8S09: H. sapiens MCM2-7 double hexamer

H. sapiens MCM2-7 double hexamer bound to double stranded DNA. Determined by electron microscopy at 3.1 Å resolution. Released 2 Oct 2024.

Method: Electron microscopy
Resolution: 3.1 Å
Organisms: synthetic construct, Homo sapiens
Chains: 14
Atoms: 64,107
Mol. weight: 1126.72 kDa
Ligands: ATP, ZN, ADP, MG
Released: 2 Oct 2024

Explore 8S09 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8S09 contains 348 α-helices and 368 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains 2 and A: 32 helices, 30 β-strands

Element	Residues	Length	Sheet
α-helix	182-187	6
α-helix	189-205	17
α-helix	214-223	10
β-strand	229-232	4	1
α-helix	234-240	7
α-helix	242-247	6
α-helix	252-270	19
α-helix	274-277	4
β-strand	282-285	4	1
α-helix	289-292	4
α-helix	299-301	3
β-strand	305-315	11	2
β-strand	319-323	5	2
β-strand	325-329	5	3
β-strand	335-339	5	3
β-strand	361-363	3	3
β-strand	369-379	11	2
α-helix	386	1
β-strand	393-399	7	2
α-helix	400-402	3
β-strand	411-419	9	2
β-strand	426	1	4
β-strand	434	1	5
β-strand	435	1	4
β-strand	438-445	8	2
α-helix	459-469	11
α-helix	473-480	8
α-helix	489-500	12
β-strand	505	1	6
β-strand	513	1	6
β-strand	519-523	5	7
α-helix	529-539	11
β-strand	543-547	5	7
β-strand	559-562	4	8
β-strand	569-572	4	8
α-helix	575-578	4
β-strand	582-587	6	7
α-helix	589-591	3
α-helix	594-605	12
β-strand	608-613	6	9
β-strand	616-621	6	9
β-strand	624-630	7	7
α-helix	643-646	4
α-helix	651-656	6
β-strand	659-663	5	7
α-helix	669-685	17
α-helix	714-716	3
α-helix	717-730	14
β-strand	734	1	10
α-helix	740-757	18
α-helix	764-780	17
β-strand	785	1	10
α-helix	788-804	17
α-helix	808-817	10
α-helix	819-822	4
α-helix	828-851	24
β-strand	859-861	3	11
α-helix	862-871	10
α-helix	878-882	5
α-helix	884-888	5
β-strand	892-894	3	11
β-strand	899-901	3	11

Chains 3 and B: 27 helices, 35 β-strands

Element	Residues	Length	Sheet
β-strand	5-6	2	12
α-helix	10-22	13
α-helix	32-42	11
β-strand	46-50	5	13
α-helix	51-57	7
α-helix	59-67	9
α-helix	70-87	18
α-helix	91-93	3
β-strand	99-103	5	13
α-helix	107-109	3
β-strand	110	1	14
α-helix	118-120	3
β-strand	124-134	11	14
β-strand	138-148	11	15
β-strand	153-158	6	15
β-strand	177	1	16
β-strand	183	1	16
β-strand	185-186	2	15
β-strand	192-196	5	15
β-strand	197-202	6	14
α-helix	209	1
β-strand	216-221	6	14
β-strand	234-244	11	14
α-helix	245-248	4
β-strand	251-252	2	17
β-strand	255	1	18
β-strand	257-267	11	14
α-helix	282-291	10
α-helix	293-301	9
α-helix	311-322	12
β-strand	327-328	2	19
β-strand	334-335	2	19
β-strand	340-345	6	20
α-helix	351-361	11
β-strand	365-367	3	20
α-helix	375-378	4
β-strand	380-384	5	21
β-strand	391-395	5	21
α-helix	397-400	4
β-strand	404-409	6	20
α-helix	411-413	3
α-helix	416-427	12
β-strand	430-435	6	22
β-strand	438-443	6	22
β-strand	446-452	7	20
α-helix	465-469	5
α-helix	473-478	6
β-strand	481-485	5	20
α-helix	491-506	16
β-strand	516	1	23
β-strand	545	1	24
α-helix	546-548	3
α-helix	556-559	4
β-strand	563	1	24
α-helix	565-577	13
β-strand	581-582	2	25
α-helix	584-600	17
β-strand	608-609	2	26
α-helix	616-631	16
β-strand	636-637	2	25
α-helix	639-653	15
β-strand	654-655	2	26

