8W0I: Human MCM2-7 heterohexamer

Name: PDB 8W0I: Cryo-EM structure of the human MCM2-7 heterohexamer
Published: 2024-10-02
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: replication

Cryo-EM structure of the human MCM2-7 heterohexamer. Determined by electron microscopy at 3.5 Å resolution. Released 2 Oct 2024.

Method: Electron microscopy
Resolution: 3.5 Å
Organism: Homo sapiens
Chains: 6
Atoms: 28,381
Mol. weight: 549.99 kDa
Ligands: ZN, MG, ATP, ADP
Released: 2 Oct 2024

Explore 8W0I in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8W0I contains 163 α-helices and 151 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 2: 28 helices, 23 β-strands

Element	Residues	Length	Sheet
α-helix	182-187	6
α-helix	189-205	17
α-helix	214-225	12
β-strand	229-233	5	1
α-helix	234-240	7
α-helix	243-250	8
α-helix	252-270	19
β-strand	282-286	5	1
β-strand	291	1	2
α-helix	294-296	3
α-helix	299-301	3
β-strand	304-316	13	2
β-strand	319	1	2
β-strand	322-328	7	3
β-strand	335	1	3
α-helix	336-338	3
β-strand	339-341	3	3
β-strand	362-369	8	3
β-strand	373-380	8	2
α-helix	381	1
α-helix	390-392	3
β-strand	393-399	7	2
β-strand	411-421	11	2
α-helix	432-434	3
β-strand	436-443	8	2
α-helix	448-450	3
α-helix	458-469	12
α-helix	473-481	9
α-helix	489-500	12
β-strand	519-523	5	4
α-helix	529-539	11
β-strand	543-547	5	5
β-strand	558-562	5	2
β-strand	569-573	5	2
α-helix	575-579	5
β-strand	583-587	5	5
α-helix	594-606	13
β-strand	608-613	6	6
β-strand	616-621	6	6
β-strand	625-626	2	5
β-strand	629-630	2	4
α-helix	651-655	5
β-strand	659-663	5	4
α-helix	669-685	17
α-helix	688-690	3
α-helix	717-730	14
α-helix	740-753	14
α-helix	764-780	17
α-helix	788-804	17
α-helix	808-817	10
α-helix	819-824	6

Chain 3: 30 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	10-23	14
α-helix	31-42	12
β-strand	46-50	5	7
α-helix	51-57	7
α-helix	59-67	9
α-helix	70-87	18
α-helix	89-94	6
β-strand	99-103	5	7
β-strand	110-111	2	8
α-helix	118-120	3
β-strand	124-135	12	8
β-strand	138-148	11	8
β-strand	153-158	6	8
β-strand	177	1	9
β-strand	183	1	9
β-strand	185-186	2	8
β-strand	192-202	11	8
α-helix	213-214	2
β-strand	216-222	7	8
α-helix	223-225	3
β-strand	234-243	10	8
α-helix	244-245	2
β-strand	258-267	10	8
α-helix	268-269	2
α-helix	278-290	13
α-helix	292-301	10
α-helix	311-322	12
β-strand	327-328	2	10
β-strand	334-335	2	10
β-strand	341-345	5	11
α-helix	351-361	11
β-strand	365-369	5	11
β-strand	373	1	12
β-strand	377	1	12
β-strand	381-384	4	8
β-strand	391-394	4	8
α-helix	397-400	4
β-strand	405-409	5	11
α-helix	411-413	3
α-helix	416-428	13
β-strand	430-433	4	13
α-helix	435-437	3
β-strand	440-443	4	13
β-strand	447-452	6	11
α-helix	453-454	2
α-helix	465-469	5
α-helix	474-478	5
β-strand	481-485	5	11
α-helix	491-506	16
α-helix	518-520	3
α-helix	562-564	3
α-helix	565-577	13
β-strand	581	1	14
α-helix	584-600	17
α-helix	611-613	3
α-helix	615-631	17
β-strand	636	1	14
α-helix	639-653	15

Chain 4: 23 helices, 22 β-strands

Element	Residues	Length	Sheet
α-helix	159-171	13
α-helix	192-203	12
β-strand	208-211	4	15
α-helix	212-218	7
α-helix	220-228	9
α-helix	230-247	18
β-strand	260-263	4	15
α-helix	276-278	3
β-strand	282-291	10	16
α-helix	294-295	2
β-strand	296-306	11	16
β-strand	313-316	4	16
β-strand	337-339	3	16
β-strand	345-356	12	16
α-helix	357	1
β-strand	369-375	7	16
β-strand	387-397	11	16
β-strand	400	1	17
β-strand	408-409	2	17
β-strand	411	1	18
β-strand	413-423	11	16
α-helix	443-454	12
α-helix	458-465	8
α-helix	475-485	11
α-helix	487-489	3
β-strand	506-510	5	19
α-helix	516-524	9
β-strand	531-534	4	19
β-strand	546-549	4	20
β-strand	556-559	4	20
α-helix	562-565	4
β-strand	570-574	5	19
α-helix	581-593	13
β-strand	595-600	6	21
β-strand	603-608	6	21
β-strand	612-617	6	19
α-helix	624-625	2
α-helix	630-634	5
α-helix	638-643	6
β-strand	646-650	5	19
α-helix	656-670	15
α-helix	684-697	14
α-helix	704-722	19
α-helix	731-748	18
α-helix	755-772	18

