8H7G: Human SAGA complex

Name: PDB 8H7G: Cryo-EM structure of the human SAGA complex
Published: 2022-12-14
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

Cryo-EM structure of the human SAGA complex. Determined by electron microscopy at 3.7 Å resolution. Released 14 Dec 2022.

Method: Electron microscopy
Resolution: 3.7 Å
Organism: Homo sapiens
Chains: 14
Atoms: 52,609
Mol. weight: 1098.28 kDa
Released: 14 Dec 2022

Explore 8H7G in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8H7G contains 314 α-helices and 185 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 17 helices, 110 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	8
β-strand	16-20	5	9
β-strand	29-33	5	9
β-strand	37-42	6	9
β-strand	51-57	7	9
β-strand	62-68	7	10
β-strand	77-82	6	10
β-strand	86-93	8	10
β-strand	98-106	9	10
β-strand	120-123	4	11
β-strand	129-133	5	11
β-strand	136	1	12
β-strand	139-143	5	11
β-strand	144-146	3	13
β-strand	152-154	3	13
α-helix	156-157	2
β-strand	158-159	2	11
β-strand	165-173	9	12
β-strand	181-188	8	12
β-strand	207-214	8	12
β-strand	219-227	9	12
β-strand	232-237	6	14
β-strand	248-252	5	14
β-strand	255-259	5	14
β-strand	267-270	4	14
β-strand	273-274	2	15
β-strand	287-293	7	16
β-strand	300-305	6	16
β-strand	309-311	3	17
β-strand	312-313	2	16
β-strand	314-317	4	18
β-strand	322-327	6	18
β-strand	329-332	4	17
β-strand	336-342	7	19
β-strand	346-351	6	19
β-strand	357-360	4	19
α-helix	371-372	2
β-strand	373-374	2	18
β-strand	386-387	2	15
β-strand	397-400	4	19
α-helix	403-406	4
β-strand	407-413	7	20
α-helix	421	1
β-strand	422-427	6	20
α-helix	430-432	3
β-strand	434-439	6	20
β-strand	445-450	6	21
β-strand	458-463	6	22
β-strand	471-477	7	22
β-strand	482-485	4	22
β-strand	493	1	22
β-strand	508-509	2	23
β-strand	516-520	5	23
β-strand	523-527	5	23
β-strand	533-537	5	23
α-helix	538	1
β-strand	544-549	6	24
β-strand	553-558	6	24
β-strand	562-568	7	24
β-strand	574-576	3	24
β-strand	582	1	24
β-strand	587-591	5	25
α-helix	593-596	4
β-strand	606-609	4	25
β-strand	613-614	2	26
β-strand	615-616	2	25
β-strand	617	1	27
α-helix	621-623	3
β-strand	627	1	27
β-strand	631-632	2	26
β-strand	637-644	8	28
β-strand	663-669	7	28
β-strand	675-678	4	28
β-strand	687	1	28
β-strand	702-706	5	29
β-strand	709-714	6	29
β-strand	719-722	4	29
β-strand	724	1	30
β-strand	729	1	30
β-strand	732-734	3	29
β-strand	741-745	5	21
β-strand	753-758	6	21
β-strand	761-766	6	21
β-strand	775-777	3	20
β-strand	785-790	6	31
β-strand	797-801	5	31
α-helix	809-826	18
α-helix	839-844	6
α-helix	849-852	4
β-strand	865-869	5	31
β-strand	876-881	6	31
β-strand	886-887	2	32
β-strand	891-894	4	32
β-strand	904-911	8	32
β-strand	922-928	7	32
β-strand	931	1	33
β-strand	936	1	33
β-strand	939-941	3	32
β-strand	944-945	2	32
β-strand	949-952	4	34
β-strand	955	1	35
β-strand	958	1	35
β-strand	959-963	5	34
β-strand	966-971	6	34
α-helix	977	1
β-strand	978-983	6	34
β-strand	990-995	6	36
β-strand	1000-1004	5	36
β-strand	1010-1014	5	36
β-strand	1021-1025	5	36
β-strand	1026-1027	2	37
β-strand	1036-1038	3	38
β-strand	1043-1046	4	38
β-strand	1052-1057	6	38
β-strand	1088-1089	2	37
β-strand	1090-1096	7	38
β-strand	1101	1	39
β-strand	1105-1108	4	8
β-strand	1115-1120	6	8
β-strand	1121	1	39
β-strand	1126-1129	4	8
α-helix	1135-1151	17
α-helix	1160-1164	5
β-strand	1173-1175	3	8
α-helix	1179-1184	6
α-helix	1187-1196	10
α-helix	1201-1215	15