Chains 4 and C: 24 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	159-172	14
α-helix	192-203	12
β-strand	207-211	5	27
α-helix	212-218	7
α-helix	220-228	9
α-helix	230-248	19
β-strand	259-263	5	27
α-helix	271-273	3
α-helix	276-278	3
β-strand	282-292	11	28
β-strand	296-306	11	28
β-strand	312-316	5	28
β-strand	318	1	29
β-strand	321-324	4	29
β-strand	327	1	30
β-strand	334	1	30
β-strand	337-356	20	28
β-strand	369-375	7	28
α-helix	376-378	3
β-strand	387-397	11	28
β-strand	400	1	31
β-strand	408-409	2	31
β-strand	411	1	32
β-strand	413-422	10	28
α-helix	432-435	4
α-helix	443-454	12
α-helix	458-465	8
α-helix	474-485	12
β-strand	506-509	4	33
α-helix	516-526	11
β-strand	530-534	5	33
α-helix	535-537	3
β-strand	538	1	34
β-strand	545-548	4	35
β-strand	556-560	5	35
α-helix	562-565	4
β-strand	570-574	5	33
α-helix	581-593	13
β-strand	595-600	6	36
β-strand	603-608	6	36
β-strand	612-617	6	33
α-helix	630-634	5
α-helix	638-642	5
β-strand	646-649	4	33
α-helix	656-668	13
α-helix	684-697	14
β-strand	701-702	2	37
α-helix	704-721	18
α-helix	727-729	3
α-helix	732-747	16
β-strand	752-753	2	37
α-helix	755-768	14

Chains 5 and D: 33 helices, 36 β-strands

Element	Residues	Length	Sheet
β-strand	10-11	2	38
α-helix	28-41	14
β-strand	44-46	3	39
β-strand	50-52	3	39
α-helix	54-65	12
β-strand	69-73	5	40
α-helix	74-80	7
α-helix	82-88	7
α-helix	92-110	19
α-helix	114-115	2
α-helix	120-123	4
β-strand	125-129	5	40
α-helix	137-139	3
α-helix	142-144	3
β-strand	148-158	11	18
α-helix	159-161	3
β-strand	162-172	11	18
β-strand	178-183	6	18
α-helix	184-185	2
β-strand	189	1	41
β-strand	191-192	2	17
β-strand	212-214	3	18
α-helix	216-218	3
β-strand	220-230	11	18
α-helix	236-237	2
β-strand	244-250	7	18
α-helix	251-253	3
β-strand	262-271	10	18
β-strand	273	1	41
α-helix	277-279	3
β-strand	289	1	2
β-strand	292-301	10	18
α-helix	317-326	10
α-helix	331-338	8
α-helix	347-358	12
β-strand	363-364	2	42
β-strand	370-371	2	42
β-strand	376-381	6	43
α-helix	388-397	10
β-strand	401-405	5	43
β-strand	408	1	43
β-strand	411	1	9
β-strand	417-420	4	44
β-strand	427-430	4	44
β-strand	441-445	5	43
α-helix	452-463	12
β-strand	466-471	6	45
β-strand	474-479	6	45
β-strand	483-488	6	43
α-helix	508-512	5
β-strand	516-520	5	43
α-helix	526-542	17
α-helix	553-555	3
α-helix	556-569	14
β-strand	570	1	23
β-strand	573	1	46
α-helix	576-600	25
α-helix	610-625	16
β-strand	631	1	46
α-helix	634-644	11
α-helix	645-649	5
α-helix	650-652	3
α-helix	668-682	15
α-helix	684	1
β-strand	688-690	3	47
α-helix	691-700	10
α-helix	705-718	14
β-strand	721-723	3	47
β-strand	729-732	4	47

