8JFK: PhK holoenzyme in inactive state, muscle isoform

PhK holoenzyme in inactive state, muscle isoform. Determined by electron microscopy at 2.9 Å resolution. Released 3 Apr 2024.

Method: Electron microscopy
Resolution: 2.9 Å
Organism: Homo sapiens
Chains: 16
Atoms: 81,428
Mol. weight: 1299.41 kDa
Ligands: FAR
Released: 3 Apr 2024

Explore 8JFK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8JFK contains 578 α-helices and 373 β-strands across 16 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 57 helices, 39 β-strands

Element	Residues	Length	Sheet
α-helix	3-5	3
α-helix	6-21	16
α-helix	23-25	3
β-strand	41-43	3	31
α-helix	44-50	7
α-helix	52-63	12
α-helix	68-93	26
α-helix	96-104	9
α-helix	112-113	2
β-strand	115-117	3	31
β-strand	122	1	31
α-helix	137-150	14
α-helix	159-173	15
β-strand	180	1	32
β-strand	196	1	32
α-helix	199-211	13
β-strand	215-216	2	33
α-helix	224-226	3
β-strand	227-228	2	33
α-helix	229	1
α-helix	232-245	14
α-helix	257-259	3
α-helix	260-263	4
α-helix	273-286	14
β-strand	288	1	34
β-strand	293-294	2	34
α-helix	316-321	6
α-helix	325-326	2
β-strand	327-328	2	34
α-helix	330-342	13
α-helix	345-355	11
α-helix	359	1
β-strand	360-362	3	35
β-strand	366-368	3	35
β-strand	372-374	3	34
α-helix	377-379	3
α-helix	380-385	6
β-strand	393-395	3	34
α-helix	401-414	14
α-helix	420-423	4
α-helix	428-431	4
α-helix	436-439	4
β-strand	440-446	7	36
α-helix	449-457	9
β-strand	463-464	2	36
β-strand	472-474	3	37
α-helix	476-482	7
α-helix	483-485	3
β-strand	489	1	38
β-strand	494	1	38
α-helix	504-507	4
β-strand	510-513	4	37
β-strand	516-520	5	37
α-helix	523-525	3
α-helix	531-534	4
α-helix	536-553	18
β-strand	561-566	6	36
α-helix	568-570	3
β-strand	571	1	39
β-strand	578	1	39
α-helix	580-591	12
β-strand	593	1	40
β-strand	598	1	40
β-strand	599-601	3	36
β-strand	613-615	3	37
α-helix	617-619	3
α-helix	660-668	9
α-helix	780-788	9
α-helix	811-820	10
α-helix	823-832	10
α-helix	840-848	9
β-strand	853-856	4	41
β-strand	865-867	3	41
α-helix	873-884	12
α-helix	888-907	20
α-helix	909-912	4
β-strand	917-919	3	41
α-helix	920-933	14
α-helix	939-948	10
α-helix	951-963	13
α-helix	1053-1058	6
α-helix	1071-1079	9
β-strand	1084-1086	3	42
β-strand	1093	1	42
α-helix	1094-1099	6
α-helix	1105-1115	11
α-helix	1122-1140	19
β-strand	1141	1	43
β-strand	1148-1150	3	42
α-helix	1151-1169	19
β-strand	1178	1	44
β-strand	1185	1	44
α-helix	1186-1190	5
β-strand	1194	1	45
α-helix	1199-1214	16
β-strand	1220	1	43