Chain B: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	32-39	8
α-helix	40-42	3
α-helix	47-56	10
α-helix	61-70	10

Chain C: 201 helices, 19 β-strands

Element	Residues	Length	Sheet
α-helix	25-27	3
α-helix	28-32	5
α-helix	39-44	6
α-helix	66-74	9
α-helix	87-97	11
α-helix	107-110	4
α-helix	113-115	3
α-helix	131-142	12
α-helix	157-163	7
α-helix	165-171	7
α-helix	230-236	7
α-helix	243-249	7
α-helix	280-291	12
α-helix	310-318	9
α-helix	328-338	11
α-helix	348-350	3
α-helix	372-386	15
α-helix	392-405	14
α-helix	414-436	23
α-helix	442-461	20
α-helix	463-466	4
α-helix	543-565	23
α-helix	580-582	3
α-helix	583-599	17
α-helix	602-605	4
α-helix	627-636	10
α-helix	644-653	10
α-helix	655-664	10
α-helix	668-673	6
α-helix	674-676	3
α-helix	682-695	14
α-helix	697-699	3
α-helix	705-723	19
α-helix	729-732	4
α-helix	736-746	11
β-strand	749-750	2	1
α-helix	754-767	14
α-helix	776-779	4
α-helix	780-782	3
α-helix	783-793	11
α-helix	801-810	10
α-helix	821-827	7
α-helix	829-834	6
α-helix	839-854	16
α-helix	858-865	8
α-helix	866-868	3
α-helix	869-878	10
α-helix	888-897	10
α-helix	905-906	2
α-helix	909-911	3
β-strand	923-927	5	2
β-strand	934-938	5	2
α-helix	940-950	11
α-helix	957-974	18
α-helix	983-988	6
α-helix	997-999	3
α-helix	1013-1028	16
α-helix	1039-1054	16
α-helix	1064-1066	3
α-helix	1074-1076	3
α-helix	1091-1100	10
α-helix	1108-1124	17
α-helix	1129-1133	5
α-helix	1137-1146	10
α-helix	1147-1149	3
α-helix	1155-1170	16
α-helix	1173-1178	6
α-helix	1180-1193	14
β-strand	1199-1200	2	1
α-helix	1203-1217	15
α-helix	1228-1245	18
α-helix	1254-1270	17
α-helix	1283-1286	4
α-helix	1302-1315	14
α-helix	1332-1340	9
α-helix	1363-1375	13
α-helix	1384-1394	11
α-helix	1399-1412	14
α-helix	1420-1426	7
α-helix	1428-1432	5
α-helix	1442-1451	10
α-helix	1461-1481	21
α-helix	1510-1523	14
α-helix	1529-1531	3
α-helix	1532-1546	15
α-helix	1556-1562	7
α-helix	1566-1573	8
α-helix	1576-1579	4
α-helix	1582-1592	11
α-helix	1598-1605	8
α-helix	1608-1615	8
α-helix	1636-1651	16
α-helix	1662-1673	12
α-helix	1674-1676	3
α-helix	1692-1703	12
α-helix	1733-1739	7
α-helix	1753-1754	2
α-helix	1755-1759	5
α-helix	1767-1783	17
α-helix	1807-1814	8
α-helix	1828-1841	14
α-helix	1858-1864	7
α-helix	1877-1890	14
α-helix	1900-1903	4
α-helix	1905-1908	4
α-helix	1917-1924	8
α-helix	1942-1951	10
α-helix	1962-1964	3
