8Q7K: IRGQ LIR2 peptide

IRGQ LIR2 peptide in complex with LC3B. Determined by X-ray diffraction at 1.6 Å resolution. Released 28 Aug 2024.

Method: X-ray diffraction
Resolution: 1.6 Å
Organism: Homo sapiens
Chains: 4
Atoms: 2,318
Mol. weight: 31.78 kDa
Released: 28 Aug 2024

Explore 8Q7K in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8Q7K contains 14 α-helices and 16 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	7-10	4
α-helix	13-26	14
β-strand	30-37	8	1
α-helix	38	1
α-helix	45-47	3
β-strand	51-55	5	1
β-strand	59	1	2
α-helix	60-70	11
β-strand	80-82	3	1
β-strand	87	1	1
β-strand	94	1	2
α-helix	95-102	8
α-helix	108	1
β-strand	109-114	6	1

Chain B: 7 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	7-10	4
α-helix	13-26	14
β-strand	31-37	7	3
α-helix	45-47	3
β-strand	51-54	4	3
β-strand	59	1	4
α-helix	60-70	11
β-strand	80-83	4	3
β-strand	86-87	2	3
α-helix	88	1
β-strand	94	1	4
α-helix	95-102	8
α-helix	108	1
β-strand	109-114	6	3

Chain C: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	422-423	2	1

Chain D: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	421-423	3	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Microtubule-associated proteins 1A/1B light chain 3B	A, B	protein	125	Homo sapiens	Q9GZQ8 (AlphaFold model)
Immunity-related GTPase family Q protein	C, D	protein	9	Homo sapiens	Q8WZA9 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>8Q7K_1 Microtubule-associated proteins 1A/1B light chain 3B (chains A, B)
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM
SELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFG
MKLSV

Sequence of entity 2 (C, D), FASTA

>8Q7K_2 Immunity-related GTPase family Q protein (chains C, D)
EDETWEVLE

Primary citation

IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion. Herhaus, L., Gestal-Mato, U., Eapen, V.V. et al. Cell (2024) 187:7285-7302.e29. DOI 10.1016/j.cell.2024.09.048 · PubMed

Other PDB entries of the same protein (UniProt Q9GZQ8 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8Q53 1.36 Å, Crystal structure of truncated human Microtubule-associated proteins 1A/1B light chain…
6LAN 1.41 Å, Structure of CCDC50 and LC3B complex
5D94 1.53 Å, Crystal structure of LC3-LIR peptide complex
5MS5 1.53 Å, Low-salt structure of RavZ LIR2-fused human LC3B
2ZJD 1.56 Å, Crystal Structure of LC3-p62 complex
7GAG 1.59 Å, PanDDA analysis group deposition -- Crystal Structure of MAP1LC3B in complex with…
7GAU 1.59 Å, PanDDA analysis group deposition of ground-state model of MAP1LC3B
7ELG 1.6 Å, LC3B modificated with a covalent probe
3VTU 1.6 Å, Crystal structure of human LC3B_2-119
7GAP 1.68 Å, PanDDA analysis group deposition -- Crystal Structure of MAP1LC3B in complex with…
7GAO 1.69 Å, PanDDA analysis group deposition -- Crystal Structure of MAP1LC3B in complex with…
3VTV 1.7 Å, Crystal structure of Optineurin LIR-fused human LC3B_2-119

Browse structure collections

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