8XVT: The core subcomplex of human NuA4/TIP60 complex

The core subcomplex of human NuA4/TIP60 complex. Determined by electron microscopy at 3.2 Å resolution. Released 24 Jul 2024.

Method: Electron microscopy
Resolution: 3.2 Å
Organism: Homo sapiens
Chains: 13
Atoms: 38,987
Mol. weight: 970.14 kDa
Ligands: ADP
Released: 24 Jul 2024

Explore 8XVT in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8XVT contains 272 α-helices and 264 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 23 helices, 26 β-strands

Element	Residues	Length	Sheet
β-strand	15	1	1
β-strand	26	1	2
α-helix	31	1
β-strand	32	1	2
α-helix	33	1
β-strand	35-36	2	3
β-strand	39-40	2	3
α-helix	43-58	16
β-strand	61	1	4
β-strand	65-69	5	5
α-helix	76-87	12
β-strand	93-97	5	5
α-helix	98-101	4
α-helix	108-118	11
β-strand	120-130	11	6
β-strand	133-141	9	7
β-strand	156-162	7	7
β-strand	167-172	6	7
α-helix	174-182	9
β-strand	190-193	4	7
β-strand	194	1	6
β-strand	199-202	4	7
α-helix	222-224	3
β-strand	230-239	10	6
α-helix	240-247	8
α-helix	255-257	3
β-strand	270	1	8
α-helix	272-276	5
α-helix	277-288	12
β-strand	292-296	5	6
β-strand	298-302	5	5
α-helix	304-306	3
α-helix	309-318	10
β-strand	326-330	5	5
β-strand	336-337	2	9
α-helix	338	1
β-strand	345-346	2	9
α-helix	347-349	3
α-helix	352-355	4
β-strand	358-362	5	5
α-helix	364-367	4
α-helix	368-382	15
β-strand	386	1	10
α-helix	388-400	13
α-helix	403-420	18
β-strand	425	1	10
α-helix	427-436	10
β-strand	438	1	11
α-helix	440-447	8

Chain B: 22 helices, 27 β-strands

Element	Residues	Length	Sheet
β-strand	22	1	12
α-helix	24-26	3
β-strand	33	1	13
β-strand	39	1	13
β-strand	43	1	14
β-strand	46	1	14
α-helix	50-65	16
β-strand	68	1	1
β-strand	72-77	6	11
α-helix	83-94	12
β-strand	100-104	5	11
α-helix	115-124	10
β-strand	127-137	11	15
β-strand	138	1	16
β-strand	141	1	17
β-strand	161	1	18
β-strand	172	1	18
α-helix	176-179	4
β-strand	192	1	17
β-strand	195	1	16
α-helix	227-229	3
β-strand	234-242	9	15
α-helix	246-249	4
α-helix	256-259	4
α-helix	273-283	11
β-strand	289-293	5	15
β-strand	295-299	5	11
α-helix	301-303	3
β-strand	305	1	19
α-helix	306-315	10
α-helix	321-322	2
β-strand	323-328	6	11
β-strand	332-334	3	20
α-helix	335	1
β-strand	336	1	19
β-strand	341-343	3	20
α-helix	348-351	4
β-strand	354-359	6	11
α-helix	360-362	3
α-helix	364-377	14
β-strand	382	1	21
α-helix	384-396	13
α-helix	399-415	17
β-strand	421	1	21
α-helix	423-432	10
β-strand	434	1	22
α-helix	435	1
α-helix	436-441	6
α-helix	442-445	4

