8S0A: H. sapiens MCM2-7 hexamer

H. sapiens MCM2-7 hexamer bound to double stranded DNA. Determined by electron microscopy at 3.2 Å resolution. Released 2 Oct 2024.

Method: Electron microscopy
Resolution: 3.2 Å
Organisms: synthetic construct, Homo sapiens
Chains: 8
Atoms: 31,433
Mol. weight: 563.03 kDa
Ligands: ATP, ADP, ZN, MG
Released: 2 Oct 2024

Explore 8S0A in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8S0A contains 187 α-helices and 183 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 2: 34 helices, 32 β-strands

Element	Residues	Length	Sheet
α-helix	182-187	6
α-helix	189-205	17
α-helix	214-224	11
β-strand	229-232	4	1
α-helix	234-240	7
α-helix	242-247	6
α-helix	252-270	19
α-helix	274-277	4
β-strand	282-285	4	1
α-helix	299-301	3
β-strand	305-315	11	2
β-strand	319-323	5	2
β-strand	325	1	3
β-strand	327-328	2	4
α-helix	334	1
β-strand	335	1	4
α-helix	336-338	3
β-strand	339	1	3
β-strand	362-363	2	4
β-strand	369-379	11	2
α-helix	382-384	3
α-helix	386	1
β-strand	393-399	7	2
α-helix	400-402	3
β-strand	411-419	9	2
β-strand	426	1	5
β-strand	434	1	6
β-strand	435	1	5
β-strand	438-445	8	2
α-helix	459-468	10
α-helix	473-480	8
α-helix	489-500	12
β-strand	505	1	7
β-strand	513	1	7
β-strand	519-523	5	8
α-helix	529-539	11
β-strand	543-547	5	8
β-strand	559-562	4	9
β-strand	569-572	4	9
α-helix	575-578	4
β-strand	582-587	6	8
α-helix	589-591	3
α-helix	594-605	12
β-strand	608-613	6	10
β-strand	616-621	6	10
β-strand	624-630	7	8
α-helix	644-646	3
α-helix	651-656	6
β-strand	659-663	5	8
α-helix	669-685	17
α-helix	714-716	3
α-helix	717-730	14
β-strand	734	1	11
α-helix	740-757	18
α-helix	764-780	17
β-strand	785	1	11
α-helix	788-804	17
α-helix	808-817	10
α-helix	819-822	4
α-helix	828-851	24
β-strand	859-861	3	12
α-helix	862-871	10
α-helix	878-882	5
α-helix	884-888	5
β-strand	892-894	3	12
β-strand	899-901	3	12

Chain 3: 32 helices, 33 β-strands

Element	Residues	Length	Sheet
α-helix	11-23	13
α-helix	26-28	3
α-helix	32-41	10
β-strand	46-50	5	13
α-helix	51-57	7
α-helix	59-67	9
α-helix	70-92	23
β-strand	99-103	5	13
α-helix	107-109	3
β-strand	110	1	14
α-helix	113-115	3
α-helix	118-120	3
β-strand	124-134	11	14
β-strand	138-148	11	14
β-strand	153-158	6	14
β-strand	177	1	15
β-strand	183	1	15
β-strand	185-186	2	14
β-strand	192-202	11	14
α-helix	209	1
β-strand	216-222	7	14
α-helix	223-228	6
β-strand	234-244	11	14
α-helix	245-247	3
β-strand	251-252	2	16
β-strand	255-256	2	17
β-strand	257-267	11	14
α-helix	280-291	12
α-helix	294-301	8
α-helix	311-322	12
β-strand	327-328	2	18
β-strand	334-335	2	18
β-strand	340-345	6	19
α-helix	351-361	11
β-strand	365-367	3	19
α-helix	375-378	4
β-strand	381-384	4	20
β-strand	391-394	4	20
α-helix	397-400	4
β-strand	405-408	4	19
α-helix	411-413	3
α-helix	416-428	13
β-strand	430-435	6	21
β-strand	438-443	6	21
β-strand	447-452	6	19
α-helix	465-469	5
α-helix	473-478	6
β-strand	481-485	5	19
α-helix	491-506	16
β-strand	516	1	22
β-strand	545	1	23
α-helix	546-548	3
α-helix	556-559	4
α-helix	562	1
β-strand	563	1	23
α-helix	564	1
α-helix	565-577	13
β-strand	581	1	24
α-helix	584-599	16
α-helix	600-602	3
β-strand	608-609	2	25
α-helix	615-631	17
β-strand	636	1	24
α-helix	639-653	15
β-strand	654-655	2	25