Chain 5: 24 helices, 26 β-strands

Element	Residues	Length	Sheet
α-helix	28-41	14
β-strand	44-46	3	22
β-strand	50-52	3	22
α-helix	54-64	11
β-strand	69-73	5	23
α-helix	74-80	7
α-helix	82-90	9
α-helix	92-110	19
β-strand	125-129	5	23
α-helix	133-134	2
α-helix	142-144	3
β-strand	148-159	12	24
β-strand	162-171	10	25
β-strand	178-183	6	25
β-strand	213-214	2	25
β-strand	220-224	5	25
β-strand	225-230	6	24
α-helix	236-237	2
α-helix	241-243	3
β-strand	244-249	6	24
β-strand	262-270	9	24
β-strand	293-301	9	24
α-helix	316-327	12
α-helix	331-338	8
α-helix	349-358	10
β-strand	363-364	2	26
β-strand	370-371	2	26
β-strand	377-380	4	27
α-helix	387-397	11
β-strand	401-405	5	27
β-strand	417-421	5	24
β-strand	426-430	5	24
α-helix	433-436	4
β-strand	441-445	5	27
α-helix	447-449	3
α-helix	452-463	12
β-strand	466-471	6	28
β-strand	474-479	6	28
β-strand	483-488	6	27
α-helix	508-511	4
β-strand	516-519	4	27
α-helix	556-569	14
β-strand	573-574	2	29
α-helix	576-592	17
α-helix	610-626	17
β-strand	631-632	2	29
α-helix	634-657	24
α-helix	666-682	17
α-helix	691-700	10
α-helix	705-717	13

Chain 6: 27 helices, 26 β-strands

Element	Residues	Length	Sheet
α-helix	21-36	16
α-helix	45-53	9
β-strand	60-64	5	30
α-helix	65-71	7
α-helix	73-81	9
α-helix	83-99	17
β-strand	111-115	5	30
β-strand	120-121	2	31
α-helix	123-125	3
α-helix	128-130	3
β-strand	134-144	11	31
α-helix	145-147	3
β-strand	148-158	11	31
β-strand	164-169	6	31
β-strand	191-193	3	31
β-strand	199-209	11	31
α-helix	215-216	2
α-helix	220-222	3
β-strand	223-229	7	31
α-helix	230-232	3
β-strand	241-252	12	31
β-strand	294-305	12	31
α-helix	322-328	7
α-helix	331-342	12
α-helix	346-354	9
α-helix	362-373	12
β-strand	378-379	2	32
β-strand	385-386	2	32
α-helix	387	1
β-strand	392-396	5	33
α-helix	402-412	11
β-strand	416-420	5	33
β-strand	432-435	4	31
β-strand	442-445	4	31
α-helix	448-451	4
β-strand	456-460	5	33
α-helix	462-464	3
α-helix	467-479	13
β-strand	481-486	6	34
β-strand	489-494	6	34
β-strand	498-503	6	33
α-helix	516-519	4
α-helix	524-528	5
β-strand	532-536	5	33
α-helix	542-557	16
α-helix	569-580	12
β-strand	585	1	35
α-helix	588-604	17
β-strand	612	1	36
α-helix	618-635	18
β-strand	639	1	35
α-helix	642-655	14
β-strand	658	1	36

Chain 7: 31 helices, 26 β-strands

Element	Residues	Length	Sheet
α-helix	6-18	13
β-strand	22-24	3	37
α-helix	25-27	3
β-strand	28-30	3	37
α-helix	32-41	10
β-strand	47-51	5	38
α-helix	52-56	5
α-helix	60-68	9
α-helix	70-88	19
α-helix	97-111	15
α-helix	128-130	3
β-strand	135-139	5	38
α-helix	145-146	2
α-helix	149-151	3
α-helix	154-156	3
β-strand	160-171	12	18
α-helix	172-173	2
β-strand	174-183	10	18
β-strand	190-194	5	18
β-strand	199-200	2	17
β-strand	205	1	39
α-helix	209-214	6
α-helix	218	1
β-strand	219	1	39
α-helix	220	1
β-strand	221-239	19	18
β-strand	252-258	7	18
α-helix	259-261	3
β-strand	270-280	11	18
β-strand	293	1	8
β-strand	295-305	11	18
α-helix	321-328	8
α-helix	331-339	9
α-helix	348-359	12
β-strand	377-381	5	40
α-helix	387-397	11
β-strand	401-404	4	40
β-strand	417-419	3	18
β-strand	428-430	3	18
α-helix	433-437	5
β-strand	441-444	4	40
α-helix	447-449	3
α-helix	452-464	13
β-strand	466-469	4	41
β-strand	476-479	4	41
β-strand	483-488	6	40
α-helix	509-514	6
β-strand	517-521	5	40
α-helix	527-543	17
α-helix	546-548	3
α-helix	552-555	4
α-helix	556-568	13
β-strand	572	1	42
α-helix	575-594	20
α-helix	603-620	18
β-strand	624	1	42
α-helix	627-643	17