Chains 6 and E: 31 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	21-36	16
α-helix	45-52	8
β-strand	60-63	4	48
α-helix	65-71	7
α-helix	73-81	9
α-helix	83-101	19
β-strand	111-114	4	48
α-helix	128-130	3
β-strand	134-144	11	5
α-helix	145-147	3
β-strand	148-151	4	5
β-strand	153-158	6	49
β-strand	164-169	6	49
β-strand	191-193	3	49
α-helix	195-197	3
β-strand	200-209	10	5
α-helix	212-214	3
α-helix	220-222	3
β-strand	223-229	7	5
α-helix	230-233	4
β-strand	241-252	12	5
β-strand	263-266	4	29
α-helix	280-286	7
β-strand	291	1	29
β-strand	294-305	12	5
α-helix	322-328	7
α-helix	331-341	11
α-helix	345-354	10
α-helix	362-373	12
β-strand	378-379	2	50
β-strand	385-386	2	50
β-strand	392-396	5	51
α-helix	402-412	11
β-strand	416-420	5	51
β-strand	424	1	36
β-strand	431-435	5	52
β-strand	442-446	5	52
α-helix	448-451	4
β-strand	456-460	5	51
α-helix	462-464	3
α-helix	467-479	13
β-strand	481-486	6	53
β-strand	489-494	6	53
β-strand	498-503	6	51
α-helix	516-518	3
α-helix	524-529	6
β-strand	532-536	5	51
α-helix	544-557	14
α-helix	569-579	11
β-strand	585-586	2	54
α-helix	588-603	16
β-strand	612	1	55
α-helix	618-635	18
β-strand	639-640	2	54
α-helix	642-655	14
β-strand	658	1	55
α-helix	718-737	20
α-helix	745-756	12
α-helix	763-778	16
α-helix	779-784	6

Chains 7 and F: 27 helices, 26 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
α-helix	32-41	10
β-strand	47-51	5	56
α-helix	55-57	3
α-helix	60-68	9
α-helix	70-88	19
α-helix	98-113	16
α-helix	122-124	3
α-helix	126-127	2
α-helix	128-131	4
β-strand	135-139	5	56
α-helix	145-146	2
β-strand	147	1	57
α-helix	149-151	3
α-helix	154-156	3
β-strand	160-170	11	57
α-helix	171-173	3
β-strand	174-183	10	32
β-strand	190-194	5	32
β-strand	199-200	2	31
β-strand	205	1	58
α-helix	209-214	6
β-strand	219	1	58
β-strand	221-232	12	32
β-strand	233-238	6	57
β-strand	252-257	6	57
β-strand	270-281	12	57
β-strand	293	1	15
β-strand	294-304	11	57
α-helix	348-359	12
β-strand	377-381	5	59
α-helix	388-397	10
β-strand	401-404	4	59
α-helix	407-409	3
α-helix	411-413	3
β-strand	416-419	4	60
β-strand	428-431	4	60
α-helix	433-436	4
β-strand	441-444	4	59
α-helix	447-449	3
α-helix	452-463	12
β-strand	466-471	6	34
β-strand	474-479	6	34
β-strand	483-488	6	59
α-helix	509-514	6
β-strand	517-521	5	59
α-helix	527-543	17
α-helix	557-566	10
β-strand	572	1	61
α-helix	575-594	20
α-helix	603-620	18
β-strand	624	1	61
α-helix	627-641	15

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA (45-mer)	X	DNA	45	synthetic construct
DNA (45-mer)	Y	DNA	45	synthetic construct
DNA replication licensing factor MCM2	2, A	protein	904	Homo sapiens	P49736 (AlphaFold model)
DNA replication licensing factor MCM3	3, B	protein	810	Homo sapiens	P25205 (AlphaFold model)
DNA replication licensing factor MCM4	4, C	protein	863	Homo sapiens	P33991 (AlphaFold model)
DNA replication licensing factor MCM5	5, D	protein	734	Homo sapiens	P33992 (AlphaFold model)
DNA replication licensing factor MCM6	6, E	protein	821	Homo sapiens	Q14566
DNA replication licensing factor MCM7	7, F	protein	719	Homo sapiens	P33993

