8QRI: TRRAP and EP400 in the human Tip60 complex

TRRAP and EP400 in the human Tip60 complex. Determined by electron microscopy at 3.5 Å resolution. Released 7 Aug 2024.

Method
Electron microscopy
Resolution
3.5 Å
Organism
Homo sapiens
Chains
2
Atoms
27,204
Mol. weight
782.01 kDa
Released
7 Aug 2024

Explore 8QRI in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8QRI contains 228 α-helices and 23 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix2370-238213
α-helix2401-24099
α-helix2418-24247
α-helix2425-24295
α-helix2430-24345
α-helix2444-24518
α-helix2455-247319
α-helix2513-25208
Chain C: 220 helices, 23 β-strands
ElementResiduesLengthSheet
α-helix39-424
α-helix43-453
α-helix57-604
α-helix62-7211
α-helix86-927
α-helix93-986
α-helix107-1093
α-helix111-1188
α-helix130-14112
α-helix151-1533
α-helix154-1574
α-helix158-1603
α-helix227-2359
α-helix236-2383
α-helix240-2423
α-helix247-2493
α-helix251-2544
α-helix278-29518
α-helix307-3126
α-helix313-3197
α-helix320-3223
α-helix328-33912
α-helix343-3464
α-helix348-3525
α-helix355-3573
α-helix367-38620
α-helix392-40514
α-helix413-43422
α-helix439-46224
α-helix464-4663
α-helix542-56524
α-helix581-60323
α-helix628-63710
α-helix644-6529
α-helix655-6628
α-helix669-6779
α-helix678-6814
α-helix684-69613
α-helix697-6993
α-helix704-72320
α-helix725-7328
α-helix736-74712
β-strand74911
α-helix754-76714
α-helix774-7796
α-helix780-7823
α-helix783-79412
α-helix800-81011
α-helix821-8277
α-helix828-8358
α-helix839-85315
α-helix858-8658
α-helix866-8683
α-helix869-87911
α-helix885-89713
α-helix900-9023
α-helix905-9062
α-helix909-9135
β-strand923-92752
α-helix930-9323
β-strand934-93852
α-helix940-95112
α-helix957-97317
β-strand97513
α-helix981-9888
α-helix1005-10073
α-helix1013-103018
α-helix1035-105622
α-helix1064-10663
α-helix1074-10763
α-helix1091-110111
α-helix1105-11073
α-helix1108-112619
α-helix1129-11346
α-helix1137-114711
α-helix1148-11503
α-helix1154-117017
α-helix1173-119321
β-strand119911
α-helix1202-121817
α-helix1228-124720
α-helix1254-127017
α-helix1275-12795
α-helix1280-12867
α-helix1297-12993
α-helix1302-131716
α-helix1332-134413
α-helix1354-13574
α-helix1363-137513
α-helix1380-13823
α-helix1383-139412
α-helix1399-141214
α-helix1419-14235
α-helix1428-14347
α-helix1442-145312
α-helix1456-14583
α-helix1461-148121
α-helix1510-152314
α-helix1529-15313
α-helix1532-154615
α-helix1555-156410
α-helix1566-15683
α-helix1569-15724
α-helix1576-15783
α-helix1582-159312
α-helix1595-15973
α-helix1598-16058
