8W8E: DNA-directed RNA polymerase subunit

Name: PDB 8W8E: human co-transcriptional RNA capping enzyme RNGTT
Published: 2024-04-10
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

human co-transcriptional RNA capping enzyme RNGTT. Determined by electron microscopy at 3.9 Å resolution. Released 10 Apr 2024.

Method: Electron microscopy
Resolution: 3.9 Å
Organisms: Sus scrofa, Homo sapiens
Chains: 22
Atoms: 50,912
Mol. weight: 988.37 kDa
Ligands: GTP, ZN, MG
Released: 10 Apr 2024

Explore 8W8E in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8W8E contains 307 α-helices and 299 β-strands across 19 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 21 helices, 31 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	86
β-strand	20	1	86
β-strand	24-28	5	86
α-helix	29-30	2
α-helix	33-35	3
α-helix	41-43	3
α-helix	47-56	10
β-strand	62-66	5	86
α-helix	76-80	5
β-strand	85-88	4	86
α-helix	96-99	4
α-helix	100-110	11
β-strand	122-126	5	86
α-helix	131-143	13
α-helix	149-159	11
α-helix	167-177	11
α-helix	180-182	3
α-helix	183-189	7
β-strand	241-243	3	87
α-helix	247-261	15
β-strand	271-274	4	88
α-helix	281-284	4
β-strand	290-295	6	88
β-strand	298-304	7	87
β-strand	310-313	4	87
β-strand	319-322	4	87
β-strand	328	1	89
β-strand	336	1	89
β-strand	340-351	12	87
β-strand	354-366	13	87
β-strand	367	1	90
β-strand	370	1	90
α-helix	372-374	3
α-helix	377-384	8
α-helix	385-389	5
α-helix	390-395	6
β-strand	409-412	4	87
β-strand	416	1	88
α-helix	418-424	7
β-strand	437-443	7	88
β-strand	451-459	9	88
β-strand	467	1	91
β-strand	470-474	5	92
β-strand	486-491	6	92
β-strand	492	1	93
β-strand	494-501	8	92
α-helix	507-509	3
β-strand	513-514	2	92
β-strand	515-520	6	91
β-strand	523-529	7	91
β-strand	538	1	93
α-helix	539-550	12

Chain A: 75 helices, 66 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15	1	1
β-strand	20-25	6	2
α-helix	26-27	2
α-helix	28-34	7
β-strand	47	1	3
β-strand	52	1	3
α-helix	53	1
β-strand	86-88	3	4
β-strand	94-95	2	5
α-helix	100-109	10
α-helix	124-132	9
α-helix	137-147	11
β-strand	192-194	3	6
β-strand	197-200	4	6
β-strand	214-215	2	6
α-helix	218-225	8
α-helix	230-235	6
α-helix	245-247	3
β-strand	249-250	2	5
β-strand	253-255	3	4
α-helix	256	1
α-helix	275-292	18
α-helix	293-297	5
α-helix	302-318	17
α-helix	326-328	3
β-strand	329	1	7
α-helix	334	1
β-strand	335	1	7
α-helix	336-337	2
α-helix	339-344	6
α-helix	350-355	6
β-strand	357-359	3	8
β-strand	362-369	8	9
β-strand	377-380	4	9
α-helix	382-385	4
β-strand	389-393	5	10
α-helix	394	1
α-helix	399-408	10
β-strand	416-420	5	10
β-strand	426-428	3	10
α-helix	435-438	4
β-strand	445-449	5	10
α-helix	450	1
β-strand	455-459	5	9
α-helix	466-468	3
β-strand	469-476	8	9
β-strand	482-484	3	9
α-helix	489-492	4
β-strand	500-504	5	9
α-helix	509-518	10
β-strand	520	1	9
α-helix	521-524	4
β-strand	526-527	2	11
β-strand	532-533	2	11
α-helix	539-548	10
β-strand	554-555	2	12
α-helix	557-564	8
α-helix	574	1
β-strand	575	1	13
α-helix	576-577	2
β-strand	579	1	14
β-strand	585	1	14
β-strand	586-587	2	12
α-helix	588-595	8
β-strand	602-605	4	15
β-strand	627-631	5	15
β-strand	634-637	4	15
α-helix	642-645	4
α-helix	652-659	8
α-helix	663-683	21
β-strand	685-686	2	16
α-helix	689-692	4
α-helix	696-721	26
α-helix	733-756	24
α-helix	765-772	8
α-helix	778-785	8
β-strand	789-790	2	17
β-strand	793	1	18
β-strand	796	1	18
α-helix	811	1
β-strand	822-823	2	17
α-helix	833-867	35
β-strand	872-873	2	19
β-strand	879-880	2	19
β-strand	886-888	3	19
α-helix	891-893	3
β-strand	896	1	20
β-strand	902-905	4	21
α-helix	913-920	8
α-helix	927-933	7
β-strand	934	1	22
α-helix	936-944	9
α-helix	947-969	23
β-strand	976-979	4	21
α-helix	983-994	12
α-helix	1001	1
β-strand	1002	1	22
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1051-1053	3
α-helix	1054-1058	5
α-helix	1062-1078	17
β-strand	1080	1	20
α-helix	1081-1082	2
α-helix	1087-1101	15
α-helix	1114-1116	3
α-helix	1121-1128	8
β-strand	1139-1140	2	23
β-strand	1142	1	24
β-strand	1143	1	25
α-helix	1146-1149	4
α-helix	1151-1161	11
β-strand	1164	1	26
β-strand	1170-1177	8	27
α-helix	1192-1196	5
β-strand	1210-1216	7	27
α-helix	1218-1223	6
α-helix	1228-1239	12
β-strand	1243-1246	4	27
β-strand	1255-1261	7	27
α-helix	1283-1294	12
β-strand	1299	1	26
β-strand	1308-1310	3	24
β-strand	1319-1322	4	28
β-strand	1328-1331	4	28
β-strand	1335-1337	3	24
β-strand	1352	1	25
β-strand	1358-1359	2	23
α-helix	1362-1368	7
α-helix	1372-1387	16
α-helix	1395-1404	10
α-helix	1416-1419	4
α-helix	1426-1430	5
α-helix	1436-1444	9
β-strand	1448-1449	2	2
α-helix	1455-1460	6
β-strand	1472-1475	4	29
α-helix	1479-1481	3
α-helix	1484-1486	3