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA replication licensing factor MCM2	2	protein	904	Homo sapiens	P49736 (AlphaFold model)
DNA replication licensing factor MCM3	3	protein	810	Homo sapiens	P25205 (AlphaFold model)
DNA replication licensing factor MCM4	4	protein	866	Homo sapiens	P33991 (AlphaFold model)
DNA replication licensing factor MCM5	5	protein	734	Homo sapiens	P33992 (AlphaFold model)
DNA replication licensing factor MCM6	6	protein	821	Homo sapiens	Q14566
DNA replication licensing factor MCM7	7	protein	719	Homo sapiens	P33993

Sequence of entity 1 (2), FASTA

>8W0I_1 DNA replication licensing factor MCM2 (chains 2)
MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTE
GPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQR
DREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGH
SVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAR
EHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQL
HLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGP
FEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHN
NYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFAS
IAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVS
SRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSI
HEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDIL
CVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVL
KKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARI
HLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLV
AEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMI
LQQF

Sequence of entity 2 (3), FASTA

>8W0I_2 DNA replication licensing factor MCM3 (chains 3)
SNAAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKN
EKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTS
CFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKD
EENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVV
GTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQ
LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYV
LCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMD
RTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSR
FDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQED
QQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLR
SQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVL
EKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMP
QVHTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEE
PFSSVEIQAALSKMQDDNQVMVSEGIIFLI

Sequence of entity 3 (4), FASTA

>8W0I_3 DNA replication licensing factor MCM4 (chains 4)
SNAMSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGV
DLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPD
LGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPL
AKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTF
DMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIP
EMQEAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQES
PEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHID
VIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIK
KGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKG
SSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLS
IAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEA
YDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDM
RKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPR
TGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITK
DMFEEALRALADDDFLTVTGKTVRLL

Sequence of entity 4 (5), FASTA

>8W0I_4 DNA replication licensing factor MCM5 (chains 5)
MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELK
RHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEV
LQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLT
NIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGE
MPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQ
VDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGG
SRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMR
DPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNS
RCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLH
VSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDS
DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGV
EGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQLMLRRGE
IQHRMQRKVLYRLK

Sequence of entity 5 (6), FASTA

>8W0I_5 DNA replication licensing factor MCM6 (chains 6)
MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNT
LVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTR
HKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNIC
RNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGD
KCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLA
CCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHG
NDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTS
GKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQ
TISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDEC
NEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKH
LRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVE
TPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEY
CRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVIHRL
THYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLED

Sequence of entity 6 (7), FASTA

>8W0I_6 DNA replication licensing factor MCM7 (chains 7)
MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDP
ELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVR
SPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVA
TYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEH
SDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEA
HRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVG
GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLR
DSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNA
RCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYV
HQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATY
TSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADV
IFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	5
MG	Magnesium ion	Mg	5
ATP	Adenosine-5'-triphosphate	C10 H16 N5 O13 P3	4
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	1

Primary citation

Multiple mechanisms for licensing human replication origins. Yang, R., Hunker, O., Wise, M. et al. Nature (2024) 636:488-498. DOI 10.1038/s41586-024-08237-8 · PubMed

Other PDB entries of the same protein (UniProt P49736 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6YA7 1.67 Å, Cdc7-Dbf4 bound to an Mcm2-S40 derived bivalent substrate
7CIZ 1.8 Å, Crystal structure of DNAJC9 HBD helix2 in complex with H3.3-H4 dimer and MCM2 HBD
5BNX 2.31 Å, Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.3-H4 dimer
5JA4 2.42 Å, Crystal structure of human TONSL and MCM2 HBDs binding to a histone H3-H4 tetramer
7CJ0 2.5 Å, Crystal structure of DNAJC9 HBD in complex with H3.3-H4 dimer and MCM2 HBD
7W1Y 2.59 Å, Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA)
9E2Z 2.6 Å, Cryo-EM structure of human CMG helicase stalled at G4-containing DNA template
5BNV 2.79 Å, Crystal structure of Human MCM2 HBD chaperoning a histone H3-H4 tetramer
7PLO 2.8 Å, H. sapiens replisome-CUL2/LRR1 complex
8W0F 2.8 Å, Cryo-EM structure of a human MCM2-7 double hexamer on dsDNA
4UUZ 2.9 Å, MCM2-histone complex
5BO0 2.91 Å, Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.2-H4 dimer

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