Sequence of entity 1 (X), FASTA

>8S09_1 DNA (45-mer) (chains X)
GCATGCATGCGCATGCATGCATTATGCATGCATGCGCATGCATGC

Sequence of entity 2 (Y), FASTA

>8S09_2 DNA (45-mer) (chains Y)
GCATGCATGCGCATGCATGCATAATGCATGCATGCGCATGCATGC

Sequence of entity 3 (2, A), FASTA

>8S09_3 DNA replication licensing factor MCM2 (chains 2, A)
MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTE
GPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQR
DREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGH
SVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAR
EHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQL
HLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGP
FEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHN
NYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFAS
IAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVS
SRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSI
HEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDIL
CVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVL
KKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARI
HLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLV
AEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMI
LQQF

Sequence of entity 4 (3, B), FASTA

>8S09_4 DNA replication licensing factor MCM3 (chains 3, B)
GEMAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKN
EKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTS
CFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKD
EENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVV
GTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQ
LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYV
LCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMD
RTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSR
FDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQED
QQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLR
SQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVL
EKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMP
QVHTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEE
PFSSVEIQAALSKMQDDNQVMVSEGIIFLI

Sequence of entity 5 (4, C), FASTA

>8S09_5 DNA replication licensing factor MCM4 (chains 4, C)
MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQ
SPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGS
AQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKE
EENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMA
VNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQ
EAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPED
MPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIH
YRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGI
LLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSA
VGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAK
AGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDR
RLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKI
GSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGI
VDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMF
EEALRALADDDFLTVTGKTVRLL

Sequence of entity 6 (5, D), FASTA

>8S09_6 DNA replication licensing factor MCM5 (chains 5, D)
MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELK
RHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEV
LQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLT
NIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGE
MPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQ
VDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGG
SRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMR
DPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNS
RCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLH
VSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDS
DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGV
EGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQLMLRRGE
IQHRMQRKVLYRLK

Sequence of entity 7 (6, E), FASTA

>8S09_7 DNA replication licensing factor MCM6 (chains 6, E)
MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNT
LVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTR
HKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNIC
RNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGD
KCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLA
CCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHG
NDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTS
GKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQ
TISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDEC
NEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKH
LRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVE
TPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEY
CRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVIHRL
THYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLED

Sequence of entity 8 (7, F), FASTA

>8S09_8 DNA replication licensing factor MCM7 (chains 7, F)
MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDP
ELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVR
SPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVA
TYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEH
SDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEA
HRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVG
GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLR
DSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNA
RCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYV
HQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATY
TSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADV
IFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV

Ligands and cofactors

ID	Name	Formula	Copies
ATP	Adenosine-5'-triphosphate	C10 H16 N5 O13 P3	2
ZN	Zinc ion	Zn	10
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	8
MG	Magnesium ion	Mg	8

Primary citation

MCM double hexamer loading visualized with human proteins. Weissmann, F., Greiwe, J.F., Puhringer, T. et al. Nature (2024) 636:499-508. DOI 10.1038/s41586-024-08263-6 · PubMed

Other PDB entries of the same protein (UniProt P49736 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6YA7 1.67 Å, Cdc7-Dbf4 bound to an Mcm2-S40 derived bivalent substrate
7CIZ 1.8 Å, Crystal structure of DNAJC9 HBD helix2 in complex with H3.3-H4 dimer and MCM2 HBD
5BNX 2.31 Å, Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.3-H4 dimer
5JA4 2.42 Å, Crystal structure of human TONSL and MCM2 HBDs binding to a histone H3-H4 tetramer
7CJ0 2.5 Å, Crystal structure of DNAJC9 HBD in complex with H3.3-H4 dimer and MCM2 HBD
7W1Y 2.59 Å, Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA)
9E2Z 2.6 Å, Cryo-EM structure of human CMG helicase stalled at G4-containing DNA template
5BNV 2.79 Å, Crystal structure of Human MCM2 HBD chaperoning a histone H3-H4 tetramer
7PLO 2.8 Å, H. sapiens replisome-CUL2/LRR1 complex
8W0F 2.8 Å, Cryo-EM structure of a human MCM2-7 double hexamer on dsDNA
4UUZ 2.9 Å, MCM2-histone complex
5BO0 2.91 Å, Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.2-H4 dimer

Browse structure collections

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