Chain B: 55 helices, 38 β-strands

Element	Residues	Length	Sheet
α-helix	45-55	11
α-helix	56-60	5
α-helix	61-63	3
β-strand	81-83	3	1
α-helix	84-101	18
α-helix	110-130	21
α-helix	133-141	9
α-helix	149-150	2
β-strand	152-154	3	1
α-helix	172-187	16
α-helix	196-210	15
α-helix	212-214	3
β-strand	217	1	2
β-strand	233	1	2
α-helix	236-249	14
β-strand	252-253	2	3
α-helix	261-263	3
β-strand	264-265	2	3
α-helix	269-282	14
β-strand	293	1	4
α-helix	296-300	5
α-helix	310-324	15
β-strand	325	1	5
β-strand	330	1	5
β-strand	333	1	4
α-helix	354-358	5
β-strand	364	1	6
β-strand	365	1	5
α-helix	367-379	13
α-helix	382-395	14
β-strand	397-398	2	7
β-strand	404-405	2	7
β-strand	410-411	2	6
α-helix	417-422	6
β-strand	430-431	2	6
α-helix	442-455	14
β-strand	494-497	4	8
β-strand	499-501	3	9
β-strand	503	1	10
α-helix	504-511	8
β-strand	527-529	3	11
α-helix	531-538	8
β-strand	544	1	12
β-strand	549	1	12
α-helix	559-563	5
β-strand	566-568	3	11
β-strand	571-575	5	11
α-helix	578-580	3
α-helix	591-608	18
α-helix	614-615	2
β-strand	616	1	8
β-strand	619-621	3	9
α-helix	623-626	4
α-helix	628-630	3
α-helix	631-643	13
β-strand	645-646	2	8
β-strand	649-653	5	8
α-helix	658-660	3
β-strand	666-667	2	11
α-helix	670-673	4
α-helix	680-682	3
β-strand	688	1	10
α-helix	716-720	5
α-helix	727-733	7
α-helix	737-750	14
β-strand	756	1	13
β-strand	761	1	13
α-helix	762-776	15
α-helix	779-788	10
α-helix	796-805	10
β-strand	809-812	4	14
β-strand	820-822	3	14
α-helix	828-833	6
α-helix	834-838	5
α-helix	845-863	19
α-helix	865-868	4
β-strand	873-875	3	14
α-helix	876-891	16
α-helix	896-898	3
α-helix	904-915	12
α-helix	924-933	10
α-helix	937-938	2
α-helix	941-950	10
β-strand	956-957	2	15
β-strand	963	1	15
α-helix	965-971	7
α-helix	978-986	9
α-helix	993-1012	20
β-strand	1022-1023	2	15
α-helix	1024-1042	19
α-helix	1052-1056	5
α-helix	1065-1077	13
α-helix	1083-1085	3

Chains C and G: 22 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	13-17	5
β-strand	20-27	8	118
β-strand	32-39	8	118
β-strand	44-52	9	118
α-helix	55-57	3
α-helix	61-80	20
β-strand	87	1	119
β-strand	92-95	4	118
β-strand	99-105	7	118
β-strand	111	1	119
α-helix	112-118	7
α-helix	124-143	20
β-strand	147	1	120
α-helix	153-155	3
β-strand	156-158	3	119
β-strand	164-166	3	119
β-strand	173	1	120
α-helix	174-176	3
β-strand	181	1	121
α-helix	188-190	3
α-helix	193-200	8
β-strand	207	1	121
α-helix	211-225	15
α-helix	235-244	10
α-helix	253-255	3
α-helix	259-269	11
α-helix	273-275	3
α-helix	279-282	4
α-helix	286-288	3
α-helix	301-324	24
α-helix	325-328	4
α-helix	330-335	6
α-helix	341-354	14
α-helix	367-370	4
β-strand	371	1	45
α-helix	376-379	4

Chains D, H, L and P: 8 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	7-20	14
β-strand	28-29	2	117
α-helix	30-39	10
α-helix	46-57	12
β-strand	63-64	2	117
α-helix	66-73	8
α-helix	79-93	15
α-helix	103-113	11
α-helix	119-129	11
α-helix	139-147	9