α-helix	1966-1970	5
α-helix	1982-1992	11
α-helix	2006-2019	14
α-helix	2093-2105	13
α-helix	2123-2131	9
α-helix	2144-2147	4
α-helix	2163-2179	17
α-helix	2191-2196	6
α-helix	2210-2219	10
α-helix	2238-2251	14
α-helix	2266-2281	16
α-helix	2290-2304	15
α-helix	2317-2331	15
α-helix	2343-2347	5
α-helix	2348-2356	9
α-helix	2363-2375	13
α-helix	2389-2398	10
α-helix	2413-2426	14
α-helix	2440-2445	6
α-helix	2452-2463	12
α-helix	2470-2475	6
α-helix	2476-2480	5
α-helix	2492-2500	9
β-strand	2508	1	3
β-strand	2510	1	2
α-helix	2517-2519	3
α-helix	2523-2526	4
α-helix	2587-2602	16
β-strand	2606	1	3
α-helix	2608-2620	13
α-helix	2622-2639	18
α-helix	2645-2656	12
α-helix	2663-2665	3
α-helix	2673-2678	6
α-helix	2691-2699	9
α-helix	2703-2713	11
α-helix	2739	1
α-helix	2743-2754	12
α-helix	2758-2768	11
α-helix	2774-2782	9
α-helix	2786-2806	21
α-helix	2815-2829	15
α-helix	2834-2840	7
α-helix	2849-2855	7
α-helix	2856-2858	3
α-helix	2863-2867	5
α-helix	2870-2874	5
α-helix	2881-2893	13
α-helix	2904-2919	16
α-helix	2928-2930	3
α-helix	2931-2952	22
α-helix	2955-2957	3
α-helix	2961-2963	3
α-helix	2965-2976	12
α-helix	2985-2999	15
α-helix	3002-3006	5
α-helix	3029-3050	22
α-helix	3055-3061	7
α-helix	3062-3066	5
α-helix	3072-3088	17
α-helix	3098-3103	6
α-helix	3120-3130	11
α-helix	3138-3146	9
α-helix	3153-3166	14
α-helix	3173-3175	3
α-helix	3176-3186	11
α-helix	3196-3206	11
α-helix	3214-3222	9
α-helix	3228-3231	4
α-helix	3235-3243	9
α-helix	3248-3250	3
α-helix	3251-3260	10
α-helix	3267-3282	16
α-helix	3295-3308	14
α-helix	3312-3323	12
α-helix	3326-3328	3
α-helix	3332-3353	22
α-helix	3362-3364	3
α-helix	3365-3378	14
α-helix	3420-3424	5
α-helix	3435-3451	17
α-helix	3452-3454	3
α-helix	3478	1
β-strand	3479	1	4
α-helix	3480	1
β-strand	3495	1	4
β-strand	3498-3505	8	5
β-strand	3514-3519	6	5
β-strand	3525-3531	7	5
α-helix	3536-3539	4
α-helix	3541-3552	12
α-helix	3553-3556	4
α-helix	3561-3564	4
β-strand	3574-3576	3	5
β-strand	3582-3585	4	5
β-strand	3590-3592	3	6
α-helix	3593-3603	11
α-helix	3610-3623	14
α-helix	3631-3644	14
α-helix	3650-3658	9
α-helix	3662-3685	24
β-strand	3688	1	7
β-strand	3696-3699	4	6
β-strand	3705-3707	3	6
β-strand	3712	1	7
α-helix	3733-3739	7
α-helix	3746-3760	15
α-helix	3767-3784	18
α-helix	3805-3823	19
α-helix	3835-3842	8
α-helix	3845-3848	4
α-helix	3853-3855	3