Chain C: 24 helices, 27 β-strands

Element	Residues	Length	Sheet
α-helix	13-14	2
β-strand	15	1	23
β-strand	23	1	24
β-strand	26	1	25
β-strand	32	1	25
β-strand	35-36	2	26
β-strand	38	1	24
β-strand	39-40	2	26
α-helix	43-58	16
β-strand	61	1	12
β-strand	65-67	3	22
α-helix	76-87	12
β-strand	93-97	5	22
α-helix	98-101	4
α-helix	108-119	12
β-strand	121-137	17	27
β-strand	157-162	6	27
β-strand	167-172	6	27
α-helix	174-176	3
β-strand	187-192	6	27
β-strand	200-206	7	27
β-strand	215	1	28
β-strand	220	1	27
α-helix	222-224	3
β-strand	229-239	11	27
α-helix	240-248	9
α-helix	256-261	6
α-helix	272-273	2
α-helix	274-278	5
α-helix	279-288	10
β-strand	292-295	4	27
β-strand	298-302	5	22
α-helix	304-306	3
α-helix	309-319	11
β-strand	326-330	5	22
β-strand	336-337	2	29
α-helix	338	1
β-strand	345-346	2	29
α-helix	347-349	3
α-helix	352-357	6
β-strand	359-360	2	22
α-helix	363-367	5
α-helix	368-382	15
β-strand	386	1	30
α-helix	388-400	13
α-helix	403-420	18
β-strand	425	1	30
α-helix	427-436	10
β-strand	438	1	31
α-helix	439	1
α-helix	440-445	6

Chain D: 22 helices, 25 β-strands

Element	Residues	Length	Sheet
β-strand	22	1	32
β-strand	33	1	33
β-strand	39	1	33
β-strand	42-43	2	34
β-strand	46-47	2	34
α-helix	50-65	16
β-strand	68	1	23
β-strand	72-77	6	31
α-helix	83-94	12
β-strand	100-104	5	31
α-helix	105-107	3
α-helix	115-125	11
β-strand	127-135	9	35
β-strand	137-144	8	28
β-strand	147-149	3	28
β-strand	158-164	7	28
β-strand	169-174	6	28
α-helix	175	1
α-helix	176-184	9
β-strand	191-196	6	28
β-strand	204-207	4	28
α-helix	221-227	7
β-strand	236-243	8	35
α-helix	244-247	4
α-helix	248-251	4
α-helix	256-260	5
α-helix	273-286	14
β-strand	289-293	5	35
β-strand	295-299	5	31
α-helix	301-303	3
α-helix	306-315	10
β-strand	323-328	6	31
β-strand	332-334	3	36
α-helix	335	1
β-strand	341-343	3	36
α-helix	348-353	6
β-strand	355-359	5	31
α-helix	360-362	3
α-helix	364-378	15
β-strand	382	1	37
α-helix	384-396	13
α-helix	399-416	18
β-strand	421	1	37
α-helix	423-432	10
β-strand	434	1	38
α-helix	436-442	7
α-helix	443-445	3

Chain E: 24 helices, 30 β-strands

Element	Residues	Length	Sheet
β-strand	15	1	39
β-strand	23	1	40
β-strand	36	1	41
β-strand	38	1	40
β-strand	39	1	41
α-helix	43-58	16
β-strand	61	1	32
β-strand	65-67	3	38
α-helix	76-87	12
β-strand	93-97	5	38
α-helix	98-101	4
α-helix	108-119	12
β-strand	120-134	15	42
β-strand	137-138	2	42
β-strand	142	1	28
β-strand	153-154	2	28
β-strand	157-162	6	42
β-strand	167-172	6	42
α-helix	174-176	3
α-helix	177-182	6
β-strand	189-194	6	42
β-strand	201-206	6	42
α-helix	207-209	3
β-strand	214-215	2	43
β-strand	220-221	2	42
α-helix	222-225	4
β-strand	229-237	9	42
α-helix	240-248	9
α-helix	272-273	2
α-helix	274-278	5
α-helix	279-289	11
β-strand	292-296	5	42
β-strand	298-302	5	38
α-helix	304-306	3
β-strand	308	1	44
α-helix	309-318	10
β-strand	326-330	5	38
β-strand	336-337	2	45
α-helix	338	1
β-strand	339	1	44
β-strand	345-346	2	45
α-helix	347-349	3
α-helix	352-355	4
β-strand	358-360	3	38
α-helix	364-367	4
α-helix	368-382	15
β-strand	386	1	46
α-helix	388-400	13
α-helix	403-408	6
α-helix	410-420	11
β-strand	425	1	46
α-helix	427-436	10
β-strand	438	1	47
α-helix	440-443	4