Chain B: 48 helices, 75 β-strands

Element	Residues	Length	Sheet
α-helix	22-36	15
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
α-helix	63-64	2
β-strand	65-67	3	30
β-strand	84-93	10	30
β-strand	97-98	2	31
β-strand	106-107	2	31
α-helix	110-115	6
β-strand	121-131	11	30
β-strand	141-153	13	30
β-strand	155	1	32
α-helix	168-173	6
β-strand	185-187	3	32
β-strand	190-194	5	32
β-strand	196-200	5	33
α-helix	201	1
β-strand	205-208	4	34
β-strand	215-223	9	34
β-strand	233-240	8	34
β-strand	256-259	4	34
β-strand	263	1	35
β-strand	267-268	2	34
α-helix	269-275	7
α-helix	281-288	8
α-helix	295-307	13
α-helix	314-322	9
β-strand	325	1	35
α-helix	336-345	10
α-helix	358-377	20
α-helix	381-384	4
β-strand	391-394	4	33
α-helix	396-423	28
α-helix	431-434	4
α-helix	438-449	12
β-strand	467-469	3	32
α-helix	470	1
α-helix	475-481	7
β-strand	484-486	3	33
α-helix	503-505	3
β-strand	509	1	36
β-strand	523-525	3	33
β-strand	526	1	36
β-strand	531-532	2	37
α-helix	539-547	9
β-strand	550-552	3	38
α-helix	553-555	3
β-strand	565-569	5	38
β-strand	572-577	6	38
α-helix	584-591	8
β-strand	602-606	5	38
β-strand	611-615	5	38
β-strand	621-627	7	37
β-strand	628	1	39
β-strand	633	1	39
α-helix	637-644	8
α-helix	653-658	6
β-strand	662-666	5	37
α-helix	667-670	4
β-strand	675-676	2	37
α-helix	679-682	4
β-strand	695-696	2	37
α-helix	700-703	4
α-helix	719-729	11
β-strand	732	1	40
β-strand	748-751	4	41
β-strand	755	1	42
β-strand	759-760	2	43
α-helix	764-767	4
β-strand	776-782	7	44
β-strand	783-784	2	16
β-strand	793-797	5	44
α-helix	798-802	5
β-strand	808-817	10	41
β-strand	827-829	3	45
β-strand	837-838	2	45
β-strand	848	1	46
β-strand	853	1	47
β-strand	854	1	46
α-helix	855	1
β-strand	859-860	2	41
β-strand	865-867	3	47
β-strand	869-871	3	45
β-strand	888-891	4	45
β-strand	894-895	2	47
α-helix	896-897	2
β-strand	902-911	10	41
β-strand	917-927	11	41
β-strand	934-936	3	44
β-strand	942-949	8	44
β-strand	956	1	48
α-helix	961-963	3
β-strand	965-967	3	44
α-helix	971-975	5
α-helix	978-993	16
β-strand	997-998	2	43
α-helix	1008-1016	9
β-strand	1025-1026	2	44
α-helix	1028	1
β-strand	1029	1	48
α-helix	1030	1
α-helix	1035	1
β-strand	1036	1	48
α-helix	1037	1
β-strand	1041-1050	10	44
β-strand	1051	1	40
β-strand	1060	1	9
β-strand	1067	1	49
β-strand	1074	1	49
α-helix	1082-1083	2
β-strand	1084-1086	3	8
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1115-1119	5	1
β-strand	1125	1	1
α-helix	1126	1
β-strand	1127-1129	3	50
β-strand	1134-1136	3	50
β-strand	1146-1150	5	1
α-helix	1153-1164	12
β-strand	1167-1172	6	2