α-helix1609-16124
α-helix1636-165217
α-helix1660-167718
α-helix1692-170413
α-helix1711-17155
α-helix1723-17253
α-helix1726-173914
α-helix1753-17564
α-helix1768-178316
α-helix1808-18169
α-helix1827-183610
α-helix1858-18658
α-helix1867-18693
α-helix1877-189317
α-helix1901-19088
α-helix1917-193014
α-helix1931-19333
α-helix1935-19384
α-helix1943-195210
α-helix1966-19705
α-helix1981-19844
α-helix1987-19904
α-helix2004-201916
α-helix2091-210515
α-helix2120-213011
α-helix2143-215311
α-helix2163-218018
α-helix2185-21884
α-helix2191-21977
α-helix2201-22033
α-helix2207-222216
α-helix2237-225317
α-helix2266-227813
α-helix2283-22853
α-helix2287-22904
α-helix2293-230513
α-helix2320-233415
α-helix2340-235516
α-helix2361-237414
α-helix2389-240214
α-helix2413-242412
α-helix2440-24478
α-helix2452-246211
α-helix2470-24767
α-helix2483-24853
α-helix2492-25009
β-strand250814
α-helix25091
β-strand251813
α-helix2519-25202
α-helix2523-25275
α-helix2587-260115
β-strand260614
α-helix2608-262013
α-helix2622-263918
α-helix2642-265716
α-helix2659-26668
α-helix2671-26799
α-helix2685-26873
α-helix2692-26998
α-helix2703-271715
α-helix2743-275412
α-helix2758-27658
α-helix2772-278211
α-helix2786-280419
α-helix2811-28133
α-helix2814-283017
α-helix2834-28418
α-helix2849-28568
α-helix2864-28685
α-helix2870-28756
α-helix2881-289313
α-helix2904-291916
α-helix2928-29303
α-helix2931-295121
α-helix2961-297414
α-helix2985-300521
α-helix3028-305023
α-helix3054-30629
α-helix3063-30664
α-helix3072-308716
α-helix3098-31069
α-helix3117-313115
α-helix3136-314510
α-helix3153-316715
α-helix3173-318917
α-helix3196-320510
α-helix3206-32083
α-helix3214-32229
α-helix3228-32314
α-helix3232-32343
α-helix3235-32428
α-helix3247-326014
α-helix3262-328221
α-helix3295-330713
α-helix3312-332514
α-helix3326-33283
α-helix3332-335322
β-strand336215
α-helix3365-337814
α-helix3416-342510
α-helix3428-34303
β-strand343315
α-helix3434-345118
α-helix3452-34543
β-strand3459-346026
α-helix3467-34704
β-strand347917
α-helix3483-34853
β-strand349517
β-strand3496-3505106
β-strand3514-352076
β-strand3525-353286
α-helix3536-355217
α-helix3553-35575
α-helix3560-35634
β-strand3574-357526
β-strand3581-358556
β-strand3590-359238
α-helix3593-360210
α-helix3610-362415
α-helix3631-364414
α-helix3650-36589
α-helix3662-368524
β-strand368819
β-strand3696-369948
β-strand3705-370738
β-strand371219
α-helix3733-374513
α-helix3747-375913
α-helix3768-37714
α-helix3773-378412
α-helix3805-382319
α-helix3835-38439
α-helix3845-38484
α-helix3853-38553