Chain F: 22 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	22	1	4
β-strand	33	1	48
β-strand	39	1	48
β-strand	42	1	49
β-strand	47	1	49
α-helix	50-65	16
β-strand	68	1	39
β-strand	72-76	5	47
α-helix	83-93	11
β-strand	100-104	5	47
α-helix	105-108	4
α-helix	115-125	11
β-strand	127-145	19	43
β-strand	160-164	5	43
β-strand	169-174	6	43
α-helix	176-184	9
β-strand	192-196	5	43
β-strand	201-205	5	43
α-helix	210-213	4
α-helix	226-228	3
β-strand	233-243	11	43
α-helix	244-248	5
β-strand	261	1	8
α-helix	269-270	2
α-helix	271-277	7
α-helix	278-286	9
β-strand	289-293	5	43
β-strand	295-299	5	47
α-helix	301-303	3
α-helix	306-315	10
α-helix	322	1
β-strand	323-327	5	47
β-strand	332-334	3	50
α-helix	335	1
β-strand	341-343	3	50
α-helix	348-351	4
β-strand	354-358	5	47
α-helix	364-377	14
β-strand	382	1	51
α-helix	384-396	13
α-helix	399-416	18
β-strand	421	1	51
α-helix	423-432	10
β-strand	434	1	5
α-helix	436-441	6
α-helix	442-445	4

Chain G: 11 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	61-62	2	52
β-strand	74	1	53
α-helix	84-88	5
α-helix	93-94	2
β-strand	95-100	6	54
α-helix	103-105	3
β-strand	111-116	6	54
α-helix	117-119	3
α-helix	125-129	5
α-helix	140-145	6
α-helix	154-167	14
α-helix	171-177	7
α-helix	188-206	19
α-helix	230-244	15
α-helix	248-274	27

Chain H: 47 helices, 22 β-strands

Element	Residues	Length	Sheet
α-helix	741-750	10
α-helix	764-765	2
β-strand	766-767	2	55
α-helix	768	1
β-strand	772	1	56
α-helix	775-857	83
α-helix	1057-1065	9
α-helix	1067-1072	6
β-strand	1077-1079	3	57
α-helix	1086-1100	15
β-strand	1107-1111	5	57
α-helix	1113-1115	3
α-helix	1116-1125	10
β-strand	1132-1133	2	57
α-helix	1141-1145	5
β-strand	1157-1161	5	57
α-helix	1162-1165	4
α-helix	1169-1172	4
β-strand	1179-1183	5	57
α-helix	1185-1188	4
α-helix	1195-1200	6
β-strand	1206-1211	6	57
α-helix	1219-1229	11
α-helix	1256-1263	8
α-helix	1273-1276	4
β-strand	1283-1290	8	58
α-helix	1294-1304	11
α-helix	1308-1312	5
α-helix	1318-1331	14
α-helix	1335-1338	4
α-helix	1345-1347	3
α-helix	1349-1351	3
β-strand	1353-1354	2	59
α-helix	1358-1361	4
α-helix	1378-1382	5
α-helix	1386-1393	8
α-helix	1396-1398	3
α-helix	1728-1740	13
α-helix	1741-1743	3
α-helix	1751-1754	4
α-helix	1791-1797	7
β-strand	1811-1812	2	59
α-helix	1819-1833	15
α-helix	1839-1844	6
α-helix	1845-1847	3
α-helix	1851-1853	3
α-helix	1855-1859	5
α-helix	1862-1877	16
β-strand	1881-1884	4	58
α-helix	1888-1901	14
β-strand	1905-1908	4	58
α-helix	1914-1924	11
β-strand	1932-1935	4	58
β-strand	1951-1954	4	58
α-helix	1963-1974	12
β-strand	1980-1987	8	58
α-helix	1991-1997	7
α-helix	2001-2004	4
α-helix	2019-2023	5
α-helix	2149-2179	31
β-strand	2186	1	53
α-helix	2189-2192	4
β-strand	2198-2200	3	60
β-strand	2206-2208	3	60
β-strand	2212	1	61
α-helix	2213-2218	6
β-strand	2224	1	56
α-helix	2228-2232	5
β-strand	2234-2236	3	62