Chain 4: 29 helices, 31 β-strands

Element	Residues	Length	Sheet
α-helix	159-172	14
α-helix	192-203	12
β-strand	207-211	5	26
α-helix	212-218	7
α-helix	220-228	9
α-helix	230-248	19
β-strand	259-263	5	26
α-helix	266	1
β-strand	267	1	27
α-helix	268	1
α-helix	271-273	3
α-helix	276-278	3
β-strand	282-292	11	27
β-strand	296-306	11	27
β-strand	312-316	5	27
β-strand	318	1	28
β-strand	321-324	4	28
β-strand	327	1	29
β-strand	334	1	29
β-strand	337-356	20	27
α-helix	365-367	3
β-strand	368-375	8	27
α-helix	376-378	3
β-strand	387-397	11	27
β-strand	400-402	3	30
β-strand	405-409	5	30
β-strand	411	1	31
β-strand	413-422	10	27
α-helix	429-430	2
α-helix	432-435	4
α-helix	443-454	12
α-helix	458-465	8
α-helix	474-485	12
β-strand	506-510	5	32
α-helix	516-526	11
β-strand	530-534	5	32
α-helix	535-537	3
β-strand	538	1	33
β-strand	545-548	4	34
β-strand	557-560	4	34
α-helix	562-565	4
β-strand	569-574	6	32
α-helix	576-578	3
α-helix	581-593	13
β-strand	595-600	6	35
β-strand	603-608	6	35
β-strand	611-617	7	32
α-helix	630-634	5
α-helix	638-642	5
β-strand	646-650	5	32
α-helix	656-668	13
α-helix	684-695	12
β-strand	701-702	2	36
α-helix	704-721	18
α-helix	727-728	2
α-helix	731-747	17
β-strand	752-753	2	36
α-helix	755-768	14
β-strand	774	1	37
β-strand	781	1	37

Chain 5: 33 helices, 32 β-strands

Element	Residues	Length	Sheet
α-helix	27-41	15
α-helix	54-65	12
β-strand	69-73	5	38
α-helix	74-80	7
α-helix	82-90	9
α-helix	92-110	19
α-helix	114-115	2
α-helix	121-123	3
β-strand	125-129	5	38
α-helix	132-134	3
α-helix	137-139	3
α-helix	142-144	3
β-strand	148-158	11	17
α-helix	159-161	3
β-strand	162-172	11	17
β-strand	178-183	6	17
β-strand	189	1	39
β-strand	191-192	2	16
β-strand	212-214	3	17
α-helix	216-218	3
β-strand	220-230	11	17
α-helix	237	1
β-strand	244-250	7	17
α-helix	251-253	3
β-strand	262-271	10	17
β-strand	273	1	39
β-strand	289	1	2
β-strand	292-301	10	17
α-helix	317-326	10
α-helix	331-338	8
α-helix	347-358	12
β-strand	363-364	2	40
β-strand	370-371	2	40
β-strand	376-381	6	41
α-helix	388-397	10
β-strand	401-404	4	41
β-strand	411	1	10
β-strand	417-420	4	42
β-strand	427-430	4	42
α-helix	433-436	4
β-strand	441-444	4	41
α-helix	447-449	3
α-helix	452-463	12
β-strand	466-471	6	43
β-strand	474-479	6	43
β-strand	483-488	6	41
α-helix	508-513	6
β-strand	516-520	5	41
α-helix	526-542	17
α-helix	553-555	3
α-helix	556-569	14
β-strand	570	1	22
β-strand	573	1	44
α-helix	576-600	25
α-helix	610-626	17
β-strand	631	1	44
α-helix	634-644	11
α-helix	645-649	5
α-helix	650-653	4
α-helix	668-682	15
β-strand	688-690	3	45
α-helix	691-700	10
α-helix	705-718	14
β-strand	721-725	5	45
β-strand	729-732	4	45

