8RU4: Human Catenin Beta-1

Crystal structure of Human Catenin Beta-1 in complex with stitched peptide inhibitor. Determined by X-ray diffraction at 2.13 Å resolution. Released 4 Sept 2024.

Method
X-ray diffraction
Resolution
2.13 Å
Organism
Homo sapiens
Chains
3
Atoms
8,174
Mol. weight
117.3 kDa
Ligands
GLC
Released
4 Sept 2024

Explore 8RU4 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8RU4 contains 78 α-helices and 4 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 39 helices, 2 β-strands

ElementResiduesLengthSheet
α-helix153-1608
α-helix165-17814
α-helix182-1909
α-helix194-20411
α-helix208-22114
α-helix225-2339
α-helix236-2427
α-helix243-2453
α-helix249-26517
α-helix269-2757
α-helix278-2847
α-helix285-2873
α-helix291-30515
α-helix309-3179
α-helix320-33011
α-helix334-34714
α-helix353-3597
α-helix362-3676
α-helix375-38814
α-helix389-3913
α-helix399-40810
α-helix414-42815
α-helix432-4409
α-helix443-45412
α-helix458-47114
α-helix478-48710
α-helix491-4966
α-helix504-51714
α-helix521-5233
α-helix524-5296
α-helix532-54918
β-strand56111
β-strand56411
α-helix566-58015
α-helix584-5929
α-helix596-6016
α-helix602-6043
α-helix608-62114
α-helix625-6339
α-helix637-6437
α-helix649-66214
Chain B: 38 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix154-1585
α-helix168-18013
α-helix186-1905
α-helix195-2039
α-helix208-22114
α-helix225-2339
α-helix236-2427
α-helix243-2453
α-helix249-26517
α-helix269-2757
α-helix278-2847
α-helix285-2873
α-helix291-30515
α-helix309-3179
α-helix320-33011
α-helix334-34714
α-helix353-3597
α-helix362-3676
α-helix375-38814
α-helix389-3913
α-helix399-40810
α-helix414-42815
α-helix432-4409
α-helix443-45412
α-helix458-47114
α-helix478-48710
α-helix491-4966
α-helix504-51714
α-helix521-5233
α-helix524-5296
α-helix532-54918
β-strand56112
β-strand56412
α-helix566-58015
α-helix584-5929
α-helix596-6016
α-helix608-62114
α-helix625-6339
α-helix637-6437
α-helix649-66315
Chain C: 1 helix, 0 β-strands
ElementResiduesLengthSheet
α-helix3-119

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Catenin beta-1A, Bprotein523Homo sapiensP35222 (AlphaFold model)
Axin-1Cprotein13Homo sapiensO15169 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>8RU4_1 Catenin beta-1 (chains A, B)
GPDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTM
QNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNL
LLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQ
ALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCL
WTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVG
GIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPS
HWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVE
GVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELA
QDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSED
Sequence of entity 2 (C), FASTA
>8RU4_2 Axin-1 (chains C)
XXILDXHLXRVWX

Ligands and cofactors

IDNameFormulaCopies
GLCalpha-D-glucopyranoseC6 H12 O67

Water and common crystallization additives (TRS, CL, NA) are not listed.

Primary citation

Structure-Based Design of Bicyclic Helical Peptides That Target the Oncogene beta-Catenin. Yeste-Vazquez, A., Paulussen, F.M., Wendt, M. et al. Angew Chem Int Ed Engl (2024) 63:e202411749-e202411749. DOI 10.1002/anie.202411749 · PubMed

Other PDB entries of the same protein (UniProt P35222 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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