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Transformation/transcription domain-associated proteinCprotein3859Homo sapiensQ9Y4A5
E1A-binding protein p400Aprotein3159Homo sapiensQ96L91
Sequence of entity 1 (C), FASTA
>8QRI_1 Transformation/transcription domain-associated protein (chains C)
MAFVATQGATVVDQTTLMKKYLQFVAALTDVNTPDETKLKMMQEVSENFENVTSSPQYST
FLEHIIPRFLTFLQDGEVQFLQEKPAQQLRKLVLEIIHRIPTNEHLRPHTKNVLSVMFRF
LETENEENVLICLRIIIELHKQFRPPITQEIHHFLDFVKQIYKELPKVVNRYFENPQVIP
ENTVPPPEMVGMITTIAVKVNPEREDSETRTHSIIPRGSLSLKVLAELPIIVVLMYQLYK
LNIHNVVAEFVPLIMNTIAIQVSAQARQHKLYNKELYADFIAAQIKTLSFLAYIIRIYQE
LVTKYSQQMVKGMLQLLSNCPAETAHLRKELLIAAKHILTTELRNQFIPCMDKLFDESIL
IGSGYTARETLRPLAYSTLADLVHHVRQHLPLSDLSLAVQLFAKNIDDESLPSSIQTMSC
KLLLNLVDCIRSKSEQESGNGRDVLMRMLEVFVLKFHTIARYQLSAIFKKCKPQSELGAV
EAALPGVPTAPAAPGPAPSPAPVPAPPPPPPPPPPATPVTPAPVPPFEKQGEKDKEDKQT
FQVTDCRSLVKTLVCGVKTITWGITSCKAPGEAQFIPNKQLQPKETQIYIKLVKYAMQAL
DIYQVQIAGNGQTYIRVANCQTVRMKEEKEVLEHFAGVFTMMNPLTFKEIFQTTVPYMVE
RISKNYALQIVANSFLANPTTSALFATILVEYLLDRLPEMGSNVELSNLYLKLFKLVFGS
VSLFAAENEQMLKPHLHKIVNSSMELAQTAKEPYNYFLLLRALFRSIGGGSHDLLYQEFL
PLLPNLLQGLNMLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSQT
LVSQGLRTLELCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPADSISHVAYRVLGKFGG
SNRKMLKESQKLHYVVTEVQGPSITVEFSDCKASLQLPMEKAIETALDCLKSANTEPYYR
RQAWEVIKCFLVAMMSLEDNKHALYQLLAHPNFTEKTIPNVIISHRYKAQDTPARKTFEQ
ALTGAFMSAVIKDLRPSALPFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMFHSE
ENGSKGMDPLVLIDAIAICMAYEEKELCKIGEVALAVIFDVASIILGSKERACQLPLFSY
IVERLCACCYEQAWYAKLGGVVSIKFLMERLPLTWVLQNQQTFLKALLFVMMDLTGEVSN
GAVAMAKTTLEQLLMRCATPLKDEERAEEIVAAQEKSFHHVTHDLVREVTSPNSTVRKQA
MHSLQVLAQVTGKSVTVIMEPHKEVLQDMVPPKKHLLRHQPANAQIGLMEGNTFCTTLQP
RLFTMDLNVVEHKVFYTELLNLCEAEDSALTKLPCYKSLPSLVPLRIAALNALAACNYLP
QSREKIIAALFKALNSTNSELQEAGEACMRKFLEGATIEVDQIHTHMRPLLMMLGDYRSL
TLNVVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVITHKGGQRSDGNESISECGRC
PLSPFCQFEEMKICSAIINLFHLIPAAPQTLVKPLLEVVMKTERAMLIEAGSPFREPLIK
FLTRHPSQTVELFMMEATLNDPQWSRMFMSFLKHKDARPLRDVLAANPNRFITLLLPGGA
QTAVRPGSPSTSTMRLDLQFQAIKIISIIVKNDDSWLASQHSLVSQLRRVWVSENFQERH
RKENMAATNWKEPKLLAYCLLNYCKRNYGDIELLFQLLRAFTGRFLCNMTFLKEYMEEEI
PKNYSIAQKRALFFRFVDFNDPNFGDELKAKVLQHILNPAFLYSFEKGEGEQLLGPPNPE
GDNPESITSVFITKVLDPEKQADMLDSLRIYLLQYATLLVEHAPHHIHDNNKNRNSKLRR
LMTFAWPCLLSKACVDPACKYSGHLLLAHIIAKFAIHKKIVLQVFHSLLKAHAMEARAIV
RQAMAILTPAVPARMEDGHQMLTHWTRKIIVEEGHTVPQLVHILHLIVQHFKVYYPVRHH
LVQHMVSAMQRLGFTPSVTIEQRRLAVDLSEVVIKWELQRIKDQQPDSDMDPNSSGEGVN
SVSSSIKRGLSVDSAQEVKRFRTATGAISAVFGRSQSLPGADSLLAKPIDKQHTDTVVNF
LIRVACQVNDNTNTAGSPGEVLSRRCVNLLKTALRPDMWPKSELKLQWFDKLLMTVEQPN
QVNYGNICTGLEVLSFLLTVLQSPAILSSFKPLQRGIAACMTCGNTKVLRAVHSLLSRLM
SIFPTEPSTSSVASKYEELECLYAAVGKVIYEGLTNYEKATNANPSQLFGTLMILKSACS
NNPSYIDRLISVFMRSLQKMVREHLNPQAASGSTEATSGTSELVMLSLELVKTRLAVMSM