5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
RuvB-like 1	A, C, E	protein	456	Homo sapiens	Q9Y265 (AlphaFold model)
RuvB-like 2	B, D, F	protein	463	Homo sapiens	Q9Y230 (AlphaFold model)
DNA methyltransferase 1-associated protein 1	G	protein	467	Homo sapiens	Q9NPF5 (AlphaFold model)
Isoform 2 of E1A-binding protein p400	H	protein	3123	Homo sapiens	Q96L91
Actin-like protein 6A	I, J	protein	429	Homo sapiens	O96019
Actin, cytoplasmic 1	K	protein	375	Homo sapiens	P60709
Isoform 2 of Enhancer of polycomb homolog 1	M	protein	813	Homo sapiens	Q9H2F5
Vacuolar protein sorting-associated protein 72 homolog	N	protein	364	Homo sapiens	Q15906

Sequence of entity 1 (A, C, E), FASTA

>8XVT_1 RuvB-like 1 (chains A, C, E)
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAI
GLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL
QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTL
HDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLF
VDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMI
IRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN
GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK

Sequence of entity 2 (B, D, F), FASTA

>8XVT_2 RuvB-like 2 (chains B, D, F)
MATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVL
EMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALT
QAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIE
SLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVH
TVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDE
VHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTT
PYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTE
VQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS

Sequence of entity 3 (G), FASTA

>8XVT_3 DNA methyltransferase 1-associated protein 1 (chains G)
MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYAL
LYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEE
GKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDH
QQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQ
VAEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAE
KPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEEL
VHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGGPATPASGPGPASAE
PAVTEPGLGPDPKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP

Sequence of entity 4 (H), FASTA

>8XVT_4 Isoform 2 of E1A-binding protein p400 (chains H)
MHHGTGPQNVQHQLQRSRACPGSEGEEQPAHPNPPPSPAAPFAPSASPSAPQSPSYQIQQ
LMNRSPATGQNVNITLQSVGPVVGGNQQITLAPLPLPSPTSPGFQFSAQPRRFEHGSPSY
IQVTSPLSQQVQTQSPTQPSPGPGQALQNVRAGAPGPGLGLCSSSPTGGFVDASVLVRQI
SLSPSSGGHFVFQDGSGLTQIAQGAQVQLQHPGTPITVRERRPSQPHTQSGGTIHHLGPQ
SPAAAGGAGLQPLASPSHITTANLPPQISSIIQGQLVQQQQVLQGPPLPRPLGFERTPGV
LLPGAGGAAGFGMTSPPPPTSPSRTAVPPGLSSLPLTSVGNTGMKKVPKKLEEIPPASPE
MAQMRKQCLDYHYQEMQALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHYAPLQAYLRQ
NDLDIEEEEEEEEEEEEKSEVINDEQQALAGSLVAGAGSTVETDLFKRQQAMPSTGMAEQ
SKRPRLEVGHQGVVFQHPGADAGVPLQQLMPTAQGGMPPTPQAAQLAGQRQSQQQYDPST
GPPVQNAASLHTPLPQLPGRLPPAGVPTAALSSALQFAQQPQVVEAQTQLQIPVKTQQPN
VPIPAPPSSQLPIPPSQPAQLALHVPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPR
PLPTSSTSSLAPVSGSGPGPSPARSSPVNRPSSATNKALSPVTSRTPGVVASAPTKPQSP
AQNATSSQDSSQDTLTEQITLENQVHQRIAELRKAGLWSQRRLPKLQEAPRPKSHWDYLL
EEMQWMATDFAQERRWKVAAAKKLVRTVVRHHEEKQLREERGKKEEQSRLRRIAASTARE
IECFWSNIEQVVEIKLRVELEEKRKKALNLQKVSRRGKELRPKGFDALQESSLDSGMSGR
KRKASISLTDDEVDDEEETIEEEEANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFLP
SSQWPRPKPDGEDTSGEEDADDCPGDRESRKDLVLIDSLFIMDQFKAAERMNIGKPNAKD
IADVTAVAEAILPKGSARVTTSVKFNAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILAD
EAGLGKTVQIIAFFAHLACNEGNWGPHLVVVRSCNILKWELELKRWCPGLKILSYIGSHR
ELKAKRQEWAEPNSFHVCITSYTQFFRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVF
TLQSQQRLLLIDSPLHNTFLELWTMVHFLVPGISRPYLSSPLRAPSEESQDYYHKVVIRL
HRVTQPFILRRTKRDVEKQLTKKYEHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVN
VLSILVRLQRICNHPGLVEPRHPGSSYVAGPLEYPSASLILKALERDFWKEADLSMFDLI
GLENKITRHEAELLSKKKIPRKLMEEISTSAAPAARPAAAKLKASRLFQPVQYGQKPEGR
TVAFPSTHPPRTAAPTTASAAPQGPLRGRPPIATFSANPEAKAAAAPFQTSQASASAPRH
QPASASSTAASPAHPAKLRAQTTAQASTPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQA
RLPSGEVVKIAQLASITGPQSRVAQPETPVTLQFQGSKFTLSHSQLRQLTAGQPLQLQGS
VLQIVSAPGQPYLRAPGPVVMQTVSQAGAVHGALGSKPPAGGPSPAPLTPQVGVPGRVAV
NALAVGEPGTASKPASPIGGPTQEEKTRLLKERLDQIYLVNERRCSQAPVYGRDLLRICA
LPSHGRVQWRGSLDGRRGKEAGPAHSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIP
PVVAAPPSLRVPRPPPLYSHRMRILRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFD
SGKLEALAILLQKLKSEGRRVLILSQMILMLDILEMFLNFHYLTYVRIDENASSEQRQEL
MRSFNRDRRIFCAILSTHSRTTGINLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDI
HIYRLVSGNSIEEKLLKNGTKDLIREVAAQGNDYSMAFLTQRTIQELFEVYSPMDDAGFP
VKAEEFVVLSQEPSVTETIAPKIARPFIEALKSIEYLEEDAQKSAQEGVLGPHTDALSSD
SENMPCDEEPSQLEELADFMEQLTPIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAW
EFWNLKTLQEREARLRLEQEEAELLTYTREDAYSMEYVYEDVDGQTEVMPLWTPPTPPQD
DSDIYLDSVMCLMYEATPIPEAKLPPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRS
LFDRATPGLLKIRREGKEQKKNILLKQQVPFAKPLPTFAKPTAEPGQDNPEWLISEDWAL
LQAVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGK
SKNNRPLRTSQIYAQDENATHTQLYTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHAS
VLAESGINYDKPLPPIQVASLRAERIAKEKKALADQQKAQQPAVAQPPPPQPQPPPPPQQ
PPPPLPQPQAAGSQPPAGPPAVQPQPQPQPQTQPQPVQAPAKAQPAITTGGSAAVLAGTI
KTSVTGTSMPTGAVSGNVIVNTIAGVPAATFQSINKRLASPVAPGALTTPGGSAPAQVVH
TQPPPRAVGSPATATPDLVSMATTQGVRAVTSVTASAVVTTNLTPVQTPARSLVPQVSQA
TGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQI
QGQAQSPAQIKAVGKLTPEHLIKMQKQKLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQ
QQSPQLTTVTAPRPGALLTGTTVANLQVARLTRVPTSQLQAQGQMQTQAPQPAQVALAKP
PVVSVPAAVVSSPGVTTLPMNVAGISVAIGQPQKAAGQTVVAQPVHMQQLLKLKQQAVQQ
QKAIQPQAAQGPAAVQQKITAQQITTPGAQQKVAYAAQPALKTQFLTTPISQAQKLAGAQ
QVQTQIQVAKLPQVVQQQTPVASIQQVASASQQASPQTVALTQATAAGQQVQMIPAVTAT
AQVVQQKLIQQQVVTTASAPLQTPGAPNPAQVPASSDSPSQQPKLQMRVPAVRLKTPTKP
PCQ