Chain 6: 31 helices, 30 β-strands

Element	Residues	Length	Sheet
α-helix	21-36	16
α-helix	45-50	6
α-helix	51-54	4
β-strand	60-63	4	46
α-helix	65-69	5
α-helix	73-81	9
α-helix	83-101	19
β-strand	111-114	4	46
α-helix	123-125	3
α-helix	128-130	3
β-strand	131	1	47
β-strand	134-144	11	47
β-strand	148-151	4	6
β-strand	153-158	6	48
β-strand	164-169	6	48
β-strand	191-193	3	48
β-strand	200-203	4	6
β-strand	204-209	6	47
α-helix	212-214	3
α-helix	220-222	3
β-strand	223-228	6	47
α-helix	230-233	4
β-strand	241-252	12	47
β-strand	263-266	4	28
β-strand	294-305	12	47
α-helix	322-328	7
α-helix	331-341	11
α-helix	346-354	9
α-helix	362-373	12
β-strand	378-379	2	49
β-strand	385-386	2	49
β-strand	392-396	5	50
α-helix	404-412	9
β-strand	416-420	5	50
α-helix	421-423	3
β-strand	424	1	35
β-strand	431-435	5	51
β-strand	442-446	5	51
α-helix	448-451	4
β-strand	456-460	5	50
α-helix	462-464	3
α-helix	467-479	13
β-strand	481-486	6	52
β-strand	489-494	6	52
β-strand	498-503	6	50
α-helix	524-529	6
β-strand	532-536	5	50
α-helix	542-557	16
α-helix	569-579	11
β-strand	585-586	2	53
α-helix	588-603	16
α-helix	610-611	2
β-strand	612	1	54
α-helix	618-635	18
β-strand	639-640	2	53
α-helix	642-655	14
β-strand	658	1	54
α-helix	718-737	20
α-helix	745-756	12
α-helix	763-778	16
α-helix	779-783	5

Chain 7: 28 helices, 25 β-strands

Element	Residues	Length	Sheet
α-helix	6-18	13
α-helix	32-41	10
β-strand	47-51	5	55
α-helix	52-55	4
α-helix	61-68	8
α-helix	70-88	19
α-helix	98-108	11
α-helix	128-131	4
β-strand	135-139	5	55
β-strand	147	1	31
α-helix	149-151	3
α-helix	154-156	3
β-strand	160-170	11	31
α-helix	171-173	3
β-strand	174-184	11	31
β-strand	190-194	5	31
β-strand	199-200	2	30
α-helix	201-203	3
β-strand	205	1	56
α-helix	209-214	6
β-strand	219	1	56
β-strand	220-238	19	31
β-strand	252-258	7	31
α-helix	259-261	3
β-strand	270-280	11	31
β-strand	293	1	14
β-strand	295-305	11	31
α-helix	348-350	3
α-helix	352-359	8
β-strand	377-381	5	57
α-helix	387-397	11
β-strand	401-404	4	57
α-helix	407-409	3
α-helix	411-413	3
β-strand	416-420	5	58
β-strand	427-431	5	58
α-helix	433-436	4
β-strand	441-444	4	57
α-helix	447-449	3
α-helix	452-464	13
β-strand	466-471	6	33
β-strand	474-479	6	33
β-strand	483-488	6	57
α-helix	509-514	6
β-strand	517-521	5	57
α-helix	527-543	17
α-helix	546-548	3
α-helix	556-566	11
β-strand	572	1	59
α-helix	577-594	18
α-helix	603-619	17
β-strand	624	1	59
α-helix	627-641	15

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA (22-mer)	X	DNA	22	synthetic construct
DNA (22-mer)	Y	DNA	22	synthetic construct
DNA replication licensing factor MCM2	2	protein	904	Homo sapiens	P49736 (AlphaFold model)
DNA replication licensing factor MCM3	3	protein	810	Homo sapiens	P25205 (AlphaFold model)
DNA replication licensing factor MCM4	4	protein	863	Homo sapiens	P33991 (AlphaFold model)
DNA replication licensing factor MCM5	5	protein	734	Homo sapiens	P33992 (AlphaFold model)
DNA replication licensing factor MCM6	6	protein	821	Homo sapiens	Q14566
DNA replication licensing factor MCM7	7	protein	719	Homo sapiens	P33993