Chain E: 54 helices, 39 β-strands

Element	Residues	Length	Sheet
α-helix	3-5	3
α-helix	6-21	16
α-helix	23-25	3
β-strand	42-43	2	102
α-helix	44-50	7
α-helix	52-63	12
α-helix	68-93	26
α-helix	96-104	9
α-helix	108-110	3
α-helix	112-113	2
β-strand	115-116	2	102
α-helix	137-150	14
α-helix	159-173	15
α-helix	174-176	3
β-strand	180	1	103
β-strand	196	1	103
α-helix	199-211	13
β-strand	215-216	2	104
α-helix	224-226	3
β-strand	227-228	2	104
α-helix	232-245	14
β-strand	256	1	105
α-helix	257-259	3
α-helix	260-263	4
α-helix	273-286	14
β-strand	288	1	106
β-strand	293-294	2	106
β-strand	296	1	105
α-helix	315-321	7
α-helix	325-326	2
β-strand	327-328	2	106
α-helix	330-342	13
α-helix	345-356	12
β-strand	360-362	3	107
β-strand	366-368	3	107
β-strand	372-374	3	106
α-helix	380-385	6
β-strand	393-395	3	106
α-helix	401-414	14
α-helix	420-423	4
α-helix	428-430	3
β-strand	439-446	8	108
α-helix	449-457	9
β-strand	463-464	2	108
β-strand	472-475	4	109
α-helix	476-482	7
β-strand	489	1	110
β-strand	494	1	110
α-helix	504-508	5
β-strand	510-513	4	109
β-strand	516-521	6	109
α-helix	522	1
α-helix	523-525	3
α-helix	531-534	4
α-helix	536-552	17
β-strand	561-566	6	108
α-helix	568-570	3
β-strand	571	1	111
β-strand	578	1	111
α-helix	580-591	12
β-strand	593-594	2	108
β-strand	597-601	5	108
β-strand	614-615	2	109
α-helix	660-668	9
α-helix	780-788	9
α-helix	811-820	10
α-helix	823-832	10
α-helix	840-849	10
β-strand	853-856	4	112
β-strand	865-867	3	112
α-helix	873-884	12
α-helix	888-907	20
α-helix	909-912	4
β-strand	917-919	3	112
α-helix	920-933	14
α-helix	939-946	8
α-helix	951-963	13
α-helix	1053-1058	6
α-helix	1071-1079	9
β-strand	1084-1086	3	113
β-strand	1093	1	113
α-helix	1094-1099	6
α-helix	1105-1115	11
α-helix	1122-1140	19
β-strand	1141	1	114
β-strand	1148-1150	3	113
α-helix	1151-1169	19
β-strand	1178	1	115
β-strand	1185	1	115
α-helix	1186-1190	5
β-strand	1194	1	116
α-helix	1199-1214	16
β-strand	1220	1	114

Chain F: 59 helices, 39 β-strands

Element	Residues	Length	Sheet
α-helix	45-55	11
α-helix	56-61	6
β-strand	81-83	3	88
α-helix	84-100	17
α-helix	101-103	3
α-helix	110-130	21
α-helix	133-141	9
α-helix	149-150	2
β-strand	152-154	3	88
β-strand	160	1	88
α-helix	172-187	16
α-helix	196-209	14
β-strand	217	1	89
β-strand	233	1	89
α-helix	236-249	14
β-strand	253	1	90
α-helix	261-263	3
β-strand	264	1	90
α-helix	265-266	2
α-helix	269-282	14
β-strand	293	1	91
α-helix	294-296	3
α-helix	297-300	4
α-helix	310-324	15
β-strand	325	1	92
β-strand	330-331	2	92
β-strand	333	1	91
α-helix	352-358	7
α-helix	362-363	2
β-strand	364-365	2	92
α-helix	367-378	12
α-helix	383-395	13
β-strand	397-398	2	93
β-strand	404-405	2	93
β-strand	410-411	2	92
α-helix	414-416	3
α-helix	417-422	6
β-strand	430-431	2	92
α-helix	442-456	15
α-helix	461-464	4
β-strand	478	1	94
β-strand	483	1	94
β-strand	494-501	8	95
α-helix	504-512	9
β-strand	518	1	95
β-strand	526-529	4	96
α-helix	531-539	9
β-strand	544	1	97
β-strand	549	1	97
α-helix	559-563	5
β-strand	565-568	4	96
β-strand	571-575	5	96
α-helix	576-577	2
α-helix	578-580	3
α-helix	591-608	18
α-helix	614-615	2
β-strand	616-621	6	95
α-helix	623-626	4
α-helix	628-630	3
α-helix	631-643	13
β-strand	645-646	2	95
β-strand	649-653	5	95
α-helix	658-660	3
α-helix	665	1
β-strand	666-668	3	96
α-helix	670-673	4
α-helix	716-720	5
α-helix	727-733	7
α-helix	737-750	14
β-strand	756	1	98
β-strand	761	1	98
α-helix	762-776	15
α-helix	781-787	7
α-helix	796-805	10
β-strand	809-811	3	99
β-strand	821-822	2	99
α-helix	828-833	6
α-helix	834-838	5
α-helix	845-863	19
α-helix	865-868	4
β-strand	873-875	3	99
α-helix	876-891	16
α-helix	896-898	3
α-helix	904-915	12
α-helix	924-934	11
α-helix	941-950	10
β-strand	956-957	2	100
β-strand	962-963	2	100
α-helix	968-971	4
α-helix	977-987	11
α-helix	993-1012	20
β-strand	1016	1	101
β-strand	1022-1023	2	100
α-helix	1024-1042	19
α-helix	1052-1055	4
α-helix	1065-1078	14
β-strand	1082	1	101
α-helix	1083-1085	3

