8XOV: Ribosomal protein S6 kinase alpha-1

The Crystal Structure of N-terminal kinase domain of human RSK-1 from Biortus. Determined by X-ray diffraction at 2.55 Å resolution. Released 6 Mar 2024.

Method: X-ray diffraction
Resolution: 2.55 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,207
Mol. weight: 37.47 kDa
Ligands: ANP
Released: 6 Mar 2024

Explore 8XOV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8XOV contains 14 α-helices and 10 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 14 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	59-61	3
β-strand	62-71	10	1
β-strand	74-81	8	1
β-strand	90-96	7	1
β-strand	121	1	2
β-strand	124	1	2
β-strand	127-132	6	1
β-strand	137-142	6	1
β-strand	147-148	2	2
α-helix	149-153	5
α-helix	161-180	20
α-helix	190-192	3
β-strand	193-195	3	2
β-strand	201-203	3	2
α-helix	226-228	3
α-helix	231-234	4
α-helix	242-257	16
α-helix	267-275	9
α-helix	277-282	6
α-helix	287-296	10
α-helix	301-303	3
α-helix	312-316	5
α-helix	319-321	3
α-helix	326-330	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ribosomal protein S6 kinase alpha-1	A	protein	321	Homo sapiens	Q15418 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>8XOV_1 Ribosomal protein S6 kinase alpha-1 (chains A)
QPSKDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYA
MKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTR
LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEA
IDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMT
LILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRR
EIKPPFKPAVAQPDDTFYFDT

Ligands and cofactors

ID	Name	Formula	Copies
ANP	Phosphoaminophosphonic acid-adenylate ester	C10 H17 N6 O12 P3	1

Water and common crystallization additives (EDO) are not listed.

Primary citation

The Crystal Structure of N-terminal kinase domain of human RSK-1 from Biortus. Wang, F., Cheng, W., Lv, Z. et al. To be published.

Other PDB entries of the same protein (UniProt Q15418 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5V62 1.9 Å, Phospho-ERK2 bound to bivalent inhibitor SBP3
7P74 1.9 Å, The PDZ domain of SYNJ2BP complexed with the phosphorylated PDZ-binding motif of RSK1
2Z7Q 2.0 Å, Crystal structure of the N-terminal kinase domain of human RSK-1 bound to AMP-PCP
2Z7R 2.0 Å, Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Staurosporine
2Z7S 2.1 Å, Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Purvalnol A
5CSI 2.13 Å, S100B-RSK1 crystal structure A'
4NIF 2.15 Å, Heterodimeric structure of ERK2 and RSK1
5V61 2.2 Å, Phospho-ERK2 bound to bivalent inhibitor SBP2
4H3P 2.3 Å, Crystal structure of human ERK2 complexed with a MAPK docking peptide
5N7D 2.3 Å, MAGI-1 complexed with a RSK1 peptide
5N7F 2.3 Å, MAGI-1 complexed with a pRSK1 peptide
6TWY 2.3 Å, MAGI1_2 complexed with a phosphomimetic RSK1 peptide

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