8QVX: PBD of human SRP68/72

Structure of the PBD of human SRP68/72 (cryoSPARC 3DFlex). Determined by electron microscopy at 2.7 Å resolution. Released 30 Oct 2024.

Method
Electron microscopy
Resolution
2.7 Å
Organism
Homo sapiens
Chains
2
Atoms
3,948
Mol. weight
141.61 kDa
Released
30 Oct 2024

Explore 8QVX in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8QVX contains 32 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix554-5563
α-helix565-5684
α-helix579-5813
α-helix585-5895
α-helix595-5973
α-helix604-6063
Chain B: 26 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix11-2414
α-helix28-4013
α-helix45-5814
α-helix61-7515
α-helix81-9010
α-helix94-1029
α-helix109-12113
α-helix125-13814
α-helix144-15714
α-helix158-1625
α-helix176-18914
α-helix193-21119
α-helix223-23917
α-helix242-25413
α-helix261-27414
α-helix279-28911
α-helix294-2974
α-helix300-31617
α-helix320-33314
α-helix341-35010
α-helix355-36713
α-helix372-38211
α-helix389-3979
α-helix406-41813
α-helix422-43918
α-helix444-46017

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Signal recognition particle subunit SRP68Aprotein577Homo sapiensQ9UHB9 (AlphaFold model)
Signal recognition particle subunit SRP72Bprotein674Homo sapiensO76094 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>8QVX_1 Signal recognition particle subunit SRP68 (chains A)
MKEFGDSLSLEILQIIKESQQQHGLRHGDFQRYRGYCSRRQRRLRKTLNFKMGNRHKFTG
KKVTEELLTDNRYLLLVLMDAERAWSYAMQLKQEANTEPRKRFHLLSRLRKAVKHAEELE
RLCESNRVDAKTKLEAQAYTAYLSGMLRFEHQEWKAAIEAFNKCKTIYEKLASAFTEEQA
VLYNQRVEEISPNIRYCAYNIGDQSAINELMQMRLRSGGTEGLLAEKLEALITQTRAKQA
ATMSEVEWRGRTVPVKIDKVRIFLLGLADNEAAIVQAESEETKERLFESMLSECRDAIQV
VREELKPDQKQRDYILEGEPGKVSNLQYLHSYLTYIKLSTAIKRNENMAKGLQRALLQQQ
PEDDSKRSPRPQDLIRLYDIILQNLVELLQLPGLEEDKAFQKEIGLKTLVFKAYRCFFIA
QSYVLVKKWSEALVLYDRVLKYANEVNSDAGAFKNSLKDLPDVQELITQVRSEKCSLQAA
AILDANDAHQTETSSSQVKDNKPLVERFETFCLDPSLVTKQANLVHFPPGFQPIPCKPLF
FDLALNHVAFPPLEDKLEQKTKSGLTGYIKGIFGFRS
Sequence of entity 2 (B), FASTA
>8QVX_2 Signal recognition particle subunit SRP72 (chains B)
SNAMASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQ
NGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQ
VLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHE
LCYNTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDPQAELAIIHGQMAYILQ
LQGRTEEALQLYNQIIKLKPTDVGLLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFK
LSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKA
IELLQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVTMYS
HEEDIDSAIEVFTQAIQWYQNHQPKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQN
PKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSAGATYIRKKGGKV
TGDSQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQ
IGKGTQGATAGASSELDASKTVSSPPTSPRPGSAATVSASTSNIIPPRHQKPAGAPATKK
KQQQKKKKGGKGGW

Primary citation

Cryo-EM structure of SRP68/72 reveals an extended dimerization domain with RNA-binding activity. Zhong, Y., Feng, J., Koh, A.F. et al. Nucleic Acids Res (2024) 52:5285-5300. DOI 10.1093/nar/gkae107 · PubMed

Other PDB entries of the same protein (UniProt Q9UHB9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 8QVX directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.