Chain I: 57 helices, 39 β-strands

Element	Residues	Length	Sheet
α-helix	3-5	3
α-helix	6-21	16
α-helix	23-25	3
β-strand	41-43	3	73
α-helix	44-50	7
α-helix	52-62	11
α-helix	68-93	26
α-helix	96-104	9
α-helix	108-110	3
α-helix	112-113	2
β-strand	115-117	3	73
α-helix	135-151	17
α-helix	159-173	15
α-helix	174-177	4
β-strand	180	1	74
β-strand	196	1	74
α-helix	199-211	13
β-strand	215-216	2	75
α-helix	224-226	3
β-strand	227-228	2	75
α-helix	232-245	14
α-helix	257-259	3
α-helix	260-263	4
α-helix	273-286	14
β-strand	288	1	76
β-strand	293-294	2	76
α-helix	315-321	7
β-strand	327-328	2	76
α-helix	330-342	13
α-helix	345-356	12
β-strand	360-362	3	77
β-strand	366-368	3	77
β-strand	372-374	3	76
α-helix	375-376	2
α-helix	380-385	6
β-strand	393-395	3	76
α-helix	401-414	14
α-helix	420-423	4
α-helix	428-432	5
α-helix	436-438	3
β-strand	439-446	8	78
α-helix	449-457	9
β-strand	463-464	2	78
β-strand	472-474	3	79
α-helix	476-482	7
α-helix	483-485	3
β-strand	488-489	2	80
β-strand	494-495	2	80
α-helix	504-507	4
β-strand	510-513	4	79
β-strand	516-520	5	79
α-helix	523-525	3
α-helix	536-553	18
β-strand	559	1	81
β-strand	561-566	6	78
α-helix	567	1
α-helix	568-570	3
β-strand	571	1	82
β-strand	578	1	82
α-helix	580-590	11
β-strand	593-594	2	78
β-strand	597-602	6	78
α-helix	606-608	3
β-strand	611	1	81
β-strand	613-615	3	79
α-helix	617-619	3
α-helix	660-668	9
α-helix	780-788	9
α-helix	810-820	11
α-helix	823-832	10
α-helix	840-849	10
β-strand	853-856	4	83
β-strand	865-867	3	83
α-helix	873-884	12
α-helix	888-907	20
α-helix	909-912	4
β-strand	917-919	3	83
α-helix	920-933	14
α-helix	939-946	8
α-helix	951-963	13
α-helix	1055-1058	4
α-helix	1071-1079	9
β-strand	1084-1087	4	84
β-strand	1090-1093	4	84
α-helix	1095-1099	5
α-helix	1105-1115	11
α-helix	1121-1140	20
β-strand	1141	1	85
β-strand	1148-1150	3	84
α-helix	1151-1169	19
β-strand	1178	1	86
β-strand	1185	1	86
α-helix	1186-1190	5
β-strand	1194	1	87
α-helix	1199-1214	16
β-strand	1220	1	85