Sequence of entity 5 (I, J), FASTA

>8XVT_5 Actin-like protein 6A (chains I, J)
MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDK
GKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPV
LMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTAFANGRSTGLILDSGATHTTAI
PVHDGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELVPPYMIASKEAVREGSPANWKRK
EKLPQVTRSWHNYMCNCVIQDFQASVLQVSDSTYDEQVAAQMPTVHYEFPNGYNCDFGAE
RLKIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSF
TDRLNRELSQKTPPSMRLKLIANNTTVERRFSSWIGGSILASLGTFQQMWISKQEYEEGG
KQCVERKCP

Sequence of entity 6 (K), FASTA

>8XVT_6 Actin, cytoplasmic 1 (chains K)
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF

Sequence of entity 7 (M), FASTA

>8XVT_7 Isoform 2 of Enhancer of polycomb homolog 1 (chains M)
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAIS
AQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFKMPKQLIHIQPFSLDAEQPDYDLDSE
DEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIK
KRKNCRGPSLIPSVKQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRD
LSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLGDYNGEIMSEVMAQRQPMKPTYAIP
IIPITNSSQFKHQEAMDVKEFKVNKQDKADLIRPKRKYEKKPKVLPSSAAATPQQTSPAA
LPVFNAKDLNQYDFPSSDEEPLSQVLSGSSEAEEDNDPDGPFAFRRKAGCQYYAPHLDQT
GNWPWTSPKDGGLGDVRYRYCLTTLTVPQRCIGFARRRVGRGGRVLLDRAHSDYDSVFHH
LDLEMLSSPQHSPVNQFANTSETNTSDKSFSKDLSQILVNIKSCRWRHFRPRTPSLHDSD
NDELSCRKLYRSINRTGTAQPGTQTCSTSTQSKSSSGSAHFAFTAEQYQQHQQQLALMQK
QQLAQIQQQQANSNSSTNTSQGFVSKTLDSASAQFAASALVTSEQLMGFKMKDDVVLGIG
VNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSALLQPSNITQTSSSHSALSHQVTAAN
SATTQVLIGNNIRLTVPSSVATVNSIAPINARHIPRTLSAVPSSALKLAAAANCQVSKVP
SSSSVDSVPRENHESEKPALNNIADNTVAMEVT

Sequence of entity 8 (N), FASTA

>8XVT_8 Vacuolar protein sorting-associated protein 72 homolog (chains N)
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSD
FDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPL
ELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITE
ELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPA
PSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPAL
YRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQK
IVIK

Ligands and cofactors

ID	Name	Formula	Copies
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	9

Primary citation

Structure of the human TIP60 complex. Chen, K., Wang, L., Yu, Z. et al. Nat Commun (2024) 15:7092-7092. DOI 10.1038/s41467-024-51259-z · PubMed

Other PDB entries of the same protein (UniProt Q9Y265 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2C9O 2.2 Å, 3D Structure of the human RuvB-like helicase RuvBL1
8QR1 2.4 Å, Cryo-EM structure of the human Tip60 complex
9EMA 2.4 Å, RUVBL1/2 in complex with ATP and CB-6644 inhibitor
6K0R 2.5 Å, Ruvbl1-Ruvbl2 with truncated domain II in complex with phosphorylated Cordycepin
9C57 2.75 Å, Reconstituted P400 Subcomplex of the human TIP60 complex
2XSZ 3.0 Å, The dodecameric human RuvBL1:RuvBL2 complex with truncated domains II
9CAE 3.07 Å, Cryo-EM structure of the reconstituted RuvBL lobe of the human TIP60 complex (composite…
7ZI4 3.2 Å, Cryo-EM structure of the human INO80 complex bound to a WT nucleosome
8X15 3.2 Å, Structure of nucleosome-bound SRCAP-C in the apo state
8X19 3.2 Å, Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state
8X1C 3.2 Å, Structure of nucleosome-bound SRCAP-C in the ADP-bound state
9SN2 3.2 Å, Cryo-EM reconstruction of the RUVBL1-RUVBL2-CCDC103 (R2C) complex

Browse structure collections

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