Chain D: 14 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	3-21	19
α-helix	37-47	11
α-helix	63	1
α-helix	64-68	5
α-helix	69-71	3
β-strand	76-81	6	40
β-strand	86-89	4	40
β-strand	104	1	40
α-helix	122-130	9
β-strand	137	1	41
β-strand	140	1	41
β-strand	141-147	7	40
β-strand	163-166	4	40
α-helix	170-181	12
α-helix	189-202	14
α-helix	214-224	11
α-helix	233-237	5
α-helix	245-247	3
α-helix	255-258	4
α-helix	264-272	9
β-strand	335-338	4	42
β-strand	351-356	6	42
β-strand	363-368	6	42
β-strand	394-396	3	42
α-helix	399-415	17
β-strand	424-427	4	42

Chain E: 11 helices, 0 β-strands

Element	Residues	Length
α-helix	27-33	7
α-helix	34-36	3
α-helix	46-73	28
α-helix	82-86	5
α-helix	92-102	11
α-helix	111-123	13
α-helix	163-174	12
α-helix	181-187	7
α-helix	198-203	6
α-helix	217-244	28
α-helix	283-294	12

Chain G: 11 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	109-111	3
α-helix	115-117	3
β-strand	123	1	43
α-helix	148-162	15
α-helix	170-192	23
β-strand	199-200	2	44
β-strand	204-205	2	44
α-helix	214-215	2
α-helix	219-227	9
α-helix	252-261	10
α-helix	270-274	5
β-strand	275	1	45
α-helix	277-287	11
α-helix	294-306	13
α-helix	313-326	14

Chain H: 13 helices, 33 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
α-helix	39-49	11
α-helix	70-81	12
α-helix	93-95	3
α-helix	96-110	15
α-helix	115-122	8
α-helix	134-142	9
α-helix	146-151	6
α-helix	155-159	5
β-strand	163-168	6	46
α-helix	169-178	10
α-helix	185-193	9
β-strand	195-200	6	46
α-helix	238-246	9
β-strand	259-264	6	47
β-strand	273-276	4	48
β-strand	282-286	5	48
β-strand	292-296	5	48
α-helix	304-306	3
β-strand	337-338	2	48
β-strand	345	1	49
β-strand	349	1	50
β-strand	356-357	2	51
β-strand	358	1	50
β-strand	360	1	51
β-strand	361	1	49
β-strand	365-370	6	51
β-strand	376-381	6	51
β-strand	387-392	6	52
β-strand	399-403	5	52
β-strand	408-410	3	52
β-strand	420-422	3	52
β-strand	429-434	6	53
β-strand	440-445	6	53
β-strand	449-454	6	53
β-strand	462-465	4	53
β-strand	471-476	6	54
β-strand	482-487	6	54
β-strand	492-496	5	54
β-strand	502-506	5	54
β-strand	513-518	6	55
β-strand	524-529	6	55
β-strand	533-538	6	55
β-strand	555-560	6	55
β-strand	565-570	6	47
β-strand	577-582	6	47

Chain I: 8 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	62-84	23
α-helix	144-148	5
α-helix	151-169	19
β-strand	173-174	2	56
α-helix	176-204	29
α-helix	215-223	9
α-helix	229-235	7
α-helix	236-240	5
α-helix	241-260	20

6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Transformation/transcription domain-associated protein	C	protein	3859	Homo sapiens	Q9Y4A5
Splicing factor 3B subunit 3	A	protein	1217	Homo sapiens	Q15393 (AlphaFold model)
Splicing factor 3B subunit 5	B	protein	86	Homo sapiens	Q9BWJ5 (AlphaFold model)
Transcription factor SPT20 homolog	D	protein	779	Homo sapiens	Q8NEM7 (AlphaFold model)
Transcription initiation protein SPT3 homolog	E	protein	317	Homo sapiens	O75486
Transcriptional adapter 1	G	protein	374	Homo sapiens	Q96BN2
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L	H	protein	589	Homo sapiens	O75529
STAGA complex 65 subunit gamma	I	protein	455	Homo sapiens	O94864
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L	K	protein	622	Homo sapiens	Q9Y6J9
Transcription initiation factor TFIID subunit 9	M	protein	264	Homo sapiens	Q16594
Transcription initiation factor TFIID subunit 10	O	protein	218	Homo sapiens	Q12962
Transcription initiation factor TFIID subunit 12	R	protein	161	Homo sapiens	Q16514

2 more molecules are not listed.