Chain J: 58 helices, 40 β-strands

Element	Residues	Length	Sheet
α-helix	45-59	15
α-helix	61-63	3
β-strand	72	1	59
β-strand	81-83	3	59
α-helix	84-101	18
α-helix	110-130	21
α-helix	133-141	9
α-helix	145-147	3
α-helix	149-150	2
β-strand	152-154	3	59
β-strand	160	1	59
α-helix	172-188	17
α-helix	196-210	15
α-helix	211-214	4
β-strand	217	1	60
β-strand	233	1	60
α-helix	236-249	14
β-strand	252-253	2	61
α-helix	261-263	3
β-strand	264-265	2	61
α-helix	266	1
α-helix	269-282	14
α-helix	296-300	5
α-helix	310-324	15
β-strand	325	1	62
β-strand	330-331	2	62
α-helix	355-358	4
α-helix	362-363	2
β-strand	364-365	2	62
α-helix	367-379	13
α-helix	382-395	14
β-strand	397-398	2	63
β-strand	404-405	2	63
β-strand	410-411	2	62
α-helix	417-422	6
β-strand	430-431	2	62
α-helix	442-455	14
β-strand	478	1	64
β-strand	483	1	64
β-strand	494-501	8	65
β-strand	503	1	66
α-helix	504-511	8
β-strand	518	1	65
α-helix	520-522	3
β-strand	527-529	3	67
α-helix	531-538	8
β-strand	544	1	68
β-strand	549	1	68
α-helix	559-562	4
β-strand	565-568	4	67
β-strand	571-575	5	67
α-helix	576-577	2
α-helix	578-580	3
α-helix	587-589	3
α-helix	591-608	18
α-helix	614-615	2
β-strand	616-621	6	65
α-helix	628-630	3
α-helix	631-643	13
β-strand	645-646	2	65
β-strand	649-653	5	65
α-helix	658-660	3
α-helix	664	1
β-strand	665-667	3	67
α-helix	670-673	4
β-strand	688	1	66
α-helix	716-720	5
α-helix	727-733	7
α-helix	737-750	14
β-strand	756	1	69
β-strand	761	1	69
α-helix	762-776	15
α-helix	779-788	10
α-helix	796-805	10
β-strand	810-812	3	70
β-strand	820-822	3	70
α-helix	828-833	6
α-helix	834-838	5
α-helix	844-863	20
α-helix	865-867	3
β-strand	874-875	2	70
α-helix	876-891	16
α-helix	896-898	3
α-helix	904-914	11
α-helix	924-934	11
α-helix	937-938	2
α-helix	941-951	11
β-strand	956-958	3	71
β-strand	961-963	3	71
α-helix	968-971	4
α-helix	977-986	10
α-helix	993-1012	20
β-strand	1016	1	72
β-strand	1022-1023	2	71
α-helix	1024-1043	20
α-helix	1051-1056	6
α-helix	1065-1077	13
β-strand	1082	1	72

3 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Phosphorylase b kinase regulatory subunit beta	B, F, J, N	protein	1093	Homo sapiens	Q93100 (AlphaFold model)
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform	A, E, I, M	protein	1223	Homo sapiens	P46020 (AlphaFold model)
Calmodulin-1	D, H, L, P	protein	149	Homo sapiens	P0DP23 (AlphaFold model)
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	C, G, K, O	protein	387	Homo sapiens	Q16816 (AlphaFold model)

Sequence of entity 1 (B, F, J, N), FASTA

>8JFK_1 Phosphorylase b kinase regulatory subunit beta (chains B, F, J, N)
MAGAAGLTAEVSWKVLERRARTKRSGSVYEPLKSINLPRPDNETLWDKLDHYYRIVKSTL
LLYQSPTTGLFPTKTCGGDQKAKIQDSLYCAAGAWALALAYRRIDDDKGRTHELEHSAIK
CMRGILYCYMRQADKVQQFKQDPRPTTCLHSVFNVHTGDELLSYEEYGHLQINAVSLYLL
YLVEMISSGLQIIYNTDEVSFIQNLVFCVERVYRVPDFGVWERGSKYNNGSTELHSSSVG
LAKAALEAINGFNLFGNQGCSWSVIFVDLDAHNRNRQTLCSLLPRESRSHNTDAALLPCI
SYPAFALDDEVLFSQTLDKVVRKLKGKYGFKRFLRDGYRTSLEDPNRCYYKPAEIKLFDG
IECEFPIFFLYMMIDGVFRGNPKQVQEYQDLLTPVLHHTTEGYPVVPKYYYVPADFVEYE
KNNPGSQKRFPSNCGRDGKLFLWGQALYIIAKLLADELISPKDIDPVQRYVPLKDQRNVS
MRFSNQGPLENDLVVHVALIAESQRLQVFLNTYGIQTQTPQQVEPIQIWPQQELVKAYLQ
LGINEKLGLSGRPDRPIGCLGTSKIYRILGKTVVCYPIIFDLSDFYMSQDVFLLIDDIKN
ALQFIKQYWKMHGRPLFLVLIREDNIRGSRFNPILDMLAALKKGIIGGVKVHVDRLQTLI
SGAVVEQLDFLRISDTEELPEFKSFEELEPPKHSKVKRQSSTPSAPELGQQPDVNISEWK
DKPTHEILQKLNDCSCLASQAILLGILLKREGPNFITKEGTVSDHIERVYRRAGSQKLWL
AVRYGAAFTQKFSSSIAPHITTFLVHGKQVTLGAFGHEEEVISNPLSPRVIQNIIYYKCN
THDEREAVIQQELVIHIGWIISNNPELFSGMLKIRIGWIIHAMEYELQIRGGDKPALDLY
QLSPSEVKQLLLDILQPQQNGRCWLNRRQIDGSLNRTPTGFYDRVWQILERTPNGIIVAG
KHLPQQPTLSDMTMYEMNFSLLVEDTLGNIDQPQYRQIVVELLMVVSIVLERNPELEFQD
KVDLDRLVKEAFNEFQKDQSRLKEIEKQDDMTSFYNTPPLGKRGTCSYLTKAVMNLLLEG
EVKPNNDDPCLIS