EMRKNFIQAILTSLIEKSPDAKILRAVVKIVEEWVKNNSPMAANQTPTLREKSILLVKMM
TYIEKRFPEDLELNAQFLDLVNYVYRDETLSGSELTAKLEPAFLSGLRCAQPLIRAKFFE
VFDNSMKRRVYERLLYVTCSQNWEAMGNHFWIKQCIELLLAVCEKSTPIGTSCQGAMLPS
ITNVINLADSHDRAAFAMVTHVKQEPRERENSESKEEDVEIDIELAPGDQTSTPKTKELS
EKDIGNQLHMLTNRHDKFLDTLREVKTGALLSAFVQLCHISTTLAEKTWVQLFPRLWKIL
SDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYLGKTH
NLWFRSTLMLEHQAFEKGLSLQIKPKQTTEFYEQESITPPQQEILDSLAELYSLLQEEDM
WAGLWQKRCKYSETATAIAYEQHGFFEQAQESYEKAMDKAKKEHERSNASPAIFPEYQLW
EDHWIRCSKELNQWEALTEYGQSKGHINPYLVLECAWRVSNWTAMKEALVQVEVSCPKEM
AWKVNMYRGYLAICHPEEQQLSFIERLVEMASSLAIREWRRLPHVVSHVHTPLLQAAQQI
IELQEAAQINAGLQPTNLGRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSIFMWRQHHYQ
GKPTWSGMHSSSIVTAYENSSQHDPSSNNAMLGVHASASAIIQYGKIARKQGLVNVALDI
LSRIHTIPTVPIVDCFQKIRQQVKCYLQLAGVMGKNECMQGLEVIESTNLKYFTKEMTAE
FYALKGMFLAQINKSEEANKAFSAAVQMHDVLVKAWAMWGDYLENIFVKERQLHLGVSAI
TCYLHACRHQNESKSRKYLAKVLWLLSFDDDKNTLADAVDKYCIGVPPIQWLAWIPQLLT
CLVGSEGKLLLNLISQVGRVYPQAVYFPIRTLYLTLKIEQRERYKSDPGPIRATAPMWRC
SRIMHMQRELHPTLLSSLEGIVDQMVWFRENWHEEVLRQLQQGLAKCYSVAFEKSGAVSD
AKITPHTLNFVKKLVSTFGVGLENVSNVSTMFSSAASESLARRAQATAQDPVFQKLKGQF
TTDFDFSVPGSMKLHNLISKLKKWIKILEAKTKQLPKFFLIEEKCRFLSNFSAQTAEVEI
PGEFLMPKPTHYYIKIARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESR
REERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQR
CAKKGIEHDNPISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFP
NATDYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGD
LDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTVLRDEIIA
WHKKTQEDTSSPLSAAGQPENMDSQQLVSLVQKAVTAIMTRLHNLAQFEGGESKVNTLVA
AANSLDNLCRMDPAWHPWL
Sequence of entity 2 (A), FASTA
>8QRI_2 E1A-binding protein p400 (chains A)
MHHGTGPQNVQHQLQRSRACPGSEGEEQPAHPNPPPSPAAPFAPSASPSAPQSPSYQIQQ
LMNRSPATGQNVNITLQSVGPVVGGNQQITLAPLPLPSPTSPGFQFSAQPRRFEHGSPSY
IQVTSPLSQQVQTQSPTQPSPGPGQALQNVRAGAPGPGLGLCSSSPTGGFVDASVLVRQI
SLSPSSGGHFVFQDGSGLTQIAQGAQVQLQHPGTPITVRERRPSQPHTQSGGTIHHLGPQ
SPAAAGGAGLQPLASPSHITTANLPPQISSIIQGQLVQQQQVLQGPPLPRPLGFERTPGV
LLPGAGGAAGFGMTSPPPPTSPSRTAVPPGLSSLPLTSVGNTGMKKVPKKLEEIPPASPE
MAQMRKQCLDYHYQEMQALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHYAPLQAYLRQ
NDLDIEEEEEEEEEEEEKSEVINDEVKVVTGKDGQTGTPVAIATQLPPKVSAAFSSQQQP
FQQALAGSLVAGAGSTVETDLFKRQQAMPSTGMAEQSKRPRLEVGHQGVVFQHPGADAGV
PLQQLMPTAQGGMPPTPQAAQLAGQRQSQQQYDPSTGPPVQNAASLHTPLPQLPGRLPPA
GVPTAALSSALQFAQQPQVVEAQTQLQIPVKTQQPNVPIPAPPSSQLPIPPSQPAQLALH
VPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPRPLPTSSTSSLAPVSGSGPGPSPAR
SSPVNRPSSATNKALSPVTSRTPGVVASAPTKPQSPAQNATSSQDSSQDTLTEQITLENQ
VHQRIAELRKAGLWSQRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKL
VRTVVRHHEEKQLREERGKKEEQSRLRRIAASTAREIECFWSNIEQVVEIKLRVELEEKR
KKALNLQKVSRRGKELRPKGFDALQESSLDSGMSGRKRKASISLTDDEVDDEEETIEEEE
ANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFLPSSQWPRPKPDGEDTSGEEDADDCP
