strand | 41-46 | 6 | 73 |
| β-strand | 51-59 | 9 | 73 |
| β-strand | 65-75 | 11 | 73 |
| β-strand | 91-101 | 11 | 73 |
| α-helix | 103-105 | 3 | |
| β-strand | 106-111 | 6 | 73 |
Chain 2C: 3 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-12 | 5 | 99 |
| α-helix | 20-32 | 13 | |
| β-strand | 37-41 | 5 | 99 |
| β-strand | 52-56 | 5 | 99 |
| α-helix | 59-68 | 10 | |
| β-strand | 73-74 | 2 | 100 |
| β-strand | 77-78 | 2 | 100 |
| β-strand | 80-83 | 4 | 99 |
| α-helix | 89-95 | 7 | |
Chains 2d and 5d: 2 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-14 | 8 | |
| β-strand | 18-23 | 6 | 73 |
| β-strand | 28-36 | 9 | 73 |
| β-strand | 42-51 | 10 | 73 |
| β-strand | 54-64 | 11 | 73 |
| α-helix | 66-68 | 3 | |
| β-strand | 69-74 | 6 | 73 |
Chain 2D: 9 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 161-174 | 14 | |
| α-helix | 179-189 | 11 | |
| α-helix | 192-198 | 7 | |
| α-helix | 205-218 | 14 | |
| α-helix | 241-272 | 32 | |
| β-strand | 281-284 | 4 | 101 |
| β-strand | 412 | 1 | 102 |
| β-strand | 419 | 1 | 102 |
| α-helix | 422-431 | 10 | |
| α-helix | 437-450 | 14 | |
| α-helix | 457-458 | 2 | |
| α-helix | 459-471 | 13 | |
Chains 2e and 5e: 2 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 17-27 | 11 | |
| β-strand | 30-35 | 6 | 73 |
| β-strand | 38-50 | 13 | 73 |
| β-strand | 56-65 | 10 | 73 |
| β-strand | 70-79 | 10 | 73 |
| α-helix | 81-83 | 3 | |
| β-strand | 84-90 | 7 | 73 |
45 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| pre-mRNA | A | RNA | 144 | Homo sapiens | |
| U5 snRNA | 5A | RNA | 117 | Homo sapiens | |
| Pre-mRNA-processing-splicing factor 8 | 5B | protein | 2335 | Homo sapiens | Q6P2Q9 (AlphaFold model) |
| 116 kDa U5 small nuclear ribonucleoprotein component | 5C | protein | 972 | Homo sapiens | Q15029 (AlphaFold model) |
| U5 small nuclear ribonucleoprotein 200 kDa helicase | 5D | protein | 2136 | Homo sapiens | O75643 (AlphaFold model) |
| U5 small nuclear ribonucleoprotein 40 kDa protein | 5E | protein | 357 | Homo sapiens | Q96DI7 (AlphaFold model) |
| Isoform SM-B of Small nuclear ribonucleoprotein-associated proteins B and B' | 2a, 4a, 5a | protein | 231 | Homo sapiens | P14678 |
| Small nuclear ribonucleoprotein Sm D1 | 2b, 4b, 5b | protein | 119 | Homo sapiens | P62314 |
| Small nuclear ribonucleoprotein Sm D2 | 2c, 4c, 5c | protein | 118 | Homo sapiens | P62316 |
| Small nuclear ribonucleoprotein F | 2d, 4d, 5d | protein | 86 | Homo sapiens | P62306 |
| Small nuclear ribonucleoprotein E | 2e, 4e, 5e | protein | 92 | Homo sapiens | P62304 |
| Small nuclear ribonucleoprotein G | 2f, 4f, 5f | protein | 76 | Homo sapiens | P62308 |
37 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>8H6K_1 pre-mRNA (chains A)
GGGAGGUUUCCUUGAAGCUUUCGUGCUGACCCUGUCCCUUUUUUUUCCACAGGGGCGAAU
UCGAGCUCACUCUCUUCCGCAUCGCUGUCUGCGAGGUACCCUACCAGGUGAGUAUGGAUC
CCUCUAAAAGCGGGCAUGACUUCU
Sequence of entity 2 (5A), FASTA
>8H6K_2 U5 snRNA (chains 5A)
AUACUCUGGUUUCUCUUCAGAUCGCAUAAAUCUUUCGCCUUUUACUAAAGAUUUCCGUGG
AGAGGAACAACUCUGAGUCUUAACCCAAUUUUUUGAGGCCUUGCUUUGGCAAGGCUA
Sequence of entity 3 (5B), FASTA
>8H6K_3 Pre-mRNA-processing-splicing factor 8 (chains 5B)
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKED
MPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLY
HITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYR
LANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDIN
KIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRR
ALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATK
FFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMR
QIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQF
EGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCW
KANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLT
RLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLI
LALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMD
LYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGIN
NLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYK
DMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATE
AAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARM
RLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKC
RTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIV
NKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPK
ELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFI
DSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRT
DFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEG
LFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGI
FMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSY
KMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYA
RAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPAL
YVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTT
KPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQ
IIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLY
DDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVE
VQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLT
ATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKET
GYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLP
GQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTP
GSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWN
YNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA
Sequence of entity 4 (5C), FASTA
>8H6K_4 116 kDa U5 small nuclear ribonucleoprotein component (chains 5C)
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLH
EDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLA
DLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTE
RLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLIL
SPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKA
PTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVC
KKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTK
MYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIE
VNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSEL
PKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVV
TFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQT
KYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLC
DELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPA
DCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSV
FHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLE
LAKQDVVLNYPM
Sequence of entity 5 (5D), FASTA
>8H6K_5 U5 small nuclear ribonucleoprotein 200 kDa helicase (chains 5D)
MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTK
PQMQEERRAKRRKRDEDRHDINKMKGYTLLSEGIDEMVGIIYKPKTKETRETYEVLLSFI
QAALGDQPRDILCGAADEVLAVLKNEKLRDKERRKEIDLLLGQTDDTRYHVLVNLGKKIT
DYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYGEVREEASDDDMEGDEAVVRCTL
SANLVASGELMSSKKKDLHPRDIDAFWLQRQLSRFYDDAIVSQKKADEVLEILKTASDDR
ECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLLASAQSEAEKERIMGKMEADPELSKFL
YQLHETEKEDLIREERSRRERVRQSRMDTDLETMDLDQGGEALAPRQVLDLEDLVFTQGS
HFMANKRCQLPDGSFRRQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKT
LNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIY
IAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKG
GERTYTQLVRLIILDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYED
VATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQ
VLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPY
GFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGR
WTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDM
LNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTA
ALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSL
SSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMAD
MVYVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVV
KKIEKKNFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKV
ELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFE
PLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESL
YQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVYIT
PMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWK
QRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDV
AHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSPKKPVI
VFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYL
HEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVDYP
IYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEI
VTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSK
CISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPI
RHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAI
RLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHIKRCTDKGVE
SVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQ
LEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATG
AHNYTLYFMSDAYMGCDQEYKFSVDVKEAETDSDSD
Sequence of entity 6 (5E), FASTA
>8H6K_6 U5 small nuclear ribonucleoprotein 40 kDa protein (chains 5E)
MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIM
LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD
GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD
IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG
LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI
AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ
Sequence of entity 7 (2a, 4a, 5a), FASTA
>8H6K_7 Isoform SM-B of Small nuclear ribonucleoprotein-associated proteins B and B' (chains 2a, 4a, 5a)
MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCDCDEFRKIKPKNSKQAE
REEKRVLGLVLLRGENLVSMTVEGPPPKDTGIARVPLAGAAGGPGIGRAAGRGIPAGVPM
PQAPAGLAGPVRGVGGPSQQVMTPQGRGTVAAAAAAATASIAGAPTQYPPGRGGPPPPMG
RGAPPPGMMGPPPGMRPPMGPPMGIPPGRGTPMGMPPPGMRPPPPGMRGLL
Sequence of entity 8 (2b, 4b, 5b), FASTA
>8H6K_8 Small nuclear ribonucleoprotein Sm D1 (chains 2b, 4b, 5b)
MKLVRFLMKLSHETVTIELKNGTQVHGTITGVDVSMNTHLKAVKMTLKNREPVQLETLSI
RGNNIRYFILPDSLPLDTLLVDVEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR
Sequence of entity 9 (2c, 4c, 5c), FASTA
>8H6K_9 Small nuclear ribonucleoprotein Sm D2 (chains 2c, 4c, 5c)
MSLLNKPKSEMTPEELQKREEEEFNTGPLSVLTQSVKNNTQVLINCRNNKKLLGRVKAFD
RHCNMVLENVKEMWTEVPKSGKGKKKSKPVNKDRYISKMFLRGDSVIVVLRNPLIAGK
Sequence of entity 10 (2d, 4d, 5d), FASTA
>8H6K_10 Small nuclear ribonucleoprotein F (chains 2d, 4d, 5d)
MSLPLNPKPFLNGLTGKPVMVKLKWGMEYKGYLVSVDGYMNMQLANTEEYIDGALSGHLG
EVLIRCNNVLYIRGVEEEEEDGEMRE
Sequence of entity 11 (2e, 4e, 5e), FASTA
>8H6K_11 Small nuclear ribonucleoprotein E (chains 2e, 4e, 5e)
MAYRGQGQKVQKVMVQPINLIFRYLQNRSRIQVWLYEQVNMRIEGCIIGFDEYMNLVLDD
AEEIHSKTKSRKQLGRIMLKGDNITLLQSVSN
Sequence of entity 12 (2f, 4f, 5f), FASTA
>8H6K_12 Small nuclear ribonucleoprotein G (chains 2f, 4f, 5f)
MSKAHPPELKKFMDKKLSLKLNGGRHVQGILRGFDPFMNLVIDECVEMATSGQQNNIGMV
VIRGNSIIMLEALERV
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| IHP | Inositol hexakisphosphate | C6 H18 O24 P6 | 1 |
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 1 |
| MG | Magnesium ion | Mg | 1 |
| ZN | Zinc ion | Zn | 2 |
Primary citation
Structural insights into human exon-defined spliceosome prior to activation. Zhang, W., Zhang, X., Zhan, X. et al. Cell Res (2024) 34:428-439. DOI 10.1038/s41422-024-00949-w · PubMed
Other PDB entries of the same protein (UniProt Q6P2Q9 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4JK8 1.15 Å, Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Mg ion
- 4JKB 1.3 Å, Open and closed forms of V1788D human PRP8 RNase H-like domain with bound Mg ion
- 4JKA 1.32 Å, Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Co ion
- 4JK7 1.4 Å, Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Mg ion
- 4JK9 1.5 Å, Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Co ion
- 4JKC 1.5 Å, Open and closed forms of T1800E human PRP8 RNase H-like domain with bound Mg ion
- 4JKD 1.55 Å, Open and closed forms of I1790Y human PRP8 RNase H-like domain with bound Mg ion
- 4JKE 1.65 Å, Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion
- 4JKG 1.8 Å, Open and closed forms of mixed T1789P+R1865A and R1865A human PRP8 RNase H-like domain…
- 4JKH 1.8 Å, Open and closed forms of D1781E human PRP8 RNase H-like domain with bound Mg ion
- 3ENB 1.85 Å, Crystal Structure of PRP8 core domain IV
- 3LRU 1.85 Å, hPRP8 Non-Native Subdomain
Browse structure collections
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