Chain C: 11 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	51
β-strand	18-24	7	51
α-helix	28-36	9
α-helix	37-41	5
β-strand	44-55	12	52
α-helix	61-69	9
β-strand	73	1	53
α-helix	82-84	3
α-helix	85-87	3
β-strand	99-106	8	52
β-strand	113-116	4	54
α-helix	117-119	3
β-strand	121-122	2	52
β-strand	129	1	53
α-helix	145-148	4
β-strand	149-153	5	54
β-strand	158-168	11	52
α-helix	174-176	3
β-strand	179-185	7	51
α-helix	204-206	3
α-helix	218-220	3
β-strand	229-235	7	51
α-helix	241-270	30

Chain D: 10 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	55
α-helix	17-19	3
β-strand	21	1	55
α-helix	25-27	3
α-helix	29	1
β-strand	30-31	2	29
α-helix	34-49	16
α-helix	59-70	12
α-helix	77-88	12
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-137	14

Chain E: 11 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	4-24	21
β-strand	26	1	56
α-helix	30-33	4
α-helix	37-44	8
β-strand	63	1	57
β-strand	64	1	56
β-strand	71	1	57
β-strand	75	1	58
α-helix	84-96	13
β-strand	102-105	4	58
α-helix	109-111	3
α-helix	112-119	8
β-strand	127-130	4	58
α-helix	133-135	3
α-helix	139-141	3
β-strand	147-150	4	59
α-helix	151-152	2
α-helix	153-163	11
β-strand	172-173	2	60
α-helix	178-183	6
β-strand	191-197	7	59
β-strand	201-207	7	59
β-strand	208-209	2	60

Chain F: 5 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	56	1	61
α-helix	57-58	2
α-helix	59-74	16
α-helix	77-79	3
α-helix	89-99	11
β-strand	104-109	6	29
β-strand	115-119	5	29
β-strand	124	1	61
α-helix	125	1

Chain G: 4 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	2-13	12	29
α-helix	15-17	3
α-helix	23-33	11
β-strand	38-39	2	29
β-strand	43-54	12	29
β-strand	58-59	2	29
α-helix	60	1
β-strand	66-77	12	29
β-strand	84-92	9	62
β-strand	96-101	6	62
β-strand	104-109	6	62
α-helix	110-112	3
β-strand	118-120	3	63
β-strand	127-129	3	63
β-strand	136-137	2	63
β-strand	142-150	9	62
β-strand	153	1	64
β-strand	156	1	64
β-strand	159-162	4	62
β-strand	169-170	2	62

11 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase subunit	A	protein	1970	Sus scrofa	A0A8D1DPV6
DNA-directed RNA polymerase subunit beta	B	protein	1174	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	271	Sus scrofa	I3LCH3 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB4	D	protein	142	Sus scrofa	A0A4X1VM56 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	I3LSI7
DNA-directed RNA polymerase II subunit F	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa	A0A8W4F9W9
DNA-directed RNA polymerase II subunit RPB11-a	K	protein	117	Sus scrofa	F1RKE4
RPB12	L	protein	58	Sus scrofa	A0A4X1TRS6

10 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>8W8E_1 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Sequence of entity 2 (B), FASTA

>8W8E_2 DNA-directed RNA polymerase subunit beta (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>8W8E_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDV

Sequence of entity 4 (D), FASTA

>8W8E_4 DNA-directed RNA polymerase II subunit RPB4 (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Sequence of entity 5 (E), FASTA

>8W8E_5 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>8W8E_6 DNA-directed RNA polymerase II subunit F (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 7 (G), FASTA

>8W8E_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>8W8E_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>8W8E_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>8W8E_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>8W8E_11 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>8W8E_12 RPB12 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
GTP	Guanosine-5'-triphosphate	C10 H16 N5 O14 P3	1
ZN	Zinc ion	Zn	8
MG	Magnesium ion	Mg	1

Primary citation

Structures of co-transcriptional RNA capping enzymes on paused transcription complex. Li, Y., Wang, Q., Xu, Y. et al. Nat Commun (2024) 15:4622-4622. DOI 10.1038/s41467-024-48963-1 · PubMed

Other PDB entries of the same protein (UniProt A0A8D1DPV6), best resolution first:

9HVQ 2.0 Å, Structure of the transcribing Pol II-DSIF-PAF-SPT6-RECQL5 complex
7NVU 2.5 Å, RNA polymerase II core pre-initiation complex with open promoter DNA
8QEP 2.5 Å, RNA polymerase II bound to Alu RNA right arm
8B3D 2.6 Å, Structure of the Pol II-TCR-ELOF1 complex.
7OOB 2.7 Å, Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2)
8UHG 2.7 Å, Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated
8UI0 2.7 Å, Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated
8WAV 2.72 Å, De novo transcribing complex 12 (TC12), the early elongation complex with Pol II…
8WAX 2.75 Å, De novo transcribing complex 14 (TC14), the early elongation complex with Pol II…
8WAZ 2.76 Å, De novo transcribing complex 16 (TC16), the early elongation complex with Pol II…
7F4G 2.78 Å, Structure of RPAP2-bound RNA polymerase II
8WAU 2.78 Å, De novo transcribing complex 11 (TC11), the early elongation complex with Pol II…

Browse structure collections

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