Interleukin-6 receptor subunit beta (IL6ST) is a 918-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P40189.
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The mean pLDDT of this model is 74.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Functions as a shared signal-transducing subunit not only for IL6 but also for other cytokine receptor complexes, including IL6, LIF, OSM, CNTF, IL11, CTF1, BSF3, MT-RNR2/humanin, CLCF1 and the heterodimeric complex CRLF1-CLCF1 (PubMed:11285233, PubMed:11294841, PubMed:1542794, PubMed:19386761, PubMed:2261637, PubMed:27384491, PubMed:36930708, PubMed:39532904, PubMed:8272873, PubMed:8999038, PubMed:9030543, PubMed:9188471). Engages site 2 of CNTF, CLCF1, LIF, and IL-6, and site 3 of IL27 and IL6 (PubMed:36930708). Initiates signal transmission through three mechanisms (PubMed:11285233, PubMed:11294841, PubMed:1542794, PubMed:19386761, PubMed:19915009, PubMed:2261637, PubMed:23294003).…
Homodimer in the IL6 complex receptor (PubMed:36930708). Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; associates with the complex IL6:IL6R but does not interact with IL6 (PubMed:12829785, PubMed:2261637, PubMed:36930708). Forms heterodimers composed of LIFR and IL6ST (type I OSM receptor) which are activated by LIF and OSM (PubMed:36930708, PubMed:8999038). Also forms…
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3L5I | X-ray | 1.9 Å | A=323-612 |
| 1BQU | X-ray | 2.0 Å | A/B=119-333 |
| 1I1R | X-ray | 2.4 Å | A=23-325 |
| 1PVH | X-ray | 2.5 Å | A/C=123-323 |
| 8D74 | EM | 3.03 Å | A=23-619 |
| 3L5J | X-ray | 3.04 Å | A/B=323-610 |
| 8D82 | EM | 3.22 Å | A/E=23-700 |
| 8UPA | X-ray | 3.3 Å | B/D=124-321 |
| 7U7N | EM | 3.47 Å | B=23-321 |
| 8DPS | EM | 3.47 Å | A/D=22-324 |
| 8D6A | EM | 3.54 Å | A=23-619 |
| 8V2A | EM | 3.59 Å | B=23-619 |
| 3L5H | X-ray | 3.6 Å | A=24-612 |
| 1P9M | X-ray | 3.65 Å | A=23-321 |
| 8DPU | X-ray | 3.78 Å | A/D/G/J/M/P=22-324 |
| 8D85 | EM | 3.81 Å | B=23-619 |
| 8D7R | EM | 3.9 Å | A=23-619 |
| 8V29 | EM | 3.99 Å | B=23-619 |
| 8DPT | EM | 4.0 Å | A/D=22-612 |
| 1BJ8 | NMR | A=219-325 |
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