Sequence of entity 1 (X), FASTA

>8S0A_1 DNA (22-mer) (chains X)
ATGCATGCATGCGCATGCATGC

Sequence of entity 2 (Y), FASTA

>8S0A_2 DNA (22-mer) (chains Y)
GCATGCATGCGCATGCATGCAT

Sequence of entity 3 (2), FASTA

>8S0A_3 DNA replication licensing factor MCM2 (chains 2)
MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTE
GPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQR
DREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGH
SVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAR
EHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQL
HLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGP
FEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHN
NYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFAS
IAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVS
SRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSI
HEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDIL
CVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVL
KKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARI
HLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLV
AEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMI
LQQF

Sequence of entity 4 (3), FASTA

>8S0A_4 DNA replication licensing factor MCM3 (chains 3)
GEMAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKN
EKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTS
CFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKD
EENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVV
GTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQ
LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYV
LCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMD
RTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSR
FDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQED
QQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLR
SQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVL
EKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMP
QVHTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEE
PFSSVEIQAALSKMQDDNQVMVSEGIIFLI

Sequence of entity 5 (4), FASTA

>8S0A_5 DNA replication licensing factor MCM4 (chains 4)
MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQ
SPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGS
AQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKE
EENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMA
VNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQ
EAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPED
MPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIH
YRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGI
LLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSA
VGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAK
AGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDR
RLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKI
GSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGI
VDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMF
EEALRALADDDFLTVTGKTVRLL

Sequence of entity 6 (5), FASTA

>8S0A_6 DNA replication licensing factor MCM5 (chains 5)
MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELK
RHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEV
LQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLT
NIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGE
MPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQ
VDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGG
SRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMR
DPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNS
RCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLH
VSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDS
DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGV
EGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQLMLRRGE
IQHRMQRKVLYRLK

Sequence of entity 7 (6), FASTA

>8S0A_7 DNA replication licensing factor MCM6 (chains 6)
MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNT
LVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTR
HKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNIC
RNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGD
KCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLA
CCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHG
NDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTS
GKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQ
TISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDEC
NEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKH
LRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVE
TPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEY
CRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVIHRL
THYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLED

Sequence of entity 8 (7), FASTA

>8S0A_8 DNA replication licensing factor MCM7 (chains 7)
MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDP
ELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVR
SPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVA
TYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEH
SDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEA
HRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVG
GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLR
DSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNA
RCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYV
HQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATY
TSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADV
IFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV

Ligands and cofactors

ID	Name	Formula	Copies
ATP	Adenosine-5'-triphosphate	C10 H16 N5 O13 P3	1
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	4
ZN	Zinc ion	Zn	5
MG	Magnesium ion	Mg	5

Primary citation

MCM double hexamer loading visualized with human proteins. Weissmann, F., Greiwe, J.F., Puhringer, T. et al. Nature (2024) 636:499-508. DOI 10.1038/s41586-024-08263-6 · PubMed

Other PDB entries of the same protein (UniProt P49736 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6YA7 1.67 Å, Cdc7-Dbf4 bound to an Mcm2-S40 derived bivalent substrate
7CIZ 1.8 Å, Crystal structure of DNAJC9 HBD helix2 in complex with H3.3-H4 dimer and MCM2 HBD
5BNX 2.31 Å, Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.3-H4 dimer
5JA4 2.42 Å, Crystal structure of human TONSL and MCM2 HBDs binding to a histone H3-H4 tetramer
7CJ0 2.5 Å, Crystal structure of DNAJC9 HBD in complex with H3.3-H4 dimer and MCM2 HBD
7W1Y 2.59 Å, Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA)
9E2Z 2.6 Å, Cryo-EM structure of human CMG helicase stalled at G4-containing DNA template
5BNV 2.79 Å, Crystal structure of Human MCM2 HBD chaperoning a histone H3-H4 tetramer
7PLO 2.8 Å, H. sapiens replisome-CUL2/LRR1 complex
8W0F 2.8 Å, Cryo-EM structure of a human MCM2-7 double hexamer on dsDNA
4UUZ 2.9 Å, MCM2-histone complex
5BO0 2.91 Å, Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.2-H4 dimer

Browse structure collections

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