Sequence of entity 2 (A, E, I, M), FASTA

>8JFK_2 Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (chains A, E, I, M)
MRSRSNSGVRLDGYARLVQQTILCHQNPVTGLLPASYDQKDAWVRDNVYSILAVWGLGLA
YRKNADRDEDKAKAYELEQSVVKLMRGLLHCMIRQVDKVESFKYSQSTKDSLHAKYNTKT
CATVVGDDQWGHLQLDATSVYLLFLAQMTASGLHIIHSLDEVNFIQNLVFYIEAAYKTAD
FGIWERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQS
ILNSLLPRASTSKEVDASLLSVVSFPAFAVEDSQLVELTKQEIITKLQGRYGCCRFLRDG
YKTPKEDPNRLYYEPAELKLFENIECEWPLFWTYFILDGVFSGNAEQVQEYKEALEAVLI
KGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFLAP
GEIDPLNRRFSTVPKPDVVVQVSILAETEEIKTILKDKGIYVETIAEVYPIRVQPARILS
HIYSSLGCNNRMKLSGRPYRHMGVLGTSKLYDIRKTIFTFTPQFIDQQQFYLALDNKMIV
EMLRTDLSYLCSRWRMTGQPTITFPISHSMLDEDGTSLNSSILAALRKMQDGYFGGARVQ
TGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDDNYDYLESGNWMNDYDSTSHARCGDEV
ARYLDHLLAHTAPHPKLAPTSQKGGLDRFQAAVQTTCDLMSLVTKAKELHVQNVHMYLPT
KLFQASRPSFNLLDSPHPRQENQVPSVRVEIHLPRDQSGEVDFKALVLQLKETSSLQEQA
DILYMLYTMKGPDWNTELYNERSATVRELLTELYGKVGEIRHWGLIRYISGILRKKVEAL
DEACTDLLSHQKHLTVGLPPEPREKTISAPLPYEALTQLIDEASEGDMSISILTQEIMVY
LAMYMRTQPGLFAEMFRLRIGLIIQVMATELAHSLRCSAEEATEGLMNLSPSAMKNLLHH
ILSGKEFGVERSVRPTDSNVSPAISIHEIGAVGATKTERTGIMQLKSEIKQVEFRRLSIS
AESQSPGTSMTPSSGSFPSAYDQQSSKDSRQGQWQRRRRLDGALNRVPVGFYQKVWKVLQ
KCHGLSVEGFVLPSSTTREMTPGEIKFSVHVESVLNRVPQPEYRQLLVEAILVLTMLADI
EIHSIGSIIAVEKIVHIANDLFLQEQKTLGADDTMLAKDPASGICTLLYDSAPSGRFGTM
TYLSKAAATYVQEFLPHSICAMQ

Sequence of entity 3 (D, H, L, P), FASTA

>8JFK_3 Calmodulin-1 (chains D, H, L, P)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 4 (C, G, K, O), FASTA

>8JFK_4 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (chains C, G, K, O)
MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFS
PEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKV
TLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGER
LREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLR
MIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFS
PRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVK
KGQQQNRAALFENTPKAVLLSLAEEDY

Ligands and cofactors

ID	Name	Formula	Copies
FAR	Farnesyl	C15 H26	8

Primary citation

Architecture and activation of human muscle phosphorylase kinase. Yang, X., Zhu, M., Lu, X. et al. Nat Commun (2024) 15:2719-2719. DOI 10.1038/s41467-024-47049-2 · PubMed

Other PDB entries of the same protein (UniProt Q93100 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8XYA 2.7 Å, hPhK alpha-beta-gamma-delta subcomplex in inactive state
8JFL 2.9 Å, PhK holoenzyme in active state, muscle isoform
8Z5P 3.41 Å, human phosphorylase kinase - inactive state
8Z5T 3.74 Å, human phosphorylase kinase - phosphorylation and Ca2+ bound state
8Z5Q 4.24 Å, human phosphorylase kinase - inactive state

Browse structure collections

About this viewer

MolViewer shows 8JFK directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.