Sequence of entity 1 (C), FASTA

>8H7G_1 Transformation/transcription domain-associated protein (chains C)
MAFVATQGATVVDQTTLMKKYLQFVAALTDVNTPDETKLKMMQEVSENFENVTSSPQYST
FLEHIIPRFLTFLQDGEVQFLQEKPAQQLRKLVLEIIHRIPTNEHLRPHTKNVLSVMFRF
LETENEENVLICLRIIIELHKQFRPPITQEIHHFLDFVKQIYKELPKVVNRYFENPQVIP
ENTVPPPEMVGMITTIAVKVNPEREDSETRTHSIIPRGSLSLKVLAELPIIVVLMYQLYK
LNIHNVVAEFVPLIMNTIAIQVSAQARQHKLYNKELYADFIAAQIKTLSFLAYIIRIYQE
LVTKYSQQMVKGMLQLLSNCPAETAHLRKELLIAAKHILTTELRNQFIPCMDKLFDESIL
IGSGYTARETLRPLAYSTLADLVHHVRQHLPLSDLSLAVQLFAKNIDDESLPSSIQTMSC
KLLLNLVDCIRSKSEQESGNGRDVLMRMLEVFVLKFHTIARYQLSAIFKKCKPQSELGAV
EAALPGVPTAPAAPGPAPSPAPVPAPPPPPPPPPPATPVTPAPVPPFEKQGEKDKEDKQT
FQVTDCRSLVKTLVCGVKTITWGITSCKAPGEAQFIPNKQLQPKETQIYIKLVKYAMQAL
DIYQVQIAGNGQTYIRVANCQTVRMKEEKEVLEHFAGVFTMMNPLTFKEIFQTTVPYMVE
RISKNYALQIVANSFLANPTTSALFATILVEYLLDRLPEMGSNVELSNLYLKLFKLVFGS
VSLFAAENEQMLKPHLHKIVNSSMELAQTAKEPYNYFLLLRALFRSIGGGSHDLLYQEFL
PLLPNLLQGLNMLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSQT
LVSQGLRTLELCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPADSISHVAYRVLGKFGG
SNRKMLKESQKLHYVVTEVQGPSITVEFSDCKASLQLPMEKAIETALDCLKSANTEPYYR
RQAWEVIKCFLVAMMSLEDNKHALYQLLAHPNFTEKTIPNVIISHRYKAQDTPARKTFEQ
ALTGAFMSAVIKDLRPSALPFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMFHSE
ENGSKGMDPLVLIDAIAICMAYEEKELCKIGEVALAVIFDVASIILGSKERACQLPLFSY
IVERLCACCYEQAWYAKLGGVVSIKFLMERLPLTWVLQNQQTFLKALLFVMMDLTGEVSN
GAVAMAKTTLEQLLMRCATPLKDEERAEEIVAAQEKSFHHVTHDLVREVTSPNSTVRKQA
MHSLQVLAQVTGKSVTVIMEPHKEVLQDMVPPKKHLLRHQPANAQIGLMEGNTFCTTLQP
RLFTMDLNVVEHKVFYTELLNLCEAEDSALTKLPCYKSLPSLVPLRIAALNALAACNYLP
QSREKIIAALFKALNSTNSELQEAGEACMRKFLEGATIEVDQIHTHMRPLLMMLGDYRSL
TLNVVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVITHKGGQRSDGNESISECGRC
PLSPFCQFEEMKICSAIINLFHLIPAAPQTLVKPLLEVVMKTERAMLIEAGSPFREPLIK
FLTRHPSQTVELFMMEATLNDPQWSRMFMSFLKHKDARPLRDVLAANPNRFITLLLPGGA
QTAVRPGSPSTSTMRLDLQFQAIKIISIIVKNDDSWLASQHSLVSQLRRVWVSENFQERH
RKENMAATNWKEPKLLAYCLLNYCKRNYGDIELLFQLLRAFTGRFLCNMTFLKEYMEEEI
PKNYSIAQKRALFFRFVDFNDPNFGDELKAKVLQHILNPAFLYSFEKGEGEQLLGPPNPE
GDNPESITSVFITKVLDPEKQADMLDSLRIYLLQYATLLVEHAPHHIHDNNKNRNSKLRR
