Ribosomal protein S6 kinase alpha-1 (RPS6KA1) is a 735-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15418.
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The mean pLDDT of this model is 76.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent…
Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation. Interacts with ETV1/ER81 and FGFR1
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5V62 | X-ray | 1.9 Å | I=713-729 |
| 7P74 | X-ray | 1.9 Å | B=725-735 |
| 2Z7Q | X-ray | 2.0 Å | A=33-353 |
| 2Z7R | X-ray | 2.0 Å | A=33-353 |
| 2Z7S | X-ray | 2.1 Å | A=33-353 |
| 5CSI | X-ray | 2.13 Å | C=689-735 |
| 4NIF | X-ray | 2.15 Å | A/D=411-735 |
| 5V61 | X-ray | 2.2 Å | I=713-729 |
| 4H3P | X-ray | 2.3 Å | B/E=712-735 |
| 5N7D | X-ray | 2.3 Å | C=688-735 |
| 5N7F | X-ray | 2.3 Å | C=688-735 |
| 6TWY | X-ray | 2.3 Å | C=725-735 |
| 2WNT | X-ray | 2.4 Å | A/B=404-719 |
| 3TEI | X-ray | 2.4 Å | B=712-735 |
| 5CSF | X-ray | 2.4 Å | C=683-735 |
| 7QQL | X-ray | 2.44 Å | D/E/F=725-735 |
| 7PC8 | X-ray | 2.5 Å | C/D=726-735 |
| 8XOV | X-ray | 2.55 Å | A=33-353 |
| 8WF4 | X-ray | 2.65 Å | A/B=411-735 |
| 3RNY | X-ray | 2.7 Å | A/B=410-735 |
Showing 20 of 23 experimental structures (best resolution first).
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