GDRESRKDLVLIDSLFIMDQFKAAERMNIGKPNAKDIADVTAVAEAILPKGSARVTTSVK
FNAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNW
GPHLVVVRSCNILKWELELKRWCPGLKILSYIGSHRELKAKRQEWAEPNSFHVCITSYTQ
FFRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNTFLELWT
MVHFLVPGISRPYLSSPLRAPSEESQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKY
EHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVNVLSILVRLQRICNHPGLVEPRHPG
SSYVAGPLEYPSASLILKALERDFWKEADLSMFDLIGLENKITRHEAELLSKKKIPRKLM
EEISTSAAPAARPAAAKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRTAAPTTASAAPQG
PLRGRPPIATFSANPEAKAAAAPFQTSQASASAPRHQPASASSTAASPAHPAKLRAQTTA
QASTPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQARLPSGEVVKIAQLASITGPQSRVA
QPETPVTLQFQGSKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTV
SQAGAVHGALGSKPPAGGPSPAPLTPQVGVPGRVAVNALAVGEPGTASKPASPIGGPTQE
EKTRLLKERLDQIYLVNERRCSQAPVYGRDLLRICALPSHGRVQWRGSLDGRRGKEAGPA
HSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIPPVVAAPPSLRVPRPPPLYSHRMRI
LRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLIL
SQMILMLDILEMFLNFHYLTYVRIDENASSEQRQELMRSFNRDRRIFCAILSTHSRTTGI
NLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEEKLLKNGTKDLI
REVAAQGNDYSMAFLTQRTIQELFEVYSPMDDAGFPVKAEEFVVLSQEPSVTETIAPKIA
RPFIEALKSIEYLEEDAQKSAQEGVLGPHTDALSSDSENMPCDEEPSQLEELADFMEQLT
PIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAWEFWNLKTLQEREARLRLEQEEAEL
LTYTREDAYSMEYVYEDVDGQTEVMPLWTPPTPPQDDSDIYLDSVMCLMYEATPIPEAKL
PPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRATPGLLKIRREGKEQKKNIL
LKQQVPFAKPLPTFAKPTAEPGQDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPN
WDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGKSKNNRPLRTSQIYAQDENATHTQL
YTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAE
RIAKEKKALADQQKAQQPAVAQPPPPQPQPPPPPQQPPPPLPQPQAAGSQPPAGPPAVQP
QPQPQPQTQPQPVQAPAKAQPAITTGGSAAVLAGTIKTSVTGTSMPTGAVSGNVIVNTIA
GVPAATFQSINKRLASPVAPGALTTPGGSAPAQVVHTQPPPRAVGSPATATPDLVSMATT
QGVRAVTSVTASAVVTTNLTPVQTPARSLVPQVSQATGVQLPGKTITPAHFQLLRQQQQQ
QQQQQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKM
QKQKLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVA
NLQVARLTRVPTSQLQAQGQMQTQAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAG
ISVAIGQPQKAAGQTVVAQPVHMQQLLKLKQQAVQQQKAIQPQAAQGPAAVQQKITAQQI
TTPGAQQKVAYAAQPALKTQFLTTPISQAQKLAGAQQVQTQIQVAKLPQVVQQQTPVASI
QQVASASQQASPQTVALTQATAAGQQVQMIPAVTATAQVVQQKLIQQQVVTTASAPLQTP
GAPNPAQVPASSDSPSQQPKLQMRVPAVRLKTPTKPPCQ

Primary citation

Structure of the human TIP60-C histone exchange and acetyltransferase complex. Li, C., Smirnova, E., Schnitzler, C. et al. Nature (2024) 635:764-769. DOI 10.1038/s41586-024-08011-w · PubMed

Other PDB entries of the same protein (UniProt Q9Y4A5), best resolution first:

Browse structure collections

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