LMTFAWPCLLSKACVDPACKYSGHLLLAHIIAKFAIHKKIVLQVFHSLLKAHAMEARAIV
RQAMAILTPAVPARMEDGHQMLTHWTRKIIVEEGHTVPQLVHILHLIVQHFKVYYPVRHH
LVQHMVSAMQRLGFTPSVTIEQRRLAVDLSEVVIKWELQRIKDQQPDSDMDPNSSGEGVN
SVSSSIKRGLSVDSAQEVKRFRTATGAISAVFGRSQSLPGADSLLAKPIDKQHTDTVVNF
LIRVACQVNDNTNTAGSPGEVLSRRCVNLLKTALRPDMWPKSELKLQWFDKLLMTVEQPN
QVNYGNICTGLEVLSFLLTVLQSPAILSSFKPLQRGIAACMTCGNTKVLRAVHSLLSRLM
SIFPTEPSTSSVASKYEELECLYAAVGKVIYEGLTNYEKATNANPSQLFGTLMILKSACS
NNPSYIDRLISVFMRSLQKMVREHLNPQAASGSTEATSGTSELVMLSLELVKTRLAVMSM
EMRKNFIQAILTSLIEKSPDAKILRAVVKIVEEWVKNNSPMAANQTPTLREKSILLVKMM
TYIEKRFPEDLELNAQFLDLVNYVYRDETLSGSELTAKLEPAFLSGLRCAQPLIRAKFFE
VFDNSMKRRVYERLLYVTCSQNWEAMGNHFWIKQCIELLLAVCEKSTPIGTSCQGAMLPS
ITNVINLADSHDRAAFAMVTHVKQEPRERENSESKEEDVEIDIELAPGDQTSTPKTKELS
EKDIGNQLHMLTNRHDKFLDTLREVKTGALLSAFVQLCHISTTLAEKTWVQLFPRLWKIL
SDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYLGKTH
NLWFRSTLMLEHQAFEKGLSLQIKPKQTTEFYEQESITPPQQEILDSLAELYSLLQEEDM
WAGLWQKRCKYSETATAIAYEQHGFFEQAQESYEKAMDKAKKEHERSNASPAIFPEYQLW
EDHWIRCSKELNQWEALTEYGQSKGHINPYLVLECAWRVSNWTAMKEALVQVEVSCPKEM
AWKVNMYRGYLAICHPEEQQLSFIERLVEMASSLAIREWRRLPHVVSHVHTPLLQAAQQI
IELQEAAQINAGLQPTNLGRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSIFMWRQHHYQ
GKPTWSGMHSSSIVTAYENSSQHDPSSNNAMLGVHASASAIIQYGKIARKQGLVNVALDI
LSRIHTIPTVPIVDCFQKIRQQVKCYLQLAGVMGKNECMQGLEVIESTNLKYFTKEMTAE
FYALKGMFLAQINKSEEANKAFSAAVQMHDVLVKAWAMWGDYLENIFVKERQLHLGVSAI
TCYLHACRHQNESKSRKYLAKVLWLLSFDDDKNTLADAVDKYCIGVPPIQWLAWIPQLLT
CLVGSEGKLLLNLISQVGRVYPQAVYFPIRTLYLTLKIEQRERYKSDPGPIRATAPMWRC
SRIMHMQRELHPTLLSSLEGIVDQMVWFRENWHEEVLRQLQQGLAKCYSVAFEKSGAVSD
AKITPHTLNFVKKLVSTFGVGLENVSNVSTMFSSAASESLARRAQATAQDPVFQKLKGQF
TTDFDFSVPGSMKLHNLISKLKKWIKILEAKTKQLPKFFLIEEKCRFLSNFSAQTAEVEI
PGEFLMPKPTHYYIKIARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESR
REERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQR
CAKKGIEHDNPISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFP
NATDYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGD
LDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTVLRDEIIA
WHKKTQEDTSSPLSAAGQPENMDSQQLVSLVQKAVTAIMTRLHNLAQFEGGESKVNTLVA
AANSLDNLCRMDPAWHPWL

