DNA methyltransferase 1-associated protein 1 (DMAP1) is a 467-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NPF5.
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The mean pLDDT of this model is 73.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other…
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1,…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4IEJ | X-ray | 1.45 Å | A=121-212 |
| 3HM5 | X-ray | 1.8 Å | A=121-212 |
| 8QR1 | EM | 2.4 Å | F=1-467 |
| 9C57 | EM | 2.75 Å | I=1-467 |
| 9CAE | EM | 3.07 Å | N=1-467 |
| 8X15 | EM | 3.2 Å | V=1-467 |
| 8X19 | EM | 3.2 Å | V=1-467 |
| 8X1C | EM | 3.2 Å | V=1-467 |
| 8XVT | EM | 3.2 Å | G=1-467 |
| 9C6N | EM | 3.29 Å | I=1-467 |
| 9CAC | EM | 3.43 Å | N=1-467 |
| 9C62 | EM | 5.28 Å | I=1-467 |
| 8XVG | EM | 9.4 Å | G=1-467 |
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