Sequence of entity 2 (A), FASTA

>8H7G_2 Splicing factor 3B subunit 3 (chains A)
MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFG
VIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQF
LAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENP
MFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPG
GSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFF
FLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQ
IAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDT
PQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVN
ATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPG
KKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQ
RSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSI
GFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSW
LSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFP
LQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAA
AFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTG
EDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVL
IGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQ
LIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRG
LLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDF
FQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRT
PPEVSKKLEDIRTRYAF

Sequence of entity 3 (B), FASTA

>8H7G_3 Splicing factor 3B subunit 5 (chains B)
MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENES
KARVRFNLMEKMLQPCGPPADKPEEN

Sequence of entity 4 (D), FASTA

>8H7G_4 Transcription factor SPT20 homolog (chains D)
MQQALELALDRAEYVIESARQRPPKRKYLSSGRKSVFQKLYDLYIEECEKEPEVKKLRRN
VNLLEKLVMQETLSCLVVNLYPGNEGYSLMLRGKNGSDSETIRLPYEEGELLEYLDAEEL
PPILVDLLEKSQVNIFHCGCVIAEIRDYRQSSNMKSPGYQSRHILLRPTMQTLICDVHSI
TSDNHKWTQEDKLLLESQLILATAEPLCLDPSIAVTCTANRLLYNKQKMNTRPMKRCFKR
YSRSSLNRQQDLSHCPPPPQLRLLDFLQKRKERKAGQHYDLKISKAGNCVDMWKRSPCNL
AIPSEVDVEKYAKVEKSIKSDDSQPTVWPAHDVKDDYVFECEAGTQYQKTKLTILQSLGD
PLYYGKIQPCKADEESDSQMSPSHSSTDDHSNWFIIGSKTDAERVVNQYQELVQNEAKCP
VKMSHSSSGSASLSQVSPGKETDQTETVSVQSSVLGKGVKHRPPPIKLPSSSGNSSSGNY
FTPQQTSSFLKSPTPPPSSKPSSIPRKSSVDLNQVSMLSPAALSPASSSQRTTATQVMAN
SAGLNFINVVGSVCGAQALMSGSNPMLGCNTGAITPAGINLSGLLPSGGLLPNALPSAMQ
AASQAGVPFGLKNTSSLRPLNLLQLPGGSLIFNTLQQQQQQLSQFTPQQPQQPTTCSPQQ
PGEQGSEQGSTSQEQALSAQQAAVINLTGVGSFMQSQAAVLSQLGSAENRPEQSLPQQRF
QLSSAFQQQQQQIQQLRFLQHQMAMAAAAAQTAQLHHHRHTGSQSKSKMKRGTPTTPKF

Sequence of entity 5 (E), FASTA

>8H7G_5 Transcription initiation protein SPT3 homolog (chains E)
MNNTAASPMSTATSSSGRSTGKSISFATELQSMMYSLGDARRPLHETAVLVEDVVHTQLI
NLLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDEDDLL
EDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSA
QYAEFCESRQLSFSKKASKFRDWLDCSSMEIKPNVVAMEILAYLAYETVAQLVDLALLVR
QDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRIGPL
SPFTNAYRRNGMAFLAC

Sequence of entity 6 (G), FASTA

>8H7G_6 Transcriptional adapter 1 (chains G)
MDYKDHDGDYKDHDIDYKDDDDKGGSGGSLEVLFQGPLDMATFVSELEAAKKNLSEALGD
NVKQYWANLKLWFKQKISKEEFDLEAHRLLTQDNVHSHNDFLLAILTRCQILVSTPDGAG
SLPWPGGSAAKPGKPKGKKKLSSVRQKFDHRFQPQNPLSGAQQFVAKDPQDDDDLKLCSH
TMMLPTRGQLEGRMIVTAYEHGLDNVTEEAVSAVVYAVENHLKDILTSVVSRRKAYRLRD
GHFKYAFGSNVTPQPYLKNSVVAYNNLIESPPAFTAPCAGQNPASHPPPDDAEQQAALLL
ACSGDTLPASLPPVNMYDLFEALQVHREVIPTHTVYALNIERIITKLWHPNHEELQQDKV
HRQRLAAKEGLLLC

Sequence of entity 7 (H), FASTA

>8H7G_7 TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (chains H)
MKRVRTEQIQMAVSCYLKRRQYVDSDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSA
APCQAEPQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNLVQNSPKSTVESFY
SRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRAFLDNKYVVRLQEDSYNYLIRYLQ
SDNNTALCKVLTLHIHLDVQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQNEAALE
VLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSK
KLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSC
SEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLR
IYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG
KYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR
NTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTGITQENQEH

Sequence of entity 8 (I), FASTA

>8H7G_8 STAGA complex 65 subunit gamma (chains I)
MNLQRYWGEIPISSSQTNRSSFDLLPREFRLVEVHDPPLHQPSANKPKPPTMLDIPSEPC
SLTIHTIQLIQHNRRLRNLIATAQAQNQQQTEGVKTEESEPLPSCPGSPPLPDDLLPLDC
KNPNAPFQIRHSDPESDFYRGKGEPVTELSWHSCRQLLYQAVATILAHAGFDCANESVLE
TLTDVAHEYCLKFTKLLRFAVDREARLGQTPFPDVMEQVFHEVGIGSVLSLQKFWQHRIK
DYHSYMLQISKQLSEEYERIVNPEKATEDAKPVKIKEEPVSDITFPVSEELEADLASGDQ
SLPMGVLGAQSERFPSNLEVEASPQASSAEVNASPLWNLAHVKMEPQESEEGNVSGHGVL
GSDVFEEPMSGMSEAGIPQSPDDSDSSYGSHSTDSLMGSSPVFNQRCKKRMRKIGSENLY
FQGSGTSTAWSHPQFEKTGVSITSSGSWSHPQFEK

Sequence of entity 9 (K), FASTA

>8H7G_9 TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (chains K)
MSEREERRFVEIPRESVRLMAESTGLELSDEVAALLAEDVCYRLREATQNSSQFMKHTKR
RKLTVEDFNRALRWSSVEAVCGYGSQEALPMRPAREGELYFPEDREVNLVELALATNIPK
GCAETAVRVHVSYLDGKGNLAPQGSVPSAVSSLTDDLLKYYHQVTRAVLGDDPQLMKVAL
QDLQTNSKIGALLPYFVYVVSGVKSVSHDLEQLHRLLQVARSLFRNPHLCLGPYVRCLVG
SVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQHILLSLQKILADP
VRPLCCHYGAVVGLHALGWKAVERVLYPHLSTYWTNLQAVLDDYSVSNAQVKADGHKVYG
AILVAVERLLKMKAQAAEPNRGGPGGRGCRRLDDLPWDSLLFQESSSGGGAEPSFGSGLP
LPPGGAGPEDPSLSVTLADIYRELYAFFGDSLATRFGTGQPAPTAPRPPGDKKEPAAAPD
SVRKMPQLTASAIVSPHGDESPRGSGGGGPASASGPAASESRPLPRVHRARGAPRQQGPG
TGTRDVFQKSRFAPRGAPHFRFIIAGRQAGRRCRGRLFQTAFPAPYGPSPASRYVQKLPM
IGRTSRPARRWALSDYSLYLPL

Sequence of entity 10 (M), FASTA

>8H7G_10 Transcription initiation factor TFIID subunit 9 (chains M)
MESGKTASPKSMPKDAQMMAQILKDMGITEYEPRVINQMLEFAFRYVTTILDDAKIYSSH
AKKATVDADDVRLAIQCRADQSFTSPPPRDFLLDIARQRNQTPLPLIKPYSGPRLPPDRY
CLTAPNYRLKSLQKKASTSAGRITVPRLSVGSVTSRPSTPTLGTPTPQTMSVSTKVGTPM
SLTGQRFTVQMPTSQSPAVKASIPATSAVQNVLINPSLIGSKNILITTNMMSSQNTANES
SNALKRKREDDDDDDDDDDDYDNL

Sequence of entity 11 (O), FASTA

>8H7G_11 Transcription initiation factor TFIID subunit 10 (chains O)
MSCSGSGADPEAAPASAASAPGPAPPVSAPAALPSSTAAENKASPAGTAGGPGAGAAAGG
TGPLAARAGEPAERRGAAPVSAGGAAPPEGAISNGVYVLPSAANGDVKPVVSSTPLVDFL
MQLEDYTPTIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMKGTA
SGSSRSKSKDRKYTLTMEDLTPALSEYGINVKKPHYFT

Sequence of entity 12 (R), FASTA

>8H7G_12 Transcription initiation factor TFIID subunit 12 (chains R)
MNQFGPSALINLSNFSSIKPEPASTPPQGSMANSTAVVKIPGTPGAGGRLSPENNQVLTK
KKLQDLVREVDPNEQLDEDVEEMLLQIADDFIESVVTAACQLARHRKSSTLEVKDVQLHL
ERQWNMWIPGFGSEEIRPYKKACTTEAHKQRMALIRKTTKK

Primary citation

Cryo-EM structure of human SAGA transcriptional coactivator complex. Zhang, Y., Yin, C., Yin, Y. et al. Cell Discov (2022) 8:125-125. DOI 10.1038/s41421-022-00489-w · PubMed

Other PDB entries of the same protein (UniProt Q9Y4A5), best resolution first:

9CAF 2.35 Å, Cryo-EM structure of the reconstituted TRRAP lobe of the human TIP60 complex (composite…
9RDK 2.41 Å, Cryo-EM structure of the human SAGA co-activator complex
7KTR 2.93 Å, Cryo-EM structure of the human SAGA coactivator complex (TRRAP, core)
9CAD 3.05 Å, Cryo-EM structure of the TRRAP lobe of the native human TIP60 complex (composite…
8XVV 3.2 Å, The TRRAP module of human NuA4/TIP60 complex
9C47 3.4 Å, TRRAP module of the human TIP60 complex
8QRI 3.5 Å, TRRAP and EP400 in the human Tip60 complex
8XVG 9.4 Å, Structure of human NuA4/TIP60 complex

Browse structure collections

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